ATRX_HUMAN - dbPTM
ATRX_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ATRX_HUMAN
UniProt AC P46100
Protein Name Transcriptional regulator ATRX
Gene Name ATRX
Organism Homo sapiens (Human).
Sequence Length 2492
Subcellular Localization Nucleus. Chromosome, telomere. Nucleus, PML body. Associated with pericentromeric heterochromatin during interphase and mitosis, probably by interacting with CBX5/HP1 alpha. Colocalizes with histone H3.3, DAXX, HIRA and ASF1A at PML-nuclear bodies. C
Protein Description Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomers. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomers nor to increase expression of telomeric RNA in fibroblasts. [PubMed: 24500201 May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as negative regulator of chromatin incorporation of transcriptionally repressive histone H2AFY, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes]
Protein Sequence MTAEPMSESKLNTLVQKLHDFLAHSSEESEETSSPPRLAMNQNTDKISGSGSNSDMMENSKEEGTSSSEKSKSSGSSRSKRKPSIVTKYVESDDEKPLDDETVNEDASNENSENDITMQSLPKGTVIVQPEPVLNEDKDDFKGPEFRSRSKMKTENLKKRGEDGLHGIVSCTACGQQVNHFQKDSIYRHPSLQVLICKNCFKYYMSDDISRDSDGMDEQCRWCAEGGNLICCDFCHNAFCKKCILRNLGRKELSTIMDENNQWYCYICHPEPLLDLVTACNSVFENLEQLLQQNKKKIKVDSEKSNKVYEHTSRFSPKKTSSNCNGEEKKLDDSCSGSVTYSYSALIVPKEMIKKAKKLIETTANMNSSYVKFLKQATDNSEISSATKLRQLKAFKSVLADIKKAHLALEEDLNSEFRAMDAVNKEKNTKEHKVIDAKFETKARKGEKPCALEKKDISKSEAKLSRKQVDSEHMHQNVPTEEQRTNKSTGGEHKKSDRKEEPQYEPANTSEDLDMDIVSVPSSVPEDIFENLETAMEVQSSVDHQGDGSSGTEQEVESSSVKLNISSKDNRGGIKSKTTAKVTKELYVKLTPVSLSNSPIKGADCQEVPQDKDGYKSCGLNPKLEKCGLGQENSDNEHLVENEVSLLLEESDLRRSPRVKTTPLRRPTETNPVTSNSDEECNETVKEKQKLSVPVRKKDKRNSSDSAIDNPKPNKLPKSKQSETVDQNSDSDEMLAILKEVSRMSHSSSSDTDINEIHTNHKTLYDLKTQAGKDDKGKRKRKSSTSGSDFDTKKGKSAKSSIISKKKRQTQSESSNYDSELEKEIKSMSKIGAARTTKKRIPNTKDFDSSEDEKHSKKGMDNQGHKNLKTSQEGSSDDAERKQERETFSSAEGTVDKDTTIMELRDRLPKKQQASASTDGVDKLSGKEQSFTSLEVRKVAETKEKSKHLKTKTCKKVQDGLSDIAEKFLKKDQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNTKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDKLRTETQNALKEEEERRKRIAEREREREKLREVIEIEDASPTKCPITTKLVLDEDEETKEPLVQVHRNMVIKLKPHQVDGVQFMWDCCCESVKKTKKSPGSGCILAHCMGLGKTLQVVSFLHTVLLCDKLDFSTALVVCPLNTALNWMNEFEKWQEGLKDDEKLEVSELATVKRPQERSYMLQRWQEDGGVMIIGYEMYRNLAQGRNVKSRKLKEIFNKALVDPGPDFVVCDEGHILKNEASAVSKAMNSIRSRRRIILTGTPLQNNLIEYHCMVNFIKENLLGSIKEFRNRFINPIQNGQCADSTMVDVRVMKKRAHILYEMLAGCVQRKDYTALTKFLPPKHEYVLAVRMTSIQCKLYQYYLDHLTGVGNNSEGGRGKAGAKLFQDFQMLSRIWTHPWCLQLDYISKENKGYFDEDSMDEFIASDSDETSMSLSSDDYTKKKKKGKKGKKDSSSSGSGSDNDVEVIKVWNSRSRGGGEGNVDETGNNPSVSLKLEESKATSSSNPSSPAPDWYKDFVTDADAEVLEHSGKMVLLFEILRMAEEIGDKVLVFSQSLISLDLIEDFLELASREKTEDKDKPLIYKGEGKWLRNIDYYRLDGSTTAQSRKKWAEEFNDETNVRGRLFIISTKAGSLGINLVAANRVIIFDASWNPSYDIQSIFRVYRFGQTKPVYVYRFLAQGTMEDKIYDRQVTKQSLSFRVVDQQQVERHFTMNELTELYTFEPDLLDDPNSEKKKKRDTPMLPKDTILAELLQIHKEHIVGYHEHDSLLDHKEEEELTEEERKAAWAEYEAEKKGLTMRFNIPTGTNLPPVSFNSQTPYIPFNLGALSAMSNQQLEDLINQGREKVVEATNSVTAVRIQPLEDIISAVWKENMNLSEAQVQALALSRQASQELDVKRREAIYNDVLTKQQMLISCVQRILMNRRLQQQYNQQQQQQMTYQQATLGHLMMPKPPNLIMNPSNYQQIDMRGMYQPVAGGMQPPPLQRAPPPMRSKNPGPSQGKSM
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
10SumoylationAEPMSESKLNTLVQK
CCCCCHHHHHHHHHH		41.5328112733
25PhosphorylationLHDFLAHSSEESEET
HHHHHHCCCCCCCCC		33.5623401153
26PhosphorylationHDFLAHSSEESEETS
HHHHHCCCCCCCCCC		35.2029255136
29PhosphorylationLAHSSEESEETSSPP
HHCCCCCCCCCCCCC		36.3629255136
29 (in isoform 4)Phosphorylation-36.36-
32PhosphorylationSSEESEETSSPPRLA
CCCCCCCCCCCCCCC		30.3829255136
33PhosphorylationSEESEETSSPPRLAM
CCCCCCCCCCCCCCC		44.0923401153
33 (in isoform 4)Phosphorylation-44.09-
34PhosphorylationEESEETSSPPRLAMN
CCCCCCCCCCCCCCC		46.4729255136
34 (in isoform 4)Phosphorylation-46.47-
44PhosphorylationRLAMNQNTDKISGSG
CCCCCCCCCCCCCCC		28.9824850871
48PhosphorylationNQNTDKISGSGSNSD
CCCCCCCCCCCCCCH		32.4223663014
50PhosphorylationNTDKISGSGSNSDMM
CCCCCCCCCCCCHHH		32.0529255136
52PhosphorylationDKISGSGSNSDMMEN
CCCCCCCCCCHHHHC		34.5529255136
54PhosphorylationISGSGSNSDMMENSK
CCCCCCCCHHHHCCC		28.6929255136
60PhosphorylationNSDMMENSKEEGTSS
CCHHHHCCCCCCCCC		28.3023927012
65PhosphorylationENSKEEGTSSSEKSK
HCCCCCCCCCCHHHC		28.8123927012
65 (in isoform 4)Phosphorylation-28.81-
66PhosphorylationNSKEEGTSSSEKSKS
CCCCCCCCCCHHHCC		42.6023927012
67PhosphorylationSKEEGTSSSEKSKSS
CCCCCCCCCHHHCCC		42.2123403867
68PhosphorylationKEEGTSSSEKSKSSG
CCCCCCCCHHHCCCC		49.1323403867
71PhosphorylationGTSSSEKSKSSGSSR
CCCCCHHHCCCCCCC		33.4520068231
71 (in isoform 4)Phosphorylation-33.45-
73PhosphorylationSSSEKSKSSGSSRSK
CCCHHHCCCCCCCCC		47.2020068231
74PhosphorylationSSEKSKSSGSSRSKR
CCHHHCCCCCCCCCC		46.5620068231
74 (in isoform 3)Phosphorylation-46.5621406692
74 (in isoform 4)Phosphorylation-46.56-
76PhosphorylationEKSKSSGSSRSKRKP
HHHCCCCCCCCCCCC		25.2420068231
77PhosphorylationKSKSSGSSRSKRKPS
HHCCCCCCCCCCCCC		44.0620068231
84PhosphorylationSRSKRKPSIVTKYVE
CCCCCCCCEEEEEEC		32.5025159151
84 (in isoform 4)Phosphorylation-32.50-
87PhosphorylationKRKPSIVTKYVESDD
CCCCCEEEEEECCCC		18.2621955146
87 (in isoform 4)Phosphorylation-18.26-
89PhosphorylationKPSIVTKYVESDDEK
CCCEEEEEECCCCCC		10.4930278072
89 (in isoform 4)Phosphorylation-10.4922210691
92PhosphorylationIVTKYVESDDEKPLD
EEEEEECCCCCCCCC		40.0725159151
92 (in isoform 4)Phosphorylation-40.0722210691
102PhosphorylationEKPLDDETVNEDASN
CCCCCCCCCCCCCCC		35.3130278072
102 (in isoform 4)Phosphorylation-35.3122210691
108PhosphorylationETVNEDASNENSEND
CCCCCCCCCCCCCCC		57.9325159151
108 (in isoform 4)Phosphorylation-57.9322210691
112PhosphorylationEDASNENSENDITMQ
CCCCCCCCCCCCEEE		31.4330278072
112 (in isoform 2)Phosphorylation-31.43-
112 (in isoform 4)Phosphorylation-31.4322210691
112 (in isoform 6)Phosphorylation-31.4325159151
117PhosphorylationENSENDITMQSLPKG
CCCCCCCEEEECCCC		16.4223927012
117 (in isoform 4)Phosphorylation-16.4222210691
120PhosphorylationENDITMQSLPKGTVI
CCCCEEEECCCCEEE		35.5023927012
138SumoylationEPVLNEDKDDFKGPE
CCCCCCCCCCCCCHH		53.6828112733
138UbiquitinationEPVLNEDKDDFKGPE
CCCCCCCCCCCCCHH		53.68-
142SumoylationNEDKDDFKGPEFRSR
CCCCCCCCCHHHHCH		79.24-
142SumoylationNEDKDDFKGPEFRSR
CCCCCCCCCHHHHCH		79.2428112733
142UbiquitinationNEDKDDFKGPEFRSR
CCCCCCCCCHHHHCH		79.24-
150PhosphorylationGPEFRSRSKMKTENL
CHHHHCHHHHCHHHH		38.0530622161
153SumoylationFRSRSKMKTENLKKR
HHCHHHHCHHHHHHH		57.32-
153SumoylationFRSRSKMKTENLKKR
HHCHHHHCHHHHHHH		57.32-
154PhosphorylationRSRSKMKTENLKKRG
HCHHHHCHHHHHHHC		26.9730622161
163 (in isoform 6)Ubiquitination-68.7121890473
164 (in isoform 4)Ubiquitination-18.4421890473
164 (in isoform 5)Ubiquitination-18.4421890473
191PhosphorylationDSIYRHPSLQVLICK
CCCCCCCCCEEEEEC		25.8821406692
202UbiquitinationLICKNCFKYYMSDDI
EEECCCHHHHCCCCC		37.36-
202 (in isoform 1)Ubiquitination-37.3621890473
203PhosphorylationICKNCFKYYMSDDIS
EECCCHHHHCCCCCC		5.5526552605
204PhosphorylationCKNCFKYYMSDDISR
ECCCHHHHCCCCCCC		7.2526552605
206PhosphorylationNCFKYYMSDDISRDS
CCHHHHCCCCCCCCC		18.9330108239
210PhosphorylationYYMSDDISRDSDGMD
HHCCCCCCCCCCCCH		36.7123401153
213PhosphorylationSDDISRDSDGMDEQC
CCCCCCCCCCCHHHH		34.6522617229
241AcetylationFCHNAFCKKCILRNL
CCCCHHHHHHHHHHC		44.2026051181
254PhosphorylationNLGRKELSTIMDENN
HCCCHHHHHHCCCCC		19.5826074081
255PhosphorylationLGRKELSTIMDENNQ
CCCHHHHHHCCCCCC		32.7126074081
264PhosphorylationMDENNQWYCYICHPE
CCCCCCEEEEEECCH		2.5726074081
266PhosphorylationENNQWYCYICHPEPL
CCCCEEEEEECCHHH		7.2926074081
278 (in isoform 4)Phosphorylation-32.56-
299SumoylationQQNKKKIKVDSEKSN
HHCCCCCCCCHHHHH		49.20-
299SumoylationQQNKKKIKVDSEKSN
HHCCCCCCCCHHHHH		49.2025218447
302PhosphorylationKKKIKVDSEKSNKVY
CCCCCCCHHHHHHHH		50.3329396449
307UbiquitinationVDSEKSNKVYEHTSR
CCHHHHHHHHHCCCC		53.97-
309PhosphorylationSEKSNKVYEHTSRFS
HHHHHHHHHCCCCCC		12.0023927012
312PhosphorylationSNKVYEHTSRFSPKK
HHHHHHCCCCCCCCC		15.0623401153
313PhosphorylationNKVYEHTSRFSPKKT
HHHHHCCCCCCCCCC		32.9823401153
316PhosphorylationYEHTSRFSPKKTSSN
HHCCCCCCCCCCCCC		34.4022167270
329AcetylationSNCNGEEKKLDDSCS
CCCCCCCCCCCCCCC		55.1019811649
334PhosphorylationEEKKLDDSCSGSVTY
CCCCCCCCCCCCEEE		15.1729214152
336PhosphorylationKKLDDSCSGSVTYSY
CCCCCCCCCCEEEEE		37.7529214152
338PhosphorylationLDDSCSGSVTYSYSA
CCCCCCCCEEEEEEE		8.5921712546
340PhosphorylationDSCSGSVTYSYSALI
CCCCCCEEEEEEEEE		14.4027080861
341PhosphorylationSCSGSVTYSYSALIV
CCCCCEEEEEEEEEC		11.9430576142
343PhosphorylationSGSVTYSYSALIVPK
CCCEEEEEEEEECCH		6.3730576142
362PhosphorylationKAKKLIETTANMNSS
HHHHHHHHHHCCCHH		24.9826074081
362 (in isoform 2)Phosphorylation-24.98-
363PhosphorylationAKKLIETTANMNSSY
HHHHHHHHHCCCHHH		11.8426074081
368PhosphorylationETTANMNSSYVKFLK
HHHHCCCHHHHHHHH		16.5726074081
369PhosphorylationTTANMNSSYVKFLKQ
HHHCCCHHHHHHHHH		29.0126074081
370PhosphorylationTANMNSSYVKFLKQA
HHCCCHHHHHHHHHC		13.8926074081
372UbiquitinationNMNSSYVKFLKQATD
CCCHHHHHHHHHCCC		36.42-
375AcetylationSSYVKFLKQATDNSE
HHHHHHHHHCCCCCC		40.8126051181
375MethylationSSYVKFLKQATDNSE
HHHHHHHHHCCCCCC		40.81-
375UbiquitinationSSYVKFLKQATDNSE
HHHHHHHHHCCCCCC		40.81-
378PhosphorylationVKFLKQATDNSEISS
HHHHHHCCCCCCCCH		32.9722210691
381PhosphorylationLKQATDNSEISSATK
HHHCCCCCCCCHHHH		38.8322210691
384PhosphorylationATDNSEISSATKLRQ
CCCCCCCCHHHHHHH		15.1829396449
385PhosphorylationTDNSEISSATKLRQL
CCCCCCCHHHHHHHH		45.6921815630
387PhosphorylationNSEISSATKLRQLKA
CCCCCHHHHHHHHHH		32.3420068231
387 (in isoform 2)Phosphorylation-32.34-
388UbiquitinationSEISSATKLRQLKAF
CCCCHHHHHHHHHHH		41.19-
390 (in isoform 2)Phosphorylation-41.14-
392 (in isoform 2)Phosphorylation-3.32-
394 (in isoform 2)Phosphorylation-26.20-
403UbiquitinationKSVLADIKKAHLALE
HHHHHHHHHHHHHHH		44.44-
430 (in isoform 2)Phosphorylation-68.18-
438SumoylationEHKVIDAKFETKARK
CCCEECHHHHHHCCC		39.73-
438SumoylationEHKVIDAKFETKARK
CCCEECHHHHHHCCC		39.7328112733
438UbiquitinationEHKVIDAKFETKARK
CCCEECHHHHHHCCC		39.73-
458PhosphorylationALEKKDISKSEAKLS
CCCCCCCCHHHHHHH		40.02-
458 (in isoform 2)Phosphorylation-40.02-
460PhosphorylationEKKDISKSEAKLSRK
CCCCCCHHHHHHHHH		35.68-
465PhosphorylationSKSEAKLSRKQVDSE
CHHHHHHHHHHCCHH		36.40-
470 (in isoform 2)Phosphorylation-45.90-
471PhosphorylationLSRKQVDSEHMHQNV
HHHHHCCHHHHHCCC		30.4618669648
471 (in isoform 2)Phosphorylation-30.46-
473 (in isoform 2)Phosphorylation-23.99-
477 (in isoform 3)Phosphorylation-27.3621406692
479 (in isoform 3)Phosphorylation-41.4621406692
480PhosphorylationHMHQNVPTEEQRTNK
HHHCCCCCHHHHCCC		48.1217081983
480 (in isoform 2)Phosphorylation-48.12-
481 (in isoform 3)Phosphorylation-46.1721406692
488PhosphorylationEEQRTNKSTGGEHKK
HHHHCCCCCCCCCCC		34.0622985185
499 (in isoform 2)Phosphorylation-72.00-
502 (in isoform 2)Phosphorylation-43.05-
525 (in isoform 2)Phosphorylation-35.18-
527 (in isoform 2)Phosphorylation-44.82-
528 (in isoform 4)Phosphorylation-4.44-
534PhosphorylationDIFENLETAMEVQSS
HHHHCHHHHHHHHHH		34.1722468782
541PhosphorylationTAMEVQSSVDHQGDG
HHHHHHHHCCCCCCC		17.9317081983
541 (in isoform 2)Phosphorylation-17.93-
549PhosphorylationVDHQGDGSSGTEQEV
CCCCCCCCCCCCEEE		30.2722468782
550PhosphorylationDHQGDGSSGTEQEVE
CCCCCCCCCCCEEEE		56.0922468782
551 (in isoform 3)Phosphorylation-34.6621406692
552PhosphorylationQGDGSSGTEQEVESS
CCCCCCCCCEEEECC		36.1222468782
553 (in isoform 3)Phosphorylation-48.5521406692
553 (in isoform 4)Phosphorylation-48.55-
555 (in isoform 2)Phosphorylation-41.86-
556 (in isoform 4)Phosphorylation-9.63-
557 (in isoform 3)Phosphorylation-44.1221406692
558PhosphorylationGTEQEVESSSVKLNI
CCCEEEECCEEEEEE		32.8419664995
558 (in isoform 3)Phosphorylation-32.8421406692
558 (in isoform 4)Phosphorylation-32.84-
560PhosphorylationEQEVESSSVKLNISS
CEEEECCEEEEEECC		32.3319664995
560 (in isoform 3)Phosphorylation-32.3321406692
560 (in isoform 4)Phosphorylation-32.33-
566PhosphorylationSSVKLNISSKDNRGG
CEEEEEECCCCCCCC		30.2024732914
567PhosphorylationSVKLNISSKDNRGGI
EEEEEECCCCCCCCC		39.9924732914
567 (in isoform 3)Phosphorylation-39.9921406692
568AcetylationVKLNISSKDNRGGIK
EEEEECCCCCCCCCC		52.8325953088
568UbiquitinationVKLNISSKDNRGGIK
EEEEECCCCCCCCCC		52.83-
575AcetylationKDNRGGIKSKTTAKV
CCCCCCCCCCCCCCC		49.537661801
577AcetylationNRGGIKSKTTAKVTK
CCCCCCCCCCCCCCC		44.917661809
581AcetylationIKSKTTAKVTKELYV
CCCCCCCCCCCHHEE		48.637661817
584UbiquitinationKTTAKVTKELYVKLT
CCCCCCCCHHEEEEC		49.02-
586 (in isoform 3)Phosphorylation-6.7621406692
587PhosphorylationAKVTKELYVKLTPVS
CCCCCHHEEEECCCC		9.1622199227
589UbiquitinationVTKELYVKLTPVSLS
CCCHHEEEECCCCCC		32.84-
589 (in isoform 3)Phosphorylation-32.8421406692
591PhosphorylationKELYVKLTPVSLSNS
CHHEEEECCCCCCCC		18.8729255136
594O-linked_GlycosylationYVKLTPVSLSNSPIK
EEEECCCCCCCCCCC		27.5523301498
594PhosphorylationYVKLTPVSLSNSPIK
EEEECCCCCCCCCCC		27.5529255136
596PhosphorylationKLTPVSLSNSPIKGA
EECCCCCCCCCCCCC		27.9629255136
596 (in isoform 4)Phosphorylation-27.96-
598PhosphorylationTPVSLSNSPIKGADC
CCCCCCCCCCCCCCC		25.3219664994
601AcetylationSLSNSPIKGADCQEV
CCCCCCCCCCCCCCC		51.97-
601UbiquitinationSLSNSPIKGADCQEV
CCCCCCCCCCCCCCC		51.97-
601 (in isoform 2)Acetylation-51.97-
602 (in isoform 2)Acetylation-27.63-
612 (in isoform 3)Phosphorylation-48.0521406692
614 (in isoform 3)Phosphorylation-37.1921406692
615PhosphorylationVPQDKDGYKSCGLNP
CCCCCCCHHCCCCCC		15.1724732914
616UbiquitinationPQDKDGYKSCGLNPK
CCCCCCHHCCCCCCC		44.81-
617PhosphorylationQDKDGYKSCGLNPKL
CCCCCHHCCCCCCCH		12.6326074081
623SumoylationKSCGLNPKLEKCGLG
HCCCCCCCHHHCCCC		69.11-
623AcetylationKSCGLNPKLEKCGLG
HCCCCCCCHHHCCCC		69.1123749302
623SumoylationKSCGLNPKLEKCGLG
HCCCCCCCHHHCCCC		69.1125114211
623UbiquitinationKSCGLNPKLEKCGLG
HCCCCCCCHHHCCCC		69.11-
624 (in isoform 4)Phosphorylation-8.85-
634PhosphorylationCGLGQENSDNEHLVE
CCCCCCCCCCHHHHH		40.8530278072
636 (in isoform 4)Phosphorylation-38.11-
637 (in isoform 4)Phosphorylation-43.52-
639 (in isoform 4)Phosphorylation-4.16-
645PhosphorylationHLVENEVSLLLEESD
HHHHHHHHHHHHHHH		13.7123663014
645 (in isoform 2)Phosphorylation-13.71-
646 (in isoform 2)Phosphorylation-8.37-
646 (in isoform 4)Phosphorylation-8.37-
651PhosphorylationVSLLLEESDLRRSPR
HHHHHHHHHHCCCCC		32.3522199227
656PhosphorylationEESDLRRSPRVKTTP
HHHHHCCCCCCCCCC		15.6025159151
660UbiquitinationLRRSPRVKTTPLRRP
HCCCCCCCCCCCCCC		48.22-
661PhosphorylationRRSPRVKTTPLRRPT
CCCCCCCCCCCCCCC		30.6827273156
662PhosphorylationRSPRVKTTPLRRPTE
CCCCCCCCCCCCCCC		18.0127273156
665 (in isoform 4)Phosphorylation-43.68-
666 (in isoform 2)Phosphorylation-50.61-
667 (in isoform 2)Phosphorylation-28.31-
668PhosphorylationTTPLRRPTETNPVTS
CCCCCCCCCCCCCCC		54.3422167270
668 (in isoform 4)Phosphorylation-54.34-
670PhosphorylationPLRRPTETNPVTSNS
CCCCCCCCCCCCCCC		47.5022167270
671 (in isoform 2)Phosphorylation-23.86-
672 (in isoform 2)Phosphorylation-37.88-
674PhosphorylationPTETNPVTSNSDEEC
CCCCCCCCCCCHHHH		24.3722167270
675PhosphorylationTETNPVTSNSDEECN
CCCCCCCCCCHHHHH		34.2722167270
677PhosphorylationTNPVTSNSDEECNET
CCCCCCCCHHHHHHH		46.2829255136
683 (in isoform 2)Phosphorylation-67.64-
684PhosphorylationSDEECNETVKEKQKL
CHHHHHHHHHHHHHC		23.9222167270
685 (in isoform 2)Phosphorylation-6.51-
686 (in isoform 2)Phosphorylation-67.62-
690UbiquitinationETVKEKQKLSVPVRK
HHHHHHHHCCCCCCC		54.52-
691 (in isoform 4)Phosphorylation-6.05-
692PhosphorylationVKEKQKLSVPVRKKD
HHHHHHCCCCCCCCC		31.2625159151
693 (in isoform 4)Phosphorylation-8.02-
695 (in isoform 3)Phosphorylation-15.2521406692
697 (in isoform 3)Phosphorylation-66.6121406692
698 (in isoform 3)Phosphorylation-58.9021406692
702 (in isoform 3)Phosphorylation-52.1621406692
703PhosphorylationRKKDKRNSSDSAIDN
CCCCCCCCCCCCCCC		39.2829255136
704PhosphorylationKKDKRNSSDSAIDNP
CCCCCCCCCCCCCCC		38.8523401153
706PhosphorylationDKRNSSDSAIDNPKP
CCCCCCCCCCCCCCC		29.1323927012
707 (in isoform 4)Phosphorylation-20.39-
715UbiquitinationIDNPKPNKLPKSKQS
CCCCCCCCCCCCCCC		74.76-
719PhosphorylationKPNKLPKSKQSETVD
CCCCCCCCCCCCCCC		33.7123403867
721 (in isoform 4)Phosphorylation-54.30-
722PhosphorylationKLPKSKQSETVDQNS
CCCCCCCCCCCCCCC		38.6822167270
724PhosphorylationPKSKQSETVDQNSDS
CCCCCCCCCCCCCCH		34.3322167270
729PhosphorylationSETVDQNSDSDEMLA
CCCCCCCCCHHHHHH		32.6222167270
731PhosphorylationTVDQNSDSDEMLAIL
CCCCCCCHHHHHHHH		34.9822167270
732 (in isoform 3)Phosphorylation-50.7621406692
733 (in isoform 3)Phosphorylation-39.7921406692
745PhosphorylationLKEVSRMSHSSSSDT
HHHHHHCCCCCCCCC		21.0723927012
747PhosphorylationEVSRMSHSSSSDTDI
HHHHCCCCCCCCCCH		25.3023927012
748PhosphorylationVSRMSHSSSSDTDIN
HHHCCCCCCCCCCHH		28.5625159151
749PhosphorylationSRMSHSSSSDTDINE
HHCCCCCCCCCCHHH		34.9425159151
750PhosphorylationRMSHSSSSDTDINEI
HCCCCCCCCCCHHHH		46.6125159151
752PhosphorylationSHSSSSDTDINEIHT
CCCCCCCCCHHHHHC		40.5025159151
758 (in isoform 3)Phosphorylation-17.9021406692
759PhosphorylationTDINEIHTNHKTLYD
CCHHHHHCCCCCHHH		44.6823403867
759 (in isoform 3)Phosphorylation-44.6821406692
763 (in isoform 2)Acetylation-24.01-
763 (in isoform 2)Ubiquitination-24.0121890473
767AcetylationNHKTLYDLKTQAGKD
CCCCHHHHHHCCCCC		4.0119608861
767 (in isoform 4)Acetylation-4.01-
768AcetylationHKTLYDLKTQAGKDD
CCCHHHHHHCCCCCC		35.3819608861
768UbiquitinationHKTLYDLKTQAGKDD
CCCHHHHHHCCCCCC		35.38-
768 (in isoform 4)Acetylation-35.38-
770 (in isoform 2)Phosphorylation-46.67-
770 (in isoform 3)Phosphorylation-46.6721406692
772 (in isoform 3)Phosphorylation-24.9021406692
773 (in isoform 2)Phosphorylation-66.81-
773 (in isoform 3)Phosphorylation-66.8121406692
774 (in isoform 2)Phosphorylation-63.03-
783PhosphorylationKGKRKRKSSTSGSDF
CCCCCCCCCCCCCCC		42.7729255136
784PhosphorylationGKRKRKSSTSGSDFD
CCCCCCCCCCCCCCC		29.6329255136
785PhosphorylationKRKRKSSTSGSDFDT
CCCCCCCCCCCCCCC		44.1729255136
786PhosphorylationRKRKSSTSGSDFDTK
CCCCCCCCCCCCCCC		37.9425159151
788PhosphorylationRKSSTSGSDFDTKKG
CCCCCCCCCCCCCCC		34.5725159151
792PhosphorylationTSGSDFDTKKGKSAK
CCCCCCCCCCCCCHH		34.3523663014
797PhosphorylationFDTKKGKSAKSSIIS
CCCCCCCCHHHHHHC		49.9926425664
799UbiquitinationTKKGKSAKSSIISKK
CCCCCCHHHHHHCHH		52.40-
800PhosphorylationKKGKSAKSSIISKKK
CCCCCHHHHHHCHHH		26.8722210691
801PhosphorylationKGKSAKSSIISKKKR
CCCCHHHHHHCHHHC		24.2026425664
805AcetylationAKSSIISKKKRQTQS
HHHHHHCHHHCCCCC		52.4819608861
806AcetylationKSSIISKKKRQTQSE
HHHHHCHHHCCCCCC		46.5319608861
807 (in isoform 2)Phosphorylation-54.17-
808 (in isoform 2)Phosphorylation-54.37-
809 (in isoform 2)Phosphorylation-53.42-
810PhosphorylationISKKKRQTQSESSNY
HCHHHCCCCCCCCCC		37.7923927012
811 (in isoform 4)Phosphorylation-36.54-
812PhosphorylationKKKRQTQSESSNYDS
HHHCCCCCCCCCCHH		42.7225159151
812 (in isoform 4)Phosphorylation-42.72-
814PhosphorylationKRQTQSESSNYDSEL
HCCCCCCCCCCHHHH		29.1823927012
815PhosphorylationRQTQSESSNYDSELE
CCCCCCCCCCHHHHH		35.0423927012
817PhosphorylationTQSESSNYDSELEKE
CCCCCCCCHHHHHHH		23.8523927012
819PhosphorylationSESSNYDSELEKEIK
CCCCCCHHHHHHHHH		33.4525159151
832 (in isoform 4)Phosphorylation-19.54-
833 (in isoform 4)Phosphorylation-9.39-
836PhosphorylationSKIGAARTTKKRIPN
HHHCCCCCCCCCCCC		37.9423312004
837PhosphorylationKIGAARTTKKRIPNT
HHCCCCCCCCCCCCC		29.0823312004
837 (in isoform 4)Phosphorylation-29.08-
838 (in isoform 4)Phosphorylation-39.17-
844PhosphorylationTKKRIPNTKDFDSSE
CCCCCCCCCCCCCCH		27.0025219547
849PhosphorylationPNTKDFDSSEDEKHS
CCCCCCCCCHHHHHH		35.3022167270
849 (in isoform 4)Phosphorylation-35.30-
850PhosphorylationNTKDFDSSEDEKHSK
CCCCCCCCHHHHHHH		51.4129255136
851 (in isoform 4)Phosphorylation-74.31-
852 (in isoform 4)Phosphorylation-72.67-
856PhosphorylationSSEDEKHSKKGMDNQ
CCHHHHHHHCCCCCH		47.3222167270
857 (in isoform 2)Phosphorylation-53.73-
858AcetylationEDEKHSKKGMDNQGH
HHHHHHHCCCCCHHH		63.5826051181
859 (in isoform 2)Phosphorylation-32.20-
870PhosphorylationQGHKNLKTSQEGSSD
HHHHCCCCCCCCCCC		38.5228176443
871PhosphorylationGHKNLKTSQEGSSDD
HHHCCCCCCCCCCCH		25.3317525332
875PhosphorylationLKTSQEGSSDDAERK
CCCCCCCCCCHHHHH		29.8226055452
876PhosphorylationKTSQEGSSDDAERKQ
CCCCCCCCCHHHHHH		50.8226055452
887PhosphorylationERKQERETFSSAEGT
HHHHHHHHHHCCCCC		34.7329255136
889PhosphorylationKQERETFSSAEGTVD
HHHHHHHHCCCCCCC		35.7429255136
890PhosphorylationQERETFSSAEGTVDK
HHHHHHHCCCCCCCC		26.5829255136
894PhosphorylationTFSSAEGTVDKDTTI
HHHCCCCCCCCCCCH		19.6223927012
894 (in isoform 3)Phosphorylation-19.6221406692
895 (in isoform 3)Phosphorylation-14.6721406692
896 (in isoform 3)Phosphorylation-42.8421406692
897UbiquitinationSAEGTVDKDTTIMEL
CCCCCCCCCCCHHHH		53.27-
899PhosphorylationEGTVDKDTTIMELRD
CCCCCCCCCHHHHHH		24.7823403867
899 (in isoform 6)Ubiquitination-24.7821890473
900PhosphorylationGTVDKDTTIMELRDR
CCCCCCCCHHHHHHH		28.5823403867
911SumoylationLRDRLPKKQQASAST
HHHHCCHHHHCCCCC		45.78-
911SumoylationLRDRLPKKQQASAST
HHHHCCHHHHCCCCC		45.78-
915PhosphorylationLPKKQQASASTDGVD
CCHHHHCCCCCCCHH		20.5829449344
917PhosphorylationKKQQASASTDGVDKL
HHHHCCCCCCCHHHC		25.2421815630
918PhosphorylationKQQASASTDGVDKLS
HHHCCCCCCCHHHCC		36.1724275569
923UbiquitinationASTDGVDKLSGKEQS
CCCCCHHHCCCCCCC		41.99-
925PhosphorylationTDGVDKLSGKEQSFT
CCCHHHCCCCCCCCC		54.2625850435
929AcetylationDKLSGKEQSFTSLEV
HHCCCCCCCCCHHHH		47.5319608861
929UbiquitinationDKLSGKEQSFTSLEV
HHCCCCCCCCCHHHH		47.5319608861
929 (in isoform 4)Acetylation-47.53-
929 (in isoform 4)Ubiquitination-47.5321890473
929 (in isoform 5)Ubiquitination-47.5321890473
930PhosphorylationKLSGKEQSFTSLEVR
HCCCCCCCCCHHHHH		31.4230576142
932PhosphorylationSGKEQSFTSLEVRKV
CCCCCCCCHHHHHHH		37.3327732954
933PhosphorylationGKEQSFTSLEVRKVA
CCCCCCCHHHHHHHH		22.1127732954
936 (in isoform 4)Phosphorylation-9.71-
937 (in isoform 2)Phosphorylation-20.53-
939 (in isoform 4)Phosphorylation-4.00-
940 (in isoform 4)Phosphorylation-23.06-
944 (in isoform 3)Phosphorylation-70.7221406692
956UbiquitinationLKTKTCKKVQDGLSD
CCCCHHHHHHHHHHH		47.47-
962PhosphorylationKKVQDGLSDIAEKFL
HHHHHHHHHHHHHHH		32.2829255136
967AcetylationGLSDIAEKFLKKDQS
HHHHHHHHHHHHCCC		47.1519608861
967UbiquitinationGLSDIAEKFLKKDQS
HHHHHHHHHHHHCCC		47.1519608861
967 (in isoform 1)Ubiquitination-47.1521890473
971AcetylationIAEKFLKKDQSDETS
HHHHHHHHCCCCCCC		64.2530583585
973 (in isoform 4)Phosphorylation-62.76-
974PhosphorylationKFLKKDQSDETSEDD
HHHHHCCCCCCCHHH		47.7728176443
974 (in isoform 4)Phosphorylation-47.77-
975 (in isoform 4)Phosphorylation-58.52-
977PhosphorylationKKDQSDETSEDDKKQ
HHCCCCCCCHHHHHH		42.2728176443
978PhosphorylationKDQSDETSEDDKKQS
HCCCCCCCHHHHHHH		36.6628176443
989PhosphorylationKKQSKKGTEEKKKPS
HHHHHHCCCCCCCCC		50.2622468782
9992-HydroxyisobutyrylationKKKPSDFKKKVIKME
CCCCCHHHHHHHHHH		57.59-
1004SumoylationDFKKKVIKMEQQYES
HHHHHHHHHHHHHHC		39.10-
1004SumoylationDFKKKVIKMEQQYES
HHHHHHHHHHHHHHC		39.1028112733
1009PhosphorylationVIKMEQQYESSSDGT
HHHHHHHHHCCCCCC		19.9223898821
1011PhosphorylationKMEQQYESSSDGTEK
HHHHHHHCCCCCCCC		30.1522617229
1012PhosphorylationMEQQYESSSDGTEKL
HHHHHHCCCCCCCCC		22.1025159151
1013PhosphorylationEQQYESSSDGTEKLP
HHHHHCCCCCCCCCC		49.7122617229
1016PhosphorylationYESSSDGTEKLPERE
HHCCCCCCCCCCCHH		34.6323663014
1023 (in isoform 4)Phosphorylation-50.48-
1025 (in isoform 4)Phosphorylation-1.57-
1033 (in isoform 2)Phosphorylation-55.42-
1039PhosphorylationIKQIKNGTTDGEKKS
CHHCCCCCCCCCHHH		30.9829083192
1040PhosphorylationKQIKNGTTDGEKKSK
HHCCCCCCCCCHHHH		43.3229083192
1040 (in isoform 2)Phosphorylation-43.32-
1041 (in isoform 2)Phosphorylation-64.19-
1049 (in isoform 2)Phosphorylation-8.71-
1061PhosphorylationSKKKDELSDYAEKST
HCCHHHHHHHHHHHC		26.9129255136
1063PhosphorylationKKDELSDYAEKSTGK
CHHHHHHHHHHHCCC		17.1823927012
1066UbiquitinationELSDYAEKSTGKGDS
HHHHHHHHHCCCCCC		45.18-
1067PhosphorylationLSDYAEKSTGKGDSC
HHHHHHHHCCCCCCC		33.6224275569
1068PhosphorylationSDYAEKSTGKGDSCD
HHHHHHHCCCCCCCC		54.7229632367
1073PhosphorylationKSTGKGDSCDSSEDK
HHCCCCCCCCCCCCC		28.6129632367
1076PhosphorylationGKGDSCDSSEDKKSK
CCCCCCCCCCCCCCC		39.7029632367
1077PhosphorylationKGDSCDSSEDKKSKN
CCCCCCCCCCCCCCC		36.2429632367
1099AcetylationKRCKLLGKSSRKRQD
HHHHHCCCCCCCCCC		45.2725953088
1103 (in isoform 4)Phosphorylation-57.25-
1108PhosphorylationSRKRQDCSSSDTEKY
CCCCCCCCCCHHHHH		40.9630177828
1109PhosphorylationRKRQDCSSSDTEKYS
CCCCCCCCCHHHHHC		38.2728985074
1110PhosphorylationKRQDCSSSDTEKYSM
CCCCCCCCHHHHHCC		32.0525849741
1112PhosphorylationQDCSSSDTEKYSMKE
CCCCCCHHHHHCCCC		36.0030177828
1115PhosphorylationSSSDTEKYSMKEDGC
CCCHHHHHCCCCCCC		14.0426074081
1116PhosphorylationSSDTEKYSMKEDGCN
CCHHHHHCCCCCCCC		34.1526074081
1118 (in isoform 2)Phosphorylation-46.87-
1120 (in isoform 2)Phosphorylation-62.52-
1122 (in isoform 2)Phosphorylation-7.45-
1124PhosphorylationMKEDGCNSSDKRLKR
CCCCCCCCHHHHHHH		43.9526074081
1124 (in isoform 2)Phosphorylation-43.95-
1125PhosphorylationKEDGCNSSDKRLKRI
CCCCCCCHHHHHHHH		32.9126074081
1141PhosphorylationLRERRNLSSKRNTKE
HHHHHCCCCCCCCCC		37.0420166139
1142PhosphorylationRERRNLSSKRNTKEI
HHHHCCCCCCCCCCC		38.51-
1142 (in isoform 2)Phosphorylation-38.51-
1144 (in isoform 2)Phosphorylation-58.98-
1148 (in isoform 2)Phosphorylation-44.19-
1151PhosphorylationRNTKEIQSGSSSSDA
CCCCCCCCCCCCCCC		46.4325072903
1153PhosphorylationTKEIQSGSSSSDAEE
CCCCCCCCCCCCCHH		32.0925072903
1154PhosphorylationKEIQSGSSSSDAEES
CCCCCCCCCCCCHHC		37.0725072903
1155PhosphorylationEIQSGSSSSDAEESS
CCCCCCCCCCCHHCC		33.6530576142
1156PhosphorylationIQSGSSSSDAEESSE
CCCCCCCCCCHHCCH		42.6730576142
1161PhosphorylationSSSDAEESSEDNKKK
CCCCCHHCCHHHHHH		30.4525072903
1162PhosphorylationSSDAEESSEDNKKKK
CCCCHHCCHHHHHHH		52.8525072903
1188PhosphorylationVKEKKRNSLRTSTKR
EEHHHHHCCCCCCCC		24.2227282143
1199 (in isoform 4)Phosphorylation-42.05-
1204PhosphorylationQADITSSSSSDIEDD
HCCCCCCCCCCCCCC		33.3628985074
1205PhosphorylationADITSSSSSDIEDDD
CCCCCCCCCCCCCCC		33.7028348404
1205 (in isoform 3)Phosphorylation-33.7021406692
1206PhosphorylationDITSSSSSDIEDDDQ
CCCCCCCCCCCCCCC		44.5520068231
1206 (in isoform 4)Phosphorylation-44.55-
1207 (in isoform 3)Phosphorylation-50.6921406692
1207 (in isoform 4)Phosphorylation-50.69-
1209 (in isoform 3)Phosphorylation-61.4521406692
1215PhosphorylationIEDDDQNSIGEGSSD
CCCCCCCCCCCCCCC		26.7418669648
1215 (in isoform 4)Phosphorylation-26.74-
1230PhosphorylationEQKIKPVTENLVLSS
HHHCCCCCCCEEECC		27.9028450419
1231 (in isoform 3)Phosphorylation-49.1221406692
1235 (in isoform 3)Phosphorylation-4.9821406692
1236PhosphorylationVTENLVLSSHTGFCQ
CCCCEEECCCCCCCC		16.7623927012
1236 (in isoform 2)Phosphorylation-16.76-
1237PhosphorylationTENLVLSSHTGFCQS
CCCEEECCCCCCCCC		22.4023927012
1238 (in isoform 2)Phosphorylation-27.00-
1239PhosphorylationNLVLSSHTGFCQSSG
CEEECCCCCCCCCCC		33.6223927012
1244PhosphorylationSHTGFCQSSGDEALS
CCCCCCCCCCCCHHH		37.1526503892
1245PhosphorylationHTGFCQSSGDEALSK
CCCCCCCCCCCHHHC		25.1226503892
1251PhosphorylationSSGDEALSKSVPVTV
CCCCCHHHCCCCEEC		29.9023927012
1253PhosphorylationGDEALSKSVPVTVDD
CCCHHHCCCCEECCC		28.4225159151
1257PhosphorylationLSKSVPVTVDDDDDD
HHCCCCEECCCCCCC		16.4922199227
1274SumoylationPENRIAKKMLLEEIK
HHHHHHHHHHHHHHH		26.26-
1274SumoylationPENRIAKKMLLEEIK
HHHHHHHHHHHHHHH		26.26-
1275SulfoxidationENRIAKKMLLEEIKA
HHHHHHHHHHHHHHH		5.2130846556
1284 (in isoform 4)Phosphorylation-6.57-
1285PhosphorylationEEIKANLSSDEDGSS
HHHHHHCCCCCCCCC		35.2325159151
1286PhosphorylationEIKANLSSDEDGSSD
HHHHHCCCCCCCCCC		48.4625159151
1286 (in isoform 4)Phosphorylation-48.46-
1288 (in isoform 4)Phosphorylation-67.24-
1290 (in isoform 4)Phosphorylation-27.31-
1291PhosphorylationLSSDEDGSSDDEPEE
CCCCCCCCCCCCCHH		42.8025159151
1292PhosphorylationSSDEDGSSDDEPEEG
CCCCCCCCCCCCHHH		55.3925159151
1302MethylationEPEEGKKRTGKQNEE
CCHHHHHCCCCCCCC		52.80-
1308 (in isoform 4)Phosphorylation-57.57-
1310 (in isoform 4)Phosphorylation-39.41-
1314 (in isoform 4)Phosphorylation-66.81-
1317 (in isoform 3)Phosphorylation-51.7121406692
1318 (in isoform 3)Phosphorylation-59.0721406692
1319 (in isoform 3)Phosphorylation-34.7521406692
1322PhosphorylationEAKNQVNSESDSDSE
HHHHHCCCCCCCCCH		39.3525072903
1323 (in isoform 2)Phosphorylation-54.05-
1324PhosphorylationKNQVNSESDSDSEES
HHHCCCCCCCCCHHH		42.0825072903
1325 (in isoform 2)Phosphorylation-53.03-
1325 (in isoform 3)Phosphorylation-53.0321406692
1326PhosphorylationQVNSESDSDSEESKK
HCCCCCCCCCHHHHC		52.9225072903
1328PhosphorylationNSESDSDSEESKKPR
CCCCCCCCHHHHCHH		47.4123663014
1331PhosphorylationSDSDSEESKKPRYRH
CCCCCHHHHCHHHHH		41.7627732954
1346PhosphorylationRLLRHKLTVSDGESG
HHHHCCCCCCCCCCC		23.8329255136
1348PhosphorylationLRHKLTVSDGESGEE
HHCCCCCCCCCCCCC		34.3629255136
1352PhosphorylationLTVSDGESGEEKKTK
CCCCCCCCCCCCCCC		57.9729255136
1357UbiquitinationGESGEEKKTKPKEHK
CCCCCCCCCCCCCCC		66.13-
1358PhosphorylationESGEEKKTKPKEHKE
CCCCCCCCCCCCCCC		64.7425219547
1359UbiquitinationSGEEKKTKPKEHKEV
CCCCCCCCCCCCCCC		64.07-
1361UbiquitinationEEKKTKPKEHKEVKG
CCCCCCCCCCCCCCC		74.20-
1376PhosphorylationRNRRKVSSEDSEDSD
CCCCCCCCCCCCCCC		48.7030576142
1379PhosphorylationRKVSSEDSEDSDFQE
CCCCCCCCCCCCHHH		38.9730576142
1387PhosphorylationEDSDFQESGVSEEVS
CCCCHHHCCCCHHHC		33.4430576142
1402 (in isoform 4)Phosphorylation-41.51-
1404PhosphorylationEDEQRPRTRSAKKAE
CCCCCCCCHHHHHHH		31.49-
1404 (in isoform 4)Phosphorylation-31.49-
1410 (in isoform 3)Phosphorylation-26.3721406692
1412 (in isoform 3)Phosphorylation-13.7921406692
1429UbiquitinationKKKRRRIKVQEDSSS
HHHHHCCCCCCCCCC		35.73-
1434PhosphorylationRIKVQEDSSSENKSN
CCCCCCCCCCCCCCC		34.7025849741
1435PhosphorylationIKVQEDSSSENKSNS
CCCCCCCCCCCCCCC		54.7321406692
1436PhosphorylationKVQEDSSSENKSNSE
CCCCCCCCCCCCCCH		49.4921406692
1440PhosphorylationDSSSENKSNSEEEEE
CCCCCCCCCCHHHHH		58.1125849741
1442PhosphorylationSSENKSNSEEEEEEK
CCCCCCCCHHHHHHH		54.1729255136
1488SumoylationRKILKDDKLRTETQN
HHHHHCHHHHHHHHH		50.42-
1488SumoylationRKILKDDKLRTETQN
HHHHHCHHHHHHHHH		50.4228112733
1489 (in isoform 4)Phosphorylation-12.02-
1491PhosphorylationLKDDKLRTETQNALK
HHCHHHHHHHHHHHH		54.5420068231
1491 (in isoform 4)Phosphorylation-54.54-
1493PhosphorylationDDKLRTETQNALKEE
CHHHHHHHHHHHHHH		26.8923312004
1498AcetylationTETQNALKEEEERRK
HHHHHHHHHHHHHHH		61.7526051181
1527PhosphorylationVIEIEDASPTKCPIT
HEECCCCCCCCCCCE		45.4819664994
1529PhosphorylationEIEDASPTKCPITTK
ECCCCCCCCCCCEEE		42.6629255136
1530AcetylationIEDASPTKCPITTKL
CCCCCCCCCCCEEEE		41.2026051181
1530UbiquitinationIEDASPTKCPITTKL
CCCCCCCCCCCEEEE		41.20-
1534PhosphorylationSPTKCPITTKLVLDE
CCCCCCCEEEEEECC		11.7423927012
1535PhosphorylationPTKCPITTKLVLDED
CCCCCCEEEEEECCC		24.0923927012
1536SumoylationTKCPITTKLVLDEDE
CCCCCEEEEEECCCC		28.13-
1536SumoylationTKCPITTKLVLDEDE
CCCCCEEEEEECCCC		28.13-
1536UbiquitinationTKCPITTKLVLDEDE
CCCCCEEEEEECCCC		28.13-
1537 (in isoform 3)Phosphorylation-4.3121406692
1546SumoylationLDEDEETKEPLVQVH
ECCCCCCCCCCEEEE		61.69-
1546SumoylationLDEDEETKEPLVQVH
ECCCCCCCCCCEEEE		61.69-
1546UbiquitinationLDEDEETKEPLVQVH
ECCCCCCCCCCEEEE		61.69-
1568 (in isoform 2)Phosphorylation-3.25-
1570 (in isoform 2)Ubiquitination-5.0621890473
1584UbiquitinationESVKKTKKSPGSGCI
HHHHHHCCCCCCCCH		68.09-
1650SumoylationEGLKDDEKLEVSELA
HCCCCCHHCCHHHHE		57.87-
1650SumoylationEGLKDDEKLEVSELA
HCCCCCHHCCHHHHE		57.87-
1654PhosphorylationDDEKLEVSELATVKR
CCHHCCHHHHEECCC		19.9521406692
1658PhosphorylationLEVSELATVKRPQER
CCHHHHEECCCHHHH		38.9025072903
1660UbiquitinationVSELATVKRPQERSY
HHHHEECCCHHHHHH		54.74-
1699UbiquitinationGRNVKSRKLKEIFNK
CCCCCHHHHHHHHHH		71.63-
1701SumoylationNVKSRKLKEIFNKAL
CCCHHHHHHHHHHHH		52.37-
17012-HydroxyisobutyrylationNVKSRKLKEIFNKAL
CCCHHHHHHHHHHHH		52.37-
1701SumoylationNVKSRKLKEIFNKAL
CCCHHHHHHHHHHHH		52.37-
1701UbiquitinationNVKSRKLKEIFNKAL
CCCHHHHHHHHHHHH		52.37-
1706UbiquitinationKLKEIFNKALVDPGP
HHHHHHHHHHCCCCC		32.14-
1706 (in isoform 6)Ubiquitination-32.1421890473
1709 (in isoform 2)Phosphorylation-11.31-
1714 (in isoform 2)Phosphorylation-55.69-
1715 (in isoform 2)Phosphorylation-5.09-
1720 (in isoform 2)Phosphorylation-47.77-
1724 (in isoform 2)Phosphorylation-3.96-
1725UbiquitinationCDEGHILKNEASAVS
CCCCCCCCCHHHHHH		52.73-
1732PhosphorylationKNEASAVSKAMNSIR
CCHHHHHHHHHHHHH		17.8922210691
1733UbiquitinationNEASAVSKAMNSIRS
CHHHHHHHHHHHHHH		45.09-
1734 (in isoform 4)Phosphorylation-8.55-
1736 (in isoform 4)Ubiquitination-38.8621890473
1736 (in isoform 5)Ubiquitination-38.8621890473
1737PhosphorylationAVSKAMNSIRSRRRI
HHHHHHHHHHHCCCE		13.2922210691
1772PhosphorylationIKENLLGSIKEFRNR
HHHHHHHHHHHHHHH		30.3820068231
1774SumoylationENLLGSIKEFRNRFI
HHHHHHHHHHHHHCC		53.12-
1774SumoylationENLLGSIKEFRNRFI
HHHHHHHHHHHHHCC		53.12-
1774UbiquitinationENLLGSIKEFRNRFI
HHHHHHHHHHHHHCC		53.12-
1774 (in isoform 1)Ubiquitination-53.1221890473
1774 (in isoform 3)Ubiquitination-53.1221890473
1776 (in isoform 2)Phosphorylation-7.72-
1778 (in isoform 2)Ubiquitination-48.8421890473
1783 (in isoform 2)Ubiquitination-25.4021890473
1785 (in isoform 2)Phosphorylation-49.62-
1786 (in isoform 2)Phosphorylation-43.13-
1787 (in isoform 2)Phosphorylation-13.94-
1788 (in isoform 2)Phosphorylation-27.12-
1791 (in isoform 2)Phosphorylation-52.87-
1792PhosphorylationQNGQCADSTMVDVRV
CCCCCCCCCCEEHHH		10.4020068231
1792 (in isoform 2)Phosphorylation-10.40-
1798 (in isoform 2)Phosphorylation-20.53-
1818UbiquitinationLAGCVQRKDYTALTK
HHHHHHCCCCHHHHH		37.69-
1825UbiquitinationKDYTALTKFLPPKHE
CCCHHHHHCCCCCCC		45.84-
1833PhosphorylationFLPPKHEYVLAVRMT
CCCCCCCEEEEEEEH		10.6522210691
1841PhosphorylationVLAVRMTSIQCKLYQ
EEEEEEHHHHHHHHH		11.0022210691
1847PhosphorylationTSIQCKLYQYYLDHL
HHHHHHHHHHHHHHH		4.6726552605
1849PhosphorylationIQCKLYQYYLDHLTG
HHHHHHHHHHHHHCC		7.7626552605
1850PhosphorylationQCKLYQYYLDHLTGV
HHHHHHHHHHHHCCC		7.0726552605
1855PhosphorylationQYYLDHLTGVGNNSE
HHHHHHHCCCCCCCC		26.8026552605
1856 (in isoform 3)Phosphorylation-31.5321406692
1861PhosphorylationLTGVGNNSEGGRGKA
HCCCCCCCCCCCCHH		41.4326552605
1867UbiquitinationNSEGGRGKAGAKLFQ
CCCCCCCHHHHHHHH		42.14-
1871SumoylationGRGKAGAKLFQDFQM
CCCHHHHHHHHHHHH		49.25-
1871UbiquitinationGRGKAGAKLFQDFQM
CCCHHHHHHHHHHHH		49.25-
1874 (in isoform 3)Phosphorylation-62.1321406692
1875 (in isoform 3)Phosphorylation-28.5421406692
1875 (in isoform 4)Phosphorylation-28.54-
1878 (in isoform 3)Phosphorylation-3.5621406692
1879 (in isoform 3)Phosphorylation-1.8521406692
1880 (in isoform 4)Phosphorylation-19.17-
1881 (in isoform 4)Phosphorylation-25.22-
1886 (in isoform 4)Phosphorylation-18.99-
1890 (in isoform 4)Phosphorylation-29.20-
1899UbiquitinationDYISKENKGYFDEDS
HHHCCCCCCCCCCCC		56.96-
1906PhosphorylationKGYFDEDSMDEFIAS
CCCCCCCCHHHHHCC		26.53-
1913PhosphorylationSMDEFIASDSDETSM
CHHHHHCCCCCCCCC		32.6018669648
1914 (in isoform 6)Ubiquitination-51.6021890473
1918PhosphorylationIASDSDETSMSLSSD
HCCCCCCCCCCCCCC		34.4218669648
1919PhosphorylationASDSDETSMSLSSDD
CCCCCCCCCCCCCCH		12.3418669648
1919 (in isoform 6)Ubiquitination-12.3421890473
1921PhosphorylationDSDETSMSLSSDDYT
CCCCCCCCCCCCHHH		25.52-
1923PhosphorylationDETSMSLSSDDYTKK
CCCCCCCCCCHHHHH		25.14-
1924PhosphorylationETSMSLSSDDYTKKK
CCCCCCCCCHHHHHH		39.5318669648
1928PhosphorylationSLSSDDYTKKKKKGK
CCCCCHHHHHHCCCC		43.3018669648
1930AcetylationSSDDYTKKKKKGKKG
CCCHHHHHHCCCCCC		63.12129937
1933AcetylationDYTKKKKKGKKGKKD
HHHHHHCCCCCCCCC		82.1370737
1935AcetylationTKKKKKGKKGKKDSS
HHHHCCCCCCCCCCC		68.2070741
1936AcetylationKKKKKGKKGKKDSSS
HHHCCCCCCCCCCCC		82.0070729
1939AcetylationKKGKKGKKDSSSSGS
CCCCCCCCCCCCCCC		72.0870733
1941PhosphorylationGKKGKKDSSSSGSGS
CCCCCCCCCCCCCCC		40.7923663014
1942PhosphorylationKKGKKDSSSSGSGSD
CCCCCCCCCCCCCCC		38.3623403867
1942 (in isoform 4)Phosphorylation-38.36-
1943PhosphorylationKGKKDSSSSGSGSDN
CCCCCCCCCCCCCCC		42.5423663014
1944PhosphorylationGKKDSSSSGSGSDND
CCCCCCCCCCCCCCC		38.6423663014
1944 (in isoform 4)Ubiquitination-38.6421890473
1944 (in isoform 5)Ubiquitination-38.6421890473
1946PhosphorylationKDSSSSGSGSDNDVE
CCCCCCCCCCCCCCE		36.7523663014
1948PhosphorylationSSSSGSGSDNDVEVI
CCCCCCCCCCCCEEE		34.6325159151
1949 (in isoform 4)Ubiquitination-59.8921890473
1949 (in isoform 5)Ubiquitination-59.8921890473
1951 (in isoform 4)Phosphorylation-42.83-
1952 (in isoform 4)Phosphorylation-8.74-
1953 (in isoform 4)Phosphorylation-41.19-
1954 (in isoform 4)Phosphorylation-5.29-
1956UbiquitinationDNDVEVIKVWNSRSR
CCCCEEEEEEECCCC		46.50-
1957 (in isoform 4)Phosphorylation-3.93-
1958 (in isoform 4)Phosphorylation-7.65-
1962PhosphorylationIKVWNSRSRGGGEGN
EEEEECCCCCCCCCC		34.7925159151
1963MethylationKVWNSRSRGGGEGNV
EEEECCCCCCCCCCC		46.82-
1964 (in isoform 4)Phosphorylation-50.10-
1973PhosphorylationGEGNVDETGNNPSVS
CCCCCCCCCCCCCCE		40.5221406692
1978PhosphorylationDETGNNPSVSLKLEE
CCCCCCCCCEEEEEC		26.8528985074
1980PhosphorylationTGNNPSVSLKLEESK
CCCCCCCEEEEECCC		24.9121815630
1982SumoylationNNPSVSLKLEESKAT
CCCCCEEEEECCCCC		46.47-
1982SumoylationNNPSVSLKLEESKAT
CCCCCEEEEECCCCC		46.4725114211
1982UbiquitinationNNPSVSLKLEESKAT
CCCCCEEEEECCCCC		46.47-
1982 (in isoform 1)Ubiquitination-46.4721890473
1982 (in isoform 3)Ubiquitination-46.4721890473
1987SumoylationSLKLEESKATSSSNP
EEEEECCCCCCCCCC		59.9928112733
1987UbiquitinationSLKLEESKATSSSNP
EEEEECCCCCCCCCC		59.99-
1987 (in isoform 1)Ubiquitination-59.9921890473
1987 (in isoform 3)Ubiquitination-59.9921890473
1989PhosphorylationKLEESKATSSSNPSS
EEECCCCCCCCCCCC		32.6426846344
1990PhosphorylationLEESKATSSSNPSSP
EECCCCCCCCCCCCC		36.3126846344
1991PhosphorylationEESKATSSSNPSSPA
ECCCCCCCCCCCCCC		29.7626846344
1992PhosphorylationESKATSSSNPSSPAP
CCCCCCCCCCCCCCC		53.1526846344
1995PhosphorylationATSSSNPSSPAPDWY
CCCCCCCCCCCCHHH		53.8826846344
1996PhosphorylationTSSSNPSSPAPDWYK
CCCCCCCCCCCHHHH		26.7426846344
2002PhosphorylationSSPAPDWYKDFVTDA
CCCCCHHHHHCCCHH		14.2026846344
2003UbiquitinationSPAPDWYKDFVTDAD
CCCCHHHHHCCCHHC		40.20-
2007PhosphorylationDWYKDFVTDADAEVL
HHHHHCCCHHCHHHH		26.0124732914
2016 (in isoform 2)Phosphorylation-37.38-
2017PhosphorylationDAEVLEHSGKMVLLF
CHHHHHHCCHHHHHH		30.6324732914
2065UbiquitinationSREKTEDKDKPLIYK
HHCCCCCCCCCCEEE		62.51-
2067SumoylationEKTEDKDKPLIYKGE
CCCCCCCCCCEEECC		47.68-
2067SumoylationEKTEDKDKPLIYKGE
CCCCCCCCCCEEECC		47.68-
2067UbiquitinationEKTEDKDKPLIYKGE
CCCCCCCCCCEEECC		47.68-
2072UbiquitinationKDKPLIYKGEGKWLR
CCCCCEEECCCCEEC		43.42-
2076SumoylationLIYKGEGKWLRNIDY
CEEECCCCEECCCEE		38.46-
2076AcetylationLIYKGEGKWLRNIDY
CEEECCCCEECCCEE		38.4612655553
2076SumoylationLIYKGEGKWLRNIDY
CEEECCCCEECCCEE		38.46-
2076UbiquitinationLIYKGEGKWLRNIDY
CEEECCCCEECCCEE		38.46-
2078 (in isoform 2)Ubiquitination-3.2421890473
2083PhosphorylationKWLRNIDYYRLDGST
CEECCCEEEECCCCC		6.16-
2084PhosphorylationWLRNIDYYRLDGSTT
EECCCEEEECCCCCC		10.8430576142
2089PhosphorylationDYYRLDGSTTAQSRK
EEEECCCCCCHHHHH		23.42-
2090PhosphorylationYYRLDGSTTAQSRKK
EEECCCCCCHHHHHH		31.51-
2091PhosphorylationYRLDGSTTAQSRKKW
EECCCCCCHHHHHHH		25.13-
2094PhosphorylationDGSTTAQSRKKWAEE
CCCCCHHHHHHHHHH		43.5330576142
2096UbiquitinationSTTAQSRKKWAEEFN
CCCHHHHHHHHHHHC		58.89-
2097SumoylationTTAQSRKKWAEEFND
CCHHHHHHHHHHHCC		50.99-
2097SumoylationTTAQSRKKWAEEFND
CCHHHHHHHHHHHCC		50.99-
2097UbiquitinationTTAQSRKKWAEEFND
CCHHHHHHHHHHHCC		50.99-
2152PhosphorylationIQSIFRVYRFGQTKP
HHHHHEEEECCCCCC		8.9326074081
2157PhosphorylationRVYRFGQTKPVYVYR
EEEECCCCCCEEEEE		37.3826074081
2158UbiquitinationVYRFGQTKPVYVYRF
EEECCCCCCEEEEEE		25.30-
2161PhosphorylationFGQTKPVYVYRFLAQ
CCCCCCEEEEEECCC		10.5726074081
2163PhosphorylationQTKPVYVYRFLAQGT
CCCCEEEEEECCCCC		4.3026074081
2174UbiquitinationAQGTMEDKIYDRQVT
CCCCCCCCCCCCCCC		29.84-
2176PhosphorylationGTMEDKIYDRQVTKQ
CCCCCCCCCCCCCCC		15.71-
2182UbiquitinationIYDRQVTKQSLSFRV
CCCCCCCCCEEEEEE		38.75-
2182 (in isoform 4)Phosphorylation-38.75-
2186PhosphorylationQVTKQSLSFRVVDQQ
CCCCCEEEEEECCHH		19.0924719451
2209PhosphorylationNELTELYTFEPDLLD
HHCHHHHCCCHHHCC		33.8630576142
2214 (in isoform 6)Ubiquitination-9.1621890473
2220PhosphorylationDLLDDPNSEKKKKRD
HHCCCCCCHHHCCCC		57.0618669648
2222UbiquitinationLDDPNSEKKKKRDTP
CCCCCCHHHCCCCCC		70.48-
2224UbiquitinationDPNSEKKKKRDTPML
CCCCHHHCCCCCCCC		65.20-
2233UbiquitinationRDTPMLPKDTILAEL
CCCCCCCHHHHHHHH		64.64-
2244 (in isoform 4)Ubiquitination-19.2521890473
2244 (in isoform 5)Ubiquitination-19.2521890473
2245UbiquitinationAELLQIHKEHIVGYH
HHHHHHHHHHHCCCC		53.25-
2261SumoylationHDSLLDHKEEEELTE
CCCCCCHHHHHHCCH		67.50-
2261UbiquitinationHDSLLDHKEEEELTE
CCCCCCHHHHHHCCH		67.50-
2272UbiquitinationELTEEERKAAWAEYE
HCCHHHHHHHHHHHH		45.82-
2282UbiquitinationWAEYEAEKKGLTMRF
HHHHHHHHCCCEEEE		60.22-
2282 (in isoform 1)Ubiquitination-60.2221890473
2282 (in isoform 3)Ubiquitination-60.2221890473
2283SumoylationAEYEAEKKGLTMRFN
HHHHHHHCCCEEEEE		51.13-
2283SumoylationAEYEAEKKGLTMRFN
HHHHHHHCCCEEEEE		51.13-
2283UbiquitinationAEYEAEKKGLTMRFN
HHHHHHHCCCEEEEE		51.13-
2334UbiquitinationLINQGREKVVEATNS
HHHHCHHHHHHHCCC		50.66-
2339PhosphorylationREKVVEATNSVTAVR
HHHHHHHCCCEEEEE		17.9628258704
2341PhosphorylationKVVEATNSVTAVRIQ
HHHHHCCCEEEEEEE		19.2528258704
2355PhosphorylationQPLEDIISAVWKENM
EEHHHHHHHHHHHCC		19.66-
2375PhosphorylationQVQALALSRQASQEL
HHHHHHHHHHHHHHH		19.4224719451
2379PhosphorylationLALSRQASQELDVKR
HHHHHHHHHHHCHHH		18.8221815630
2385UbiquitinationASQELDVKRREAIYN
HHHHHCHHHHHHHHH		45.46-
2391PhosphorylationVKRREAIYNDVLTKQ
HHHHHHHHHHHCCHH		16.6222985185
2397UbiquitinationIYNDVLTKQQMLISC
HHHHHCCHHHHHHHH		34.08-
2474DimethylationMQPPPLQRAPPPMRS
CCCCCCCCCCCCCCC		57.66-
2474MethylationMQPPPLQRAPPPMRS
CCCCCCCCCCCCCCC		57.66-
2480DimethylationQRAPPPMRSKNPGPS
CCCCCCCCCCCCCCC		50.70-
2480MethylationQRAPPPMRSKNPGPS
CCCCCCCCCCCCCCC		50.70-
2481PhosphorylationRAPPPMRSKNPGPSQ
CCCCCCCCCCCCCCC		30.4520068231
2487PhosphorylationRSKNPGPSQGKSM--
CCCCCCCCCCCCC--		58.44-
2490AcetylationNPGPSQGKSM-----
CCCCCCCCCC-----		35.3923749302
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
-KUbiquitinationE3 ubiquitin ligaseICP0P08393
PMID:22787211
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ATRX_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ATRX_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
EZH2_HUMANEZH2physical
9499421
CCSE2_HUMANCCSER2physical
16169070
CE126_HUMANKIAA1377physical
16169070
LC7L2_HUMANLUC7L2physical
16169070
PTN_HUMANPTNphysical
16169070
PTN4_HUMANPTPN4physical
16169070
RAD51_HUMANRAD51physical
10851248
RAD51_HUMANRAD51physical
15466868
MUS81_YEASTMUS81physical
19129197
MMS4_YEASTMMS4physical
19129197
SMC1A_HUMANSMC1Aphysical
20159591
H33_HUMANH3F3Aphysical
20110566
DAXX_HUMANDAXXphysical
12953102
CBX5_HUMANCBX5physical
15882967
CBX5_HUMANCBX5physical
10699177
DAXX_HUMANDAXXphysical
14990586
H31_HUMANHIST1H3Aphysical
21421568
WRN_HUMANWRNphysical
17118963
ZBED1_HUMANZBED1physical
22021382
DAXX_HUMANDAXXphysical
20147399
H32_HUMANHIST2H3Cphysical
21666679
H32_HUMANHIST2H3Cphysical
21666677
BLM_HUMANBLMphysical
19671661
RAD51_HUMANRAD51physical
19671661
RAD51_HUMANRAD51physical
9321665
DAXX_HUMANDAXXphysical
23135716
PP71_HCMVMUL82physical
23135716
DAXX_HUMANDAXXphysical
23329831
PRKDC_HUMANPRKDCphysical
23329831
RAD50_HUMANRAD50physical
23329831
XRCC5_HUMANXRCC5physical
23329831
MRE11_HUMANMRE11Aphysical
23329831
XRCC6_HUMANXRCC6physical
23329831
SP16H_HUMANSUPT16Hphysical
23329831
NBN_HUMANNBNphysical
23329831
SSRP1_HUMANSSRP1physical
23329831
H2B2E_HUMANHIST2H2BEphysical
23329831
RFA1_HUMANRPA1physical
23329831
P53_HUMANTP53physical
23329831
H12_HUMANHIST1H1Cphysical
23329831
RAD9A_HUMANRAD9Aphysical
23329831
H2B1L_HUMANHIST1H2BLphysical
23329831
RAD1_HUMANRAD1physical
23329831
RAD51_HUMANRAD51physical
23801766
ZN274_HUMANZNF274physical
27029610
TIF1B_HUMANTRIM28physical
27029610
SETB1_HUMANSETDB1physical
27029610
DAXX_HUMANDAXXphysical
27029610
EAF1_HUMANEAF1physical
27173435
NAF1_HUMANNAF1physical
27173435
DPOD1_HUMANPOLD1physical
27173435
RBM14_HUMANRBM14physical
27173435
MFAP1_HUMANMFAP1physical
27173435
MRE11_HUMANMRE11Aphysical
27171262
NBN_HUMANNBNphysical
27171262
H2AX_HUMANH2AFXphysical
28190324
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
301040Alpha-thalassemia mental retardation syndrome, X-linked (ATRX)
309580Mental retardation, X-linked, syndromic, with hypotonic facies 1 (MRXSHF1)
300448Alpha-thalassemia myelodysplasia syndrome (ATMDS)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ATRX_HUMAN

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Related Literatures of Post-Translational Modification
Acetylation
ReferencePubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-967, AND MASS SPECTROMETRY.
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-34; TYR-89; SER-112;SER-729; SER-731 AND SER-1996, AND MASS SPECTROMETRY.
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-729; SER-731; SER-1348;SER-1352; SER-1991; SER-1992 AND SER-1996, AND MASS SPECTROMETRY.
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-594; SER-598; THR-674;SER-675; SER-677; SER-729; SER-731; SER-871; SER-875; SER-876;SER-1348; SER-1352; SER-1991; SER-1996 AND SER-2220, AND MASSSPECTROMETRY.
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage.";
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
Science 316:1160-1166(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-871, AND MASSSPECTROMETRY.
"Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry.";
Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.;
Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-71 AND SER-74, AND MASSSPECTROMETRY.
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-34; SER-634; SER-729;SER-731; SER-849; SER-850; SER-1348; SER-1352 AND SER-1527, AND MASSSPECTROMETRY.
"Large-scale characterization of HeLa cell nuclear phosphoproteins.";
Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-34, AND MASSSPECTROMETRY.
"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.";
Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.;
J. Proteome Res. 6:4150-4162(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-87, AND MASSSPECTROMETRY.

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