CCSE2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CCSE2_HUMAN
• UniProt AC: Q9H7U1
• Protein Name: Serine-rich coiled-coil domain-containing protein 2
• Gene Name: CCSER2
• Organism: Homo sapiens (Human).
• Sequence Length: 834
• Protein Sequence: MEEKTQIKTFLGSKLPKYGTKSVRSTLQPMPNGTPVNLLGTSKNSNVKSYIKNNGSDCPSSHSFNWRKANKYQLCAQGVEEPNNTQNSHDKIIDPEKRVPTQGMFDKNGIKGGLKSVSLFTSKLAKPSTMFVSSTEELNQKSFSGPSNLGKFTKGTLLGRTSYSSINTPKSQLNGFYGNRSAGSMQRPRANSCATRSSSGESLAQSPDSSKSINCEKMVRSQSFSHSIQNSFLPPSSITRSHSFNRAVDLTKPYQNQQLSIRVPLRSSMLTRNSRQPEVLNGNEHLGYGFNRPYAAGGKKLALPNGPGVTSTLGYRMVHPSLLKSSRSPFSGTMTVDGNKNSPADTCVEEDATVLAKDRAANKDQELIENESYRTKNNQTMKHDAKMRYLSDDVDDISLSSLSSSDKNDLSEDFSDDFIDIEDSNRTRITPEEMSLKEEKHENGPPQDMFDSPKENEKAFSKTDEWIDISVSDRSECTKHTSGNNLVSPDTDYRAGSSFELSPSDSSDGTYMWDEEGLEPIGNVHPVGSYESSEMNSIDILNNLESCDLEDDDLMLDVDLPEDAPLENVECDNMNRFDRPDRNVRQPQEGFWKRPPQRWSGQEHYHLSHPDHYHHHGKSDLSRGSPYRESPLGHFESYGGMPFFQAQKMFVDVPENTVILDEMTLRHMVQDCTAVKTQLLKLKRLLHQHDGSGSLHDIQLSLPSSPEPEDGDKVYKNEDLLNEIKQLKDEIKKKDEKIQLLELQLATQHICHQKCKEEKCTYADKYTQTPWRRIPGGYSAPSFSPWQGSFQGIPRTVPPHRRQTSSTTAFQQPSQTHRSHPGKTNKATTYRGPQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
22	Phosphorylation	LPKYGTKSVRSTLQP CCCCCCCCHHHCCEE		24719451
34	Phosphorylation	LQPMPNGTPVNLLGT CEECCCCCEEEEEEE		24719451
45	Phosphorylation	LLGTSKNSNVKSYIK EEEECCCCCHHHHHH		-
103	Ubiquitination	EKRVPTQGMFDKNGI HHCCCCCCCCCCCCC		29967540
111	Acetylation	MFDKNGIKGGLKSVS CCCCCCCCCCHHHHH		7960593
115	Acetylation	NGIKGGLKSVSLFTS CCCCCCHHHHHHHHH		7960603
116	Phosphorylation	GIKGGLKSVSLFTSK CCCCCHHHHHHHHHC		29052541
118	Phosphorylation	KGGLKSVSLFTSKLA CCCHHHHHHHHHCCC		29052541
121	Phosphorylation	LKSVSLFTSKLAKPS HHHHHHHHHCCCCCC		29052541
122	Phosphorylation	KSVSLFTSKLAKPST HHHHHHHHCCCCCCE		29052541
133	Phosphorylation	KPSTMFVSSTEELNQ CCCEEEECCHHHHHH		28450419
134	Phosphorylation	PSTMFVSSTEELNQK CCEEEECCHHHHHHC		28450419
135	Phosphorylation	STMFVSSTEELNQKS CEEEECCHHHHHHCC		28450419
143	Ubiquitination	EELNQKSFSGPSNLG HHHHHCCCCCCCCCC		29967540
152	Ubiquitination	GPSNLGKFTKGTLLG CCCCCCCCCCCCCCC		29967540
153	Phosphorylation	PSNLGKFTKGTLLGR CCCCCCCCCCCCCCC		-
156	Phosphorylation	LGKFTKGTLLGRTSY CCCCCCCCCCCCCCC		-
162	Phosphorylation	GTLLGRTSYSSINTP CCCCCCCCCCCCCCC		22210691
163	Phosphorylation	TLLGRTSYSSINTPK CCCCCCCCCCCCCCH		-
168	Phosphorylation	TSYSSINTPKSQLNG CCCCCCCCCHHHHCC		22210691
177	Phosphorylation	KSQLNGFYGNRSAGS HHHHCCCCCCCCCCC		-
184	Phosphorylation	YGNRSAGSMQRPRAN CCCCCCCCCCCCCCC		22210691
197	Phosphorylation	ANSCATRSSSGESLA CCCCCCCCCCCCCHH		26434776
198	Phosphorylation	NSCATRSSSGESLAQ CCCCCCCCCCCCHHC		26434776
199	Phosphorylation	SCATRSSSGESLAQS CCCCCCCCCCCHHCC		26434776
202	Phosphorylation	TRSSSGESLAQSPDS CCCCCCCCHHCCCCC		28450419
206	Phosphorylation	SGESLAQSPDSSKSI CCCCHHCCCCCCCCC		21712546
209	Phosphorylation	SLAQSPDSSKSINCE CHHCCCCCCCCCCHH		28450419
210	Phosphorylation	LAQSPDSSKSINCEK HHCCCCCCCCCCHHH		28450419
212	Phosphorylation	QSPDSSKSINCEKMV CCCCCCCCCCHHHHH		23312004
221	Phosphorylation	NCEKMVRSQSFSHSI CHHHHHHHCCCCHHH		23927012
223	Phosphorylation	EKMVRSQSFSHSIQN HHHHHHCCCCHHHHC		23927012
225	Phosphorylation	MVRSQSFSHSIQNSF HHHHCCCCHHHHCCC		23403867
227	Phosphorylation	RSQSFSHSIQNSFLP HHCCCCHHHHCCCCC		23403867
231	Phosphorylation	FSHSIQNSFLPPSSI CCHHHHCCCCCHHHH		23403867
241	Phosphorylation	PPSSITRSHSFNRAV CHHHHCCCCCCCCEE		26699800
243	Phosphorylation	SSITRSHSFNRAVDL HHHCCCCCCCCEECC		30576142
262	Dimethylation	QNQQLSIRVPLRSSM CCCCEEEECCCCHHH		-
262	Methylation	QNQQLSIRVPLRSSM CCCCEEEECCCCHHH		-
315	Phosphorylation	GVTSTLGYRMVHPSL CCHHHHCCEECCHHH		22817900
316	Methylation	VTSTLGYRMVHPSLL CHHHHCCEECCHHHH		-
321	Phosphorylation	GYRMVHPSLLKSSRS CCEECCHHHHHCCCC		24719451
328	Phosphorylation	SLLKSSRSPFSGTMT HHHHCCCCCCCEEEE		25159151
342	Phosphorylation	TVDGNKNSPADTCVE EECCCCCCCCCCCCC		25159151
389	Phosphorylation	KHDAKMRYLSDDVDD CHHHHHHHHCCCCCC		-
427	Phosphorylation	DIEDSNRTRITPEEM ECCCCCCCCCCHHHH		28450419
430	Phosphorylation	DSNRTRITPEEMSLK CCCCCCCCHHHHCHH		27794612
435	Phosphorylation	RITPEEMSLKEEKHE CCCHHHHCHHHHHHH		27732954
452	Phosphorylation	PPQDMFDSPKENEKA CCHHHCCCHHHCHHH		27050516
461	Phosphorylation	KENEKAFSKTDEWID HHCHHHHHCCCCCEE		-
463	Phosphorylation	NEKAFSKTDEWIDIS CHHHHHCCCCCEEEE		27732954
470	Phosphorylation	TDEWIDISVSDRSEC CCCCEEEECCCHHHH		27732954
472	Phosphorylation	EWIDISVSDRSECTK CCEEEECCCHHHHCC		27732954
482	Phosphorylation	SECTKHTSGNNLVSP HHHCCCCCCCCCCCC		27732954
488	Phosphorylation	TSGNNLVSPDTDYRA CCCCCCCCCCCCCCC		25159151
491	Phosphorylation	NNLVSPDTDYRAGSS CCCCCCCCCCCCCCC		27732954
493	Phosphorylation	LVSPDTDYRAGSSFE CCCCCCCCCCCCCEE		27642862
625	Phosphorylation	KSDLSRGSPYRESPL CCCCCCCCCCCCCCC		26055452
630	Phosphorylation	RGSPYRESPLGHFES CCCCCCCCCCCCCCC		24719451
676	Ubiquitination	VQDCTAVKTQLLKLK HHHHHHHHHHHHHHH		29967540
677	O-linked_Glycosylation	QDCTAVKTQLLKLKR HHHHHHHHHHHHHHH		30379171
692	Phosphorylation	LLHQHDGSGSLHDIQ HHHHCCCCCCEEEEE		24144214
694	Phosphorylation	HQHDGSGSLHDIQLS HHCCCCCCEEEEEEE		30177828
701	Phosphorylation	SLHDIQLSLPSSPEP CEEEEEEECCCCCCC		20363803
704	Phosphorylation	DIQLSLPSSPEPEDG EEEEECCCCCCCCCC		20363803
705	Phosphorylation	IQLSLPSSPEPEDGD EEEECCCCCCCCCCC		20363803
715	Phosphorylation	PEDGDKVYKNEDLLN CCCCCCCCCCHHHHH		24144214
716	Ubiquitination	EDGDKVYKNEDLLNE CCCCCCCCCHHHHHH		29967540
725	Ubiquitination	EDLLNEIKQLKDEIK HHHHHHHHHHHHHHH		29967540
747	Phosphorylation	LLELQLATQHICHQK HHHHHHHHHHHHHHH		-
761	O-linked_Glycosylation	KCKEEKCTYADKYTQ HHHHCCCCHHHCCCC		30379171
908 (in isoform 3)	Phosphorylation	-		22199227
908	Phosphorylation	--------------------------------------------------------------------------------- ---------------------------------------------------------------------------------		-
913 (in isoform 3)	Phosphorylation	-		27794612
915 (in isoform 3)	Phosphorylation	-		27794612
919 (in isoform 3)	Phosphorylation	-		22210691
929 (in isoform 3)	Phosphorylation	-		22210691
930 (in isoform 3)	Phosphorylation	-		22210691
950	Phosphorylation	--------------------------------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------------------------------		-
950 (in isoform 3)	Phosphorylation	-		22199227
964 (in isoform 3)	Phosphorylation	-		29514088
965 (in isoform 3)	Phosphorylation	-		29514088
966 (in isoform 3)	Phosphorylation	-		29514088
968 (in isoform 3)	Phosphorylation	-		29514088
985 (in isoform 3)	Phosphorylation	-		29514088
987	Phosphorylation	---------------------------------------------------------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------		-
987 (in isoform 3)	Phosphorylation	-		29514088
989	Methylation	------------------------------------------------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------------------------------------------------		-
993 (in isoform 3)	Phosphorylation	-		25159151
995	Phosphorylation	------------------------------------------------------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------------------------------------------------------		-
995 (in isoform 3)	Phosphorylation	-		25159151
1002 (in isoform 3)	Phosphorylation	-		28985074

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CCSE2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CCSE2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CCSE2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.