PTN4_HUMAN - dbPTM
PTN4_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PTN4_HUMAN
UniProt AC P29074
Protein Name Tyrosine-protein phosphatase non-receptor type 4
Gene Name PTPN4
Organism Homo sapiens (Human).
Sequence Length 926
Subcellular Localization Cell membrane
Peripheral membrane protein
Cytoplasmic side. Cytoplasm, cytoskeleton.
Protein Description May act at junctions between the membrane and the cytoskeleton..
Protein Sequence MTSRFRLPAGRTYNVRASELARDRQHTEVVCNILLLDNTVQAFKVNKHDQGQVLLDVVFKHLDLTEQDYFGLQLADDSTDNPRWLDPNKPIRKQLKRGSPYSLNFRVKFFVSDPNKLQEEYTRYQYFLQIKQDILTGRLPCPSNTAALLASFAVQSELGDYDQSENLSGYLSDYSFIPNQPQDFEKEIAKLHQQHIGLSPAEAEFNYLNTARTLELYGVEFHYARDQSNNEIMIGVMSGGILIYKNRVRMNTFPWLKIVKISFKCKQFFIQLRKELHESRETLLGFNMVNYRACKNLWKACVEHHTFFRLDRPLPPQKNFFAHYFTLGSKFRYCGRTEVQSVQYGKEKANKDRVFARSPSKPLARKLMDWEVVSRNSISDDRLETQSLPSRSPPGTPNHRNSTFTQEGTRLRPSSVGHLVDHMVHTSPSEVFVNQRSPSSTQANSIVLESSPSQETPGDGKPPALPPKQSKKNSWNQIHYSHSQQDLESHINETFDIPSSPEKPTPNGGIPHDNLVLIRMKPDENGRFGFNVKGGYDQKMPVIVSRVAPGTPADLCVPRLNEGDQVVLINGRDIAEHTHDQVVLFIKASCERHSGELMLLVRPNAVYDVVEEKLENEPDFQYIPEKAPLDSVHQDDHSLRESMIQLAEGLITGTVLTQFDQLYRKKPGMTMSCAKLPQNISKNRYRDISPYDATRVILKGNEDYINANYINMEIPSSSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERGRVKCHQYWPEPTGSSSYGCYQVTCHSEEGNTAYIFRKMTLFNQEKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNKRAGKEEPVVVHCSAGIGRTGVLITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILKVYEEGFVKPLTTSTNK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
217PhosphorylationTARTLELYGVEFHYA
HCHHEEEECEEEEEE		15.1122817900
223PhosphorylationLYGVEFHYARDQSNN
EECEEEEEEECCCCC		14.5122817900
228PhosphorylationFHYARDQSNNEIMIG
EEEEECCCCCCEEEE		46.01-
238PhosphorylationEIMIGVMSGGILIYK
CEEEEEEECCEEEEE		31.31-
244PhosphorylationMSGGILIYKNRVRMN
EECCEEEEECCEECC		9.96-
262PhosphorylationWLKIVKISFKCKQFF
CEEEEEEEEHHHHHH		16.9724719451
324PhosphorylationQKNFFAHYFTLGSKF
CCCEEEEEEECCCCC		8.5327642862
358PhosphorylationKDRVFARSPSKPLAR
CCCEEECCCCCHHHH		30.0524719451
360PhosphorylationRVFARSPSKPLARKL
CEEECCCCCHHHHHH		48.4224719451
374PhosphorylationLMDWEVVSRNSISDD
HCCCEECCCCCCCCC		30.8127732954
377PhosphorylationWEVVSRNSISDDRLE
CEECCCCCCCCCCCC		23.5126471730
379PhosphorylationVVSRNSISDDRLETQ
ECCCCCCCCCCCCCC		33.0226471730
385PhosphorylationISDDRLETQSLPSRS
CCCCCCCCCCCCCCC		28.2227732954
387PhosphorylationDDRLETQSLPSRSPP
CCCCCCCCCCCCCCC		50.0623401153
390PhosphorylationLETQSLPSRSPPGTP
CCCCCCCCCCCCCCC		51.1623401153
392PhosphorylationTQSLPSRSPPGTPNH
CCCCCCCCCCCCCCC		39.5227251275
396PhosphorylationPSRSPPGTPNHRNST
CCCCCCCCCCCCCCC		27.0523401153
414PhosphorylationEGTRLRPSSVGHLVD
CCCCCCCCHHHHHHH		31.0828348404
415PhosphorylationGTRLRPSSVGHLVDH
CCCCCCCHHHHHHHC		34.5028348404
474PhosphorylationPKQSKKNSWNQIHYS
CCCCCCCCCCCCCCC		35.96-
594PhosphorylationKASCERHSGELMLLV
EEEECCCCCEEEEEE		39.9426074081
607PhosphorylationLVRPNAVYDVVEEKL
EECCCCCHHHHHHHH		10.7026074081
654PhosphorylationAEGLITGTVLTQFDQ
HHHHCHHHHHHHHHH		12.0524719451
657PhosphorylationLITGTVLTQFDQLYR
HCHHHHHHHHHHHHH		23.8924719451
663PhosphorylationLTQFDQLYRKKPGMT
HHHHHHHHHCCCCCC		18.1126074081
666SumoylationFDQLYRKKPGMTMSC
HHHHHHCCCCCCCCH		37.49-
666SumoylationFDQLYRKKPGMTMSC
HHHHHHCCCCCCCCH		37.49-
897PhosphorylationQRAMMIQTPSQYRFV
HHCCCCCCHHHHHHH		17.6223403867
899PhosphorylationAMMIQTPSQYRFVCE
CCCCCCHHHHHHHHH		43.1423403867
901PhosphorylationMIQTPSQYRFVCEAI
CCCCHHHHHHHHHHH		15.4523403867
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PTN4_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PTN4_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PTN4_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ZZEF1_HUMANZZEF1physical
16169070
LIPL_HUMANLPLphysical
16169070
KAT5_HUMANKAT5physical
16169070
EF1A1_HUMANEEF1A1physical
16169070
EF1G_HUMANEEF1Gphysical
16169070
GRID2_HUMANGRID2physical
10748123
NMDE1_HUMANGRIN2Aphysical
10748123
ADHX_HUMANADH5physical
27880917
CADM1_HUMANCADM1physical
27880917
GOLI4_HUMANGOLIM4physical
27880917
LTBP1_HUMANLTBP1physical
27880917
MPP7_HUMANMPP7physical
27880917
PAK4_HUMANPAK4physical
27880917
PEX19_HUMANPEX19physical
27880917
SHKB1_HUMANSHKBP1physical
27880917
SMD1_HUMANSNRPD1physical
27880917
1433G_HUMANYWHAGphysical
27880917
1433F_HUMANYWHAHphysical
27880917
1433T_HUMANYWHAQphysical
27880917
1433Z_HUMANYWHAZphysical
27880917
PTN4_HUMANPTPN4physical
27432908
CRKL_HUMANCRKLphysical
27432908
CR025_HUMANC18orf25physical
27432908
UN13B_HUMANUNC13Bphysical
27432908
1433F_HUMANYWHAHphysical
27432908
CSK21_HUMANCSNK2A1physical
27432908
CSK22_HUMANCSNK2A2physical
27432908
1433G_HUMANYWHAGphysical
27432908
SIR1_HUMANSIRT1physical
27432908
1433Z_HUMANYWHAZphysical
27432908
1433B_HUMANYWHABphysical
27432908
1433T_HUMANYWHAQphysical
27432908
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB00630Alendronate
Regulatory Network of PTN4_HUMAN

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Related Literatures of Post-Translational Modification

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