GRID2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GRID2_HUMAN
• UniProt AC: O43424
• Protein Name: Glutamate receptor ionotropic, delta-2
• Gene Name: GRID2
• Organism: Homo sapiens (Human).
• Sequence Length: 1007
• Subcellular Localization: Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
• Protein Description: Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. Promotes synaptogenesis and mediates the D-Serine-dependent long term depression signals and AMPA receptor endocytosis of cerebellar parallel fiber-Purkinje cell (PF-PC) synapses through the beta-NRX1-CBLN1-GRID2 triad complex. [PubMed: 27418511]
• Protein Sequence: MEVFPFLLVLSVWWSRTWDSANADSIIHIGAIFDESAKKDDEVFRTAVGDLNQNEEILQTEKITFSVTFVDGNNPFQAVQEACELMNQGILALVSSIGCTSAGSLQSLADAMHIPHLFIQRSTAGTPRSGCGLTRSNRNDDYTLSVRPPVYLHDVILRVVTEYAWQKFIIFYDSEYDIRGIQEFLDKVSQQGMDVALQKVENNINKMITTLFDTMRIEELNRYRDTLRRAILVMNPATAKSFITEVVETNLVAFDCHWIIINEEINDVDVQELVRRSIGRLTIIRQTFPVPQNISQRCFRGNHRISSTLCDPKDPFAQNMEISNLYIYDTVLLLANAFHKKLEDRKWHSMASLSCIRKNSKPWQGGRSMLETIKKGGVSGLTGELEFGENGGNPNVHFEILGTNYGEELGRGVRKLGCWNPVTGLNGSLTDKKLENNMRGVVLRVVTVLEEPFVMVSENVLGKPKKYQGFSIDVLDALSNYLGFNYEIYVAPDHKYGSPQEDGTWNGLVGELVFKRADIGISALTITPDRENVVDFTTRYMDYSVGVLLRRAEKTVDMFACLAPFDLSLWACIAGTVLLVGLLVYLLNWLNPPRLQMGSMTSTTLYNSMWFVYGSFVQQGGEVPYTTLATRMMMGAWWLFALIVISSYTANLAAFLTITRIESSIQSLQDLSKQTEIPYGTVLDSAVYEHVRMKGLNPFERDSMYSQMWRMINRSNGSENNVLESQAGIQKVKYGNYAFVWDAAVLEYVAINDPDCSFYTIGNTVADRGYGIALQHGSPYRDVFSQRILELQQNGDMDILKHKWWPKNGQCDLYSSVDTKQKGGALDIKSFAGVFCILAAGIVLSCFIAMLETWWNKRKGSRVPSKEDDKEIDLEHLHRRVNSLCTDDDSPHKQFSTSSIDLTPLDIDTLPTRQALEQISDFRNTHITTTTFIPEQIQTLSRTLSAKAASGFTFGNVPEHRTGPFRHRAPNGGFFRSPIKTMSSIPYQPTPTLGLNLGNDPDRGTSI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
17	Phosphorylation	LSVWWSRTWDSANAD HHHHHHCCCCCCCCC	28.27	22210691
20	Phosphorylation	WWSRTWDSANADSII HHHCCCCCCCCCCEE	18.25	22210691
36	Phosphorylation	IGAIFDESAKKDDEV EEECCCHHHCCCCHH	47.43	22210691
223	Phosphorylation	RIEELNRYRDTLRRA CHHHHHHHHHHHHHH	16.27	28555341
238	Phosphorylation	ILVMNPATAKSFITE HHHCCHHHHHHHHHH	35.56	27251275
293	N-linked_Glycosylation	QTFPVPQNISQRCFR ECCCCCCCHHHHHCC	29.79	UniProtKB CARBOHYD
349	Phosphorylation	LEDRKWHSMASLSCI HHHCCCCCCCCHHHH	18.22	22210691
352	Phosphorylation	RKWHSMASLSCIRKN CCCCCCCCHHHHHCC	16.51	22210691
354	Phosphorylation	WHSMASLSCIRKNSK CCCCCCHHHHHCCCC	12.66	24719451
368	Phosphorylation	KPWQGGRSMLETIKK CCCCCCHHHHHHHHH	30.87	22210691
382	Phosphorylation	KGGVSGLTGELEFGE HCCCCCCEEEEEECC	31.94	22210691
426	N-linked_Glycosylation	WNPVTGLNGSLTDKK CCCCCCCCCCCCHHH	39.08	UniProtKB CARBOHYD
525	Phosphorylation	DIGISALTITPDREN CCEEEEEEECCCCHH	23.63	-
543	Phosphorylation	FTTRYMDYSVGVLLR HHHHHHCHHHHHHHH	6.69	-
663	Phosphorylation	LTITRIESSIQSLQD HHHHHHHHHHHHHHH	30.30	25850435
664	Phosphorylation	TITRIESSIQSLQDL HHHHHHHHHHHHHHH	16.32	25850435
667	Phosphorylation	RIESSIQSLQDLSKQ HHHHHHHHHHHHHHC	26.74	27794612
672	Phosphorylation	IQSLQDLSKQTEIPY HHHHHHHHHCCCCCC	30.89	27794612
713	N-linked_Glycosylation	SQMWRMINRSNGSEN HHHHHHHHCCCCCCC	31.80	-
716	N-linked_Glycosylation	WRMINRSNGSENNVL HHHHHCCCCCCCCCC	55.56	-
880	Methylation	DLEHLHRRVNSLCTD CHHHHHHHHHHHCCC	22.63	-
883	Phosphorylation	HLHRRVNSLCTDDDS HHHHHHHHHCCCCCC	23.20	-
886	Phosphorylation	RRVNSLCTDDDSPHK HHHHHHCCCCCCCCC	47.99	-
890	Phosphorylation	SLCTDDDSPHKQFST HHCCCCCCCCCCCCC	35.58	-
903	Phosphorylation	STSSIDLTPLDIDTL CCCCCCCCCCCCCCC	20.32	-
912	Phosphorylation	LDIDTLPTRQALEQI CCCCCCCHHHHHHHH	38.23	-
913	Methylation	DIDTLPTRQALEQIS CCCCCCHHHHHHHHH	20.17	-
1006	Phosphorylation	NDPDRGTSI------ CCCCCCCCC------	29.17	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GRID2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GRID2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GRID2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GRD2I_HUMAN	GRID2IP	physical	11826110
GRIA1_HUMAN	GRIA1	physical	12573530
GRIK2_HUMAN	GRIK2	physical	12573530
GOPC_HUMAN	GOPC	physical	12372286
PTN4_HUMAN	PTPN4	physical	10748123

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.