GRD2I_HUMAN - dbPTM
GRD2I_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GRD2I_HUMAN
UniProt AC A4D2P6
Protein Name Delphilin
Gene Name GRID2IP
Organism Homo sapiens (Human).
Sequence Length 1211
Subcellular Localization Cell junction, synapse, postsynaptic cell membrane.
Protein Description Postsynaptic scaffolding protein at the parallel fiber-Purkinje cell synapse, where it may serve to link GRID2 with actin cytoskeleton and various signaling molecules..
Protein Sequence MATTATPATNQGWPEDFGFRLGGSGPCFVLEVAKGSSAHAGGLRPGDQILEVEGLAVGGLSRERLVRLARRCPRVPPSLGVLPAPDGGPGPGSGPAAPTTVLRAPRCGRGLALGRELLRLAGRKRPDAVHRERRRKAQEFSRKVDEILGDQPTAKEQVFAALKQFAAEQRVDDLVWTLTLALPREACGPLLDNLRIFIPKKHRARFDEVVSQGLLGKLCRARRAQGAQRLRRSRSEERPERLLVSTRASAPPRRPDEPPPRRASLLVGGLAGPGGARRTVRVYKGNKSFGFTLRGHGPVWIESVLPGSPADNAALKSGDRILFLNGLDMRNCSHDKVVSMLQGSGAMPTLVVEEGLVPFASDSDSLDSPNPSSALTSLQWVAEILPSSIRVQGRTFSQQLEHLLTPPERYGVCRALESFFQHRNIDTLIVDVYPVLDTPAKQVLWQFIYQLLTYEEQELCQEKIACFLGYTAMTAEPEPELDLESEPTPEPQPRSSLRASSMCRRSLRSQGLEAGLSCGPSECPEMPLPLIPGERQAGDGTSLPETPNPKMMSAVYAELESRLNSSFKGKMGTVSKSRASPPGPSPAVTTGPRTLSGVSWPSERLLPSPCYHPLCSGGLASPSSSESHPYASLDSSRAPSPQPGPGPICPDSPPSPDPTRPPSRRKLFTFSHPVRSRDTDRFLDVLSEQLGPRVTIVDDFLTPENDYEEMSFHDDQGSFVTNERSSASDCISSSEEGSSLTYSSISDHIPPPPLSPPPPPPLPFHDAKPSSRSSDGSRGPAQALAKPLTQLSHPVPPPPPPPLPPPVPCAPPMLSRGLGHRRSETSHMSVKRLRWEQVENSEGTIWGQLGEDSDYDKLSDMVKYLDLELHFGTQKPAKPVPGPEPFRKKEVVEILSHKKAYNTSILLAHLKLSPAELRQVLMSMEPRRLEPAHLAQLLLFAPDADEEQRYQAFREAPGRLSEPDQFVLQMLSVPEYKTRLRSLHFQATLQEKTEEIRGSLECLRQASLELKNSRKLAKILEFVLAMGNYLNDGQPKTNKTTGFKINFLTELNSTKTVDGKSTFLHILAKSLSQHFPELLGFAQDLPTVPLAAKVNQRALTSDLADLHGTISEIQDACQSISPSSEDKFAMVMSSFLETAQPALRALDGLQREAMEELGKALAFFGEDSKATTSEAFFGIFAEFMSKFERALSDLQAGEGLRSSGMVSPLAW
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Phosphorylation-----MATTATPATN
-----CCCCCCCCCC		28.9030631047
4Phosphorylation----MATTATPATNQ
----CCCCCCCCCCC		35.2830631047
78PhosphorylationRCPRVPPSLGVLPAP
HCCCCCCCCCCEECC		31.5230624053
93PhosphorylationDGGPGPGSGPAAPTT
CCCCCCCCCCCCCCC		44.7430624053
99PhosphorylationGSGPAAPTTVLRAPR
CCCCCCCCCEECCCC		25.4730624053
100PhosphorylationSGPAAPTTVLRAPRC
CCCCCCCCEECCCCC		19.2430624053
177PhosphorylationRVDDLVWTLTLALPR
CHHHHHHHHHEECCH		11.4624114839
179PhosphorylationDDLVWTLTLALPREA
HHHHHHHHEECCHHH		11.5624719451
264PhosphorylationEPPPRRASLLVGGLA
CCCCCCCCEEECCCC		22.0328348404
292PhosphorylationGNKSFGFTLRGHGPV
CCEEECEEEECCCCE		18.8724719451
303PhosphorylationHGPVWIESVLPGSPA
CCCEEEEEECCCCCC		21.5922210691
308PhosphorylationIESVLPGSPADNAAL
EEEECCCCCCHHHHH		18.2522210691
317PhosphorylationADNAALKSGDRILFL
CHHHHHHCCCEEEEE		46.9422210691
397PhosphorylationRVQGRTFSQQLEHLL
EEECEEHHHHHHHHC		19.1924719451
405PhosphorylationQQLEHLLTPPERYGV
HHHHHHCCCHHHHCH		43.0624719451
546PhosphorylationDGTSLPETPNPKMMS
CCCCCCCCCCHHHHH		26.82-
553PhosphorylationTPNPKMMSAVYAELE
CCCHHHHHHHHHHHH		15.8729978859
556PhosphorylationPKMMSAVYAELESRL
HHHHHHHHHHHHHHH		8.2829978859
561PhosphorylationAVYAELESRLNSSFK
HHHHHHHHHHCHHCC		55.4829978859
577PhosphorylationKMGTVSKSRASPPGP
CCEECCCCCCCCCCC		26.1024702127
580PhosphorylationTVSKSRASPPGPSPA
ECCCCCCCCCCCCCC		30.4324702127
589PhosphorylationPGPSPAVTTGPRTLS
CCCCCCCCCCCCCCC		28.3024702127
590PhosphorylationGPSPAVTTGPRTLSG
CCCCCCCCCCCCCCC		38.2924702127
596PhosphorylationTTGPRTLSGVSWPSE
CCCCCCCCCCCCCHH		36.21-
599PhosphorylationPRTLSGVSWPSERLL
CCCCCCCCCCHHHCC		36.47-
602PhosphorylationLSGVSWPSERLLPSP
CCCCCCCHHHCCCCC		29.14-
621PhosphorylationLCSGGLASPSSSESH
CCCCCCCCCCCCCCC		30.29-
652PhosphorylationPGPICPDSPPSPDPT
CCCCCCCCCCCCCCC		24.69-
655PhosphorylationICPDSPPSPDPTRPP
CCCCCCCCCCCCCCC		45.37-
823PhosphorylationRGLGHRRSETSHMSV
CCCCCCCCCCCCCCE		45.2228258704
826PhosphorylationGHRRSETSHMSVKRL
CCCCCCCCCCCEEEC		17.09-
829PhosphorylationRSETSHMSVKRLRWE
CCCCCCCCEEECCCE		21.0428258704
901PhosphorylationILSHKKAYNTSILLA
HHHCCCHHCCHHHHH		28.0518083107
913PhosphorylationLLAHLKLSPAELRQV
HHHHHCCCHHHHHHH		22.0727251275
1007PhosphorylationLECLRQASLELKNSR
HHHHHHHCHHCCCHH		17.6527174698
1013PhosphorylationASLELKNSRKLAKIL
HCHHCCCHHHHHHHH		29.2527174698
1101PhosphorylationVNQRALTSDLADLHG
HCHHHHHHHHHHHHH		31.3230576142
1121PhosphorylationQDACQSISPSSEDKF
HHHHHHCCCCCHHHH		24.7930576142
1124PhosphorylationCQSISPSSEDKFAMV
HHHCCCCCHHHHHHH		53.8830576142
1192PhosphorylationSKFERALSDLQAGEG
HHHHHHHHHHHCCCC		34.9824670416
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of GRD2I_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of GRD2I_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GRD2I_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of GRD2I_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GRD2I_HUMAN

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Related Literatures of Post-Translational Modification

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