dbPTM

GOPC_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	GOPC_HUMAN
UniProt AC	Q9HD26
Protein Name	Golgi-associated PDZ and coiled-coil motif-containing protein
Gene Name	GOPC
Organism	Homo sapiens (Human).
Sequence Length	462
Subcellular Localization	Cytoplasm. Golgi apparatus membrane Peripheral membrane protein. Golgi apparatus, trans-Golgi network membrane Peripheral membrane protein. Cell junction, synapse. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell projection
Protein Description	Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes..
Protein Sequence	MSAGGPCPAAAGGGPGGASCSVGAPGGVSMFRWLEVLEKEFDKAFVDVDLLLGEIDPDQADITYEGRQKMTSLSSCFAQLCHKAQSVSQINHKLEAQLVDLKSELTETQAEKVVLEKEVHDQLLQLHSIQLQLHAKTGQSADSGTIKAKLSGPSVEELERELEANKKEKMKEAQLEAEVKLLRKENEALRRHIAVLQAEVYGARLAAKYLDKELAGRVQQIQLLGRDMKGPAHDKLWNQLEAEIHLHRHKTVIRACRGRNDLKRPMQAPPGHDQDSLKKSQGVGPIRKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQQRGEIEFEVVYVAPEVDSDDENVEYEDESGHRYRLYLDELEGGGNPGASCKDTSGEIKVLQGFNKKAVTDTHENGDLGTASETPLDDGASKLDDLHTLYHKKSY

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSAGGPCPA ------CCCCCCCCC	35.30	19413330
2	Phosphorylation	------MSAGGPCPA ------CCCCCCCCC	35.30	19413330
19	Phosphorylation	GGGPGGASCSVGAPG CCCCCCCCCCCCCCC	15.36	28348404
21	Phosphorylation	GPGGASCSVGAPGGV CCCCCCCCCCCCCCC	22.53	28348404
39	Ubiquitination	RWLEVLEKEFDKAFV HHHHHHHHHHHHHHC	60.56	29967540
86	Phosphorylation	QLCHKAQSVSQINHK HHHHHHHCHHHHCHH	28.70	25849741
88	Phosphorylation	CHKAQSVSQINHKLE HHHHHCHHHHCHHHH	30.50	30622161
93	Ubiquitination	SVSQINHKLEAQLVD CHHHHCHHHHHHHCH	43.46	32015554
93	Malonylation	SVSQINHKLEAQLVD CHHHHCHHHHHHHCH	43.46	26320211
93	Acetylation	SVSQINHKLEAQLVD CHHHHCHHHHHHHCH	43.46	20167786
102	Sumoylation	EAQLVDLKSELTETQ HHHHCHHHHHCCHHH	37.10	-
102 (in isoform 3)	Ubiquitination	-	37.10	21906983
102 (in isoform 2)	Ubiquitination	-	37.10	21906983
102	Sumoylation	EAQLVDLKSELTETQ HHHHCHHHHHCCHHH	37.10	-
102 (in isoform 1)	Ubiquitination	-	37.10	21906983
102	Ubiquitination	EAQLVDLKSELTETQ HHHHCHHHHHCCHHH	37.10	21906983
103	Phosphorylation	AQLVDLKSELTETQA HHHCHHHHHCCHHHH	45.17	26074081
106	Phosphorylation	VDLKSELTETQAEKV CHHHHHCCHHHHHHH	32.70	26074081
108	Phosphorylation	LKSELTETQAEKVVL HHHHCCHHHHHHHHH	28.04	26074081
112	2-Hydroxyisobutyrylation	LTETQAEKVVLEKEV CCHHHHHHHHHCHHH	40.43	-
112	Ubiquitination	LTETQAEKVVLEKEV CCHHHHHHHHHCHHH	40.43	29967540
136	Ubiquitination	IQLQLHAKTGQSADS EEEEEECCCCCCCCC	42.30	29967540
143	Phosphorylation	KTGQSADSGTIKAKL CCCCCCCCCEEEEEC	37.24	27251275
145	Phosphorylation	GQSADSGTIKAKLSG CCCCCCCEEEEECCC	24.21	28857561
145 (in isoform 2)	Phosphorylation	-	24.21	-
147	Ubiquitination	SADSGTIKAKLSGPS CCCCCEEEEECCCCC	39.03	27667366
147 (in isoform 1)	Ubiquitination	-	39.03	21906983
147 (in isoform 2)	Ubiquitination	-	39.03	21906983
147 (in isoform 3)	Ubiquitination	-	39.03	21906983
149	Ubiquitination	DSGTIKAKLSGPSVE CCCEEEEECCCCCHH	37.88	30230243
151	Phosphorylation	GTIKAKLSGPSVEEL CEEEEECCCCCHHHH	48.20	26657352
154	Phosphorylation	KAKLSGPSVEELERE EEECCCCCHHHHHHH	45.76	22985185
170	Sulfoxidation	EANKKEKMKEAQLEA HHHHHHHHHHHHHHH	5.07	21406390
171	Ubiquitination	ANKKEKMKEAQLEAE HHHHHHHHHHHHHHH	62.05	-
172	Ubiquitination	NKKEKMKEAQLEAEV HHHHHHHHHHHHHHH	37.84	29967540
180	Ubiquitination	AQLEAEVKLLRKENE HHHHHHHHHHHHHHH	33.05	29967540
200	Ubiquitination	IAVLQAEVYGARLAA HHHHHHHHHHHHHHH	6.31	29967540
201	Phosphorylation	AVLQAEVYGARLAAK HHHHHHHHHHHHHHH	9.14	18083107
204	Ubiquitination	QAEVYGARLAAKYLD HHHHHHHHHHHHHHC	22.09	29967540
208	Ubiquitination	YGARLAAKYLDKELA HHHHHHHHHHCHHHH	40.51	29967540
209	Phosphorylation	GARLAAKYLDKELAG HHHHHHHHHCHHHHH	18.53	18083107
212	Ubiquitination	LAAKYLDKELAGRVQ HHHHHHCHHHHHHHH	52.62	29967540
270	Ubiquitination	KRPMQAPPGHDQDSL CCCCCCCCCCCHHHH	56.62	29967540
271	Ubiquitination	RPMQAPPGHDQDSLK CCCCCCCCCCHHHHH	35.62	29967540
276	Phosphorylation	PPGHDQDSLKKSQGV CCCCCHHHHHHHCCC	36.13	28985074
278	Ubiquitination	GHDQDSLKKSQGVGP CCCHHHHHHHCCCCC	55.09	29967540
279	Ubiquitination	HDQDSLKKSQGVGPI CCHHHHHHHCCCCCC	53.99	29967540
280	Phosphorylation	DQDSLKKSQGVGPIR CHHHHHHHCCCCCCC	30.49	29743597
302	Phosphorylation	DHEGLGISITGGKEH CCCCCEEEECCCHHH	16.58	28348404
342	Ubiquitination	AILAVNGVNLRDTKH EEEEECCCCCCCCCC	5.27	33845483
350	Ubiquitination	NLRDTKHKEAVTILS CCCCCCCHHHHHHHH	49.26	33845483
369	Phosphorylation	EIEFEVVYVAPEVDS EEEEEEEEEECCCCC	8.96	26657352
376	Phosphorylation	YVAPEVDSDDENVEY EEECCCCCCCCCCEE	52.73	27362937
383	Phosphorylation	SDDENVEYEDESGHR CCCCCCEEECCCCCE	25.13	26074081
387	Phosphorylation	NVEYEDESGHRYRLY CCEEECCCCCEEEEE	52.82	26074081
391	Phosphorylation	EDESGHRYRLYLDEL ECCCCCEEEEEEEEC	10.17	26074081
394	Phosphorylation	SGHRYRLYLDELEGG CCCEEEEEEEECCCC	11.78	28796482
401	Ubiquitination	YLDELEGGGNPGASC EEEECCCCCCCCCCC	24.27	29967540
407	Phosphorylation	GGGNPGASCKDTSGE CCCCCCCCCCCCCCC	27.84	29507054
408	Ubiquitination	GGNPGASCKDTSGEI CCCCCCCCCCCCCCE	4.60	32015554
409	Ubiquitination	GNPGASCKDTSGEIK CCCCCCCCCCCCCEE	62.64	29967540
411	Phosphorylation	PGASCKDTSGEIKVL CCCCCCCCCCCEEEE	24.91	21712546
412	Phosphorylation	GASCKDTSGEIKVLQ CCCCCCCCCCEEEEE	44.56	29214152
415	Ubiquitination	CKDTSGEIKVLQGFN CCCCCCCEEEEECCC	4.22	29967540
416	Sumoylation	KDTSGEIKVLQGFNK CCCCCCEEEEECCCC	32.37	-
416	Ubiquitination	KDTSGEIKVLQGFNK CCCCCCEEEEECCCC	32.37	32015554
416	Sumoylation	KDTSGEIKVLQGFNK CCCCCCEEEEECCCC	32.37	-
423	2-Hydroxyisobutyrylation	KVLQGFNKKAVTDTH EEEECCCCCCCCCCC	39.59	-
423	Ubiquitination	KVLQGFNKKAVTDTH EEEECCCCCCCCCCC	39.59	29967540
437	Phosphorylation	HENGDLGTASETPLD CCCCCCCCCCCCCCC	34.02	26657352
439	Phosphorylation	NGDLGTASETPLDDG CCCCCCCCCCCCCCC	41.67	25159151
441	Phosphorylation	DLGTASETPLDDGAS CCCCCCCCCCCCCCC	27.02	28985074
451	Ubiquitination	DDGASKLDDLHTLYH CCCCCCHHHHHHHHC	61.23	29967540
455	Phosphorylation	SKLDDLHTLYHKKSY CCHHHHHHHHCCCCC	35.99	29978859
457	Phosphorylation	LDDLHTLYHKKSY-- HHHHHHHHCCCCC--	16.85	14729942
459	Ubiquitination	DLHTLYHKKSY---- HHHHHHCCCCC----	29.83	29967540
461	Phosphorylation	HTLYHKKSY------ HHHHCCCCC------	40.66	24719451
462	Phosphorylation	TLYHKKSY------- HHHCCCCC-------	31.30	14729942

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	UBE3A	Q05086	PMID:16878151

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of GOPC_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of GOPC_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CSPG5_HUMAN	CSPG5	physical	12885772
BECN1_HUMAN	BECN1	physical	12372286
GRID2_HUMAN	GRID2	physical	12372286
RHOQ_HUMAN	RHOQ	physical	11162552
GOPC_HUMAN	GOPC	physical	11162552
CLCN3_HUMAN	CLCN3	physical	12471024
CFTR_HUMAN	CFTR	physical	12471024
STX6_RAT	Stx6	physical	11384996
GRM5_RAT	Grm5	physical	19860857
MARH2_HUMAN	MARCH2	physical	23818989
IMA5_HUMAN	KPNA1	physical	21988832
TF65_HUMAN	RELA	physical	21988832
TGFR2_HUMAN	TGFBR2	physical	21988832
NUP62_HUMAN	NUP62	physical	21988832
ARI1_HUMAN	ARIH1	physical	22863883
NC2B_HUMAN	DR1	physical	22863883
HSF1_HUMAN	HSF1	physical	22863883
LRSM1_HUMAN	LRSAM1	physical	22863883
2A5D_HUMAN	PPP2R5D	physical	22863883
SEM4G_HUMAN	SEMA4G	physical	25416956
RM01_HUMAN	MRPL1	physical	25416956
AKIR1_HUMAN	AKIRIN1	physical	25416956
C102B_HUMAN	CCDC102B	physical	25416956
GHC2_HUMAN	SLC25A18	physical	25416956
ZN587_HUMAN	ZNF587	physical	25416956
MUM1_HUMAN	MUM1	physical	25416956
MYCD_HUMAN	MYOCD	physical	25416956
MORN4_HUMAN	MORN4	physical	25416956
RN183_HUMAN	RNF183	physical	25416956
SPAT8_HUMAN	SPATA8	physical	25416956
ZN564_HUMAN	ZNF564	physical	25416956
ZBT49_HUMAN	ZBTB49	physical	25416956
FAM9B_HUMAN	FAM9B	physical	25416956
LCLT1_HUMAN	LCLAT1	physical	25416956
ZSCA1_HUMAN	ZSCAN1	physical	25416956
CQ067_HUMAN	C17orf67	physical	25416956
ZBTB5_HUMAN	ZBTB5	physical	28514442
RTL6_HUMAN	LDOC1L	physical	28514442
FCSD2_HUMAN	FCHSD2	physical	28514442
ATG4D_HUMAN	ATG4D	physical	28514442
BAP1_HUMAN	BAP1	physical	28514442
CNTLN_HUMAN	CNTLN	physical	28514442
M18BP_HUMAN	MIS18BP1	physical	28514442
KIF1B_HUMAN	KIF1B	physical	28514442
GOGA3_HUMAN	GOLGA3	physical	28514442
CENPF_HUMAN	CENPF	physical	28514442
PKN2_HUMAN	PKN2	physical	28514442
C102A_HUMAN	CCDC102A	physical	28514442
SSNA1_HUMAN	SSNA1	physical	28514442
LIMA1_HUMAN	LIMA1	physical	28514442
CCDC8_HUMAN	CCDC8	physical	28514442
TFAM_HUMAN	TFAM	physical	28514442
GRK6_HUMAN	GRK6	physical	28514442
CABL1_HUMAN	CABLES1	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of GOPC_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Robust phosphoproteomic profiling of tyrosine phosphorylation sitesfrom human T cells using immobilized metal affinity chromatography andtandem mass spectrometry."; Brill L.M., Salomon A.R., Ficarro S.B., Mukherji M., Stettler-Gill M.,Peters E.C.; Anal. Chem. 76:2763-2772(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-457 AND TYR-462, ANDMASS SPECTROMETRY.	15144186 [Abstract]