CSPG5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CSPG5_HUMAN
• UniProt AC: O95196
• Protein Name: Chondroitin sulfate proteoglycan 5
• Gene Name: CSPG5
• Organism: Homo sapiens (Human).
• Sequence Length: 566
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein . Endoplasmic reticulum membrane ; Single-pass type I membrane protein . Golgi apparatus membrane ; Single-pass type I membrane protein . Cell surface . In neurons, localizes to synaptic junctions.
• Protein Description: May function as a growth and differentiation factor involved in neuritogenesis. May induce ERBB3 activation..
• Protein Sequence: MGRAGGGGPGRGPPPLLLFLGAALVLASGAVPAREAGSAVEAEELVKGSPAWEPPANDTREEAGPPAAGEDEASWTAPGGELAGPEEVLQESAAVTGTAWLEADSPGLGGVTAEAGSGDAQALPATLQAPHEVLGQSIMPPAIPEATEASGPPSPTPGDKLSPASELPKESPLEVWLNLGGSTPDPQGPELTYPFQGTLEPQPASDIIDIDYFEGLDGEGRGADLGSFPGSPGTSENHPDTEGETPSWSLLDLYDDFTPFDESDFYPTTSFYDDLDEEEEEEEDDKDAVGGGDLEDENELLVPTGKPGLGPGTGQPTSRWHAVPPQHTLGSVPGSSIALRPRPGEPGRDLASSENGTECRSGFVRHNGSCRSVCDLFPSYCHNGGQCYLVENIGAFCRCNTQDYIWHKGMRCESIITDFQVMCVAVGSAALVLLLLFMMTVFFAKKLYLLKTENTKLRRTNKFRTPSELHNDNFSLSTIAEGSHPNVRKLCNTPRTSSPHARALAHYDNVICQDDPSAPHKIQEVLKSCLKEEESFNIQNSMSPKLEGGKGDQADLDVNCLQNNLT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
28	Phosphorylation	GAALVLASGAVPARE HHHHHHHHCCCCHHH	24.11	28348404
38	Phosphorylation	VPAREAGSAVEAEEL CCHHHCCCCEEHHHH	35.87	28348404
57	N-linked_Glycosylation	PAWEPPANDTREEAG CCCCCCCCCCCHHHC	57.89	UniProtKB CARBOHYD
117	O-linked_Glycosylation	GVTAEAGSGDAQALP CEEEECCCCCCCCCC	40.31	-
162	O-linked_Glycosylation	PTPGDKLSPASELPK CCCCCCCCCHHHCCC	24.94	55824583
165	O-linked_Glycosylation	GDKLSPASELPKESP CCCCCCHHHCCCCCC	42.95	55824589
327 (in isoform 3)	Phosphorylation	-	28.91	26471730
328	O-linked_Glycosylation	HAVPPQHTLGSVPGS EECCCCCCCCCCCCC	27.80	55823879
329 (in isoform 3)	Phosphorylation	-	4.52	26471730
335	O-linked_Glycosylation	TLGSVPGSSIALRPR CCCCCCCCCEEEECC	16.70	OGP
352 (in isoform 3)	Phosphorylation	-	45.54	-
465	Phosphorylation	RRTNKFRTPSELHND CCCCCCCCHHHHCCC	34.01	29978859
465 (in isoform 2)	Phosphorylation	-	34.01	26471730
467	Phosphorylation	TNKFRTPSELHNDNF CCCCCCHHHHCCCCC	52.78	29978859
467 (in isoform 2)	Phosphorylation	-	52.78	26471730
475	Phosphorylation	ELHNDNFSLSTIAEG HHCCCCCCHHHHCCC	27.88	29978859
477	Phosphorylation	HNDNFSLSTIAEGSH CCCCCCHHHHCCCCC	19.30	29978859
478	Phosphorylation	NDNFSLSTIAEGSHP CCCCCHHHHCCCCCC	29.51	29978859
483	Phosphorylation	LSTIAEGSHPNVRKL HHHHCCCCCCCHHHH	27.55	-
490 (in isoform 2)	Phosphorylation	-	1.58	-
507	Phosphorylation	HARALAHYDNVICQD HHHHHHHCCCEECCC	12.01	29978859
531	Ubiquitination	EVLKSCLKEEESFNI HHHHHHHCHHHCCCC	68.36	-
541	Phosphorylation	ESFNIQNSMSPKLEG HCCCCCCCCCCCCCC	12.31	23532336
543	Phosphorylation	FNIQNSMSPKLEGGK CCCCCCCCCCCCCCC	20.78	23532336

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CSPG5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CSPG5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CSPG5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GOPC_HUMAN	GOPC	physical	12885772

Drug and Disease Associations

• Kegg Disease
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.