CNTLN_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CNTLN_HUMAN
• UniProt AC: Q9NXG0
• Protein Name: Centlein
• Gene Name: CNTLN
• Organism: Homo sapiens (Human).
• Sequence Length: 1405
• Subcellular Localization: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Colocalizes with gamma-tubulin during interphase and mitosis. Appears to associate with the mother centriole during G1 phase and with daughter centrioles towards G1/S pha
• Protein Description: Required for centrosome cohesion and recruitment of CEP68 to centrosomes..
• Protein Sequence: MAARSPPSPHPSPPARQLGPRSPRVGRGAEVHAMRSEASGFAGAAREVVADESDKIWVGEEGSGGRRGPGGAAPAHAPLLSAPMGSRRLEGISVEEAMVTRTQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEAKDRKVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRKELQELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLRNQEDVHTAESISYQKLYNELHICFETTKSNEAMLRQSVTNLQDQLLQKEQENAKLKEKLQESQGAPLPLPQESDPDYSAQVPHRPSLSSLETLMVSQKSEIEYLQEKLKIANEKLSENISANKGFSRKSIMTSAEGKHKEPPVKRSRSLSPKSSFTDSEELQKLRKAERKIENLEKALQLKSQENDELRDAHEKRKERLQMLQTNYRAVKEQLKQWEEGSGMTEIRKIKRADPQQLRQEDSDAVWNELAYFKRENQELMIQKMNLEEELDELKVHISIDKAAIQELNRCVAERREEQLFRSGEDDEVKRSTPEKNGKEMLEQTLQKVTELENRLKSFEKRSRKLKEGNKKLMKENDFLKSLLKQQQEDTETREKELEQIIKGSKDVEKENTELQVKISELETEVTSLRRQVAEANALRNENEELINPMEKSHQSADRAKSEMATMKVRSGRYDCKTTMTKVKFKAAKKNCSVGRHHTVLNHSIKVMSNVFENLSKDGWEDVSESSSDSEAQTSQTLGTIIVETSQKISPTEDGKDQKESDPTEDSQTQGKEIVQTYLNIDGKTPKDYFHDKNAKKPTFQKKNCKMQKSSHTAVPTRVNREKYKNITAQKSSSNIILLRERIISLQQQNSVLQNAKKTAELSVKEYKEVNEKLLHQQQVSDQRFQTSRQTIKKLNLDLAGLRKEKEDLLKKLESSSEITSLAEENSQVTFPRIQVTSLSPSRSMDLEMKQLQYKLKNATNELTKQSSNVKTLKFELLAKEEHIKEMHEKISRMERDITMKRHLIEDLKFRQKVNLESNKSFSEMLQNLDKKVKTLTEECSNKKVSIDSLKQRLNVAVKEKSQYEQMYQKSKEELEKKDLKLTLLVSRISETESAMAEIETAASKQLQELALQSEQVLEGAQKTLLLANEKVEEFTTFVKALAKELQNDVHVVRRQIRELKKMKKNRDACKTSTHKAQTLAASILNISRSDLEEILDTEDQVEIEKTKIDAENDKEWMLYIQKLLEGQSLTLSPRLKCNGAIMAHQNLRLPDSSSSASAS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAARSPPSP ------CCCCCCCCC	23.92	-
5	Phosphorylation	---MAARSPPSPHPS ---CCCCCCCCCCCC	36.11	25159151
8 (in isoform 2)	Phosphorylation	-	38.94	24719451
8	Phosphorylation	MAARSPPSPHPSPPA CCCCCCCCCCCCCCH	38.94	25159151
12 (in isoform 2)	Phosphorylation	-	40.25	24719451
12	Phosphorylation	SPPSPHPSPPARQLG CCCCCCCCCCHHHCC	40.25	28450419
22	Phosphorylation	ARQLGPRSPRVGRGA HHHCCCCCCCCCCCC	21.86	23186163
22 (in isoform 2)	Phosphorylation	-	21.86	24719451
27	Methylation	PRSPRVGRGAEVHAM CCCCCCCCCCCHHHH	37.99	-
102	Phosphorylation	EEAMVTRTQLLEEEL HHHHHHHHHHHHHHH	17.76	24961811
110	Phosphorylation	QLLEEELSSLKEELA HHHHHHHHHHHHHHH	36.58	24719451
111	Phosphorylation	LLEEELSSLKEELAL HHHHHHHHHHHHHHH	56.96	24961811
169	Ubiquitination	VLEILQVKDAKIQEF HHHHHHHCCCCHHHH	38.72	-
169 (in isoform 2)	Ubiquitination	-	38.72	-
172 (in isoform 2)	Ubiquitination	-	55.87	-
181	Phosphorylation	QEFEQRESVLKQEIN HHHHHHHHHHHHHHH	34.63	23403867
209 (in isoform 2)	Phosphorylation	-	42.23	27251275
209	Phosphorylation	AFLRKEFSDLEKKFK HHHHHHHHHHHHHHH	42.23	27251275
252	Phosphorylation	EENKKLSTRCTDLLN HHHHHHHHHHHHHHH	39.95	29759185
255	Phosphorylation	KKLSTRCTDLLNDLE HHHHHHHHHHHHHHH	26.79	29759185
284	Phosphorylation	STDAKIKTFEDNLIE CCCCCCCCHHHHHHH	35.41	19664994
329 (in isoform 2)	Ubiquitination	-	56.12	-
329	Ubiquitination	MDITLVRKELQELQN CCHHHHHHHHHHHHH	56.12	-
380 (in isoform 3)	Phosphorylation	-	14.16	27642862
386 (in isoform 3)	Phosphorylation	-	28.33	27642862
444	Phosphorylation	PQESDPDYSAQVPHR CCCCCCCCCCCCCCC	15.99	24275569
445	Phosphorylation	QESDPDYSAQVPHRP CCCCCCCCCCCCCCC	21.43	27251275
453 (in isoform 2)	Phosphorylation	-	40.62	27251275
453	Phosphorylation	AQVPHRPSLSSLETL CCCCCCCCCHHHCHH	40.62	24275569
455	Phosphorylation	VPHRPSLSSLETLMV CCCCCCCHHHCHHHH	36.90	27251275
456	Phosphorylation	PHRPSLSSLETLMVS CCCCCCHHHCHHHHC	35.20	27251275
459	Phosphorylation	PSLSSLETLMVSQKS CCCHHHCHHHHCCHH	26.00	27251275
513	Phosphorylation	KEPPVKRSRSLSPKS CCCCCCCCCCCCCCC	22.09	23403867
515	Phosphorylation	PPVKRSRSLSPKSSF CCCCCCCCCCCCCCC	34.15	24719451
515 (in isoform 2)	Phosphorylation	-	34.15	24719451
517	Phosphorylation	VKRSRSLSPKSSFTD CCCCCCCCCCCCCCC	31.37	23403867
517 (in isoform 2)	Phosphorylation	-	31.37	24719451
520	Phosphorylation	SRSLSPKSSFTDSEE CCCCCCCCCCCCHHH	33.78	-
521	Phosphorylation	RSLSPKSSFTDSEEL CCCCCCCCCCCHHHH	37.99	-
523	Phosphorylation	LSPKSSFTDSEELQK CCCCCCCCCHHHHHH	40.33	-
525	Phosphorylation	PKSSFTDSEELQKLR CCCCCCCHHHHHHHH	29.88	-
677	Phosphorylation	EDDEVKRSTPEKNGK CCCCHHHCCCCCCHH	42.47	-
678	Phosphorylation	DDEVKRSTPEKNGKE CCCHHHCCCCCCHHH	39.23	-
684	Acetylation	STPEKNGKEMLEQTL CCCCCCHHHHHHHHH	49.71	11688597
690	Phosphorylation	GKEMLEQTLQKVTEL HHHHHHHHHHHHHHH	23.06	-
703	Phosphorylation	ELENRLKSFEKRSRK HHHHHHHHHHHHHHH	43.14	-
727	Phosphorylation	KENDFLKSLLKQQQE HHCHHHHHHHHHHHH	40.87	24719451
727 (in isoform 2)	Phosphorylation	-	40.87	24719451
819	Phosphorylation	MKVRSGRYDCKTTMT HHHHCCCCCCCCCCH	29.26	-
849	Phosphorylation	HHTVLNHSIKVMSNV CHHHHHHHHHHHHHH	24.03	28555341
854	Phosphorylation	NHSIKVMSNVFENLS HHHHHHHHHHHHHCC	32.59	24905233
861	Phosphorylation	SNVFENLSKDGWEDV HHHHHHCCCCCCCCC	40.04	28555341
871	Phosphorylation	GWEDVSESSSDSEAQ CCCCCCCCCCCCHHH	27.86	24905233
875	Phosphorylation	VSESSSDSEAQTSQT CCCCCCCCHHHHHHH	36.46	24905233
879	Phosphorylation	SSDSEAQTSQTLGTI CCCCHHHHHHHHCEE	29.83	24905233
895	Phosphorylation	VETSQKISPTEDGKD EEECCCCCCCCCCCC	32.57	-
906	Phosphorylation	DGKDQKESDPTEDSQ CCCCCCCCCCCCCHH	56.79	25954137
909	Phosphorylation	DQKESDPTEDSQTQG CCCCCCCCCCHHHCC	58.37	25954137
923	Phosphorylation	GKEIVQTYLNIDGKT CHHHHHHHHCCCCCC	4.81	23532336
930	Phosphorylation	YLNIDGKTPKDYFHD HHCCCCCCCHHHCCC	40.89	23532336
956	Phosphorylation	NCKMQKSSHTAVPTR CCCCCCCCCCCCCCC	31.71	-
962	Phosphorylation	SSHTAVPTRVNREKY CCCCCCCCCCCHHHH	40.42	-
969	Phosphorylation	TRVNREKYKNITAQK CCCCHHHHCCCCCCC	12.43	-
973	Phosphorylation	REKYKNITAQKSSSN HHHHCCCCCCCCCCC	32.22	20068231
977	Phosphorylation	KNITAQKSSSNIILL CCCCCCCCCCCEEEE	27.24	28111955
978	Phosphorylation	NITAQKSSSNIILLR CCCCCCCCCCEEEEH	34.14	28111955
979	Phosphorylation	ITAQKSSSNIILLRE CCCCCCCCCEEEEHH	38.86	20068231
1039	Acetylation	TSRQTIKKLNLDLAG HHHHHHHHHCCCHHH	38.46	90543
1082 (in isoform 2)	Phosphorylation	-	13.94	24719451
1082	Phosphorylation	TFPRIQVTSLSPSRS CCCEEEEEECCCCCC	13.94	20068231
1083	Phosphorylation	FPRIQVTSLSPSRSM CCEEEEEECCCCCCC	28.17	19691289
1085	Phosphorylation	RIQVTSLSPSRSMDL EEEEEECCCCCCCCH	22.16	25159151
1087	Phosphorylation	QVTSLSPSRSMDLEM EEEECCCCCCCCHHH	33.34	19691289
1089	Phosphorylation	TSLSPSRSMDLEMKQ EECCCCCCCCHHHHH	22.45	30622161
1099	Phosphorylation	LEMKQLQYKLKNATN HHHHHHHHHHHHHHH	27.21	-
1112	Phosphorylation	TNELTKQSSNVKTLK HHHHHHHCCCCCHHH	25.99	20068231
1113	O-linked_Glycosylation	NELTKQSSNVKTLKF HHHHHHCCCCCHHHH	43.05	30379171
1113	Phosphorylation	NELTKQSSNVKTLKF HHHHHHCCCCCHHHH	43.05	20068231
1117	Phosphorylation	KQSSNVKTLKFELLA HHCCCCCHHHHHHHH	30.78	20068231
1137	Phosphorylation	KEMHEKISRMERDIT HHHHHHHHHHHHHHH	36.32	22210691
1158	Acetylation	EDLKFRQKVNLESNK HHHHHHHHCCCCCCC	28.91	20167786
1166	Phosphorylation	VNLESNKSFSEMLQN CCCCCCCCHHHHHHH	37.95	30622161
1168	Phosphorylation	LESNKSFSEMLQNLD CCCCCCHHHHHHHHH	29.23	30622161
1191	Phosphorylation	ECSNKKVSIDSLKQR HHHCCCCCHHHHHHH	29.56	20860994
1213	Phosphorylation	KSQYEQMYQKSKEEL HHHHHHHHHHCHHHH	16.69	-
1216	Phosphorylation	YEQMYQKSKEELEKK HHHHHHHCHHHHHHH	29.76	-
1228	Phosphorylation	EKKDLKLTLLVSRIS HHHHHHHHHHHHHHH	19.23	20068231
1232	Phosphorylation	LKLTLLVSRISETES HHHHHHHHHHHHHHH	24.70	22210691
1235	Phosphorylation	TLLVSRISETESAMA HHHHHHHHHHHHHHH	37.04	29759185
1237	Phosphorylation	LVSRISETESAMAEI HHHHHHHHHHHHHHH	28.57	29759185
1239	Phosphorylation	SRISETESAMAEIET HHHHHHHHHHHHHHH	30.66	29759185
1317	Phosphorylation	KNRDACKTSTHKAQT HCCHHHHHCHHHHHH	38.45	21082442
1319	Phosphorylation	RDACKTSTHKAQTLA CHHHHHCHHHHHHHH	32.40	21082442
1333	Phosphorylation	AASILNISRSDLEEI HHHHHCCCHHHHHHH	25.34	21082442
1343	Phosphorylation	DLEEILDTEDQVEIE HHHHHCCCCCCEEEE	37.71	-
1376	Phosphorylation	LLEGQSLTLSPRLKC HHCCCCCCCCCCCEE	30.36	-
1378	Phosphorylation	EGQSLTLSPRLKCNG CCCCCCCCCCCEECC	11.62	-
1400 (in isoform 2)	Phosphorylation	-	33.60	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CNTLN_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CNTLN_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CNTLN_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of CNTLN_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.