dbPTM

CFTR_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CFTR_HUMAN
UniProt AC	P13569
Protein Name	Cystic fibrosis transmembrane conductance regulator
Gene Name	CFTR
Organism	Homo sapiens (Human).
Sequence Length	1480
Subcellular Localization	Apical cell membrane Multi-pass membrane protein . Early endosome membrane Multi-pass membrane protein . Cell membrane Multi-pass membrane protein . Recycling endosome membrane Multi-pass membrane protein . Endoplasmic reticulum membrane Multi-p
Protein Description	Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. [PubMed: 26823428 Mediates the transport of chloride ions across the cell membrane]
Protein Sequence	MQRSPLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDRELASKKNPKLINALRRCFFWRFMFYGIFLYLGEVTKAVQPLLLGRIIASYDPDNKEERSIAIYLGIGLCLLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIGQLVSLLSNNLNKFDEGLALAHFVWIAPLQVALLMGLIWELLQASAFCGLGFLIVLALFQAGLGRMMMKYRDQRAGKISERLVITSEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRKAAYVRYFNSSAFFFSGFFVVFLSVLPYALIKGIILRKIFTTISFCIVLRMAVTRQFPWAVQTWYDSLGAINKIQDFLQKQEYKTLEYNLTTTEVVMENVTAFWEEGFGELFEKAKQNNNNRKTSNGDDSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGRISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLMGCDSFDQFSAERRNSILTETLHRFSLEGDAPVSWTETKKQSFKQTGEFGEKRKNSILNPINSIRKFSIVQKTPLQMNGIEEDSDEPLERRLSLVPDSEQGEAILPRISVISTGPTLQARRRQSVLNLMTHSVNQGQNIHRKTTASTRKVSLAPQANLTELDIYSRRLSQETGLEISEEINEEDLKECFFDDMESIPAVTTWNTYLRYITVHKSLIFVLIWCLVIFLAEVAASLVVLWLLGNTPLQDKGNSTHSRNNSYAVIITSTSSYYVFYIYVGVADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVLQAPMSTLNTLKAGGILNRFSKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATVPVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTTGEGEGRVGIILTLAMNIMSTLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPYKNGQLSKVMIIENSHVKKDDIWPSGGQMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNTEGEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPSDRVKLFPHRNSSKCKSKPQIAALKEETEEEVQDTRL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MQRSPLEKASV ----CCCCHHHHHHH	33.28	24719451
45	Phosphorylation	YQIPSVDSADNLSEK CCCCCCCCCCCHHHH	35.05	-
50	Phosphorylation	VDSADNLSEKLEREW CCCCCCHHHHHHHHH	38.65	-
94	Phosphorylation	FLYLGEVTKAVQPLL HHHHHHHHHHHHHHH	14.69	-
256	Phosphorylation	DQRAGKISERLVITS HHCCCCCCCEEEECH	21.83	-
291	Phosphorylation	MIENLRQTELKLTRK HHHHHHHHHHHHHHH	36.53	20068231
420	Ubiquitination	KQNNNNRKTSNGDDS HHCCCCCCCCCCCCC	59.43	-
421	Phosphorylation	QNNNNRKTSNGDDSL HCCCCCCCCCCCCCC	24.96	24719451
422	Phosphorylation	NNNNRKTSNGDDSLF CCCCCCCCCCCCCCC	41.68	21930781
427	Phosphorylation	KTSNGDDSLFFSNFS CCCCCCCCCCCCCCC	31.64	-
447	Sumoylation	VLKDINFKIERGQLL CCCCCCEEEECCCEE	38.89	-
447	Sumoylation	VLKDINFKIERGQLL CCCCCCEEEECCCEE	38.89	-
466	Phosphorylation	STGAGKTSLLMVIMG CCCCCHHHEEEEEEC	24.00	26657352
489	Phosphorylation	IKHSGRISFCSQFSW CCCCCCEEEEECCCC	20.88	30631047
492	Phosphorylation	SGRISFCSQFSWIMP CCCEEEEECCCCCCC	32.05	30631047
501	Phosphorylation	FSWIMPGTIKENIIF CCCCCCCCCCCCEEE	24.01	30631047
511	Phosphorylation	ENIIFGVSYDEYRYR CCEEEEECCCHHHHH	27.52	21930781
512	Phosphorylation	NIIFGVSYDEYRYRS CEEEEECCCHHHHHH	15.47	21807898
515	Phosphorylation	FGVSYDEYRYRSVIK EEECCCHHHHHHHHH	15.28	17053785
524	S-palmitoylation	YRSVIKACQLEEDIS HHHHHHHHCCHHHHH	3.94	22119790
547	Phosphorylation	VLGEGGITLSGGQRA EEECCCEECCCHHHH	20.39	25278378
549	Phosphorylation	GEGGITLSGGQRARI ECCCEECCCHHHHHH	32.02	20068231
582	Phosphorylation	FGYLDVLTEKEIFES CCCCCCCCHHHHHHH	44.88	22817900
604	Phosphorylation	NKTRILVTSKMEHLK CCCEEEEECCHHHHH	21.13	22817900
605	Phosphorylation	KTRILVTSKMEHLKK CCEEEEECCHHHHHH	23.64	-
641	Phosphorylation	QNLQPDFSSKLMGCD HHCCCCCCHHHCCCC	33.66	22817900
660	Phosphorylation	FSAERRNSILTETLH CCHHHHHHHHHHHHH	19.70	1716180
670	Phosphorylation	TETLHRFSLEGDAPV HHHHHHHCCCCCCCC	26.01	25330774
682	Phosphorylation	APVSWTETKKQSFKQ CCCCCCHHCCHHHHC	35.85	22817900
686	Phosphorylation	WTETKKQSFKQTGEF CCHHCCHHHHCCCCC	43.20	22817900
688	Ubiquitination	ETKKQSFKQTGEFGE HHCCHHHHCCCCCCH	52.80	22119790
700	Phosphorylation	FGEKRKNSILNPINS CCHHHCCCCCCHHHH	31.33	22817900
707	Phosphorylation	SILNPINSIRKFSIV CCCCHHHHHHCCEEE	25.21	22817900
712	Phosphorylation	INSIRKFSIVQKTPL HHHHHCCEEEECCCC	25.53	22817900
717	Phosphorylation	KFSIVQKTPLQMNGI CCEEEECCCCCCCCC	16.49	22119790
728	Phosphorylation	MNGIEEDSDEPLERR CCCCCCCCCCCHHHH	47.34	23879269
737	Phosphorylation	EPLERRLSLVPDSEQ CCHHHHHCCCCCHHH	26.05	21455600
753	Phosphorylation	EAILPRISVISTGPT CEECCCEEEEECCCC	18.06	22817900
768	Phosphorylation	LQARRRQSVLNLMTH HHHHHHHHHHHHHHC	27.10	21455600
774	Phosphorylation	QSVLNLMTHSVNQGQ HHHHHHHHCCCCCCC	17.73	23312004
776	Phosphorylation	VLNLMTHSVNQGQNI HHHHHHCCCCCCCCC	17.38	23312004
790	Phosphorylation	IHRKTTASTRKVSLA CCCCCCCCCCCCCCC	27.01	22817900
795	Phosphorylation	TASTRKVSLAPQANL CCCCCCCCCCCCCCC	23.11	1716180
803	Phosphorylation	LAPQANLTELDIYSR CCCCCCCCHHHHHHH	34.02	24719451
808	Phosphorylation	NLTELDIYSRRLSQE CCCHHHHHHHHHHHH	8.87	28442448
809	Phosphorylation	LTELDIYSRRLSQET CCHHHHHHHHHHHHH	15.97	22817900
813	Phosphorylation	DIYSRRLSQETGLEI HHHHHHHHHHHCCCC	24.94	21455600
816	Phosphorylation	SRRLSQETGLEISEE HHHHHHHHCCCCCHH	39.16	-
894	N-linked_Glycosylation	TPLQDKGNSTHSRNN CCCCCCCCCCCCCCC	49.85	7518437
900	N-linked_Glycosylation	GNSTHSRNNSYAVII CCCCCCCCCEEEEEE	44.83	7518437
1014	Phosphorylation	VVAVLQPYIFVATVP HHHHHHCCHHHHHHH	8.27	-
1019	Phosphorylation	QPYIFVATVPVIVAF HCCHHHHHHHHHHHH	21.75	-
1045	Phosphorylation	QQLKQLESEGRSPIF HHHHHHHHCCCCHHH	54.68	-
1171	Phosphorylation	FKFIDMPTEGKPTKS HHHCCCCCCCCCCCC	51.21	28509920
1176	Phosphorylation	MPTEGKPTKSTKPYK CCCCCCCCCCCCCCC	40.90	19413330
1246	Phosphorylation	RVGLLGRTGSGKSTL EEEEECCCCCCHHHH	33.62	28258704
1248	Phosphorylation	GLLGRTGSGKSTLLS EEECCCCCCHHHHHH	42.29	28258704
1255	Phosphorylation	SGKSTLLSAFLRLLN CCHHHHHHHHHHHHC	21.78	22210691
1344	Glutathionylation	FVLVDGGCVLSHGHK EEEEECCEEECCHHH	3.21	22833525
1359	Phosphorylation	QLMCLARSVLSKAKI HHHHHHHHHHHHCEE	23.08	20068231
1362	Phosphorylation	CLARSVLSKAKILLL HHHHHHHHHCEEHHH	28.54	20068231
1395	S-palmitoylation	LKQAFADCTVILCEH HHHHHCCCEEEEECH	2.69	22119790
1424	Phosphorylation	EENKVRQYDSIQKLL ECCCHHCHHHHHHHH	10.90	26270265
1426	Phosphorylation	NKVRQYDSIQKLLNE CCHHCHHHHHHHHHH	23.22	26270265
1444	Phosphorylation	FRQAISPSDRVKLFP HHHCCCHHHHCCCCC	31.12	22119790
1455	Phosphorylation	KLFPHRNSSKCKSKP CCCCCCCCHHCCCCH	31.00	24670416
1456	Phosphorylation	LFPHRNSSKCKSKPQ CCCCCCCHHCCCCHH	45.69	7680525
1471	Phosphorylation	IAALKEETEEEVQDT HHHHHHHHHHHHHHH	50.19	21930781

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
421	T	Phosphorylation	Kinase	CK2A1	P68400	PSP
422	S	Phosphorylation	Kinase	CK2A1	P68400	PSP
422	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
427	S	Phosphorylation	Kinase	CK2A1	P68400	PSP
511	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
511	S	Phosphorylation	Kinase	CK2-FAMILY	-	GPS
512	Y	Phosphorylation	Kinase	SYK	P43405	PSP
604	T	Phosphorylation	Kinase	PRKCA	P05696	GPS
641	S	Phosphorylation	Kinase	PRKCA	P05696	GPS
641	S	Phosphorylation	Kinase	PKCA	P17252	PSP
660	S	Phosphorylation	Kinase	PKG-FAMILY	-	GPS
660	S	Phosphorylation	Kinase	PRKCA	P17252	GPS
660	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
660	S	Phosphorylation	Kinase	PRKG1	P00516	GPS
660	S	Phosphorylation	Kinase	PKA_GROUP	-	PhosphoELM
660	S	Phosphorylation	Kinase	PKG/CGK_GROUP	-	PhosphoELM
660	S	Phosphorylation	Kinase	PKA	-	Uniprot
660	S	Phosphorylation	Kinase	PKACA	P17612	PSP
660	S	Phosphorylation	Kinase	PRKACA	P00517	GPS
670	S	Phosphorylation	Kinase	PKA	-	Uniprot
670	S	Phosphorylation	Kinase	PKACA	P17612	PSP
682	T	Phosphorylation	Kinase	PKCA	P17252	PSP
682	T	Phosphorylation	Kinase	PRKCA	P05696	GPS
686	S	Phosphorylation	Kinase	PKC_GROUP	-	PhosphoELM
686	S	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
686	S	Phosphorylation	Kinase	PKC	-	Uniprot
686	S	Phosphorylation	Kinase	KPCA	P17252	PhosphoELM
686	S	Phosphorylation	Kinase	PRKCA	P05696	GPS
700	S	Phosphorylation	Kinase	PKA	-	Uniprot
700	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
700	S	Phosphorylation	Kinase	PKG/CGK_GROUP	-	PhosphoELM
700	S	Phosphorylation	Kinase	PKG-FAMILY	-	GPS
700	S	Phosphorylation	Kinase	PRKACA	P00517	GPS
700	S	Phosphorylation	Kinase	PKACA	P17612	PSP
700	S	Phosphorylation	Kinase	PKA_GROUP	-	PhosphoELM
700	S	Phosphorylation	Kinase	PRKG1	P00516	GPS
707	S	Phosphorylation	Kinase	PRKCA	P05696	GPS
712	S	Phosphorylation	Kinase	PKA	-	Uniprot
712	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
712	S	Phosphorylation	Kinase	PRKACA	P17612	GPS
737	S	Phosphorylation	Kinase	PKG-FAMILY	-	GPS
737	S	Phosphorylation	Kinase	PRKAA1	Q13131	GPS
737	S	Phosphorylation	Kinase	PKG/CGK_GROUP	-	PhosphoELM
737	S	Phosphorylation	Kinase	PKA_GROUP	-	PhosphoELM
737	S	Phosphorylation	Kinase	PKA	-	Uniprot
737	S	Phosphorylation	Kinase	PRKACA	P17612	GPS
737	S	Phosphorylation	Kinase	LMTK2	Q8IWU2	GPS
737	S	Phosphorylation	Kinase	PRKCA	P17252	GPS
737	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
753	S	Phosphorylation	Kinase	PKA_GROUP	-	PhosphoELM
753	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
753	S	Phosphorylation	Kinase	PKA	-	Uniprot
753	S	Phosphorylation	Kinase	PRKACA	P17612	GPS
768	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
768	S	Phosphorylation	Kinase	AMPK-FAMILY	-	GPS
768	S	Phosphorylation	Kinase	PKG/CGK_GROUP	-	PhosphoELM
768	S	Phosphorylation	Kinase	PKA_GROUP	-	PhosphoELM
768	S	Phosphorylation	Kinase	PKA	-	Uniprot
768	S	Phosphorylation	Kinase	PRKAA1	Q13131	GPS
768	S	Phosphorylation	Kinase	PRKACA	P17612	GPS
768	S	Phosphorylation	Kinase	PKG-FAMILY	-	GPS
790	S	Phosphorylation	Kinase	PKC	-	Uniprot
790	S	Phosphorylation	Kinase	PKC_GROUP	-	PhosphoELM
790	S	Phosphorylation	Kinase	PRKCA	P05696	GPS
790	S	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
795	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
795	S	Phosphorylation	Kinase	PRKCA	P17252	GPS
795	S	Phosphorylation	Kinase	PKA	-	Uniprot
795	S	Phosphorylation	Kinase	PRKACA	P17612	GPS
795	S	Phosphorylation	Kinase	PKG/CGK_GROUP	-	PhosphoELM
795	S	Phosphorylation	Kinase	PKA_GROUP	-	PhosphoELM
795	S	Phosphorylation	Kinase	PKG-FAMILY	-	GPS
813	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
813	S	Phosphorylation	Kinase	PKG/CGK_GROUP	-	PhosphoELM
813	S	Phosphorylation	Kinase	PKA_GROUP	-	PhosphoELM
813	S	Phosphorylation	Kinase	PKA	-	Uniprot
813	S	Phosphorylation	Kinase	PKG-FAMILY	-	GPS
813	S	Phosphorylation	Kinase	PRKCA	P17252	GPS
813	S	Phosphorylation	Kinase	PRKACA	P17612	GPS
813	S	Phosphorylation	Kinase	PRKAA1	Q13131	GPS
-	K	Ubiquitination	E3 ubiquitin ligase	STUB1	Q9UNE7	PMID:11146634
-	K	Ubiquitination	E3 ubiquitin ligase	AMFR	Q9UKV5	PMID:18216283
-	K	Ubiquitination	E3 ubiquitin ligase	RNF5	Q99942	PMID:21148293
-	K	Ubiquitination	E3 ubiquitin ligase	RNF185	Q96GF1	PMID:22199232
-	K	Ubiquitination	E3 ubiquitin ligase	CBL	P22681	PMID:22467879
-	K	Ubiquitination	E3 ubiquitin ligase	MARCHF2	Q9P0N8	PMID:23818989

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CFTR_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CFTR_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GOPC_HUMAN	GOPC	physical	11707463
KCNJ1_HUMAN	KCNJ1	physical	14604981
NHRF4_HUMAN	PDZD3	physical	12615054
NHRF1_HUMAN	SLC9A3R1	physical	12615054
NHRF1_HUMAN	SLC9A3R1	physical	9613608
HSP7C_HUMAN	HSPA8	physical	10075921
DNJB1_HUMAN	DNAJB1	physical	10075921
DNJA1_HUMAN	DNAJA1	physical	10075921
KPCE_HUMAN	PRKCE	physical	11956211
SNP23_HUMAN	SNAP23	physical	12209004
STX1A_HUMAN	STX1A	physical	12209004
CLCN3_HUMAN	CLCN3	physical	12471024
NHRF1_HUMAN	SLC9A3R1	physical	9671706
NHRF2_HUMAN	SLC9A3R2	physical	10893422
EZRI_HUMAN	EZR	physical	10893422
NHRF1_HUMAN	SLC9A3R1	physical	9677412
NHRF1_HUMAN	SLC9A3R1	physical	12403779
NHRF3_MOUSE	Pdzk1	physical	11051556
CFTR_HUMAN	CFTR	physical	11051556
DNJC5_HUMAN	DNAJC5	physical	12039948
AMFR_HUMAN	AMFR	physical	18216283
TERA_HUMAN	VCP	physical	16621797
HSP7C_HUMAN	HSPA8	physical	15611333
COMD1_HUMAN	COMMD1	physical	21483833
CBL_HUMAN	CBL	physical	20525683
NEDD4_HUMAN	NEDD4	physical	19617352
JKAMP_HUMAN	JKAMP	physical	19269966
RNF5_HUMAN	RNF5	physical	19269966
TERA_HUMAN	VCP	physical	19828134
AMFR_HUMAN	AMFR	physical	19828134
RAB5A_HUMAN	RAB5A	physical	19398555
RB11A_HUMAN	RAB11A	physical	19398555
XPO2_DANRE	cse1l	physical	20933420
HSP74_HUMAN	HSPA4	physical	17272822
HSP7C_HUMAN	HSPA8	physical	17272822
HS90A_HUMAN	HSP90AA1	physical	17272822
TERA_HUMAN	VCP	physical	17272822
DERL1_HUMAN	DERL1	physical	16954204
TERA_HUMAN	VCP	physical	16954204
HSP74_HUMAN	HSPA4	physical	18556464
HS90A_HUMAN	HSP90AA1	physical	18556464
AHSA1_HUMAN	AHSA1	physical	18556464
HSP74_HUMAN	HSPA4	physical	19098309
CHIP_HUMAN	STUB1	physical	19098309
NHS_HUMAN	NHS	physical	14595111
CALX_HUMAN	CANX	physical	18716059
HSP74_HUMAN	HSPA4	physical	18716059
BAG1_HUMAN	BAG1	physical	23178238
HSPB1_HUMAN	HSPB1	physical	23155000
HSPB2_HUMAN	HSPB2	physical	23155000
UBP19_HUMAN	USP19	physical	19465887
CFTR_HUMAN	CFTR	physical	17110338
IMB1_HUMAN	KPNB1	physical	17110338
HSP7C_HUMAN	HSPA8	physical	17110338
DNJA1_HUMAN	DNAJA1	physical	17110338
IPO7_HUMAN	IPO7	physical	17110338
AHSA1_HUMAN	AHSA1	physical	17110338
COF1_HUMAN	CFL1	physical	17110338
DNJA2_HUMAN	DNAJA2	physical	17110338
PP2AA_HUMAN	PPP2CA	physical	17110338
XPO2_HUMAN	CSE1L	physical	17110338
2ABA_HUMAN	PPP2R2A	physical	17110338
RCN1_HUMAN	RCN1	physical	17110338
RACK1_HUMAN	GNB2L1	physical	17110338
RCN2_HUMAN	RCN2	physical	17110338
SEP11_HUMAN	SEPT11	physical	17110338
RANG_HUMAN	RANBP1	physical	17110338
XPO1_HUMAN	XPO1	physical	17110338
2AAB_HUMAN	PPP2R1B	physical	17110338
AT2A2_HUMAN	ATP2A2	physical	17110338
TCPG_HUMAN	CCT3	physical	17110338
S61A1_HUMAN	SEC61A1	physical	17110338
BAG2_HUMAN	BAG2	physical	17110338
CALX_HUMAN	CANX	physical	17110338
TNPO3_HUMAN	TNPO3	physical	17110338
NRIP3_HUMAN	NRIP3	physical	17110338
MIRO1_HUMAN	RHOT1	physical	17110338
HSP72_HUMAN	HSPA2	physical	17110338
CALU_HUMAN	CALU	physical	17110338
TCPD_HUMAN	CCT4	physical	17110338
PSA_HUMAN	NPEPPS	physical	17110338
RAN_HUMAN	RAN	physical	17110338
HS90A_HUMAN	HSP90AA1	physical	17110338
SYFA_HUMAN	FARSA	physical	17110338
P4HA1_HUMAN	P4HA1	physical	17110338
KIF5C_HUMAN	KIF5C	physical	17110338
HSP76_HUMAN	HSPA6	physical	17110338
SNX4_HUMAN	SNX4	physical	17110338
B3GN9_HUMAN	B3GNT9	physical	17110338
IPO11_HUMAN	IPO11	physical	17110338
KINH_HUMAN	KIF5B	physical	17110338
KIF3A_HUMAN	KIF3A	physical	17110338
DTL_HUMAN	DTL	physical	17110338
APC_HUMAN	APC	physical	17110338
VIPR1_HUMAN	VIPR1	physical	17110338
USP9X_HUMAN	USP9X	physical	17110338
PKD1_HUMAN	PKD1	physical	17110338
CYTB_HUMAN	CSTB	physical	17110338
ELOB_HUMAN	TCEB2	physical	17110338
S10A9_HUMAN	S100A9	physical	17110338
HS90B_HUMAN	HSP90AB1	physical	17110338
PSME2_HUMAN	PSME2	physical	17110338
LEG3_HUMAN	LGALS3	physical	17110338
S10A7_HUMAN	S100A7	physical	17110338
TFG_HUMAN	TFG	physical	17110338
THEM6_HUMAN	THEM6	physical	17110338
SQOR_HUMAN	SQRDL	physical	17110338
NHRF2_HUMAN	SLC9A3R2	physical	17110338
CH60_HUMAN	HSPD1	physical	17110338
HS71L_HUMAN	HSPA1L	physical	17110338
2AAA_HUMAN	PPP2R1A	physical	17110338
SPTC1_HUMAN	SPTLC1	physical	17110338
AIFM1_HUMAN	AIFM1	physical	17110338
UBE3A_HUMAN	UBE3A	physical	17110338
PSMD2_HUMAN	PSMD2	physical	17110338
TMM43_HUMAN	TMEM43	physical	17110338
BCR_HUMAN	BCR	physical	17110338
RYR2_HUMAN	RYR2	physical	17110338
ELOC_HUMAN	TCEB1	physical	17110338
PIMT_HUMAN	PCMT1	physical	17110338
PDCD6_HUMAN	PDCD6	physical	17110338
EMD_HUMAN	EMD	physical	17110338
S61A2_HUMAN	SEC61A2	physical	17110338
TERA_HUMAN	VCP	physical	17110338
SFXN3_HUMAN	SFXN3	physical	17110338
LEG4_HUMAN	LGALS4	physical	17110338
F120A_HUMAN	FAM120A	physical	17110338
COPB_HUMAN	COPB1	physical	17110338
LMO7_HUMAN	LMO7	physical	17110338
VPS4A_HUMAN	VPS4A	physical	17110338
ATX2L_HUMAN	ATXN2L	physical	17110338
TRIPC_HUMAN	TRIP12	physical	17110338
PRKDC_HUMAN	PRKDC	physical	17110338
HSPB1_HUMAN	HSPB1	physical	17110338
CD59_HUMAN	CD59	physical	17110338
SH3L2_HUMAN	SH3BGRL2	physical	17110338
MRP_HUMAN	MARCKSL1	physical	17110338
LIN7C_HUMAN	LIN7C	physical	17110338
HAX1_HUMAN	HAX1	physical	17110338
EPN4_HUMAN	CLINT1	physical	17110338
MS4A5_HUMAN	MS4A5	physical	17110338
GNA11_HUMAN	GNA11	physical	17110338
CLCA_HUMAN	CLTA	physical	17110338
EPCAM_HUMAN	EPCAM	physical	17110338
ATD3A_HUMAN	ATAD3A	physical	17110338
LRRF2_HUMAN	LRRFIP2	physical	17110338
EPS8_HUMAN	EPS8	physical	17110338
GNAI2_HUMAN	GNAI2	physical	17110338
CLH2_HUMAN	CLTCL1	physical	17110338
GRN_HUMAN	GRN	physical	17110338
SAP_HUMAN	PSAP	physical	17110338
CADH1_HUMAN	CDH1	physical	17110338
REPS1_HUMAN	REPS1	physical	17110338
PKHA6_HUMAN	PLEKHA6	physical	17110338
XPP3_HUMAN	XPNPEP3	physical	17110338
DAB2_HUMAN	DAB2	physical	17110338
FLOT2_HUMAN	FLOT2	physical	17110338
SNX9_HUMAN	SNX9	physical	17110338
IRPL1_HUMAN	IL1RAPL1	physical	17110338
CE170_HUMAN	CEP170	physical	17110338
RYK_HUMAN	RYK	physical	17110338
ZO3_HUMAN	TJP3	physical	17110338
MUC13_HUMAN	MUC13	physical	17110338
ADCY8_HUMAN	ADCY8	physical	17110338
CLCA1_HUMAN	CLCA1	physical	17110338
TIAM1_HUMAN	TIAM1	physical	17110338
SVIL_HUMAN	SVIL	physical	17110338
SORL_HUMAN	SORL1	physical	17110338
IMB1_MOUSE	Kpnb1	physical	17110338
RCN1_MOUSE	Rcn1	physical	17110338
GRP78_MOUSE	Hspa5	physical	17110338
RCN2_MOUSE	Rcn2	physical	17110338
HS90B_MOUSE	Hsp90ab1	physical	17110338
NHRF1_MOUSE	Slc9a3r1	physical	17110338
S10A6_MOUSE	S100a6	physical	17110338
TPP1_MOUSE	Tpp1	physical	17110338
ARF4_MOUSE	Arf4	physical	17110338
TCPE_MOUSE	Cct5	physical	17110338
UBB_MOUSE	Ubb	physical	17110338
MMS19_MOUSE	Mms19	physical	17110338
SRA1_MOUSE	Sra1	physical	17110338
TCPA_MOUSE	Tcp1	physical	17110338
FCN1_MOUSE	Fcna	physical	17110338
RUVB1_MOUSE	Ruvbl1	physical	17110338
SEPT6_MOUSE	Sept6	physical	17110338
VATA_MOUSE	Atp6v1a	physical	17110338
TRIM2_MOUSE	Trim2	physical	17110338
DPYL2_MOUSE	Dpysl2	physical	17110338
MAP4_MOUSE	Map4	physical	17110338
PCD15_MOUSE	Pcdh15	physical	17110338
RACK1_MOUSE	Gnb2l1	physical	17110338
LMNA_MOUSE	Lmna	physical	17110338
GRP75_MOUSE	Hspa9	physical	17110338
CPNS1_MOUSE	Capns1	physical	17110338
TPM3_MOUSE	Tpm3	physical	17110338
CAPR1_MOUSE	Caprin1	physical	17110338
APOA2_MOUSE	Apoa2	physical	17110338
TMOD3_MOUSE	Tmod3	physical	17110338
WSB1_MOUSE	Wsb1	physical	17110338
ZO1_MOUSE	Tjp1	physical	17110338
LIMA1_MOUSE	Lima1	physical	17110338
AT2A3_MOUSE	Atp2a3	physical	17110338
AP1B1_MOUSE	Ap1b1	physical	17110338
SHRM3_MOUSE	Shroom3	physical	17110338
NHRF1_RAT	Slc9a3r1	physical	17110338
TMM33_RAT	Tmem33	physical	17110338
UBC_RAT	Ubc	physical	17110338
GRIP1_RAT	Grip1	physical	17110338
FAT2_RAT	Fat2	physical	17110338
COF1_RAT	Cfl1	physical	17110338
DNJA1_RAT	Dnaja1	physical	17110338
HSP72_RAT	Hspa2	physical	17110338
GNA11_RAT	Gna11	physical	17110338
PLD2_RAT	Pld2	physical	17110338
ERLN2_HUMAN	ERLIN2	physical	17110338
PSB3_HUMAN	PSMB3	physical	17110338
SGMR1_HUMAN	SIGMAR1	physical	17110338
PSB1_HUMAN	PSMB1	physical	17110338
ERLN1_HUMAN	ERLIN1	physical	17110338
CCD51_HUMAN	CCDC51	physical	17110338
PSB4_HUMAN	PSMB4	physical	17110338
TEBP_HUMAN	PTGES3	physical	17110338
PPIB_HUMAN	PPIB	physical	17110338
PRS6B_HUMAN	PSMC4	physical	17110338
SARAF_HUMAN	SARAF	physical	17110338
EMC2_HUMAN	EMC2	physical	17110338
IPO9_HUMAN	IPO9	physical	17110338
CAND1_HUMAN	CAND1	physical	17110338
IPO5_HUMAN	IPO5	physical	17110338
2ABB_HUMAN	PPP2R2B	physical	17110338
SEPT6_HUMAN	SEPT6	physical	17110338
HACD3_HUMAN	PTPLAD1	physical	17110338
ESYT1_HUMAN	ESYT1	physical	17110338
PSD11_HUMAN	PSMD11	physical	17110338
ERBIN_HUMAN	ERBB2IP	physical	17110338
DCLK1_HUMAN	DCLK1	physical	17110338
SEPT9_HUMAN	SEPT9	physical	17110338
AT2A1_HUMAN	ATP2A1	physical	17110338
A2MG_HUMAN	A2M	physical	17110338
PCDB8_HUMAN	PCDHB8	physical	17110338
AKAP6_HUMAN	AKAP6	physical	17110338
MED12_HUMAN	MED12	physical	17110338
RYR3_HUMAN	RYR3	physical	17110338
XPO2_MOUSE	Cse1l	physical	17110338
CALU_MOUSE	Calu	physical	17110338
PSB1_MOUSE	Psmb1	physical	17110338
PSA5_MOUSE	Psma5	physical	17110338
PSA2_MOUSE	Psma2	physical	17110338
COF2_MOUSE	Cfl2	physical	17110338
FKBP8_MOUSE	Fkbp8	physical	17110338
PSB3_MOUSE	Psmb3	physical	17110338
TEBP_MOUSE	Ptges3	physical	17110338
EMC2_MOUSE	Emc2	physical	17110338
BAG3_MOUSE	Bag3	physical	17110338
STIP1_MOUSE	Stip1	physical	17110338
HS105_MOUSE	Hsph1	physical	17110338
PP2AB_MOUSE	Ppp2cb	physical	17110338
SEPT3_MOUSE	Sept3	physical	17110338
CDC37_MOUSE	Cdc37	physical	17110338
PRS6A_MOUSE	Psmc3	physical	17110338
RUVB2_MOUSE	Ruvbl2	physical	17110338
CADH1_MOUSE	Cdh1	physical	17110338
PDE8A_MOUSE	Pde8a	physical	17110338
GRIK5_RAT	Grik5	physical	17110338
ESYT1_RAT	Esyt1	physical	17110338
DYHC1_RAT	Dync1h1	physical	17110338
TERA_HUMAN	VCP	physical	18216283
MRP4_HUMAN	ABCC4	physical	18045536
NHRF3_HUMAN	PDZK1	physical	18045536
NHRF1_HUMAN	SLC9A3R1	physical	17110338
S61A1_MOUSE	Sec61a1	physical	17110338
ELOC_RAT	Tceb1	physical	17110338
HS105_HUMAN	HSPH1	physical	17110338
DNJA3_MOUSE	Dnaja3	physical	17110338
TCPA_RAT	Tcp1	physical	17110338
SQSTM_HUMAN	SQSTM1	physical	20711182
SQSTM_HUMAN	SQSTM1	physical	23686137
EEA1_HUMAN	EEA1	physical	23686137
NEDD4_HUMAN	NEDD4	physical	25384981
S4A7_HUMAN	SLC4A7	physical	12403779
HSPB1_HUMAN	HSPB1	physical	26627832
AP2A_HUMAN	TFAP2A	physical	20351096
DAB2_HUMAN	DAB2	physical	20351096
MYO6_HUMAN	MYO6	physical	20351096
UBP10_HUMAN	USP10	physical	22904170
RN185_HUMAN	RNF185	physical	24019521
DNJC5_HUMAN	DNAJC5	physical	16857740
HSP7C_HUMAN	HSPA8	physical	16857740
JAK1_HUMAN	JAK1	physical	27261451
CBL_HUMAN	CBL	physical	27261451
MARH2_HUMAN	MARCH2	physical	27308891

Drug and Disease Associations

Kegg Disease
H00218	Cystic fibrosis (CF)
H00933	Hereditary pancreatitis; Hereditary chronic pancreatitis
H01033	Congenital bilateral absence of vas deferens
OMIM Disease
219700	Cystic fibrosis (CF)
277180	Congenital bilateral absence of the vas deferens (CBAVD)
Kegg Drug
D00808	Suramin hexasodium (USAN); Bayer 205 (TN)
D09916	Ivacaftor (USAN/INN); Kalydeco (TN)
D10134	Lumacaftor (USAN)
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CFTR_HUMAN

Related Literatures of Post-Translational Modification

N-linked Glycosylation
Reference	PubMed
"Mapping of cystic fibrosis transmembrane conductance regulatormembrane topology by glycosylation site insertion."; Chang X.-B., Hou Y.-X., Jensen T.J., Riordan J.R.; J. Biol. Chem. 269:18572-18575(1994). Cited for: GLYCOSYLATION AT ASN-894 AND ASN-900, AND TOPOLOGY.	7518437 [Abstract]
Palmitoylation
Reference	PubMed
"Purification of CFTR for mass spectrometry analysis: identificationof palmitoylation and other post-translational modifications."; McClure M., Delucas L.J., Wilson L., Ray M., Rowe S.M., Wu X., Dai Q.,Hong J.S., Sorscher E.J., Kappes J.C., Barnes S.; Protein Eng. Des. Sel. 25:7-14(2012). Cited for: PHOSPHORYLATION AT SER-660; SER-686; SER-700; SER-712; THR-717;SER-737; SER-795; SER-1444 AND SER-1456, UBIQUITINATION AT LYS-688,PALMITOYLATION AT CYS-524 AND CYS-1395, AND MASS SPECTROMETRY.	22119790 [Abstract]
Phosphorylation
Reference	PubMed
"Purification of CFTR for mass spectrometry analysis: identificationof palmitoylation and other post-translational modifications."; McClure M., Delucas L.J., Wilson L., Ray M., Rowe S.M., Wu X., Dai Q.,Hong J.S., Sorscher E.J., Kappes J.C., Barnes S.; Protein Eng. Des. Sel. 25:7-14(2012). Cited for: PHOSPHORYLATION AT SER-660; SER-686; SER-700; SER-712; THR-717;SER-737; SER-795; SER-1444 AND SER-1456, UBIQUITINATION AT LYS-688,PALMITOYLATION AT CYS-524 AND CYS-1395, AND MASS SPECTROMETRY.	22119790 [Abstract]
"Evidence for phosphorylation of serine 753 in CFTR using a novelmetal-ion affinity resin and matrix-assisted laser desorption massspectrometry."; Neville D.C.A., Rozanas C.R., Rice E.M., Gruis D.B., Verkman A.S.,Townsend R.R.; Protein Sci. 6:2436-2445(1997). Cited for: PHOSPHORYLATION AT SER-660; SER-700; SER-712; SER-737; SER-753;SER-768; SER-795 AND SER-813.	9385646 [Abstract]
"Phosphorylation of the cystic fibrosis transmembrane conductanceregulator."; Picciotto M.R., Cohn J.A., Bertuzzi G., Greenguard P., Nairn A.C.; J. Biol. Chem. 267:12742-12752(1992). Cited for: PHOSPHORYLATION AT SER-660; SER-686; SER-700; SER-737; SER-768;SER-790; SER-795 AND SER-813.	1377674 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1176, AND MASSSPECTROMETRY.	19413330 [Abstract]
"Tyrosine phosphorylated Par3 regulates epithelial tight junctionassembly promoted by EGFR signaling."; Wang Y., Du D., Fang L., Yang G., Zhang C., Zeng R., Ullrich A.,Lottspeich F., Chen Z.; EMBO J. 25:5058-5070(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-515, AND MASSSPECTROMETRY.	17053785 [Abstract]
Ubiquitylation
Reference	PubMed
"Purification of CFTR for mass spectrometry analysis: identificationof palmitoylation and other post-translational modifications."; McClure M., Delucas L.J., Wilson L., Ray M., Rowe S.M., Wu X., Dai Q.,Hong J.S., Sorscher E.J., Kappes J.C., Barnes S.; Protein Eng. Des. Sel. 25:7-14(2012). Cited for: PHOSPHORYLATION AT SER-660; SER-686; SER-700; SER-712; THR-717;SER-737; SER-795; SER-1444 AND SER-1456, UBIQUITINATION AT LYS-688,PALMITOYLATION AT CYS-524 AND CYS-1395, AND MASS SPECTROMETRY.	22119790 [Abstract]