DNJA3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DNJA3_MOUSE
• UniProt AC: Q99M87
• Protein Name: DnaJ homolog subfamily A member 3, mitochondrial
• Gene Name: Dnaja3
• Organism: Mus musculus (Mouse).
• Sequence Length: 480
• Subcellular Localization: Mitochondrion matrix. Cytoplasm, cytosol . Cell junction, synapse, postsynaptic cell membrane ; Peripheral membrane protein . Recruited to the postsynaptic cell membrane of the neuromuscular junction through interaction with MUSK.
• Protein Description: Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma-mediated transcriptional activity (By similarity). Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway..
• Protein Sequence: MAAWCSPRWLRVAVGTPRLPAAAGRGVQQPQGGVVATSLCRKLCVSAFGLSMGAHGPRALLTLRPGVRLTGTKSFPFVCTTSFHTSASLAKDDYYQILGVPRNASQKDIKKAYYQLAKKYHPDTNKDDPKAKEKFSQLAEAYEVLSDEVKRKQYDAYGSAGFDPGTSSSGQGYWRGGPSVDPEELFRKIFGEFSSSPFGDFQNVFDQPQEYIMELTFNQAAKGVNKEFTVNIMDTCERCDGKGNEPGTKVQHCHYCGGSGMETINTGPFVMRSTCRRCGGRGSIITNPCVVCRGAGQAKQKKRVTIPVPAGVEDGQTVRMPVGKREIFVTFRVQKSPVFRRDGADIHSDLFISIAQAILGGTAKAQGLYETINVTIPAGIQTDQKIRLTGKGIPRINSYGYGDHYIHIKIRVPKRLSSRQQNLILSYAEDETDVEGTVNGVTHTSTGGRTMDSSAGSKDRREAGEDNEGFLSKLKKIFTS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
16	Phosphorylation	WLRVAVGTPRLPAAA EEEEECCCCCCCCCC	9.91	22705319
58	Methylation	SMGAHGPRALLTLRP CCCCCCCCEEEEECC	42.32	-
107	Succinylation	VPRNASQKDIKKAYY CCCCCCHHHHHHHHH	59.95	26388266
107	Acetylation	VPRNASQKDIKKAYY CCCCCCHHHHHHHHH	59.95	23201123
118	Succinylation	KAYYQLAKKYHPDTN HHHHHHHHHHCCCCC	63.56	23806337
118	Acetylation	KAYYQLAKKYHPDTN HHHHHHHHHHCCCCC	63.56	23806337
119	Acetylation	AYYQLAKKYHPDTNK HHHHHHHHHCCCCCC	43.09	23201123
126	Acetylation	KYHPDTNKDDPKAKE HHCCCCCCCCHHHHH	66.65	23864654
130	Acetylation	DTNKDDPKAKEKFSQ CCCCCCHHHHHHHHH	78.18	23201123
134	Acetylation	DDPKAKEKFSQLAEA CCHHHHHHHHHHHHH	50.00	23576753
168	Phosphorylation	GFDPGTSSSGQGYWR CCCCCCCCCCCCCCC	38.02	-
179	Phosphorylation	GYWRGGPSVDPEELF CCCCCCCCCCHHHHH	42.29	29472430
238	Methylation	NIMDTCERCDGKGNE EEEHHHHCCCCCCCC	26.44	-
242	Acetylation	TCERCDGKGNEPGTK HHHCCCCCCCCCCCE	45.36	2391551
293	Methylation	TNPCVVCRGAGQAKQ CCCCEEECCCCCCCC	26.79	-
335	Malonylation	FVTFRVQKSPVFRRD EEEEEEECCCCCCCC	54.60	26320211
385	Acetylation	AGIQTDQKIRLTGKG CCCCCCCCEEECCCC	32.38	2394701
398	Phosphorylation	KGIPRINSYGYGDHY CCCCCCCCCCCCCCE	19.98	27742792
399	Phosphorylation	GIPRINSYGYGDHYI CCCCCCCCCCCCCEE	15.18	-
417	Phosphorylation	IRVPKRLSSRQQNLI EECCCCCCHHHCCEE	27.75	23140645
418	Phosphorylation	RVPKRLSSRQQNLIL ECCCCCCHHHCCEEE	38.41	23140645
426 (in isoform 2)	Phosphorylation	-	18.46	23140645
427 (in isoform 2)	Phosphorylation	-	15.57	23140645
432 (in isoform 2)	Phosphorylation	-	58.63	23140645
437 (in isoform 2)	Phosphorylation	-	9.40	23140645
442 (in isoform 2)	Phosphorylation	-	22.34	23140645
444 (in isoform 2)	Phosphorylation	-	20.72	23140645
445 (in isoform 2)	Phosphorylation	-	19.90	23140645
446 (in isoform 2)	Phosphorylation	-	44.82	23140645

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DNJA3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DNJA3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DNJA3_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GRP75_MOUSE	Hspa9	physical	16327803

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.