dbPTM

GRP75_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	GRP75_MOUSE
UniProt AC	P38647
Protein Name	Stress-70 protein, mitochondrial
Gene Name	Hspa9
Organism	Mus musculus (Mouse).
Sequence Length	679
Subcellular Localization	Mitochondrion . Nucleus, nucleolus .
Protein Description	Chaperone protein which plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis. [PubMed: 26702583 Interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU (By similarity Regulates erythropoiesis via stabilization of ISC assembly]
Protein Sequence	MISASRAAAARLVGTAASRSPAAARPQDGWNGLSHEAFRFVSRRDYASEAIKGAVVGIDLGTTNSCVAVMEGKQAKVLENAEGARTTPSVVAFTADGERLVGMPAKRQAVTNPNNTFYATKRLIGRRYDDPEVQKDTKNVPFKIVRASNGDAWVEAHGKLYSPSQIGAFVLMKMKETAENYLGHTAKNAVITVPAYFNDSQRQATKDAGQISGLNVLRVINEPTAAALAYGLDKSEDKVIAVYDLGGGTFDISILEIQKGVFEVKSTNGDTFLGGEDFDQALLRHIVKEFKRETGVDLTKDNMALQRVREAAEKAKCELSSSVQTDINLPYLTMDASGPKHLNMKLTRAQFEGIVTDLIKRTIAPCQKAMQDAEVSKSDIGEVILVGGMTRMPKVQQTVQDLFGRAPSKAVNPDEAVAIGAAIQGGVLAGDVTDVLLLDVTPLSLGIETLGGVFTKLINRNTTIPTKKSQVFSTAADGQTQVEIKVCQGEREMAGDNKLLGQFTLIGIPPAPRGVPQIEVTFDIDANGIVHVSAKDKGTGREQQIVIQSSGGLSKDDIENMVKNAEKYAEEDRRKKERVEAVNMAEGIIHDTETKMEEFKDQLPADECNKLKEEISKMRALLAGKDSETGENIRQAASSLQQASLKLFEMAYKKMASEREGSGSSGTGEQKEDQKEEKQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Phosphorylation	AAARLVGTAASRSPA HHHHHHHHHHHCCCC	16.15	26060331
18	Phosphorylation	RLVGTAASRSPAAAR HHHHHHHHCCCCCCC	30.72	26060331
20	Phosphorylation	VGTAASRSPAAARPQ HHHHHHCCCCCCCCC	19.18	26060331
66	S-nitrosocysteine	DLGTTNSCVAVMEGK ECCCCCCEEEEECCC	2.18	-
66	S-nitrosylation	DLGTTNSCVAVMEGK ECCCCCCEEEEECCC	2.18	21278135
76	Acetylation	VMEGKQAKVLENAEG EECCCCEEEECCCCC	44.87	23576753
76	Succinylation	VMEGKQAKVLENAEG EECCCCEEEECCCCC	44.87	23954790
86	Phosphorylation	ENAEGARTTPSVVAF CCCCCCCCCCCEEEE	42.39	19060867
87	Phosphorylation	NAEGARTTPSVVAFT CCCCCCCCCCEEEEE	14.17	19060867
89	Phosphorylation	EGARTTPSVVAFTAD CCCCCCCCEEEEECC	27.42	23140645
106	Acetylation	RLVGMPAKRQAVTNP EECCCCCCCCCCCCC	38.89	7718473
106	Succinylation	RLVGMPAKRQAVTNP EECCCCCCCCCCCCC	38.89	23954790
118	Phosphorylation	TNPNNTFYATKRLIG CCCCCCCCCHHHHHC	16.01	25195567
121	Acetylation	NNTFYATKRLIGRRY CCCCCCHHHHHCCCC	36.72	23864654
121	Succinylation	NNTFYATKRLIGRRY CCCCCCHHHHHCCCC	36.72	23954790
121	Ubiquitination	NNTFYATKRLIGRRY CCCCCCHHHHHCCCC	36.72	-
121	Ubiquitination	NNTFYATKRLIGRRY CCCCCCHHHHHCCCC	36.72	22790023
128	Phosphorylation	KRLIGRRYDDPEVQK HHHHCCCCCCHHHCC	24.28	25195567
135	Acetylation	YDDPEVQKDTKNVPF CCCHHHCCCCCCCCE	72.96	23806337
135	Glutarylation	YDDPEVQKDTKNVPF CCCHHHCCCCCCCCE	72.96	24703693
135	Succinylation	YDDPEVQKDTKNVPF CCCHHHCCCCCCCCE	72.96	-
135	Succinylation	YDDPEVQKDTKNVPF CCCHHHCCCCCCCCE	72.96	23806337
135	Ubiquitination	YDDPEVQKDTKNVPF CCCHHHCCCCCCCCE	72.96	27667366
138	Acetylation	PEVQKDTKNVPFKIV HHHCCCCCCCCEEEE	67.11	23576753
138	Glutarylation	PEVQKDTKNVPFKIV HHHCCCCCCCCEEEE	67.11	24703693
138	Malonylation	PEVQKDTKNVPFKIV HHHCCCCCCCCEEEE	67.11	26320211
138	Succinylation	PEVQKDTKNVPFKIV HHHCCCCCCCCEEEE	67.11	-
138	Succinylation	PEVQKDTKNVPFKIV HHHCCCCCCCCEEEE	67.11	23806337
143	Acetylation	DTKNVPFKIVRASNG CCCCCCEEEEECCCC	33.93	23864654
148	Phosphorylation	PFKIVRASNGDAWVE CEEEEECCCCCCEEE	30.68	25521595
159	Acetylation	AWVEAHGKLYSPSQI CEEEECCEEECHHHH	34.09	23864654
161	Phosphorylation	VEAHGKLYSPSQIGA EEECCEEECHHHHHH	23.25	25195567
162	Phosphorylation	EAHGKLYSPSQIGAF EECCEEECHHHHHHH	28.63	26745281
164	Phosphorylation	HGKLYSPSQIGAFVL CCEEECHHHHHHHHH	28.61	26745281
173	Acetylation	IGAFVLMKMKETAEN HHHHHHHHCHHHHHH	42.53	23954790
175	Acetylation	AFVLMKMKETAENYL HHHHHHCHHHHHHHH	46.52	23806337
175	Succinylation	AFVLMKMKETAENYL HHHHHHCHHHHHHHH	46.52	23806337
187	Acetylation	NYLGHTAKNAVITVP HHHCCCCCCEEEEEE	46.74	23806337
187	Succinylation	NYLGHTAKNAVITVP HHHCCCCCCEEEEEE	46.74	23806337
192	Phosphorylation	TAKNAVITVPAYFND CCCCEEEEEECCCCH	17.53	-
200	Phosphorylation	VPAYFNDSQRQATKD EECCCCHHHHHHCCC	28.50	26370283
205	Phosphorylation	NDSQRQATKDAGQIS CHHHHHHCCCCCCCC	22.56	25890499
206	N6-malonyllysine	DSQRQATKDAGQISG HHHHHHCCCCCCCCC	48.90	-
206	Acetylation	DSQRQATKDAGQISG HHHHHHCCCCCCCCC	48.90	23576753
206	Malonylation	DSQRQATKDAGQISG HHHHHHCCCCCCCCC	48.90	-
206	Succinylation	DSQRQATKDAGQISG HHHHHHCCCCCCCCC	48.90	23806337
212	Phosphorylation	TKDAGQISGLNVLRV CCCCCCCCCCCEEEE	29.37	21454597
230	Phosphorylation	PTAAALAYGLDKSED HHHHHHHHCCCCCCC	21.04	25195567
234	Acetylation	ALAYGLDKSEDKVIA HHHHCCCCCCCEEEE	61.87	23576753
234	Ubiquitination	ALAYGLDKSEDKVIA HHHHCCCCCCCEEEE	61.87	22790023
234	Ubiquitination	ALAYGLDKSEDKVIA HHHHCCCCCCCEEEE	61.87	22790023
265	Acetylation	QKGVFEVKSTNGDTF ECCEEEEECCCCCCC	44.35	23864654
265	Succinylation	QKGVFEVKSTNGDTF ECCEEEEECCCCCCC	44.35	23954790
266	Phosphorylation	KGVFEVKSTNGDTFL CCEEEEECCCCCCCC	32.08	23984901
267	Phosphorylation	GVFEVKSTNGDTFLG CEEEEECCCCCCCCC	37.19	23984901
288	Acetylation	ALLRHIVKEFKRETG HHHHHHHHHHHHHHC	57.75	23576753
288	Glutarylation	ALLRHIVKEFKRETG HHHHHHHHHHHHHHC	57.75	24703693
288	Malonylation	ALLRHIVKEFKRETG HHHHHHHHHHHHHHC	57.75	26320211
288	Succinylation	ALLRHIVKEFKRETG HHHHHHHHHHHHHHC	57.75	23806337
291	Acetylation	RHIVKEFKRETGVDL HHHHHHHHHHHCCCC	50.87	24062335
291	Succinylation	RHIVKEFKRETGVDL HHHHHHHHHHHCCCC	50.87	23954790
300	Acetylation	ETGVDLTKDNMALQR HHCCCCCHHHHHHHH	55.17	23806337
300	Glutarylation	ETGVDLTKDNMALQR HHCCCCCHHHHHHHH	55.17	24703693
300	Malonylation	ETGVDLTKDNMALQR HHCCCCCHHHHHHHH	55.17	26320211
300	Succinylation	ETGVDLTKDNMALQR HHCCCCCHHHHHHHH	55.17	-
300	Succinylation	ETGVDLTKDNMALQR HHCCCCCHHHHHHHH	55.17	23806337
300	Ubiquitination	ETGVDLTKDNMALQR HHCCCCCHHHHHHHH	55.17	-
300	Ubiquitination	ETGVDLTKDNMALQR HHCCCCCHHHHHHHH	55.17	22790023
314	Acetylation	RVREAAEKAKCELSS HHHHHHHHHCCCCCC	48.71	23201123
321	Phosphorylation	KAKCELSSSVQTDIN HHCCCCCCCCCCCCC	47.34	28059163
331	Phosphorylation	QTDINLPYLTMDASG CCCCCCCEEEECCCC	20.26	28059163
337	Phosphorylation	PYLTMDASGPKHLNM CEEEECCCCCCCCCC	51.90	-
345	Acetylation	GPKHLNMKLTRAQFE CCCCCCCHHHHHHHH	45.71	23806337
345	Succinylation	GPKHLNMKLTRAQFE CCCCCCCHHHHHHHH	45.71	23806337
360	Acetylation	GIVTDLIKRTIAPCQ HHHHHHHHHHCHHHH	51.27	23806337
360	Glutarylation	GIVTDLIKRTIAPCQ HHHHHHHHHHCHHHH	51.27	24703693
360	Succinylation	GIVTDLIKRTIAPCQ HHHHHHHHHHCHHHH	51.27	-
360	Succinylation	GIVTDLIKRTIAPCQ HHHHHHHHHHCHHHH	51.27	23806337
360	Ubiquitination	GIVTDLIKRTIAPCQ HHHHHHHHHHCHHHH	51.27	-
360	Ubiquitination	GIVTDLIKRTIAPCQ HHHHHHHHHHCHHHH	51.27	22790023
366	Glutathionylation	IKRTIAPCQKAMQDA HHHHCHHHHHHHCCC	4.85	24333276
368	Acetylation	RTIAPCQKAMQDAEV HHCHHHHHHHCCCCC	53.17	23806337
368	Glutarylation	RTIAPCQKAMQDAEV HHCHHHHHHHCCCCC	53.17	24703693
368	Succinylation	RTIAPCQKAMQDAEV HHCHHHHHHHCCCCC	53.17	-
368	Succinylation	RTIAPCQKAMQDAEV HHCHHHHHHHCCCCC	53.17	23806337
377	Acetylation	MQDAEVSKSDIGEVI HCCCCCCHHHCCEEE	58.27	23864654
377	Succinylation	MQDAEVSKSDIGEVI HCCCCCCHHHCCEEE	58.27	23954790
378	Phosphorylation	QDAEVSKSDIGEVIL CCCCCCHHHCCEEEE	27.27	28973931
390	Phosphorylation	VILVGGMTRMPKVQQ EEEECCCCCCHHHHH	27.39	28973931
394	Acetylation	GGMTRMPKVQQTVQD CCCCCCHHHHHHHHH	43.25	24062335
394	Succinylation	GGMTRMPKVQQTVQD CCCCCCHHHHHHHHH	43.25	-
394	Succinylation	GGMTRMPKVQQTVQD CCCCCCHHHHHHHHH	43.25	23806337
398	Phosphorylation	RMPKVQQTVQDLFGR CCHHHHHHHHHHHCC	11.75	18779572
408	Phosphorylation	DLFGRAPSKAVNPDE HHHCCCCCCCCCHHH	32.06	27841257
467	Acetylation	RNTTIPTKKSQVFST CCCCCCCCCHHHEEE	45.10	23576753
467	Succinylation	RNTTIPTKKSQVFST CCCCCCCCCHHHEEE	45.10	24315375
468	Acetylation	NTTIPTKKSQVFSTA CCCCCCCCHHHEEEC	48.90	23806337
468	Succinylation	NTTIPTKKSQVFSTA CCCCCCCCHHHEEEC	48.90	23806337
468	Ubiquitination	NTTIPTKKSQVFSTA CCCCCCCCHHHEEEC	48.90	-
468	Ubiquitination	NTTIPTKKSQVFSTA CCCCCCCCHHHEEEC	48.90	22790023
487	S-nitrosocysteine	TQVEIKVCQGEREMA EEEEEEEECCCHHHC	3.50	-
487	S-nitrosylation	TQVEIKVCQGEREMA EEEEEEEECCCHHHC	3.50	21278135
513	Methylation	IGIPPAPRGVPQIEV EECCCCCCCCCEEEE	61.93	-
555	Acetylation	QSSGGLSKDDIENMV ECCCCCCHHHHHHHH	65.54	23864654
563	Acetylation	DDIENMVKNAEKYAE HHHHHHHHHHHHHHH	39.40	23576753
567	Acetylation	NMVKNAEKYAEEDRR HHHHHHHHHHHHHHH	47.56	23806337
567	Glutarylation	NMVKNAEKYAEEDRR HHHHHHHHHHHHHHH	47.56	24703693
567	Succinylation	NMVKNAEKYAEEDRR HHHHHHHHHHHHHHH	47.56	-
567	Succinylation	NMVKNAEKYAEEDRR HHHHHHHHHHHHHHH	47.56	23806337
595	Acetylation	IIHDTETKMEEFKDQ CCCCHHHHHHHHHHH	37.77	23954790
600	Acetylation	ETKMEEFKDQLPADE HHHHHHHHHHCCHHH	48.09	23576753
600	Glutarylation	ETKMEEFKDQLPADE HHHHHHHHHHCCHHH	48.09	24703693
600	Succinylation	ETKMEEFKDQLPADE HHHHHHHHHHCCHHH	48.09	-
600	Succinylation	ETKMEEFKDQLPADE HHHHHHHHHHCCHHH	48.09	23806337
608	S-nitrosocysteine	DQLPADECNKLKEEI HHCCHHHHHHHHHHH	5.83	-
608	Glutathionylation	DQLPADECNKLKEEI HHCCHHHHHHHHHHH	5.83	24333276
608	S-nitrosylation	DQLPADECNKLKEEI HHCCHHHHHHHHHHH	5.83	24926564
608	S-palmitoylation	DQLPADECNKLKEEI HHCCHHHHHHHHHHH	5.83	28526873
610	Acetylation	LPADECNKLKEEISK CCHHHHHHHHHHHHH	73.01	23864654
610	Succinylation	LPADECNKLKEEISK CCHHHHHHHHHHHHH	73.01	-
610	Succinylation	LPADECNKLKEEISK CCHHHHHHHHHHHHH	73.01	23806337
612	Acetylation	ADECNKLKEEISKMR HHHHHHHHHHHHHHH	55.71	23576753
617	Acetylation	KLKEEISKMRALLAG HHHHHHHHHHHHHCC	41.21	23864654
625	Acetylation	MRALLAGKDSETGEN HHHHHCCCCCCCHHH	61.06	23864654
625	Malonylation	MRALLAGKDSETGEN HHHHHCCCCCCCHHH	61.06	26320211
625	Ubiquitination	MRALLAGKDSETGEN HHHHHCCCCCCCHHH	61.06	-
625	Ubiquitination	MRALLAGKDSETGEN HHHHHCCCCCCCHHH	61.06	22790023
627	Phosphorylation	ALLAGKDSETGENIR HHHCCCCCCCHHHHH	39.84	23684622
629	Phosphorylation	LAGKDSETGENIRQA HCCCCCCCHHHHHHH	54.47	22802335
638	Phosphorylation	ENIRQAASSLQQASL HHHHHHHHHHHHHHH	34.30	20139300
646	Acetylation	SLQQASLKLFEMAYK HHHHHHHHHHHHHHH	48.94	23576753
646	Succinylation	SLQQASLKLFEMAYK HHHHHHHHHHHHHHH	48.94	-
646	Succinylation	SLQQASLKLFEMAYK HHHHHHHHHHHHHHH	48.94	23806337
653	Acetylation	KLFEMAYKKMASERE HHHHHHHHHHHHHCC	26.91	23576753
653	Succinylation	KLFEMAYKKMASERE HHHHHHHHHHHHHCC	26.91	23954790
654	Acetylation	LFEMAYKKMASEREG HHHHHHHHHHHHCCC	27.33	2392909
657	Phosphorylation	MAYKKMASEREGSGS HHHHHHHHHCCCCCC	33.42	23684622
662	Phosphorylation	MASEREGSGSSGTGE HHHHCCCCCCCCCCC	30.65	23684622
664	Phosphorylation	SEREGSGSSGTGEQK HHCCCCCCCCCCCCC	27.56	23684622
665	Phosphorylation	EREGSGSSGTGEQKE HCCCCCCCCCCCCCH	43.85	23684622
667	Phosphorylation	EGSGSSGTGEQKEDQ CCCCCCCCCCCCHHH	39.22	23684622
671	Acetylation	SSGTGEQKEDQKEEK CCCCCCCCHHHHHHH	59.98	23576753
675	Acetylation	GEQKEDQKEEKQ--- CCCCHHHHHHHC---	78.96	23576753
678	Acetylation	KEDQKEEKQ------ CHHHHHHHC------	63.50	23576753

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of GRP75_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of GRP75_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of GRP75_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of GRP75_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of GRP75_MOUSE

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Substrate and functional diversity of lysine acetylation revealed bya proteomics survey."; Kim S.C., Sprung R., Chen Y., Xu Y., Ball H., Pei J., Cheng T.,Kho Y., Xiao H., Xiao L., Grishin N.V., White M., Yang X.-J., Zhao Y.; Mol. Cell 23:607-618(2006). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-288; LYS-300 AND LYS-360,AND MASS SPECTROMETRY.	16916647 [Abstract]