JKAMP_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: JKAMP_HUMAN
• UniProt AC: Q9P055
• Protein Name: JNK1/MAPK8-associated membrane protein
• Gene Name: JKAMP
• Organism: Homo sapiens (Human).
• Sequence Length: 326
• Subcellular Localization: Endoplasmic reticulum membrane; Multi-pass membrane protein.
• Protein Description: May be a regulator of the duration of MAPK8 activity in response to various stress stimuli. Facilitates degradation of misfolded endoplasmic reticulum (ER) luminal proteins through the recruitment of components of the proteasome and endoplasmic reticulum-associated degradation (ERAD) system (By similarity)..
• Protein Sequence: MFGAAARSADLALLEKNLQAAHGCLGLYCGKTLLFKNGSTEIYGECGVCPRGQRTNAQKYCQPCTESPELYDWLYLGFMAMLPLVLHWFFIEWYSGKKSSSALFQHITALFECSMAAIITLLVSDPVGVLYIRSCRVLMLSDWYTMLYNPSPDYVTTVHCTHEAVYPLYTIVFIYYAFCLVLMMLLRPLLVKKIACGLGKSDRFKSIYAALYFFPILTVLQAVGGGLLYYAFPYIILVLSLVTLAVYMSASEIENCYDLLVRKKRLIVLFSHWLLHAYGIISISRVDKLEQDLPLLALVPTPALFYLFTAKFTEPSRILSEGANGH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10 (in isoform 3)	Ubiquitination	-	33.45	-
16 (in isoform 4)	Ubiquitination	-	64.03	-
55	Phosphorylation	VCPRGQRTNAQKYCQ CCCCCCCCCHHHHCC	27.33	22985185
185 (in isoform 4)	Ubiquitination	-	1.98	-
193	Ubiquitination	LRPLLVKKIACGLGK HHHHHHHHHHCCCCC	28.23	-
199	Ubiquitination	KKIACGLGKSDRFKS HHHHCCCCCCHHHHH	16.83	-
200	Ubiquitination	KIACGLGKSDRFKSI HHHCCCCCCHHHHHH	54.98	-
301	Phosphorylation	PLLALVPTPALFYLF CEEEECCCHHHHHHH	17.45	25332170
306	Phosphorylation	VPTPALFYLFTAKFT CCCHHHHHHHHCCCC	11.19	25332170
309	Phosphorylation	PALFYLFTAKFTEPS HHHHHHHHCCCCCHH	26.75	25332170

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	RNF5	Q99942	PMID:19269966

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of JKAMP_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of JKAMP_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RNF5_HUMAN	RNF5	physical	19269966
PRS6A_HUMAN	PSMC3	physical	19269966
PRS10_HUMAN	PSMC6	physical	19269966
PSMD2_HUMAN	PSMD2	physical	19269966
MK08_HUMAN	MAPK8	physical	16166642
ADRB2_HUMAN	ADRB2	physical	23798571
PRS6A_HUMAN	PSMC3	physical	23798571

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.