ADRB2_HUMAN - dbPTM
ADRB2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ADRB2_HUMAN
UniProt AC P07550
Protein Name Beta-2 adrenergic receptor
Gene Name ADRB2
Organism Homo sapiens (Human).
Sequence Length 413
Subcellular Localization Cell membrane
Multi-pass membrane protein . Early endosome . Colocalizes with VHL at the cell membrane (PubMed:19584355). Activated receptors are internalized into endosomes prior to their degradation in lysosomes (PubMed:20559325).
Protein Description Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine..
Protein Sequence MGQPGNGSAFLLAPNGSHAPDHDVTQERDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
6N-linked_Glycosylation--MGQPGNGSAFLLA
--CCCCCCCCEEEEC		48.18UniProtKB CARBOHYD
15N-linked_GlycosylationSAFLLAPNGSHAPDH
CEEEECCCCCCCCCC		60.02UniProtKB CARBOHYD
68PhosphorylationFERLQTVTNYFITSL
HHHHHHHHHHHHHHH		27.8217925438
132PhosphorylationCVIAVDRYFAITSPF
HHHHHHCEEECCCCC		7.9017925438
141PhosphorylationAITSPFKYQSLLTKN
ECCCCCCHHHHCCCC		12.0622817900
143PhosphorylationTSPFKYQSLLTKNKA
CCCCCHHHHCCCCCH		23.4324719451
146O-linked_GlycosylationFKYQSLLTKNKARVI
CCHHHHCCCCCHHHH		37.5531492838
219PhosphorylationLVIMVFVYSRVFQEA
HHHHHHHHHHHHHHH		4.5517925438
246PhosphorylationRFHVQNLSQVEQDGR
CEEECCHHHHCCCCC		39.4617525332
261PhosphorylationTGHGLRRSSKFCLKE
CCCCCHHCCHHHHHH		31.299461522
262PhosphorylationGHGLRRSSKFCLKEH
CCCCHHCCHHHHHHH		28.1214722251
263UbiquitinationHGLRRSSKFCLKEHK
CCCHHCCHHHHHHHH		41.15-
265S-palmitoylationLRRSSKFCLKEHKAL
CHHCCHHHHHHHHHH		6.4527481942
270UbiquitinationKFCLKEHKALKTLGI
HHHHHHHHHHHHHHH		57.41-
308PhosphorylationNLIRKEVYILLNWIG
CCCHHHHHHHHHHHH		6.2267275799
326PhosphorylationSGFNPLIYCRSPDFR
CCCCCEEEECCCHHH		6.9012436935
341S-palmitoylationIAFQELLCLRRSSLK
HHHHHHHHHHHHHHH		4.312540197
345PhosphorylationELLCLRRSSLKAYGN
HHHHHHHHHHHHHCC		33.329461522
346PhosphorylationLLCLRRSSLKAYGNG
HHHHHHHHHHHHCCC		31.889461522
348UbiquitinationCLRRSSLKAYGNGYS
HHHHHHHHHHCCCCC		41.32-
350PhosphorylationRRSSLKAYGNGYSSN
HHHHHHHHCCCCCCC		14.9922817900
354PhosphorylationLKAYGNGYSSNGNTG
HHHHCCCCCCCCCCC		16.9622817900
355PhosphorylationKAYGNGYSSNGNTGE
HHHCCCCCCCCCCCC		20.8014722251
356PhosphorylationAYGNGYSSNGNTGEQ
HHCCCCCCCCCCCCC		40.0314722251
360PhosphorylationGYSSNGNTGEQSGYH
CCCCCCCCCCCCCCC		43.4218801735
364PhosphorylationNGNTGEQSGYHVEQE
CCCCCCCCCCCCCHH		36.7011040066
372UbiquitinationGYHVEQEKENKLLCE
CCCCCHHHHCCEECC		67.30-
375UbiquitinationVEQEKENKLLCEDLP
CCHHHHCCEECCCCC		43.88-
382HydroxylationKLLCEDLPGTEDFVG
CEECCCCCCCCCCCC		61.0419584355
384PhosphorylationLCEDLPGTEDFVGHQ
ECCCCCCCCCCCCCC		30.3718801735
393PhosphorylationDFVGHQGTVPSDNID
CCCCCCCCCCCCCCC		23.7518801735
395HydroxylationVGHQGTVPSDNIDSQ
CCCCCCCCCCCCCCC		35.4819584355
396PhosphorylationGHQGTVPSDNIDSQG
CCCCCCCCCCCCCCC		38.6618801735
401PhosphorylationVPSDNIDSQGRNCST
CCCCCCCCCCCCCCC		30.6418801735
407PhosphorylationDSQGRNCSTNDSLL-
CCCCCCCCCCCCCC-		33.5218801735
408PhosphorylationSQGRNCSTNDSLL--
CCCCCCCCCCCCC--		45.2922275358
411PhosphorylationRNCSTNDSLL-----
CCCCCCCCCC-----		33.3718801735
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
132YPhosphorylationKinaseIGF1RP08069
PhosphoELM
141YPhosphorylationKinaseIGF1RP08069
PhosphoELM
261SPhosphorylationKinasePRKACAP17612
GPS
261SPhosphorylationKinasePKA-Uniprot
262SPhosphorylationKinasePRKACAP17612
GPS
262SPhosphorylationKinasePKA_GROUP-PhosphoELM
262SPhosphorylationKinasePKA-FAMILY-GPS
262SPhosphorylationKinasePKA-Uniprot
345SPhosphorylationKinasePKA-FAMILY-GPS
345SPhosphorylationKinasePRKACAP17612
GPS
345SPhosphorylationKinasePKA-Uniprot
345SPhosphorylationKinasePKA_GROUP-PhosphoELM
346SPhosphorylationKinasePKA-Uniprot
346SPhosphorylationKinasePKA-FAMILY-GPS
346SPhosphorylationKinaseAKT-FAMILY-GPS
346SPhosphorylationKinasePKA_GROUP-PhosphoELM
346SPhosphorylationKinasePRKACAP17612
GPS
346SPhosphorylationKinasePKB_GROUP-PhosphoELM
346SPhosphorylationKinaseAKT1P31749
PSP
355SPhosphorylationKinaseGRK2P21146
PSP
355SPhosphorylationKinaseGRK-SUBFAMILY-GPS
355SPhosphorylationKinaseGRK_GROUP-PhosphoELM
355SPhosphorylationKinaseGRK6P43250
PSP
355SPhosphorylationKinaseGRK2P25098
PSP
355SPhosphorylationKinaseGRK3P35626
PSP
355SPhosphorylationKinaseGRK5P34947
PSP
355SPhosphorylationKinaseGRK5P43249
PSP
356SPhosphorylationKinaseGRK2P21146
PSP
356SPhosphorylationKinaseGRK_GROUP-PhosphoELM
356SPhosphorylationKinaseGRK2P25098
PSP
356SPhosphorylationKinaseGRK3P35626
PSP
356SPhosphorylationKinaseGRK5P43249
PSP
356SPhosphorylationKinaseGRK-SUBFAMILY-GPS
356SPhosphorylationKinaseGRK5P34947
PSP
356SPhosphorylationKinaseGRK6P43250
PSP
384TPhosphorylationKinaseARBK1P25098
PhosphoELM
384TPhosphorylationKinaseGRK5P34947
PSP
393TPhosphorylationKinaseGRK5P34947
PSP
396SPhosphorylationKinaseGRK5P34947
PSP
396SPhosphorylationKinaseARBK1P25098
PhosphoELM
401SPhosphorylationKinaseARBK1P25098
PhosphoELM
401SPhosphorylationKinaseGRK5P34947
PSP
407SPhosphorylationKinaseGRK5P34947
PSP
407SPhosphorylationKinaseARBK1P25098
PhosphoELM
411SPhosphorylationKinaseGRK5P34947
PSP
411SPhosphorylationKinaseGRK2P25098
PSP
-KUbiquitinationE3 ubiquitin ligaseNEDD4P46934
PMID:18544533
-KUbiquitinationE3 ubiquitin ligaseVHLP40337
PMID:22199232
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference
265CPalmitoylation

27481942
265CPalmitoylation

27481942
265CPhosphorylation

27481942
341CPalmitoylation

2540197
345SPalmitoylation

11146000
345SPhosphorylation

11146000
346SPalmitoylation

11146000
346SPhosphorylation

11146000
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ADRB2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SRC_HUMANSRCphysical
11013230
OPRD_HUMANOPRD1physical
11278447
ADRB2_HUMANADRB2physical
11278447
EI2BA_HUMANEIF2B1physical
9235896
GRB2_HUMANGRB2physical
9830057
AKA12_HUMANAKAP12physical
11309381
ARBK1_HUMANADRBK1physical
11309381
NHRF1_HUMANSLC9A3R1physical
9671706
NHRF2_HUMANSLC9A3R2physical
9671706
PP2BA_HUMANPPP3CAphysical
9880537
AKA12_HUMANAKAP12physical
9880537
NHRF1_HUMANSLC9A3R1physical
9560162
ARRB2_RATArrb2physical
17666399
ARRD3_HUMANARRDC3physical
20559325
NEDD4_HUMANNEDD4physical
20559325
VHL_HUMANVHLphysical
19584355
CUL2_HUMANCUL2physical
19584355
ELOC_HUMANTCEB1physical
19584355
EGLN3_HUMANEGLN3physical
19584355
CAV3_HUMANCAV3physical
21362625
UCHL1_HUMANUCHL1physical
19477270
GNAS3_HUMANGNASphysical
15782186
GNAS2_HUMANGNASphysical
15782186
ALEX_HUMANGNASphysical
15782186
GNAS1_HUMANGNASphysical
15782186
GBB1_HUMANGNB1physical
15782186
GBG2_HUMANGNG2physical
15782186
GNAI2_HUMANGNAI2physical
15782186
NEDD4_HUMANNEDD4physical
23166351
UBP20_HUMANUSP20physical
23166351
UBP33_HUMANUSP33physical
23166351
MARH2_HUMANMARCH2physical
23166351
ITCH_HUMANITCHphysical
23236378
ARRD3_HUMANARRDC3physical
23236378
GBB1_HUMANGNB1physical
23798571
GBB2_HUMANGNB2physical
23798571
GBB4_HUMANGNB4physical
23798571
NSF_HUMANNSFphysical
23798571
GNAI3_HUMANGNAI3physical
23798571
UBB_HUMANUBBphysical
23798571
NHRF2_HUMANSLC9A3R2physical
23798571
GNAS3_HUMANGNASphysical
23798571
GNAS2_HUMANGNASphysical
23798571
ALEX_HUMANGNASphysical
23798571
GNAS1_HUMANGNASphysical
23798571
GBG12_HUMANGNG12physical
23798571
AMFR_HUMANAMFRphysical
23798571
RNF5_HUMANRNF5physical
23798571
TERA_HUMANVCPphysical
23798571
NPL4_HUMANNPLOC4physical
23798571
UFD1_HUMANUFD1Lphysical
23798571
GRP78_HUMANHSPA5physical
23798571
DJB11_HUMANDNAJB11physical
23798571
CALX_HUMANCANXphysical
23798571
S61A1_HUMANSEC61A1physical
23798571
PSMD2_HUMANPSMD2physical
23798571
ECM29_HUMANKIAA0368physical
23798571
ATPA_HUMANATP5A1physical
23798571
ATPB_HUMANATP5Bphysical
23798571
ATPG_HUMANATP5C1physical
23798571
AT2A2_HUMANATP2A2physical
23798571
ACTG_HUMANACTG1physical
23798571
CLGN_HUMANCLGNphysical
23798571
CPNS1_HUMANCAPNS1physical
23798571
CH60_HUMANHSPD1physical
23798571
C1QBP_HUMANC1QBPphysical
23798571
ODP2_HUMANDLATphysical
23798571
RPN1_HUMANRPN1physical
23798571
ERLN2_HUMANERLIN2physical
23798571
EF1A1_HUMANEEF1A1physical
23798571
FKBP8_HUMANFKBP8physical
23798571
G3P_HUMANGAPDHphysical
23798571
SV2A_HUMANSV2Aphysical
23798571
F162A_HUMANFAM162Aphysical
23798571
GRP75_HUMANHSPA9physical
23798571
HNRPU_HUMANHNRNPUphysical
23798571
MIC60_HUMANIMMTphysical
23798571
K2C1_HUMANKRT1physical
23798571
K1C10_HUMANKRT10physical
23798571
K22E_HUMANKRT2physical
23798571
K2C5_HUMANKRT5physical
23798571
K1C9_HUMANKRT9physical
23798571
LPPRC_HUMANLRPPRCphysical
23798571
MBRL_HUMANTMEM259physical
23798571
AT1A1_HUMANATP1A1physical
23798571
NDUA4_HUMANNDUFA4physical
23798571
PO210_HUMANNUP210physical
23798571
PRKDC_HUMANPRKDCphysical
23798571
VDAC2_HUMANVDAC2physical
23798571
PHB_HUMANPHBphysical
23798571
PHB2_HUMANPHB2physical
23798571
ODPA_HUMANPDHA1physical
23798571
RPN2_HUMANRPN2physical
23798571
MYLK2_HUMANMYLK2physical
23798571
ADT2_HUMANSLC25A5physical
23798571
TOM70_HUMANTOMM70Aphysical
23798571
TMUB1_HUMANTMUB1physical
23798571
TMM33_HUMANTMEM33physical
23798571
EFTU_HUMANTUFMphysical
23798571
TBB5_HUMANTUBBphysical
23798571
TBB2A_HUMANTUBB2Aphysical
23798571
UBC_HUMANUBCphysical
23798571
UBXN8_HUMANUBXN8physical
23798571
CNNM3_HUMANCNNM3physical
23798571
DAD1_HUMANDAD1physical
23798571
DSG2_HUMANDSG2physical
23798571
ETFB_HUMANETFBphysical
23798571
EF1B_HUMANEEF1B2physical
23798571
EF1D_HUMANEEF1Dphysical
23798571
EF1G_HUMANEEF1Gphysical
23798571
EF2_HUMANEEF2physical
23798571
IF4A1_HUMANEIF4A1physical
23798571
FLNA_HUMANFLNAphysical
23798571
EFGM_HUMANGFM1physical
23798571
GCDH_HUMANGCDHphysical
23798571
RACK1_HUMANGNB2L1physical
23798571
ROA2_HUMANHNRNPA2B1physical
23798571
HNRPF_HUMANHNRNPFphysical
23798571
HNRH1_HUMANHNRNPH1physical
23798571
HNRPK_HUMANHNRNPKphysical
23798571
1B07_HUMANHLA-Bphysical
23798571
1B18_HUMANHLA-Bphysical
23798571
DHB12_HUMANHSD17B12physical
23798571
DHB4_HUMANHSD17B4physical
23798571
HSDL2_HUMANHSDL2physical
23798571
ILVBL_HUMANILVBLphysical
23798571
IDHP_HUMANIDH2physical
23798571
IDH3A_HUMANIDH3Aphysical
23798571
IDH3G_HUMANIDH3Gphysical
23798571
IDH3B_HUMANIDH3Bphysical
23798571
IMB1_HUMANKPNB1physical
23798571
LMNB1_HUMANLMNB1physical
23798571
1C07_HUMANHLA-Cphysical
23798571
MCCB_HUMANMCCC2physical
23798571
C1TM_HUMANMTHFD1Lphysical
23798571
C1TC_HUMANMTHFD1physical
23798571
ATPO_HUMANATP5Ophysical
23798571
LONM_HUMANLONP1physical
23798571
RM12_HUMANMRPL12physical
23798571
ECHB_HUMANHADHBphysical
23798571
AT1B3_HUMANATP1B3physical
23798571
NDUA5_HUMANNDUFA5physical
23798571
NDUS2_HUMANNDUFS2physical
23798571
NDUS3_HUMANNDUFS3physical
23798571
NDUV1_HUMANNDUFV1physical
23798571
NU155_HUMANNUP155physical
23798571
NUP93_HUMANNUP93physical
23798571
OAT_HUMANOATphysical
23798571
PON2_HUMANPON2physical
23798571
AT2B4_HUMANATP2B4physical
23798571
PCBP1_HUMANPCBP1physical
23798571
PCBP2_HUMANPCBP2physical
23798571
PGRC1_HUMANPGRMC1physical
23798571
AIFM1_HUMANAIFM1physical
23798571
PDIA6_HUMANPDIA6physical
23798571
P5CS_HUMANALDH18A1physical
23798571
PYC_HUMANPCphysical
23798571
ODPB_HUMANPDHBphysical
23798571
RAB18_HUMANRAB18physical
23798571
RBP2_HUMANRANBP2physical
23798571
RAN_HUMANRANphysical
23798571
RLA1_HUMANRPLP1physical
23798571
RS5_HUMANRPS5physical
23798571
SC22B_HUMANSEC22Bphysical
23798571
SERPH_HUMANSERPINH1physical
23798571
GLYM_HUMANSHMT2physical
23798571
SPTC1_HUMANSPTLC1physical
23798571
MK14_HUMANMAPK14physical
23798571
SRPRB_HUMANSRPRBphysical
23798571
SSRD_HUMANSSR4physical
23798571
AAAT_HUMANSLC1A5physical
23798571
DIC_HUMANSLC25A10physical
23798571
M2OM_HUMANSLC25A11physical
23798571
MPCP_HUMANSLC25A3physical
23798571
CMC2_HUMANSLC25A13physical
23798571
ADT3_HUMANSLC25A6physical
23798571
S39AE_HUMANSLC39A14physical
23798571
SLIRP_HUMANSLIRPphysical
23798571
STOM_HUMANSTOMphysical
23798571
SYJ2B_HUMANSYNJ2BPphysical
23798571
TADBP_HUMANTARDBPphysical
23798571
TMX1_HUMANTMX1physical
23798571
TITIN_HUMANTTNphysical
23798571
TRAF1_HUMANTRAF1physical
23798571
TFR1_HUMANTFRCphysical
23798571
TIM50_HUMANTIMM50physical
23798571
TM9S3_HUMANTM9SF3physical
23798571
ENPL_HUMANHSP90B1physical
23798571
QCR2_HUMANUQCRC2physical
23798571
PE2R1_HUMANPTGER1physical
16670773
JKAMP_HUMANJKAMPphysical
23798571
RHOD_HUMANRHODphysical
24561123
WNK1_HUMANWNK1physical
24561123
RGS10_HUMANRGS10physical
24561123
GASR_HUMANCCKBRphysical
24561123
CD4_HUMANCD4physical
24561123
TSHR_HUMANTSHRphysical
24561123
CEAM1_HUMANCEACAM1physical
24561123
CD9_HUMANCD9physical
24561123
JIP2_HUMANMAPK8IP2physical
24561123
CNN1_HUMANCNN1physical
24561123
GMPR2_HUMANGMPR2physical
24561123
PA2GD_HUMANPLA2G2Dphysical
24561123
RACK1_HUMANGNB2L1physical
24561123
GNL3L_HUMANGNL3Lphysical
24561123
RGS8_HUMANRGS8physical
24561123
S52A2_HUMANSLC52A2physical
24561123
RGS17_HUMANRGS17physical
24561123
GPR37_HUMANGPR37physical
24561123
AGRG1_HUMANGPR56physical
24561123
HDAC6_HUMANHDAC6physical
24561123
STAT4_HUMANSTAT4physical
24561123
BACD1_HUMANKCTD13physical
24561123
RNF41_HUMANRNF41physical
24561123
RB27A_HUMANRAB27Aphysical
24561123
VAPA_HUMANVAPAphysical
24561123
VDAC1_HUMANVDAC1physical
24561123
RAN_HUMANRANphysical
24561123
RGS5_HUMANRGS5physical
24561123
RAP2C_HUMANRAP2Cphysical
24561123
GDIR1_HUMANARHGDIAphysical
24561123
RGS11_HUMANRGS11physical
24561123
TS101_HUMANTSG101physical
24561123
ALDOA_HUMANALDOAphysical
24561123
RGS2_HUMANRGS2physical
24561123
GPC5B_HUMANGPRC5Bphysical
24561123
CD81_HUMANCD81physical
24561123
RGS9_HUMANRGS9physical
24561123
IL6RA_HUMANIL6Rphysical
24561123
ADCY3_HUMANADCY3physical
24561123
ARRD1_HUMANARRDC1physical
24561123
CD68_HUMANCD68physical
24561123
GNAT2_HUMANGNAT2physical
24561123
GRK6_HUMANGRK6physical
24561123
RAB3A_HUMANRAB3Aphysical
24561123
KCNE1_HUMANKCNE1physical
24561123
VDAC2_HUMANVDAC2physical
24561123
VEGFB_HUMANVEGFBphysical
24561123
SYUG_HUMANSNCGphysical
24561123
STAT3_HUMANSTAT3physical
24561123
ARF4_HUMANARF4physical
24561123
GRIA3_HUMANGRIA3physical
24561123
RHG05_HUMANARHGAP5physical
24561123
MUC18_HUMANMCAMphysical
24561123
RGS20_HUMANRGS20physical
24561123
ARRB2_HUMANARRB2physical
24561123
REL_HUMANRELphysical
24722188
ARRD3_HUMANARRDC3physical
25220262
HGS_HUMANHGSphysical
23236378
CLH1_HUMANCLTCphysical
23236378
UBP20_HUMANUSP20physical
25666616
MLP3B_HUMANMAP1LC3Bphysical
25666616
GNAS3_HUMANGNASphysical
12036966
GNAS2_HUMANGNASphysical
12036966
ALEX_HUMANGNASphysical
12036966
GNAS1_HUMANGNASphysical
12036966
ARRD3_HUMANARRDC3physical
27226565
ARRB2_HUMANARRB2physical
27226565
RK_HUMANGRK1physical
8672451
ARBK1_HUMANADRBK1physical
8672451
ARBK2_HUMANADRBK2physical
8672451
GRK4_HUMANGRK4physical
8672451
GRK5_HUMANGRK5physical
8672451
GRK6_HUMANGRK6physical
8672451
Drug and Disease Associations
Kegg Disease
H00079 Asthma
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
D00076 Noradrenaline (JP16); Norepinephrine (INN); Nor adrenalin (TN)
D00095 Adrenaline (JP16); Epinephrine (USP/INN); Adrenalin (TN); Auvi-q (TN); Epipen (TN)
D00124 Ephedrine (USP); Ephedrine (TN)
D00255 Carvedilol (JAN/USAN/INN); Artist (TN); Coreg (TN)
D00378 Timolol (USAN); Timolol hemihydrate; Betimol (TN)
D00432 Nadolol (JP16/USP/INN); Corgard (TN)
D00483 Propranolol hydrochloride (JP16/USP); Inderal (TN); Innopran XL (TN)
D00485 Pseudoephedrine hydrochloride (USP); Sudafed (TN)
D00513 Pindolol (JP16/USP/INN); Blocklin-L (TN); Carvisken (TN); Visken (TN)
D00599 Carteolol hydrochloride (JP16/USP); Cartrol (TN); Ocupress (TN)
D00600 Labetalol hydrochloride (JP16/USP); Normodyne (TN); Trandate (TN)
D00602 Penbutolol sulfate (JP16/USP); Levatol (TN)
D00603 Timolol maleate (JP16/USP); Blocadren (TN); Istalol (TN); Timoptic (TN)
D00683 Salbutamol sulfate (JP16); Albuterol sulfate (USP); Accuneb (TN); Proventil (TN); Ventolin (TN)
D00684 Bitolterol mesilate (JAN); Bitolterol mesylate (USAN); Tornalate (TN)
D00685 Orciprenaline sulfate (JP16); Metaproterenol sulfate (USP); Alupent (TN)
D00686 Pirbuterol acetate (USAN); Maxair (TN)
D00687 Salmeterol xinafoate (JAN/USAN); Serevent (TN)
D00688 Terbutaline sulfate (JP16/USP); Brethine (TN)
D00996 Epinephrine hydrochloride (JAN); Adrenalin chloride (TN)
D01017 Dipivefrin hydrochloride (JAN/USP); Propine (TN)
D01025 Levobunolol hydrochloride (JAN/USP); Betagan (TN)
D01026 Sotalol hydrochloride (JAN/USP); Betapace (TN); Sorine (TN)
D01182 Alprenolol hydrochloride (JP16/USAN); Regletin (TN)
D01263 Ritodrine hydrochloride (JP16/USP); Yutopar (TN)
D01349 Pirbuterol hydrochloride (JAN/USAN)
D01360 Clenbuterol hydrochloride (JAN/USP); Spiropent (TN)
D01362 Tulobuterol hydrochloride (JP16); Hokunalin (TN); Respacal (TN)
D01373 Formoterol fumarate (USAN); Foradil (TN)
D01386 Ephedrine hydrochloride (JP16/USP); Ephedrine hydrochloride (TN)
D01390 dl-Isoprenaline hydrochloride (JAN); Isoproterenol hydrochloride (USP); Isuprel (TN); Proternol-S (T
D01428 Fenoterol hydrobromide (JAN); Berotec (TN)
D01444 Bunitrolol hydrochloride (JAN); Betrilol (TN)
D01454 Bupranolol hydrochloride (JP16)
D01469 Amosulalol hydrochloride (JP16); Lowgan (TN)
D01504 Bufetolol hydrochloride (JP16); Adobiol (TN)
D01512 Befunolol hydrochloride (JAN); Bentos (TN)
D01543 Nylidrin hydrochloride (JAN); Buphenine hydrochloride; Arlidin (TN)
D01589 Mabuterol hydrochloride (JAN); Broncholin (TN)
D01635 Methoxyphenamine hydrochloride (JAN); Phenamine (TN)
D01691 Nipradilol (JAN/INN); Hypadil (TN)
D01748 Isoxsuprine hydrochloride (JP16/USP); Duvadilan (TN)
D01794 Bopindolol malonate (JAN); Sandonorm (TN)
D01795 Tilisolol hydrochloride (JAN); Selecal (TN)
D01806 Oxprenolol hydrochloride (JP16/USP); Okuspurecol (TN)
D01830 Arotinolol hydrochloride (JP16); Almarl (TN)
D01835 Clorprenaline hydrochloride (JAN/USAN)
D01952 L-Methylephedrine hydrochloride (JAN)
D01958 Indenolol hydrochloride (JP16)
D01978 Trimetoquinol hydrochloride; Tretoquinol; Inolin (TN)
D02066 Isoprenaline sulfate (JAN); Isoproterenol sulfate (USP); Luf-Iso (TN); Medihaler-Iso (TN)
D02081 Metipranolol hydrochloride; Optipranolol (TN)
D02093 Isoetharine hydrochloride (USP); BETA-2 (TN)
D02109 dl-Methylephedrine hydrochloride (JP16); Methy-F (TN)
D02147 Albuterol (USP); Salbutamol; Proventil (TN)
D02149 Epinephrine bitartrate (JAN/USP); Asmatane mist (TN); Medihaler-epi (TN)
D02150 l-Isoprenaline hydrochloride (JP16); Proternol-L (TN)
D02151 Tulobuterol (JAN/INN); Atenos (TN); Hokunalin (TN)
D02281 Levalbuterol hydrochloride (USAN); Xopenex (TN)
D02349 Dipivefrin (USAN); Dipivefrine (INN)
D02359 Ritodrine (USAN/INN)
D02374 Metipranolol (USAN/INN)
D02389 Primidolol (USAN/INN)
D02396 Hexoprenaline sulfate (USAN); Delaprem (TN)
D02404 Procaterol hydrochloride (USAN); Pro-Air (TN)
D02702 Talibegron hydrochloride (USAN)
D02765 Adaprolol maleate (USAN)
D02834 Alprenoxime hydrochloride (USAN)
D02976 Arbutamine hydrochloride (USAN); Genesa (TN)
D02981 Arformoterol tartrate (USAN); Brovana (TN)
D03170 Bucindolol hydrochloride (USAN)
D03177 Bunolol hydrochloride (USAN)
D03198 Butoxamine hydrochloride (USAN)
D03402 Carbuterol hydrochloride (USAN)
D03415 Carvedilol phosphate hydrate (JAN); Carvedilol phosphate (USAN); Coreg CR (TN)
D03449 Cetamolol hydrochloride (USAN)
D03490 Cicloprolol hydrochloride (USAN)
D03502 Cimaterol (USAN/INN)
D03587 Colterol mesylate (USAN)
D03729 Dexpropranolol hydrochloride (USAN)
D03759 Diacetolol hydrochloride (USAN)
D03891 Dopexamine (USAN/INN)
D04018 Ephedrine sulfate (USP); Isofedrol (TN)
D04157 Fenoterol (USAN/INN)
D04190 Flestolol sulfate (USAN)
D04625 Isoetharine (USP); Isoetarine (INN)
D04626 Isoetharine mesylate (USP); Bronkometer (TN)
D04701 Levalbuterol sulfate (USAN)
D04703 Levalbuterol tartrate (USAN); Xopenex HFA (TN)
D04888 Medroxalol (USAN/INN)
D04889 Medroxalol hydrochloride (USAN)
D04954 Metaproterenol polistirex (USAN)
D05037 Trimetoquinol hydrochloride hydrate (JP16); Tretoquinol hydrate; Caluyon (TN)
D05206 Norepinephrine bitartrate (USP); Levophed (TN)
D05277 Formoterol fumarate hydrate (JP16); Formoterol fumarate dihydrate; Atock (TN); Foradil (TN)
D05345 Pamatolol sulfate (USAN)
D05366 Procaterol hydrochloride hydrate (JP16); Meptin (TN)
D05476 Picumeterol fumarate (USAN)
D05648 Pseudoephedrine polistirex (USAN); Pseudo-12 (TN)
D05649 Pseudoephedrine sulfate (USP); Afrinol (TN)
D05691 Ractopamine hydrochloride (USAN)
D05718 Reproterol hydrochloride (USAN)
D05730 Rimiterol hydrobromide (USAN)
D05792 Salmeterol (USAN/INN)
D05832 Sibenadet hydrochloride (USAN); Viozan (TN)
D05902 Soterenol hydrochloride (USAN)
D06374 Zinterol hydrochloride (USAN)
D07156 Alprenolol (INN)
D07181 Mepindolol (INN)
D07182 Tertatolol (INN)
D07183 Cloranolol (INN)
D07377 Bambuterol (INN)
D07451 Amosulalol (INN)
D07463 Arformoterol (INN)
D07465 Arotinolol (INN)
D07489 Bambuterol hydrochloride; Bambec (TN)
D07534 Bitolterol (INN)
D07537 Bopindolol (INN); Sandonorm (TN)
D07551 Buphenine (INN)
D07590 Bupranolol (INN)
D07608 Carazolol (INN); Conducton (TN); Suacron [veterinary] (TN)
D07624 Carteolol (INN)
D07713 Clenbuterol (INN); Contraspasmin (TN); Planipart [veterinary] (TN)
D07990 Formoterol (INN); Oxis (TN)
D08039 Hexoprenaline (INN); Ipradol (TN)
D08074 Penbutolol (INN)
D08078 Indenolol (INN)
D08090 Isoprenaline (INN)
D08092 Isoxsuprine (INN); Dilator (TN)
D08093 Isoxsuprine lactate; Duphaspasmin [veterinary] (TN)
D08106 Labetalol (INN)
D08115 Levobunolol (INN)
D08124 Levosalbutamol (INN)
D08206 Methylephedrine (BAN)
D08284 Norepinephrine hydrochoride; (-)-Noradrenaline hydrochloride; Arterenol (TN)
D08300 Orciprenaline (INN); Metaproterenol
D08318 Oxprenolol (INN); Oxprenolol (TN)
D08387 Pirbuterol (INN)
D08424 Procaterol (INN); Meptin (TN)
D08443 Propranolol (INN); Propranolol (TN)
D08449 Pseudoephedrine (INN); Neodurasina (TN); Acunaso (TN)
D08474 Reproterol (INN)
D08525 Sotalol (INN); Darob mite (TN)
D08570 Terbutaline (INN); Asthmasian (TN)
D08572 Tertatolol hydrochloride; Artex (TN)
D08598 Tilisolol (INN)
D08600 Timolol (INN); Timolol (TN); Betimol (TN)
D08629 Tretoquinol (INN)
D08945 Milveterol hydrochloride (USAN)
D09318 Indacaterol (USAN/INN)
D09319 Indacaterol maleate (JAN/USAN); Arcapta neohaler (TN)
D09696 Vilanterol (USAN)
D09697 Vilanterol trifenatate (JAN/USAN)
D09794 Norepinephrine hydrochloride (JAN); (+/-)-Noradrenaline hydrochloride
D09842 dl-Methylephedrine saccharinate (JAN)
D09843 Beradilol monoethyl maleate (JAN); TZC-5665
D10020 Olodaterol hydrochloride (JAN/USAN)
D10145 Olodaterol (USAN/INN)
D10219 abediterol (USAN/INN)
D10220 Abediterol napadisylate (USAN)
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ADRB2_HUMAN

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Related Literatures of Post-Translational Modification
Hydroxylation
ReferencePubMed
"Oxygen-regulated beta(2)-adrenergic receptor hydroxylation by EGLN3and ubiquitylation by pVHL.";
Xie L., Xiao K., Whalen E.J., Forrester M.T., Freeman R.S., Fong G.,Gygi S.P., Lefkowitz R.J., Stamler J.S.;
Sci. Signal. 2:RA33-RA33(2009).
Cited for: INTERACTION WITH EGLN3 AND VHL, SUBCELLULAR LOCATION, INDUCTION,UBIQUITINATION, HYDROXYLATION AT PRO-382 AND PRO-395, AND MASSSPECTROMETRY.
Palmitoylation
ReferencePubMed
"The palmitoylation state of the beta(2)-adrenergic receptor regulatesthe synergistic action of cyclic AMP-dependent protein kinase andbeta-adrenergic receptor kinase involved in its phosphorylation anddesensitization.";
Moffett S., Rousseau G., Lagace M., Bouvier M.;
J. Neurochem. 76:269-279(2001).
Cited for: EFFECT OF PALMITOYLATION, PHOSPHORYLATION AT SER-345 AND SER-346, ANDMUTAGENESIS OF 345-SER-SER-346.
"Palmitoylation of the human beta 2-adrenergic receptor. Mutation ofCys341 in the carboxyl tail leads to an uncoupled nonpalmitoylatedform of the receptor.";
O'Dowd B.F., Hnatowich M., Caron M.G., Lefkowitz R.J., Bouvier M.;
J. Biol. Chem. 264:7564-7569(1989).
Cited for: PALMITOYLATION AT CYS-341, AND MUTAGENESIS OF CYS-341.
Phosphorylation
ReferencePubMed
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage.";
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
Science 316:1160-1166(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-246, AND MASSSPECTROMETRY.
"The palmitoylation state of the beta(2)-adrenergic receptor regulatesthe synergistic action of cyclic AMP-dependent protein kinase andbeta-adrenergic receptor kinase involved in its phosphorylation anddesensitization.";
Moffett S., Rousseau G., Lagace M., Bouvier M.;
J. Neurochem. 76:269-279(2001).
Cited for: EFFECT OF PALMITOYLATION, PHOSPHORYLATION AT SER-345 AND SER-346, ANDMUTAGENESIS OF 345-SER-SER-346.
"Mutation of tyrosine-141 inhibits insulin-promoted tyrosinephosphorylation and increased responsiveness of the human beta 2-adrenergic receptor.";
Valiquette M., Parent S., Loisel T.P., Bouvier M.;
EMBO J. 14:5542-5549(1995).
Cited for: MUTAGENESIS OF TYR-141; TYR-350; TYR-354 AND TYR-366, ANDPHOSPHORYLATION AT TYR-141.

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