RGS5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RGS5_HUMAN
• UniProt AC: O15539
• Protein Name: Regulator of G-protein signaling 5
• Gene Name: RGS5
• Organism: Homo sapiens (Human).
• Sequence Length: 181
• Subcellular Localization: Isoform 1: Cytoplasm . Membrane .; Isoform 2: Cytoplasm .
• Protein Description: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha (By similarity)..
• Protein Sequence: MCKGLAALPHSCLERAKEIKIKLGILLQKPDSVGDLVIPYNEKPEKPAKTQKTSLDEALQWRDSLDKLLQNNYGLASFKSFLKSEFSEENLEFWIACEDYKKIKSPAKMAEKAKQIYEEFIQTEAPKEVNIDHFTKDITMKNLVEPSLSSFDMAQKRIHALMEKDSLPRFVRSEFYQELIK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	GLAALPHSCLERAKE HHHCCCHHHHHHHHH	20.61	28464451
22	Ubiquitination	RAKEIKIKLGILLQK HHHHHCHHHEEEECC	35.34	-
29	Ubiquitination	KLGILLQKPDSVGDL HHEEEECCCCCCCCE	51.25	-
40	Phosphorylation	VGDLVIPYNEKPEKP CCCEEECCCCCCCCC	25.48	18083107
43	Ubiquitination	LVIPYNEKPEKPAKT EEECCCCCCCCCCCC	55.64	-
46	Ubiquitination	PYNEKPEKPAKTQKT CCCCCCCCCCCCCCC	59.82	-
52	Ubiquitination	EKPAKTQKTSLDEAL CCCCCCCCCCHHHHH	45.36	-
64	Phosphorylation	EALQWRDSLDKLLQN HHHHHHHHHHHHHHC	29.87	27535140
67	Ubiquitination	QWRDSLDKLLQNNYG HHHHHHHHHHHCCCC	57.29	-
73	Phosphorylation	DKLLQNNYGLASFKS HHHHHCCCCHHHHHH	22.52	25884760
77	Phosphorylation	QNNYGLASFKSFLKS HCCCCHHHHHHHHHH	37.95	24719451
79	Ubiquitination	NYGLASFKSFLKSEF CCCHHHHHHHHHHCC	37.49	-
80	Phosphorylation	YGLASFKSFLKSEFS CCHHHHHHHHHHCCC	33.53	24719451
84	Phosphorylation	SFKSFLKSEFSEENL HHHHHHHHCCCHHHH	46.12	17540411
114	Ubiquitination	AKMAEKAKQIYEEFI HHHHHHHHHHHHHHH	48.58	-
117	Phosphorylation	AEKAKQIYEEFIQTE HHHHHHHHHHHHHCC	13.60	25884760
127	Ubiquitination	FIQTEAPKEVNIDHF HHHCCCCCCCCCCCC	79.80	-
136	Ubiquitination	VNIDHFTKDITMKNL CCCCCCCCCCCHHHC	46.30	-
141	Ubiquitination	FTKDITMKNLVEPSL CCCCCCHHHCCCCCC	38.18	-
156	Ubiquitination	SSFDMAQKRIHALME CHHHHHHHHHHHHHH	43.72	-
164	Ubiquitination	RIHALMEKDSLPRFV HHHHHHHHCCCCHHH	38.36	-
166	Phosphorylation	HALMEKDSLPRFVRS HHHHHHCCCCHHHHH	51.87	17540411

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
84	S	Phosphorylation	Kinase	PRKCA	P05696	GPS
166	S	Phosphorylation	Kinase	PRKCA	P05696	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RGS5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RGS5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GNAI3_HUMAN	GNAI3	physical	9079700
GNAI2_HUMAN	GNAI2	physical	9079700
GNAO_HUMAN	GNAO1	physical	9079700
GNAI1_HUMAN	GNAI1	physical	11253162
GNAI2_HUMAN	GNAI2	physical	11253162
GNAI3_HUMAN	GNAI3	physical	11253162
GNAO_HUMAN	GNAO1	physical	11253162
GNAQ_HUMAN	GNAQ	physical	11253162
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.