| UniProt ID | GNAO_HUMAN | |
|---|---|---|
| UniProt AC | P09471 | |
| Protein Name | Guanine nucleotide-binding protein G(o) subunit alpha | |
| Gene Name | GNAO1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 354 | |
| Subcellular Localization |
Cell membrane . Membrane Lipid-anchor . |
|
| Protein Description | Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14.. | |
| Protein Sequence | MGCTLSAEERAALERSKAIEKNLKEDGISAAKDVKLLLLGAGESGKSTIVKQMKIIHEDGFSGEDVKQYKPVVYSNTIQSLAAIVRAMDTLGIEYGDKERKADAKMVCDVVSRMEDTEPFSAELLSAMMRLWGDSGIQECFNRSREYQLNDSAKYYLDSLDRIGAADYQPTEQDILRTRVKTTGIVETHFTFKNLHFRLFDVGGQRSERKKWIHCFEDVTAIIFCVALSGYDQVLHEDETTNRMHESLMLFDSICNNKFFIDTSIILFLNKKDLFGEKIKKSPLTICFPEYTGPNTYEDAAAYIQAQFESKNRSPNKEIYCHMTCATDTNNIQVVFDAVTDIIIANNLRGCGLY | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Myristoylation | ------MGCTLSAEE ------CCCCCCHHH | 17.08 | 25255805 | |
| 3 | S-palmitoylation | -----MGCTLSAEER -----CCCCCCHHHH | 3.14 | - | |
| 4 | Phosphorylation | ----MGCTLSAEERA ----CCCCCCHHHHH | 20.30 | - | |
| 6 | Phosphorylation | --MGCTLSAEERAAL --CCCCCCHHHHHHH | 18.58 | 21815630 | |
| 44 | Phosphorylation | LLLGAGESGKSTIVK EEECCCCCCCCHHHE | 51.07 | 20873877 | |
| 46 (in isoform 2) | Ubiquitination | - | 54.42 | 21906983 | |
| 46 (in isoform 1) | Ubiquitination | - | 54.42 | 21906983 | |
| 46 | Ubiquitination | LGAGESGKSTIVKQM ECCCCCCCCHHHEEE | 54.42 | 21890473 | |
| 47 | Phosphorylation | GAGESGKSTIVKQMK CCCCCCCCHHHEEEE | 27.22 | 20873877 | |
| 48 | Phosphorylation | AGESGKSTIVKQMKI CCCCCCCHHHEEEEE | 33.02 | 29514088 | |
| 51 | Ubiquitination | SGKSTIVKQMKIIHE CCCCHHHEEEEEECC | 40.60 | 2190698 | |
| 51 (in isoform 2) | Ubiquitination | - | 40.60 | 21906983 | |
| 51 (in isoform 1) | Ubiquitination | - | 40.60 | 21906983 | |
| 62 | Phosphorylation | IIHEDGFSGEDVKQY EECCCCCCCCHHHHH | 46.96 | 27251275 | |
| 112 | Phosphorylation | KMVCDVVSRMEDTEP HHHHHHHHCCCCCCC | 26.26 | 21406692 | |
| 126 | Phosphorylation | PFSAELLSAMMRLWG CCCHHHHHHHHHHHC | 27.09 | 29691806 | |
| 135 | Phosphorylation | MMRLWGDSGIQECFN HHHHHCCCHHHHHHH | 33.58 | 24076635 | |
| 147 | Phosphorylation | CFNRSREYQLNDSAK HHHHCCCCCCCCHHH | 19.72 | 25954137 | |
| 152 | Phosphorylation | REYQLNDSAKYYLDS CCCCCCCHHHHHHHC | 26.11 | 25954137 | |
| 155 | Phosphorylation | QLNDSAKYYLDSLDR CCCCHHHHHHHCHHH | 14.69 | 25954137 | |
| 159 | Phosphorylation | SAKYYLDSLDRIGAA HHHHHHHCHHHCCCC | 29.58 | 24076635 | |
| 168 | Phosphorylation | DRIGAADYQPTEQDI HHCCCCCCCCCHHHH | 16.21 | 25954137 | |
| 179 | ADP-ribosylation | EQDILRTRVKTTGIV HHHHHHHHHCCCCEE | 22.85 | - | |
| 179 | ADP-ribosylation | EQDILRTRVKTTGIV HHHHHHHHHCCCCEE | 22.85 | - | |
| 182 | Phosphorylation | ILRTRVKTTGIVETH HHHHHHCCCCEEEEE | 27.65 | - | |
| 188 | Phosphorylation | KTTGIVETHFTFKNL CCCCEEEEEEEECCE | 16.05 | - | |
| 191 | Phosphorylation | GIVETHFTFKNLHFR CEEEEEEEECCEEEE | 26.54 | - | |
| 205 | Formation of an isopeptide bond | RLFDVGGQRSERKKW EEEECCCCCCCHHHH | 39.54 | - | |
| 207 | Phosphorylation | FDVGGQRSERKKWIH EECCCCCCCHHHHCH | 33.59 | 25332170 | |
| 253 | Phosphorylation | ESLMLFDSICNNKFF HHHHHHHHHHCCCEE | 23.00 | 20873877 | |
| 285 | Phosphorylation | KIKKSPLTICFPEYT HHCCCCCEEECCCCC | 21.05 | - | |
| 291 | Phosphorylation | LTICFPEYTGPNTYE CEEECCCCCCCCCHH | 19.75 | - | |
| 351 | ADP-ribosylation | IANNLRGCGLY---- HCCCCCCCCCC---- | 2.47 | - | |
| 351 | ADP-ribosylation | IANNLRGCGLY---- HCCCCCCCCCC---- | 2.47 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of GNAO_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of GNAO_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of GNAO_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| CAC1B_HUMAN | CACNA1B | physical | 11395521 | |
| OPRM_HUMAN | OPRM1 | physical | 8393523 | |
| OPRD_HUMAN | OPRD1 | physical | 8393523 | |
| RGS20_HUMAN | RGS20 | physical | 18407463 | |
| GABR1_HUMAN | GABBR1 | physical | 17185339 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| 615473 | Epileptic encephalopathy, early infantile, 17 (EIEE17) | |||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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