GABR1_HUMAN - dbPTM
GABR1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GABR1_HUMAN
UniProt AC Q9UBS5
Protein Name Gamma-aminobutyric acid type B receptor subunit 1
Gene Name GABBR1
Organism Homo sapiens (Human).
Sequence Length 961
Subcellular Localization Cell membrane
Multi-pass membrane protein . Cell junction, synapse, postsynaptic cell membrane
Multi-pass membrane protein . Cell projection, dendrite . Colocalizes with ATF4 in hippocampal neuron dendritic membranes (By similarity). Coexpression
Protein Description Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. [PubMed: 9872316]
Protein Sequence MLLLLLLAPLFLRPPGAGGAQTPNATSEGCQIIHPPWEGGIRYRGLTRDQVKAINFLPVDYEIEYVCRGEREVVGPKVRKCLANGSWTDMDTPSRCVRICSKSYLTLENGKVFLTGGDLPALDGARVDFRCDPDFHLVGSSRSICSQGQWSTPKPHCQVNRTPHSERRAVYIGALFPMSGGWPGGQACQPAVEMALEDVNSRRDILPDYELKLIHHDSKCDPGQATKYLYELLYNDPIKIILMPGCSSVSTLVAEAARMWNLIVLSYGSSSPALSNRQRFPTFFRTHPSATLHNPTRVKLFEKWGWKKIATIQQTTEVFTSTLDDLEERVKEAGIEITFRQSFFSDPAVPVKNLKRQDARIIVGLFYETEARKVFCEVYKERLFGKKYVWFLIGWYADNWFKIYDPSINCTVDEMTEAVEGHITTEIVMLNPANTRSISNMTSQEFVEKLTKRLKRHPEETGGFQEAPLAYDAIWALALALNKTSGGGGRSGVRLEDFNYNNQTITDQIYRAMNSSSFEGVSGHVVFDASGSRMAWTLIEQLQGGSYKKIGYYDSTKDDLSWSKTDKWIGGSPPADQTLVIKTFRFLSQKLFISVSVLSSLGIVLAVVCLSFNIYNSHVRYIQNSQPNLNNLTAVGCSLALAAVFPLGLDGYHIGRNQFPFVCQARLWLLGLGFSLGYGSMFTKIWWVHTVFTKKEEKKEWRKTLEPWKLYATVGLLVGMDVLTLAIWQIVDPLHRTIETFAKEEPKEDIDVSILPQLEHCSSRKMNTWLGIFYGYKGLLLLLGIFLAYETKSVSTEKINDHRAVGMAIYNVAVLCLITAPVTMILSSQQDAAFAFASLAIVFSSYITLVVLFVPKMRRLITRGEWQSEAQDTMKTGSSTNNNEEEKSRLLEKENRELEKIIAEKEERVSELRHQLQSRQQLRSRRHPPTPPEPSGGLPRGPPEPPDRLSCDGSRVHLLYK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
24N-linked_GlycosylationAGGAQTPNATSEGCQ
CCCCCCCCCCCCCCC		60.27UniProtKB CARBOHYD
30 (in isoform 2)Phosphorylation-2.0024043423
32 (in isoform 2)Phosphorylation-3.4824043423
84N-linked_GlycosylationKVRKCLANGSWTDMD
HHHHHHHCCCCCCCC		31.89UniProtKB CARBOHYD
86PhosphorylationRKCLANGSWTDMDTP
HHHHHCCCCCCCCCC		26.9829449344
86 (in isoform 3)Phosphorylation-26.98-
88PhosphorylationCLANGSWTDMDTPSR
HHHCCCCCCCCCCHH		24.1229449344
88 (in isoform 3)Phosphorylation-24.12-
92PhosphorylationGSWTDMDTPSRCVRI
CCCCCCCCCHHHHHH		19.2729449344
92 (in isoform 3)Phosphorylation-19.27-
94 (in isoform 3)Phosphorylation-40.17-
94PhosphorylationWTDMDTPSRCVRICS
CCCCCCCHHHHHHCC		40.1729449344
171PhosphorylationHSERRAVYIGALFPM
CHHHCEEEEEEEEEC		7.8330257219
179PhosphorylationIGALFPMSGGWPGGQ
EEEEEECCCCCCCCC		34.1030257219
201PhosphorylationMALEDVNSRRDILPD
HHHHHHHHCCCCCCC		28.6530257219
209PhosphorylationRRDILPDYELKLIHH
CCCCCCCCEEEEEEC		22.63-
226PhosphorylationKCDPGQATKYLYELL
CCCHHHHHHHHHHHH		16.6029759185
228PhosphorylationDPGQATKYLYELLYN
CHHHHHHHHHHHHHC		15.3429759185
407PhosphorylationWFKIYDPSINCTVDE
CCCCCCCCCCCCHHH		24.4422210691
409N-linked_GlycosylationKIYDPSINCTVDEMT
CCCCCCCCCCHHHHH		21.53UniProtKB CARBOHYD
440N-linked_GlycosylationANTRSISNMTSQEFV
CCCCCCCCCCHHHHH		35.7624305054
442PhosphorylationTRSISNMTSQEFVEK
CCCCCCCCHHHHHHH		31.3522210691
482N-linked_GlycosylationWALALALNKTSGGGG
HHHHHHHHCCCCCCC		39.7024305054
500PhosphorylationVRLEDFNYNNQTITD
CCHHHCCCCCCCHHH		18.5824043423
502N-linked_GlycosylationLEDFNYNNQTITDQI
HHHCCCCCCCHHHHH		29.97UniProtKB CARBOHYD
504PhosphorylationDFNYNNQTITDQIYR
HCCCCCCCHHHHHHH		28.1524043423
506PhosphorylationNYNNQTITDQIYRAM
CCCCCCHHHHHHHHH		25.8224043423
510PhosphorylationQTITDQIYRAMNSSS
CCHHHHHHHHHHCCC		6.1524043423
514N-linked_GlycosylationDQIYRAMNSSSFEGV
HHHHHHHHCCCCCCC		37.44UniProtKB CARBOHYD
690PhosphorylationTKIWWVHTVFTKKEE
HHHHEEEEECCCHHH		14.0129083192
693PhosphorylationWWVHTVFTKKEEKKE
HEEEEECCCHHHHHH		36.5529083192
762PhosphorylationLPQLEHCSSRKMNTW
HHCHHHHCCCCCHHH		34.7820068231
776PhosphorylationWLGIFYGYKGLLLLL
HHHHHCHHHHHHHHH		7.18-
806 (in isoform 3)Phosphorylation-9.98-
811 (in isoform 3)Phosphorylation-14.79-
868PhosphorylationITRGEWQSEAQDTMK
HHCCCHHHHHHHHHH		35.65-
873PhosphorylationWQSEAQDTMKTGSST
HHHHHHHHHHCCCCC		14.4225307156
876PhosphorylationEAQDTMKTGSSTNNN
HHHHHHHCCCCCCCC		31.3220068231
878PhosphorylationQDTMKTGSSTNNNEE
HHHHHCCCCCCCCHH		38.9420068231
879PhosphorylationDTMKTGSSTNNNEEE
HHHHCCCCCCCCHHH		36.1820068231
880PhosphorylationTMKTGSSTNNNEEEK
HHHCCCCCCCCHHHH		43.6020068231
887UbiquitinationTNNNEEEKSRLLEKE
CCCCHHHHHHHHHHH		44.12-
888PhosphorylationNNNEEEKSRLLEKEN
CCCHHHHHHHHHHHH		31.2920068231
893UbiquitinationEKSRLLEKENRELEK
HHHHHHHHHHHHHHH		61.33-
900UbiquitinationKENRELEKIIAEKEE
HHHHHHHHHHHHHHH		52.62-
905UbiquitinationLEKIIAEKEERVSEL
HHHHHHHHHHHHHHH		56.72-
924PhosphorylationQSRQQLRSRRHPPTP
HHHHHHHHCCCCCCC		42.11-
930PhosphorylationRSRRHPPTPPEPSGG
HHCCCCCCCCCCCCC		56.7920886841
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of GABR1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of GABR1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GABR1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
JKIP1_HUMANJAKMIP1physical
14718537
GABR2_HUMANGABBR2physical
9872316
ATF5_HUMANATF5physical
11087824
ATF4_HUMANATF4physical
11087824
GABR2_HUMANGABBR2physical
26817839
UBP14_HUMANUSP14physical
26817839
DDIT3_HUMANDDIT3physical
16081421
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
D00058 Gamma-Aminobutyric acid (JAN); Gammalon (TN)
D00241 Baclofen (JP16/USP/INN); Kemstro (TN); Lioresal (TN)
D08861 Arbaclofen placarbil (USAN/INN)
D09791 Arbaclofen (USAN)
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GABR1_HUMAN

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Related Literatures of Post-Translational Modification

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