dbPTM

ATF5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ATF5_HUMAN
UniProt AC	Q9Y2D1
Protein Name	Cyclic AMP-dependent transcription factor ATF-5
Gene Name	ATF5
Organism	Homo sapiens (Human).
Sequence Length	282
Subcellular Localization	Cytoplasm . Nucleus . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Actively transported to the centrosome and accumulated in the pericentriolar material (PCM) during G1 to M phase via a microtubule-dependent mechanism. During
Protein Description	Transcription factor that either stimulates or represses gene transcription through binding of different DNA regulatory elements such as cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), ATF5-specific response element (ARE) (consensus: 5'-C[CT]TCT[CT]CCTT[AT]-3') but also the amino acid response element (AARE), present in many viral and cellular promoters. Critically involved, often in a cell type-dependent manner, in cell survival, proliferation, and differentiation. [PubMed: 10373550]
Protein Sequence	MSLLATLGLELDRALLPASGLGWLVDYGKLPPAPAPLAPYEVLGGALEGGLPVGGEPLAGDGFSDWMTERVDFTALLPLEPPLPPGTLPQPSPTPPDLEAMASLLKKELEQMEDFFLDAPPLPPPSPPPLPPPPLPPAPSLPLSLPSFDLPQPPVLDTLDLLAIYCRNEAGQEEVGMPPLPPPQQPPPPSPPQPSRLAPYPHPATTRGDRKQKKRDQNKSAALRYRQRKRAEGEALEGECQGLEARNRELKERAESVEREIQYVKDLLIEVYKARSQRTRSC

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MSLLATLGLELDR --CCHHHHHCHHHHH	22.71	24043423
29	Acetylation	GWLVDYGKLPPAPAP CHHCCCCCCCCCCCC	52.14	21791614
103	Phosphorylation	PDLEAMASLLKKELE CCHHHHHHHHHHHHH	22.58	24719451
220	Phosphorylation	KKRDQNKSAALRYRQ HHHHHCHHHHHHHHH	26.73	24719451
225	Phosphorylation	NKSAALRYRQRKRAE CHHHHHHHHHHHHHH	16.37	24719451
229	Ubiquitination	ALRYRQRKRAEGEAL HHHHHHHHHHHHHHH	47.85	-
256	Phosphorylation	ELKERAESVEREIQY HHHHHHHHHHHHHHH	28.44	15221005

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ATF5_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
29	K	Acetylation	-
Acetylated at Lys-29 by EP300, the acetylation enhances the interaction with CEBPB, DNA-binding and transactivation activity.
92	S	Phosphorylation	25512613
Phosphorylated by NLK, probably at Ser-92, Thr-94, Ser-126 and Ser-190.
94	T	Phosphorylation	25512613
Phosphorylated by NLK, probably at Ser-92, Thr-94, Ser-126 and Ser-190.
126	S	Phosphorylation	25512613
Phosphorylated by NLK, probably at Ser-92, Thr-94, Ser-126 and Ser-190.
190	S	Phosphorylation	25512613
Phosphorylated by NLK, probably at Ser-92, Thr-94, Ser-126 and Ser-190.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ATF5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TRIB3_HUMAN	TRIB3	physical	18276110
CCND3_HUMAN	CCND3	physical	21988832
EP300_HUMAN	EP300	physical	21988832
GIT2_HUMAN	GIT2	physical	21988832
EP300_HUMAN	EP300	physical	21791614

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB00852	Pseudoephedrine

Regulatory Network of ATF5_HUMAN

Related Literatures of Post-Translational Modification