TRIB3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TRIB3_HUMAN
• UniProt AC: Q96RU7
• Protein Name: Tribbles homolog 3
• Gene Name: TRIB3
• Organism: Homo sapiens (Human).
• Sequence Length: 358
• Subcellular Localization: Nucleus .
• Protein Description: Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Does not display kinase activity. Inhibits the transcriptional activity of DDIT3/CHOP and is involved in DDIT3/CHOP-dependent cell death during ER stress. Can inhibit APOBEC3A editing of nuclear DNA..
• Protein Sequence: MRATPLAAPAGSLSRKKRLELDDNLDTERPVQKRARSGPQPRLPPCLLPLSPPTAPDRATAVATASRLGPYVLLEPEEGGRAYQALHCPTGTEYTCKVYPVQEALAVLEPYARLPPHKHVARPTEVLAGTQLLYAFFTRTHGDMHSLVRSRHRIPEPEAAVLFRQMATALAHCHQHGLVLRDLKLCRFVFADRERKKLVLENLEDSCVLTGPDDSLWDKHACPAYVGPEILSSRASYSGKAADVWSLGVALFTMLAGHYPFQDSEPVLLFGKIRRGAYALPAGLSAPARCLVRCLLRREPAERLTATGILLHPWLRQDPMPLAPTRSHLWEAAQVVPDGLGLDEAREEEGDREVVLYG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MRATPLAAPAG ----CCCCCCCCCCC	14.42	24719451
12	Phosphorylation	PLAAPAGSLSRKKRL CCCCCCCCCCCCCCC	25.85	26434776
14	Phosphorylation	AAPAGSLSRKKRLEL CCCCCCCCCCCCCCC	43.69	26434776
33	Ubiquitination	DTERPVQKRARSGPQ CCCCCHHHHHHCCCC	48.54	-
37	Phosphorylation	PVQKRARSGPQPRLP CHHHHHHCCCCCCCC	54.57	24706070
39	Phosphorylation	QKRARSGPQPRLPPC HHHHHCCCCCCCCCC	42.10	-
41	Phosphorylation	RARSGPQPRLPPCLL HHHCCCCCCCCCCCC	42.80	-
44	Ubiquitination	SGPQPRLPPCLLPLS CCCCCCCCCCCCCCC	20.88	-
51	Phosphorylation	PPCLLPLSPPTAPDR CCCCCCCCCCCCCCH	27.22	23312004
54	Phosphorylation	LLPLSPPTAPDRATA CCCCCCCCCCCHHHH	54.96	23312004
60	Ubiquitination	PTAPDRATAVATASR CCCCCHHHHHHHHHH	23.66	-
64	Phosphorylation	DRATAVATASRLGPY CHHHHHHHHHHHCCE	20.68	-
78	Phosphorylation	YVLLEPEEGGRAYQA EEEECCCCCCCEEEE	77.11	-
97	Ubiquitination	TGTEYTCKVYPVQEA CCCEEEEEEEEHHHH	36.68	-
124	Ubiquitination	HKHVARPTEVLAGTQ CCCCCCCHHHHHHHH	32.92	-
215	Phosphorylation	VLTGPDDSLWDKHAC EEECCCCCCCCCCCC	38.45	-
224	Ubiquitination	WDKHACPAYVGPEIL CCCCCCCCHHCHHHH	16.13	-
232	Phosphorylation	YVGPEILSSRASYSG HHCHHHHCCCCCCCC	24.36	24719451
233	Phosphorylation	VGPEILSSRASYSGK HCHHHHCCCCCCCCC	28.55	24719451
246	Ubiquitination	GKAADVWSLGVALFT CCHHHHHHHHHHHHH	18.33	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	SIAH1	Q8IUQ4	PMID:18276110

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TRIB3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TRIB3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ATF4_HUMAN	ATF4	physical	12743605
AKT1_HUMAN	AKT1	physical	12791994
TF65_HUMAN	RELA	physical	12736262
CSN6_HUMAN	COPS6	physical	16169070
GDF9_HUMAN	GDF9	physical	16169070
GIT1_HUMAN	GIT1	physical	16169070
SETB1_HUMAN	SETDB1	physical	16169070
RBM48_HUMAN	RBM48	physical	16169070
EF1G_HUMAN	EEF1G	physical	16169070
KAT5_HUMAN	KAT5	physical	16169070
ATF4_HUMAN	ATF4	physical	18276110
ATF5_HUMAN	ATF5	physical	18276110
CSK2B_HUMAN	CSNK2B	physical	18276110
FINC_HUMAN	FN1	physical	18276110
GRN_HUMAN	GRN	physical	18276110
1B07_HUMAN	HLA-B	physical	18276110
1B18_HUMAN	HLA-B	physical	18276110
LTBP4_HUMAN	LTBP4	physical	18276110
GANP_HUMAN	MCM3AP	physical	18276110
SIAH1_HUMAN	SIAH1	physical	18276110
RIDA_HUMAN	HRSP12	physical	18276110
PSA3_HUMAN	PSMA3	physical	18276110
RBM4_HUMAN	RBM4	physical	18276110
RSSA_HUMAN	RPSA	physical	18276110
TIAF1_HUMAN	TIAF1	physical	18276110
SMAD3_HUMAN	SMAD3	physical	21896644
SMUF1_HUMAN	SMURF1	physical	17576816
A4_HUMAN	APP	physical	21832049
ANM5_HUMAN	PRMT5	physical	23455924
STK40_HUMAN	STK40	physical	26186194
GALD1_HUMAN	PDDC1	physical	26186194
RFWD2_HUMAN	RFWD2	physical	26186194
SQSTM_HUMAN	SQSTM1	physical	26268733
STK40_HUMAN	STK40	physical	28514442
RFWD2_HUMAN	RFWD2	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.