LTBP4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LTBP4_HUMAN
• UniProt AC: Q8N2S1
• Protein Name: Latent-transforming growth factor beta-binding protein 4
• Gene Name: LTBP4
• Organism: Homo sapiens (Human).
• Sequence Length: 1624
• Subcellular Localization: Secreted, extracellular space, extracellular matrix .
• Protein Description: May be involved in the assembly, secretion and targeting of TGFB1 to sites at which it is stored and/or activated. May play critical roles in controlling and directing the activity of TGFB1. May have a structural role in the extracellular matrix (ECM) (By similarity)..
• Protein Sequence: MPRPGTSGRRPLLLVLLLPLFAAATSAASPSPSPSQVVEVPGVPSRPASVAVCRCCPGQTSRRSRCIRAFCRVRSCQPKKCAGPQRCLNPVPAVPSPSPSVRKRQVSLNWQPLTLQEARALLKRRRPRGPGGRGLLRRRPPQRAPAGKAPVLCPLICHNGGVCVKPDRCLCPPDFAGKFCQLHSSGARPPAPAVPGLTRSVYTMPLANHRDDEHGVASMVSVHVEHPQEASVVVHQVERVSGPWEEADAEAVARAEAAARAEAAAPYTVLAQSAPREDGYSDASGFGYCFRELRGGECASPLPGLRTQEVCCRGAGLAWGVHDCQLCSERLGNSERVSAPDGPCPTGFERVNGSCEDVDECATGGRCQHGECANTRGGYTCVCPDGFLLDSSRSSCISQHVISEAKGPCFRVLRDGGCSLPILRNITKQICCCSRVGKAWGRGCQLCPPFGSEGFREICPAGPGYHYSASDLRYNTRPLGQEPPRVSLSQPRTLPATSRPSAGFLPTHRLEPRPEPRPDPRPGPELPLPSIPAWTGPEIPESGPSSGMCQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKNLPGSFRCVCPAGFRGSACEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQECVNSPGSFQCRTCPSGHHLHRGRCTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEGTCDDVDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPTPGGGCQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNECETLQGVCGAALCENVEGSFLCVCPNSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSGRRECYFDTAAPDACDNILARNVTWQECCCTVGEGWGSGCRIQQCPGTETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVLDGSQRRCVSNESQSLDDNLGVCWQEVGADLVCSHPRLDRQATYTECCCLYGEAWGMDCALCPAQDSDDFEALCNVLRPPAYSPPRPGGFGLPYEYGPDLGPPYQGLPYGPELYPPPALPYDPYPPPPGPFARREAPYGAPRFDMPDFEDDGGPYGESEAPAPPGPGTRWPYRSRDTRRSFPEPEEPPEGGSYAGSLAEPYEELEAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFRCICRPGFAPTHQPHHCAPARPRA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5 (in isoform 3)	Methylation	-	33.52	-
24 (in isoform 3)	Phosphorylation	-	9.92	-
26 (in isoform 3)	Phosphorylation	-	19.67	-
30 (in isoform 3)	Phosphorylation	-	45.60	-
31	O-linked_Glycosylation	ATSAASPSPSPSQVV HHHCCCCCCCHHHEE	35.20	OGP
33	O-linked_Glycosylation	SAASPSPSPSQVVEV HCCCCCCCHHHEEEC	41.33	OGP
35	O-linked_Glycosylation	ASPSPSPSQVVEVPG CCCCCCHHHEEECCC	39.69	OGP
45	O-linked_Glycosylation	VEVPGVPSRPASVAV EECCCCCCCCCEEEE	48.79	OGP
50 (in isoform 2)	Phosphorylation	-	5.13	-
52 (in isoform 2)	Phosphorylation	-	1.66	-
55 (in isoform 2)	Phosphorylation	-	2.51	-
57 (in isoform 2)	Phosphorylation	-	41.37	-
96	Phosphorylation	NPVPAVPSPSPSVRK CCCCCCCCCCCCCCC	31.26	23403867
98	Phosphorylation	VPAVPSPSPSVRKRQ CCCCCCCCCCCCCCC	33.86	23403867
100	Phosphorylation	AVPSPSPSVRKRQVS CCCCCCCCCCCCCEE	38.60	23403867
231	O-linked_Glycosylation	VEHPQEASVVVHQVE ECCCCCEEEEEEEEE	18.07	OGP
267	Phosphorylation	RAEAAAPYTVLAQSA HHHHHCCCEEEECCC	12.54	22210691
268	O-linked_Glycosylation	AEAAAPYTVLAQSAP HHHHCCCEEEECCCC	14.16	OGP
268	Phosphorylation	AEAAAPYTVLAQSAP HHHHCCCEEEECCCC	14.16	22210691
280	Phosphorylation	SAPREDGYSDASGFG CCCCCCCCCCCCCCC	18.72	-
281	Phosphorylation	APREDGYSDASGFGY CCCCCCCCCCCCCCC	32.03	-
284	Phosphorylation	EDGYSDASGFGYCFR CCCCCCCCCCCCCHH	39.38	-
288	Phosphorylation	SDASGFGYCFRELRG CCCCCCCCCHHHCCC	6.02	-
300	Phosphorylation	LRGGECASPLPGLRT CCCCCCCCCCCCCCH	38.33	24245541
346	O-linked_Glycosylation	APDGPCPTGFERVNG CCCCCCCCCHHCCCC	62.31	OGP
352	N-linked_Glycosylation	PTGFERVNGSCEDVD CCCHHCCCCCCCCHH	42.77	UniProtKB CARBOHYD
425	N-linked_Glycosylation	CSLPILRNITKQICC CCHHHHCCCHHHHHC	42.72	UniProtKB CARBOHYD
468	O-linked_Glycosylation	AGPGYHYSASDLRYN CCCCCCCCHHHCCCC	14.16	OGP
476	O-linked_Glycosylation	ASDLRYNTRPLGQEP HHHCCCCCCCCCCCC	25.40	OGP
487	Phosphorylation	GQEPPRVSLSQPRTL CCCCCCCCCCCCCCC	24.47	28188228
489	Phosphorylation	EPPRVSLSQPRTLPA CCCCCCCCCCCCCCC	30.54	24719451
497	O-linked_Glycosylation	QPRTLPATSRPSAGF CCCCCCCCCCCCCCC	24.27	OGP
501	O-linked_Glycosylation	LPATSRPSAGFLPTH CCCCCCCCCCCCCCC	39.66	OGP
507	Phosphorylation	PSAGFLPTHRLEPRP CCCCCCCCCCCCCCC	23.06	22210691
530	O-linked_Glycosylation	GPELPLPSIPAWTGP CCCCCCCCCCCCCCC	49.22	OGP
535	O-linked_Glycosylation	LPSIPAWTGPEIPES CCCCCCCCCCCCCCC	44.99	OGP
542	O-linked_Glycosylation	TGPEIPESGPSSGMC CCCCCCCCCCCCCCC	51.12	OGP
579	Phosphorylation	CDSGFRLSPQGTRCI CCCCCCCCCCCCEEE	15.77	23312004
759	Phosphorylation	DVDECARSPPPCTYG CHHHHHCCCCCCCCC	24.19	28985074
823	Phosphorylation	FQCRTCPSGHHLHRG EECCCCCCCCCCCCC	53.56	29083192
833	Phosphorylation	HLHRGRCTDVDECSS CCCCCCCCCHHHHCC	37.38	-
857	Phosphorylation	HCTNTEGSFRCSCAP CCCCCCCCEEECCCC	11.86	24719451
1055	N-linked_Glycosylation	QDVDECRNRSFCGAH CCHHHHCCCCCCCCC	56.45	UniProtKB CARBOHYD
1137	Phosphorylation	GRCVPPRTSAGTFPG CCCCCCCCCCCCCCC	28.80	29978859
1138	Phosphorylation	RCVPPRTSAGTFPGS CCCCCCCCCCCCCCC	26.44	29978859
1141	Phosphorylation	PPRTSAGTFPGSQPQ CCCCCCCCCCCCCCC	26.77	29978859
1145	Phosphorylation	SAGTFPGSQPQAPAS CCCCCCCCCCCCCCC	38.64	29978859
1152	Phosphorylation	SQPQAPASPVLPARP CCCCCCCCCCCCCCC	17.93	24719451
1169	Phosphorylation	PPLPRRPSTPRQGPV CCCCCCCCCCCCCCC	49.59	23532336
1170	Phosphorylation	PLPRRPSTPRQGPVG CCCCCCCCCCCCCCC	25.77	22210691
1178	Phosphorylation	PRQGPVGSGRRECYF CCCCCCCCCCCCEEC	29.39	22210691
1200	N-linked_Glycosylation	CDNILARNVTWQECC HHCHHHCCCCHHHCC	29.93	UniProtKB CARBOHYD
1249	Phosphorylation	LAPSGDLSLRRDVDE CCCCCCCCCCCCHHH	25.27	24719451
1266	Ubiquitination	LFRDQVCKSGVCVNT HHHHCCCCCCCEEEC	51.92	-
1339	N-linked_Glycosylation	SQRRCVSNESQSLDD CCEEECCCCCCCCCC	32.32	UniProtKB CARBOHYD
1442	Phosphorylation	LPYGPELYPPPALPY CCCCCCCCCCCCCCC	16.42	20736484
1449	Phosphorylation	YPPPALPYDPYPPPP CCCCCCCCCCCCCCC	30.33	20736484
1452	Phosphorylation	PALPYDPYPPPPGPF CCCCCCCCCCCCCCC	26.02	20736484
1483	Phosphorylation	FEDDGGPYGESEAPA CCCCCCCCCCCCCCC	36.48	-
1486	Phosphorylation	DGGPYGESEAPAPPG CCCCCCCCCCCCCCC	34.39	-
1486	O-linked_Glycosylation	DGGPYGESEAPAPPG CCCCCCCCCCCCCCC	34.39	OGP
1496	Phosphorylation	PAPPGPGTRWPYRSR CCCCCCCCCCCCCCC	32.47	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LTBP4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LTBP4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LTBP4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TRIB3_HUMAN	TRIB3	physical	18276110
RAC1_HUMAN	RAC1	physical	21988832

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 613177: Urban-Rifkin-Davis syndrome (URDS)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.