dbPTM

SETB1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SETB1_HUMAN
UniProt AC	Q15047
Protein Name	Histone-lysine N-methyltransferase SETDB1
Gene Name	SETDB1
Organism	Homo sapiens (Human).
Sequence Length	1291
Subcellular Localization	Nucleus. Chromosome. Associated with non-pericentromeric regions of chromatin. Excluded from nucleoli and islands of condensed chromatin.
Protein Description	Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation. Probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1. SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells. [PubMed: 24623306 Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs)]
Protein Sequence	MSSLPGCIGLDAATATVESEEIAELQQAVVEELGISMEELRHFIDEELEKMDCVQQRKKQLAELETWVIQKESEVAHVDQLFDDASRAVTNCESLVKDFYSKLGLQYRDSSSEDESSRPTEIIEIPDEDDDVLSIDSGDAGSRTPKDQKLREAMAALRKSAQDVQKFMDAVNKKSSSQDLHKGTLSQMSGELSKDGDLIVSMRILGKKRTKTWHKGTLIAIQTVGPGKKYKVKFDNKGKSLLSGNHIAYDYHPPADKLYVGSRVVAKYKDGNQVWLYAGIVAETPNVKNKLRFLIFFDDGYASYVTQSELYPICRPLKKTWEDIEDISCRDFIEEYVTAYPNRPMVLLKSGQLIKTEWEGTWWKSRVEEVDGSLVRILFLDDKRCEWIYRGSTRLEPMFSMKTSSASALEKKQGQLRTRPNMGAVRSKGPVVQYTQDLTGTGTQFKPVEPPQPTAPPAPPFPPAPPLSPQAGDSDLESQLAQSRKQVAKKSTSFRPGSVGSGHSSPTSPALSENVSGGKPGINQTYRSPLGSTASAPAPSALPAPPAPPVFHGMLERAPAEPSYRAPMEKLFYLPHVCSYTCLSRVRPMRNEQYRGKNPLLVPLLYDFRRMTARRRVNRKMGFHVIYKTPCGLCLRTMQEIERYLFETGCDFLFLEMFCLDPYVLVDRKFQPYKPFYYILDITYGKEDVPLSCVNEIDTTPPPQVAYSKERIPGKGVFINTGPEFLVGCDCKDGCRDKSKCACHQLTIQATACTPGGQINPNSGYQYKRLEECLPTGVYECNKRCKCDPNMCTNRLVQHGLQVRLQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKILTDDFADKEGLEMGDEYFANLDHIESVENFKEGYESDAPCSSDSSGVDLKDQEDGNSGTEDPEESNDDSSDDNFCKDEDFSTSSVWRSYATRRQTRGQKENGLSETTSKDSHPPDLGPPHIPVPPSIPVGGCNPPSSEETPKNKVASWLSCNSVSEGGFADSDSHSSFKTNEGGEGRAGGSRMEAEKASTSGLGIKDEGDIKQAKKEDTDDRNKMSVVTESSRNYGYNPSPVKPEGLRRPPSKTSMHQSRRLMASAQSNPDDVLTLSSSTESEGESGTSRKPTAGQTSATAVDSDDIQTISSGSEGDDFEDKKNMTGPMKRQVAVKSTRGFALKSTHGIAIKSTNMASVDKGESAPVRKNTRQFYDGEESCYIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASKRIRAGTELTWDYNYEVGSVEGKELLCCCGAIECRGRLL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
58	Ubiquitination	MDCVQQRKKQLAELE CHHHHHHHHHHHHHH	40.30	22817900
59	Ubiquitination	DCVQQRKKQLAELET HHHHHHHHHHHHHHH	53.37	22817900
59 (in isoform 1)	Ubiquitination	-	53.37	21890473
59 (in isoform 2)	Ubiquitination	-	53.37	21890473
59 (in isoform 3)	Ubiquitination	-	53.37	21890473
94	Phosphorylation	RAVTNCESLVKDFYS HHHHCHHHHHHHHHH	40.43	25159151
97	Ubiquitination	TNCESLVKDFYSKLG HCHHHHHHHHHHHHC	47.62	29967540
102	Ubiquitination	LVKDFYSKLGLQYRD HHHHHHHHHCCCCCC	34.88	29967540
107	Phosphorylation	YSKLGLQYRDSSSED HHHHCCCCCCCCCCC	22.79	21406692
110	Phosphorylation	LGLQYRDSSSEDESS HCCCCCCCCCCCCCC	27.11	21406692
111	Phosphorylation	GLQYRDSSSEDESSR CCCCCCCCCCCCCCC	41.87	21406692
112	Phosphorylation	LQYRDSSSEDESSRP CCCCCCCCCCCCCCC	53.68	21406692
116	Phosphorylation	DSSSEDESSRPTEII CCCCCCCCCCCCEEE	43.92	25137130
117	Phosphorylation	SSSEDESSRPTEIIE CCCCCCCCCCCEEEE	39.99	25137130
120	Phosphorylation	EDESSRPTEIIEIPD CCCCCCCCEEEECCC	38.41	25137130
134	Phosphorylation	DEDDDVLSIDSGDAG CCCCCCEECCCCCCC	24.97	25137130
137	Phosphorylation	DDVLSIDSGDAGSRT CCCEECCCCCCCCCC	36.58	25137130
142	Phosphorylation	IDSGDAGSRTPKDQK CCCCCCCCCCHHHHH	34.40	21406692
144	Phosphorylation	SGDAGSRTPKDQKLR CCCCCCCCHHHHHHH	36.07	21406692
166	Ubiquitination	KSAQDVQKFMDAVNK HHHHHHHHHHHHHHH	42.37	29967540
173	Acetylation	KFMDAVNKKSSSQDL HHHHHHHHHCCCCHH	47.65	7711297
173	Ubiquitination	KFMDAVNKKSSSQDL HHHHHHHHHCCCCHH	47.65	-
174	Ubiquitination	FMDAVNKKSSSQDLH HHHHHHHHCCCCHHH	50.82	29967540
175	Phosphorylation	MDAVNKKSSSQDLHK HHHHHHHCCCCHHHH	36.51	22817900
177	Phosphorylation	AVNKKSSSQDLHKGT HHHHHCCCCHHHHCC	34.50	29214152
182	Sumoylation	SSSQDLHKGTLSQMS CCCCHHHHCCHHHHH	61.97	28112733
182	Ubiquitination	SSSQDLHKGTLSQMS CCCCHHHHCCHHHHH	61.97	22817900
189	Phosphorylation	KGTLSQMSGELSKDG HCCHHHHHCCCCCCC	22.83	28555341
207	Ubiquitination	VSMRILGKKRTKTWH EEEEECCCCCCCCCC	35.32	32015554
230	Phosphorylation	TVGPGKKYKVKFDNK EECCCCEEEEEECCC	25.21	22817900
257	Ubiquitination	DYHPPADKLYVGSRV CCCCCHHHEEEECEE	43.77	29967540
259	Phosphorylation	HPPADKLYVGSRVVA CCCHHHEEEECEEEE	14.43	20068231
288	Ubiquitination	VAETPNVKNKLRFLI EEECCCCCCCEEEEE	55.81	30230243
319	Ubiquitination	PICRPLKKTWEDIED HHHHCCCCCHHCHHH	67.56	29967540
338	Phosphorylation	DFIEEYVTAYPNRPM HHHHHHHHHCCCCCE	21.41	-
349	Ubiquitination	NRPMVLLKSGQLIKT CCCEEEEECCCEEEE	48.67	21963094
350	Phosphorylation	RPMVLLKSGQLIKTE CCEEEEECCCEEEEE	31.57	-
355	Sumoylation	LKSGQLIKTEWEGTW EECCCEEEEEEECCC	49.32	-
355	Sumoylation	LKSGQLIKTEWEGTW EECCCEEEEEEECCC	49.32	-
355	Ubiquitination	LKSGQLIKTEWEGTW EECCCEEEEEEECCC	49.32	21963094
364	Ubiquitination	EWEGTWWKSRVEEVD EEECCCHHHHEEEEC	21.68	-
383	Ubiquitination	RILFLDDKRCEWIYR EEEEECCCCCEEEEC	59.62	-
400	Phosphorylation	TRLEPMFSMKTSSAS CCCEECCCCCCCCCH	17.08	24719451
407	Phosphorylation	SMKTSSASALEKKQG CCCCCCCHHHHHHCC	35.02	21964256
411	Ubiquitination	SSASALEKKQGQLRT CCCHHHHHHCCCCCC	51.77	29967540
427	Phosphorylation	PNMGAVRSKGPVVQY CCCCCCCCCCCEEEE	35.05	23663014
434	Phosphorylation	SKGPVVQYTQDLTGT CCCCEEEEEECCCCC	8.51	23663014
435	Phosphorylation	KGPVVQYTQDLTGTG CCCEEEEEECCCCCC	9.87	23663014
439	Phosphorylation	VQYTQDLTGTGTQFK EEEEECCCCCCCCCC	40.77	23663014
441	Phosphorylation	YTQDLTGTGTQFKPV EEECCCCCCCCCCCC	31.64	23663014
443	Phosphorylation	QDLTGTGTQFKPVEP ECCCCCCCCCCCCCC	30.58	23663014
468	Phosphorylation	FPPAPPLSPQAGDSD CCCCCCCCCCCCCCH	22.27	26074081
474	Phosphorylation	LSPQAGDSDLESQLA CCCCCCCCHHHHHHH	43.08	22817900
490	Trimethylation	SRKQVAKKSTSFRPG HHHHHHHHCCCCCCC	49.59	-
490	Methylation	SRKQVAKKSTSFRPG HHHHHHHHCCCCCCC	49.59	23644510
491	Phosphorylation	RKQVAKKSTSFRPGS HHHHHHHCCCCCCCC	28.69	22496350
492	Phosphorylation	KQVAKKSTSFRPGSV HHHHHHCCCCCCCCC	40.54	23312004
493	Phosphorylation	QVAKKSTSFRPGSVG HHHHHCCCCCCCCCC	26.75	23312004
495	Methylation	AKKSTSFRPGSVGSG HHHCCCCCCCCCCCC	34.14	115916537
498	Phosphorylation	STSFRPGSVGSGHSS CCCCCCCCCCCCCCC	26.45	27732954
501	Phosphorylation	FRPGSVGSGHSSPTS CCCCCCCCCCCCCCC	31.04	27732954
504	Phosphorylation	GSVGSGHSSPTSPAL CCCCCCCCCCCCHHH	41.35	22496350
505	Phosphorylation	SVGSGHSSPTSPALS CCCCCCCCCCCHHHC	26.90	27732954
507	Phosphorylation	GSGHSSPTSPALSEN CCCCCCCCCHHHCCC	49.65	27732954
508	Phosphorylation	SGHSSPTSPALSENV CCCCCCCCHHHCCCC	16.15	27732954
512	Phosphorylation	SPTSPALSENVSGGK CCCCHHHCCCCCCCC	29.27	27732954
516	Phosphorylation	PALSENVSGGKPGIN HHHCCCCCCCCCCCC	54.10	27732954
525	Phosphorylation	GKPGINQTYRSPLGS CCCCCCCCCCCCCCC	19.20	25627689
528	Phosphorylation	GINQTYRSPLGSTAS CCCCCCCCCCCCCCC	17.67	29255136
532	Phosphorylation	TYRSPLGSTASAPAP CCCCCCCCCCCCCCC	28.60	29255136
533	Phosphorylation	YRSPLGSTASAPAPS CCCCCCCCCCCCCCC	23.88	29255136
535	Phosphorylation	SPLGSTASAPAPSAL CCCCCCCCCCCCCCC	34.57	29255136
540	Phosphorylation	TASAPAPSALPAPPA CCCCCCCCCCCCCCC	44.54	27080861
570	Ubiquitination	SYRAPMEKLFYLPHV CCCCCHHHHHCCHHH	37.33	-
579	Phosphorylation	FYLPHVCSYTCLSRV HCCHHHHHHHHHHCC	23.53	24719451
597	Ubiquitination	RNEQYRGKNPLLVPL CCHHHCCCCCCHHHH	46.52	21963094
597 (in isoform 1)	Ubiquitination	-	46.52	21890473
597 (in isoform 3)	Ubiquitination	-	46.52	21890473
598	Ubiquitination	NEQYRGKNPLLVPLL CHHHCCCCCCHHHHH	34.96	21890473
620	Acetylation	ARRRVNRKMGFHVIY HHHHHHHHCCEEEEE	37.87	26051181
627	Phosphorylation	KMGFHVIYKTPCGLC HCCEEEEEECCCCHH	14.02	-
628	Acetylation	MGFHVIYKTPCGLCL CCEEEEEECCCCHHH	34.56	26051181
673	Phosphorylation	VDRKFQPYKPFYYIL ECCCCCCCCCEEEEE	22.10	-
677	Phosphorylation	FQPYKPFYYILDITY CCCCCCEEEEEECCC	9.72	-
678	Phosphorylation	QPYKPFYYILDITYG CCCCCEEEEEECCCC	8.72	-
699	Phosphorylation	SCVNEIDTTPPPQVA HHEEECCCCCCCCEE	47.03	25627689
700	Phosphorylation	CVNEIDTTPPPQVAY HEEECCCCCCCCEEC	30.01	25627689
715	Neddylation	SKERIPGKGVFINTG CCCCCCCCCEEEECC	46.69	32015554
715	Ubiquitination	SKERIPGKGVFINTG CCCCCCCCCEEEECC	46.69	32015554
716	Neddylation	KERIPGKGVFINTGP CCCCCCCCEEEECCC	26.03	32015554
716	Ubiquitination	KERIPGKGVFINTGP CCCCCCCCEEEECCC	26.03	32015554
732	Ubiquitination	FLVGCDCKDGCRDKS CEECCCCCCCCCCCC	43.85	32015554
733	Ubiquitination	LVGCDCKDGCRDKSK EECCCCCCCCCCCCC	68.69	32015554
779	Phosphorylation	ECLPTGVYECNKRCK HHCCCCHHHCCCCCC	18.99	25159151
786	Acetylation	YECNKRCKCDPNMCT HHCCCCCCCCCCCHH	45.78	19824909
786	Ubiquitination	YECNKRCKCDPNMCT HHCCCCCCCCCCCHH	45.78	-
809	Acetylation	QVRLQLFKTQNKGWG HHHHHHEECCCCCCC	58.77	24471143
809	Ubiquitination	QVRLQLFKTQNKGWG HHHHHHEECCCCCCC	58.77	-
813	Ubiquitination	QLFKTQNKGWGIRCL HHEECCCCCCCEEEH	46.34	29967540
838	Phosphorylation	IYAGKILTDDFADKE EECCCEECCCCCCHH	36.68	16097034
862	Phosphorylation	ANLDHIESVENFKEG HCCHHHHHHHHHHCC	33.84	22817900
867	Sumoylation	IESVENFKEGYESDA HHHHHHHHCCCCCCC	62.91	-
867	Ubiquitination	IESVENFKEGYESDA HHHHHHHHCCCCCCC	62.91	-
872	Phosphorylation	NFKEGYESDAPCSSD HHHCCCCCCCCCCCC	30.50	25159151
877	Phosphorylation	YESDAPCSSDSSGVD CCCCCCCCCCCCCCC	35.80	25627689
878	Phosphorylation	ESDAPCSSDSSGVDL CCCCCCCCCCCCCCC	48.50	25627689
880	Phosphorylation	DAPCSSDSSGVDLKD CCCCCCCCCCCCCCC	30.82	25627689
905	Phosphorylation	PEESNDDSSDDNFCK CCCCCCCCCCCCCCC	38.23	22817900
906	Phosphorylation	EESNDDSSDDNFCKD CCCCCCCCCCCCCCC	56.85	22817900
917	Phosphorylation	FCKDEDFSTSSVWRS CCCCCCCCHHHHHHH	39.44	25159151
918	Phosphorylation	CKDEDFSTSSVWRSY CCCCCCCHHHHHHHH	25.64	25159151
919	Phosphorylation	KDEDFSTSSVWRSYA CCCCCCHHHHHHHHH	22.99	27732954
920	Phosphorylation	DEDFSTSSVWRSYAT CCCCCHHHHHHHHHH	26.28	25159151
972	Phosphorylation	VGGCNPPSSEETPKN CCCCCCCCCCCCCCC	52.19	25627689
973	Phosphorylation	GGCNPPSSEETPKNK CCCCCCCCCCCCCCC	45.27	25627689
976	Phosphorylation	NPPSSEETPKNKVAS CCCCCCCCCCCCCCH	35.20	25159151
983	Phosphorylation	TPKNKVASWLSCNSV CCCCCCCHHHCCCCC	31.38	23312004
986	Phosphorylation	NKVASWLSCNSVSEG CCCCHHHCCCCCCCC	12.66	23312004
991	Phosphorylation	WLSCNSVSEGGFADS HHCCCCCCCCCCCCC	30.28	30576142
998	Phosphorylation	SEGGFADSDSHSSFK CCCCCCCCCCCCCCC	37.27	24247654
1000	Phosphorylation	GGFADSDSHSSFKTN CCCCCCCCCCCCCCC	29.26	30576142
1002	Phosphorylation	FADSDSHSSFKTNEG CCCCCCCCCCCCCCC	41.23	23312004
1003	Phosphorylation	ADSDSHSSFKTNEGG CCCCCCCCCCCCCCC	25.91	30576142
1004	Phosphorylation	DSDSHSSFKTNEGGE CCCCCCCCCCCCCCC	14.69	33259812
1006	Phosphorylation	DSHSSFKTNEGGEGR CCCCCCCCCCCCCCC	36.17	23312004
1017	Phosphorylation	GEGRAGGSRMEAEKA CCCCCCCCHHHHHHH	27.77	22985185
1025	Phosphorylation	RMEAEKASTSGLGIK HHHHHHHHCCCCCCC	33.89	20873877
1026	Phosphorylation	MEAEKASTSGLGIKD HHHHHHHCCCCCCCC	31.51	20873877
1027	Phosphorylation	EAEKASTSGLGIKDE HHHHHHCCCCCCCCC	29.53	20873877
1032	Sumoylation	STSGLGIKDEGDIKQ HCCCCCCCCCCCHHH	48.18	-
1032	Acetylation	STSGLGIKDEGDIKQ HCCCCCCCCCCCHHH	48.18	26051181
1032	Sumoylation	STSGLGIKDEGDIKQ HCCCCCCCCCCCHHH	48.18	28112733
1038	Sumoylation	IKDEGDIKQAKKEDT CCCCCCHHHHHHHCC	49.28	28112733
1042	Ubiquitination	GDIKQAKKEDTDDRN CCHHHHHHHCCCCCC	64.93	-
1045	Phosphorylation	KQAKKEDTDDRNKMS HHHHHHCCCCCCCCE	40.67	-
1050	Ubiquitination	EDTDDRNKMSVVTES HCCCCCCCCEEEECC	33.18	-
1055	Phosphorylation	RNKMSVVTESSRNYG CCCCEEEECCCCCCC	28.17	20068231
1057	Phosphorylation	KMSVVTESSRNYGYN CCEEEECCCCCCCCC	25.82	20068231
1058	Phosphorylation	MSVVTESSRNYGYNP CEEEECCCCCCCCCC	20.50	28555341
1061	Phosphorylation	VTESSRNYGYNPSPV EECCCCCCCCCCCCC	21.63	23927012
1063	Phosphorylation	ESSRNYGYNPSPVKP CCCCCCCCCCCCCCC	17.34	22167270
1066	Phosphorylation	RNYGYNPSPVKPEGL CCCCCCCCCCCCCCC	38.39	22167270
1066 (in isoform 3)	Phosphorylation	-	38.39	-
1067	Phosphorylation	NYGYNPSPVKPEGLR CCCCCCCCCCCCCCC	39.13	32645325
1069	Sumoylation	GYNPSPVKPEGLRRP CCCCCCCCCCCCCCC	40.51	-
1069	Acetylation	GYNPSPVKPEGLRRP CCCCCCCCCCCCCCC	40.51	26051181
1069	Sumoylation	GYNPSPVKPEGLRRP CCCCCCCCCCCCCCC	40.51	28112733
1078	Phosphorylation	EGLRRPPSKTSMHQS CCCCCCCCCCCHHHH	51.77	24719451
1080	Phosphorylation	LRRPPSKTSMHQSRR CCCCCCCCCHHHHHH	35.30	20860994
1081	Phosphorylation	RRPPSKTSMHQSRRL CCCCCCCCHHHHHHH	20.29	20860994
1085	Phosphorylation	SKTSMHQSRRLMASA CCCCHHHHHHHHHHH	12.51	20860994
1101	Phosphorylation	SNPDDVLTLSSSTES CCCCCEEEEECCCCC	25.17	22817900
1103	Phosphorylation	PDDVLTLSSSTESEG CCCEEEEECCCCCCC	19.60	22817900
1104	Phosphorylation	DDVLTLSSSTESEGE CCEEEEECCCCCCCC	44.38	22817900
1106	Phosphorylation	VLTLSSSTESEGESG EEEEECCCCCCCCCC	45.54	22817900
1108	Phosphorylation	TLSSSTESEGESGTS EEECCCCCCCCCCCC	51.49	22817900
1112	Phosphorylation	STESEGESGTSRKPT CCCCCCCCCCCCCCC	59.22	22210691
1119	Phosphorylation	SGTSRKPTAGQTSAT CCCCCCCCCCCCCCE	46.59	25072903
1123	Phosphorylation	RKPTAGQTSATAVDS CCCCCCCCCCEEECH	21.29	21406692
1124	Phosphorylation	KPTAGQTSATAVDSD CCCCCCCCCEEECHH	18.74	21406692
1126	Phosphorylation	TAGQTSATAVDSDDI CCCCCCCEEECHHHC	27.29	21406692
1130	Phosphorylation	TSATAVDSDDIQTIS CCCEEECHHHCCEEC	30.50	20363803
1135	Phosphorylation	VDSDDIQTISSGSEG ECHHHCCEECCCCCC	24.14	25072903
1137	Phosphorylation	SDDIQTISSGSEGDD HHHCCEECCCCCCCC	31.84	25072903
1138	Phosphorylation	DDIQTISSGSEGDDF HHCCEECCCCCCCCC	42.35	25072903
1140	Phosphorylation	IQTISSGSEGDDFED CCEECCCCCCCCCCC	40.11	25072903
1149	Sumoylation	GDDFEDKKNMTGPMK CCCCCCCCCCCCCCH	65.36	-
1149	Sumoylation	GDDFEDKKNMTGPMK CCCCCCCCCCCCCCH	65.36	28112733
1152	Phosphorylation	FEDKKNMTGPMKRQV CCCCCCCCCCCHHEE	47.75	20860994
1162	Methylation	MKRQVAVKSTRGFAL CHHEEEEEECCCEEE	36.05	83136539
1163	Phosphorylation	KRQVAVKSTRGFALK HHEEEEEECCCEEEE	19.41	-
1170	"N6,N6,N6-trimethyllysine"	STRGFALKSTHGIAI ECCCEEEEECCEEEE	50.29	-
1170	Methylation	STRGFALKSTHGIAI ECCCEEEEECCEEEE	50.29	24129315
1178	"N6,N6,N6-trimethyllysine"	STHGIAIKSTNMASV ECCEEEEEECCCCCC	42.05	-
1178	Methylation	STHGIAIKSTNMASV ECCEEEEEECCCCCC	42.05	24129315
1178	Ubiquitination	STHGIAIKSTNMASV ECCEEEEEECCCCCC	42.05	29967540
1179	Phosphorylation	THGIAIKSTNMASVD CCEEEEEECCCCCCC	20.92	23312004
1180	Phosphorylation	HGIAIKSTNMASVDK CEEEEEECCCCCCCC	24.82	22817900
1180 (in isoform 3)	Phosphorylation	-	24.82	-
1184	Phosphorylation	IKSTNMASVDKGESA EEECCCCCCCCCCCC	21.78	23312004
1187	Ubiquitination	TNMASVDKGESAPVR CCCCCCCCCCCCCCC	63.52	29967540
1190	Phosphorylation	ASVDKGESAPVRKNT CCCCCCCCCCCCCCC	46.68	20068231
1190 (in isoform 3)	Phosphorylation	-	46.68	-
1197	Phosphorylation	SAPVRKNTRQFYDGE CCCCCCCCCCEECCC	28.96	20068231
1197 (in isoform 3)	Phosphorylation	-	28.96	-
1271	Phosphorylation	DYNYEVGSVEGKELL ECCCCCCCCCCCEEE	23.36	27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
976	T	Phosphorylation	Kinase	NLK	Q9UBE8	Uniprot
1066	S	Phosphorylation	Kinase	CDK2	P24941	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SETB1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SETB1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SUZ12_HUMAN	SUZ12	physical	14536086
TIF1B_HUMAN	TRIM28	physical	11959841
PO5F1_HUMAN	POU5F1	physical	19884257
DNM3A_HUMAN	DNMT3A	physical	16682412
DNM3B_HUMAN	DNMT3B	physical	16682412
ESCO2_HUMAN	ESCO2	physical	18501190
H31_HUMAN	HIST1H3A	physical	11252719
MBD1_HUMAN	MBD1	physical	15327775
CAF1A_HUMAN	CHAF1A	physical	15327775
H31_HUMAN	HIST1H3A	physical	21243721
ESCO1_HUMAN	ESCO1	physical	20331966
ZN274_HUMAN	ZNF274	physical	21170338
PSME1_HUMAN	PSME1	physical	21900206
MZT2B_HUMAN	MZT2B	physical	21900206
LC7L2_HUMAN	LUC7L2	physical	21900206
JARD2_HUMAN	JARID2	physical	22110129
PML_HUMAN	PML	physical	21921037
TCRG1_HUMAN	TCERG1	physical	15383276
LRIF1_HUMAN	LRIF1	physical	15383276
AT2A1_HUMAN	ATP2A1	physical	26186194
TTC1_HUMAN	TTC1	physical	26186194
EXOC4_HUMAN	EXOC4	physical	26186194
MCAF1_HUMAN	ATF7IP	physical	26186194
HECD1_HUMAN	HECTD1	physical	26186194
MCUB_HUMAN	CCDC109B	physical	26186194
FAF2_HUMAN	FAF2	physical	26186194
CC85C_HUMAN	CCDC85C	physical	26186194
EXOC5_HUMAN	EXOC5	physical	26186194
FBX30_HUMAN	FBXO30	physical	26186194
ACOT9_HUMAN	ACOT9	physical	26186194
MCAF1_HUMAN	ATF7IP	physical	28514442
MCUB_HUMAN	CCDC109B	physical	28514442
FAF2_HUMAN	FAF2	physical	28514442
AT2A1_HUMAN	ATP2A1	physical	28514442
EXOC4_HUMAN	EXOC4	physical	28514442
EXOC5_HUMAN	EXOC5	physical	28514442
TTC1_HUMAN	TTC1	physical	28514442
CC85C_HUMAN	CCDC85C	physical	28514442
FBX30_HUMAN	FBXO30	physical	28514442
ACOT9_HUMAN	ACOT9	physical	28514442
SUCA_HUMAN	SUCLG1	physical	27173435

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SETB1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1066, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Quantitative analysis of global ubiquitination in HeLa cells by massspectrometry."; Meierhofer D., Wang X., Huang L., Kaiser P.; J. Proteome Res. 7:4566-4576(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-175, UBIQUITINATION[LARGE SCALE ANALYSIS] AT LYS-182, AND MASS SPECTROMETRY.	18781797 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1066, AND MASSSPECTROMETRY.	18220336 [Abstract]
"Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry."; Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.; Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1179; THR-1180 ANDSER-1190, AND MASS SPECTROMETRY.	17287340 [Abstract]
"Global phosphoproteome analysis on human HepG2 hepatocytes usingreversed-phase diagonal LC."; Gevaert K., Staes A., Van Damme J., De Groot S., Hugelier K.,Demol H., Martens L., Goethals M., Vandekerckhove J.; Proteomics 5:3589-3599(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-838, AND MASSSPECTROMETRY.	16097034 [Abstract]
Ubiquitylation
Reference	PubMed
"Quantitative analysis of global ubiquitination in HeLa cells by massspectrometry."; Meierhofer D., Wang X., Huang L., Kaiser P.; J. Proteome Res. 7:4566-4576(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-175, UBIQUITINATION[LARGE SCALE ANALYSIS] AT LYS-182, AND MASS SPECTROMETRY.	18781797 [Abstract]