| UniProt ID | ZN274_HUMAN | |
|---|---|---|
| UniProt AC | Q96GC6 | |
| Protein Name | Neurotrophin receptor-interacting factor homolog | |
| Gene Name | ZNF274 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 653 | |
| Subcellular Localization | Cytoplasm. Nucleus, nucleolus . | |
| Protein Description | Probable transcription repressor. Specifically binds to the 3'-end of zinc-finger coding genes and recruiting chromatin-modifying proteins such as SETDB1 and TRIM28/KAP1, leading to transcription repression. The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions. [PubMed: 27029610] | |
| Protein Sequence | MASRLPTAWSCEPVTFEDVTLGFTPEEWGLLDLKQKSLYREVMLENYRNLVSVEHQLSKPDVVSQLEEAEDFWPVERGIPQDTIPEYPELQLDPKLDPLPAESPLMNIEVVEVLTLNQEVAGPRNAQIQALYAEDGSLSADAPSEQVQQQGKHPGDPEAARQRFRQFRYKDMTGPREALDQLRELCHQWLQPKARSKEQILELLVLEQFLGALPVKLRTWVESQHPENCQEVVALVEGVTWMSEEEVLPAGQPAEGTTCCLEVTAQQEEKQEDAAICPVTVLPEEPVTFQDVAVDFSREEWGLLGPTQRTEYRDVMLETFGHLVSVGWETTLENKELAPNSDIPEEEPAPSLKVQESSRDCALSSTLEDTLQGGVQEVQDTVLKQMESAQEKDLPQKKHFDNRESQANSGALDTNQVSLQKIDNPESQANSGALDTNQVLLHKIPPRKRLRKRDSQVKSMKHNSRVKIHQKSCERQKAKEGNGCRKTFSRSTKQITFIRIHKGSQVCRCSECGKIFRNPRYFSVHKKIHTGERPYVCQDCGKGFVQSSSLTQHQRVHSGERPFECQECGRTFNDRSAISQHLRTHTGAKPYKCQDCGKAFRQSSHLIRHQRTHTGERPYACNKCGKAFTQSSHLIGHQRTHNRTKRKKKQPTS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 7 (in isoform 4) | Phosphorylation | - | 45.40 | 24043423 | |
| 16 (in isoform 4) | Phosphorylation | - | 8.42 | 24043423 | |
| 309 | Methylation | GLLGPTQRTEYRDVM CCCCCCCCCCHHHHH | 31.81 | 24394883 | |
| 526 | Acetylation | PRYFSVHKKIHTGER CCEEEEECCEECCCC | 51.79 | 7671031 | |
| 530 | Phosphorylation | SVHKKIHTGERPYVC EEECCEECCCCCEEC | 44.18 | 25159151 | |
| 535 | Phosphorylation | IHTGERPYVCQDCGK EECCCCCEECCCCCC | 21.78 | - | |
| 548 | Phosphorylation | GKGFVQSSSLTQHQR CCCEECCCCCCCCCC | 16.57 | 27251275 | |
| 549 | Phosphorylation | KGFVQSSSLTQHQRV CCEECCCCCCCCCCC | 40.46 | 27251275 | |
| 571 | Phosphorylation | ECQECGRTFNDRSAI CHHCCCCEECCHHHH | 16.45 | 29978859 | |
| 576 | Phosphorylation | GRTFNDRSAISQHLR CCEECCHHHHHHHHH | 32.58 | 29978859 | |
| 579 | Phosphorylation | FNDRSAISQHLRTHT ECCHHHHHHHHHHCC | 15.97 | 29978859 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ZN274_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ZN274_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ZN274_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| TIF1B_HUMAN | TRIM28 | physical | 21170338 | |
| SETB1_HUMAN | SETDB1 | physical | 21170338 | |
| TIF1B_HUMAN | TRIM28 | physical | 28514442 | |
| RS27A_HUMAN | RPS27A | physical | 28514442 | |
| H11_HUMAN | HIST1H1A | physical | 28514442 | |
| RL26L_HUMAN | RPL26L1 | physical | 28514442 | |
| RM27_HUMAN | MRPL27 | physical | 28514442 | |
| RT14_HUMAN | MRPS14 | physical | 28514442 | |
| MDM2_HUMAN | MDM2 | physical | 28514442 | |
| MASU1_HUMAN | MALSU1 | physical | 28514442 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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