AT2A1_HUMAN - dbPTM
AT2A1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID AT2A1_HUMAN
UniProt AC O14983
Protein Name Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
Gene Name ATP2A1
Organism Homo sapiens (Human).
Sequence Length 1001
Subcellular Localization Endoplasmic reticulum membrane
Multi-pass membrane protein . Sarcoplasmic reticulum membrane
Multi-pass membrane protein .
Protein Description Key regulator of striated muscle performance by acting as the major Ca(2+) ATPase responsible for the reuptake of cytosolic Ca(2+) into the sarcoplasmic reticulum. Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction..
Protein Sequence MEAAHAKTTEECLAYFGVSETTGLTPDQVKRNLEKYGLNELPAEEGKTLWELVIEQFEDLLVRILLLAACISFVLAWFEEGEETITAFVEPFVILLILIANAIVGVWQERNAENAIEALKEYEPEMGKVYRADRKSVQRIKARDIVPGDIVEVAVGDKVPADIRILAIKSTTLRVDQSILTGESVSVIKHTEPVPDPRAVNQDKKNMLFSGTNIAAGKALGIVATTGVGTEIGKIRDQMAATEQDKTPLQQKLDEFGEQLSKVISLICVAVWLINIGHFNDPVHGGSWFRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCKMFIIDKVDGDICLLNEFSITGSTYAPEGEVLKNDKPVRPGQYDGLVELATICALCNDSSLDFNEAKGVYEKVGEATETALTTLVEKMNVFNTDVRSLSKVERANACNSVIRQLMKKEFTLEFSRDRKSMSVYCSPAKSSRAAVGNKMFVKGAPEGVIDRCNYVRVGTTRVPLTGPVKEKIMAVIKEWGTGRDTLRCLALATRDTPPKREEMVLDDSARFLEYETDLTFVGVVGMLDPPRKEVTGSIQLCRDAGIRVIMITGDNKGTAIAICRRIGIFGENEEVADRAYTGREFDDLPLAEQREACRRACCFARVEPSHKSKIVEYLQSYDEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMDRPPRSPKEPLISGWLFFRYMAIGGYVGAATVGAAAWWFLYAEDGPHVNYSQLTHFMQCTEDNTHFEGIDCEVFEAPEPMTMALSVLVTIEMCNALNSLSENQSLLRMPPWVNIWLLGSICLSMSLHFLILYVDPLPMIFKLRALDLTQWLMVLKISLPVIGLDEILKFVARNYLEDPEDERRK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
19PhosphorylationCLAYFGVSETTGLTP
HHHHHCCCCCCCCCH		29.60-
80UbiquitinationFVLAWFEEGEETITA
HHHHHHHCCCHHHHH		63.5321890473
120UbiquitinationENAIEALKEYEPEMG
HHHHHHHHHHCHHCC		66.3621906983
120 (in isoform 2)Ubiquitination-66.3621890473
120 (in isoform 1)Ubiquitination-66.3621890473
120AcetylationENAIEALKEYEPEMG
HHHHHHHHHHCHHCC		66.3626051181
122PhosphorylationAIEALKEYEPEMGKV
HHHHHHHHCHHCCCE		34.8924245541
127UbiquitinationKEYEPEMGKVYRADR
HHHCHHCCCEEECCH		18.02-
128UbiquitinationEYEPEMGKVYRADRK
HHCHHCCCEEECCHH		34.48-
128 (in isoform 1)Ubiquitination-34.4821890473
128 (in isoform 2)Ubiquitination-34.4821890473
170PhosphorylationIRILAIKSTTLRVDQ
CEEEEEECCEEEEEC		22.10-
178PhosphorylationTTLRVDQSILTGESV
CEEEEECHHHCCCCE		18.3328555341
181PhosphorylationRVDQSILTGESVSVI
EEECHHHCCCCEEEE		36.9130266825
184PhosphorylationQSILTGESVSVIKHT
CHHHCCCCEEEEECC		22.4930266825
186PhosphorylationILTGESVSVIKHTEP
HHCCCCEEEEECCCC		27.6630266825
191PhosphorylationSVSVIKHTEPVPDPR
CEEEEECCCCCCCCC		36.6626437602
205UbiquitinationRAVNQDKKNMLFSGT
CCCCCCCCCCCCCCC		56.74-
205MalonylationRAVNQDKKNMLFSGT
CCCCCCCCCCCCCCC		56.7426320211
205 (in isoform 1)Ubiquitination-56.7421890473
205 (in isoform 2)Ubiquitination-56.7421890473
218AcetylationGTNIAAGKALGIVAT
CCCHHCCHHCEEEEE		35.397364663
230PhosphorylationVATTGVGTEIGKIRD
EEECCCCHHHHHHHH		23.25-
242PhosphorylationIRDQMAATEQDKTPL
HHHHHCCCCCCCCHH		25.3326437602
252 (in isoform 2)Ubiquitination-44.9721890473
252 (in isoform 1)Ubiquitination-44.9721890473
252UbiquitinationDKTPLQQKLDEFGEQ
CCCHHHHHHHHHHHH		44.9721906983
261PhosphorylationDEFGEQLSKVISLIC
HHHHHHHHHHHHHHH		25.2721406692
294PhosphorylationSWFRGAIYYFKIAVA
CCHHHHHHHHHHHHH		11.43-
328UbiquitinationLGTRRMAKKNAIVRS
HCCHHHHHHCHHHHC		36.90-
329UbiquitinationGTRRMAKKNAIVRSL
CCHHHHHHCHHHHCC		41.91-
335PhosphorylationKKNAIVRSLPSVETL
HHCHHHHCCCCCCCC		33.4626437602
338PhosphorylationAIVRSLPSVETLGCT
HHHHCCCCCCCCCCC		37.5726437602
344S-nitrosylationPSVETLGCTSVICSD
CCCCCCCCCEEEEEC		2.6310493809
344S-nitrosocysteinePSVETLGCTSVICSD
CCCCCCCCCEEEEEC		2.63-
345PhosphorylationSVETLGCTSVICSDK
CCCCCCCCEEEEECC		24.9928348404
346PhosphorylationVETLGCTSVICSDKT
CCCCCCCEEEEECCC		17.3526437602
349S-nitrosylationLGCTSVICSDKTGTL
CCCCEEEEECCCCCC		3.9510493809
349S-nitrosocysteineLGCTSVICSDKTGTL
CCCCEEEEECCCCCC		3.95-
353PhosphorylationSVICSDKTGTLTTNQ
EEEEECCCCCCCCCC		40.1526437602
355PhosphorylationICSDKTGTLTTNQMS
EEECCCCCCCCCCCC		26.6026437602
356UbiquitinationCSDKTGTLTTNQMSV
EECCCCCCCCCCCCE		6.18-
357PhosphorylationSDKTGTLTTNQMSVC
ECCCCCCCCCCCCEE		24.4426437602
358PhosphorylationDKTGTLTTNQMSVCK
CCCCCCCCCCCCEEE		26.9426437602
362PhosphorylationTLTTNQMSVCKMFII
CCCCCCCCEEEEEEE		18.0126437602
390UbiquitinationSITGSTYAPEGEVLK
EECCCCCCCCCCCCC		8.85-
436AcetylationEAKGVYEKVGEATET
HHCCHHHHHHHHHHH		37.5426051181
441PhosphorylationYEKVGEATETALTTL
HHHHHHHHHHHHHHH		29.5720068231
443PhosphorylationKVGEATETALTTLVE
HHHHHHHHHHHHHHH		23.7020068231
446PhosphorylationEATETALTTLVEKMN
HHHHHHHHHHHHHHC		18.6720068231
447PhosphorylationATETALTTLVEKMNV
HHHHHHHHHHHHHCC		29.6520068231
457PhosphorylationEKMNVFNTDVRSLSK
HHHCCCCCCHHHCHH		25.1420068231
473PhosphorylationERANACNSVIRQLMK
HHHHHHHHHHHHHHC		20.8526437602
481AcetylationVIRQLMKKEFTLEFS
HHHHHHCCCCEEEEE		44.0625825284
481UbiquitinationVIRQLMKKEFTLEFS
HHHHHHCCCCEEEEE		44.06-
484PhosphorylationQLMKKEFTLEFSRDR
HHHCCCCEEEEECCC		26.8622673903
488PhosphorylationKEFTLEFSRDRKSMS
CCCEEEEECCCCCEE		24.7221712546
492AcetylationLEFSRDRKSMSVYCS
EEEECCCCCEEEEEC		55.5919818583
493PhosphorylationEFSRDRKSMSVYCSP
EEECCCCCEEEEECC		19.7226437602
495PhosphorylationSRDRKSMSVYCSPAK
ECCCCCEEEEECCCC		19.6126437602
497PhosphorylationDRKSMSVYCSPAKSS
CCCCEEEEECCCCCC		4.6626437602
499PhosphorylationKSMSVYCSPAKSSRA
CCEEEEECCCCCCCC		15.3726437602
504PhosphorylationYCSPAKSSRAAVGNK
EECCCCCCCCCCCCE		25.8226437602
515 (in isoform 1)Ubiquitination-37.7821890473
515 (in isoform 2)Ubiquitination-37.7821890473
515UbiquitinationVGNKMFVKGAPEGVI
CCCEEECCCCCCCCC		37.7821906983
515AcetylationVGNKMFVKGAPEGVI
CCCEEECCCCCCCCC		37.7825825284
527PhosphorylationGVIDRCNYVRVGTTR
CCCCCCCEEEEECCC		8.0219764811
533PhosphorylationNYVRVGTTRVPLTGP
CEEEEECCCCCCCCC		24.6026437602
538PhosphorylationGTTRVPLTGPVKEKI
ECCCCCCCCCHHHHH		33.1126437602
554PhosphorylationAVIKEWGTGRDTLRC
HHHHHHCCCHHHHHH		30.0726437602
569PhosphorylationLALATRDTPPKREEM
HHHHCCCCCCCCHHH		37.8926437602
581PhosphorylationEEMVLDDSARFLEYE
HHHCCCCHHHHHHCC		22.4726437602
587UbiquitinationDSARFLEYETDLTFV
CHHHHHHCCCCCEEE		26.69-
588UbiquitinationSARFLEYETDLTFVG
HHHHHHCCCCCEEEE		26.86-
608PhosphorylationDPPRKEVTGSIQLCR
CCCCCCCCHHHHHHH		26.7126437602
625PhosphorylationGIRVIMITGDNKGTA
CCEEEEEECCCCCHH		22.5421406692
633UbiquitinationGDNKGTAIAICRRIG
CCCCCHHHHHHHHCC		2.3921890473
684UbiquitinationARVEPSHKSKIVEYL
HCCCCCHHHHHHHHH		58.75-
713UbiquitinationNDAPALKKAEIGIAM
CCCHHHHHCCCEEEE		52.69-
713 (in isoform 2)Ubiquitination-52.6921890473
713 (in isoform 1)Ubiquitination-52.6921890473
720SulfoxidationKAEIGIAMGSGTAVA
HCCCEEEECCCHHHH		4.0821406390
722PhosphorylationEIGIAMGSGTAVAKT
CCEEEECCCHHHHHC		21.64-
724PhosphorylationGIAMGSGTAVAKTAS
EEEECCCHHHHHCHH		21.4730278072
729PhosphorylationSGTAVAKTASEMVLA
CCHHHHHCHHHHHCC		26.1930278072
731PhosphorylationTAVAKTASEMVLADD
HHHHHCHHHHHCCCC		31.3030278072
733SulfoxidationVAKTASEMVLADDNF
HHHCHHHHHCCCCCC		2.5128183972
741PhosphorylationVLADDNFSTIVAAVE
HCCCCCCHHHHHHHH		24.3924719451
742PhosphorylationLADDNFSTIVAAVEE
CCCCCCHHHHHHHHH		18.48-
758 (in isoform 2)Ubiquitination-44.1521890473
758 (in isoform 1)Ubiquitination-44.1521890473
758UbiquitinationRAIYNNMKQFIRYLI
HHHHHCHHHHHHHHH		44.1521890473
758AcetylationRAIYNNMKQFIRYLI
HHHHHCHHHHHHHHH		44.1525825284
823PhosphorylationIMDRPPRSPKEPLIS
CCCCCCCCCCCCCCC		46.2023312004
830PhosphorylationSPKEPLISGWLFFRY
CCCCCCCCHHHHHHH		31.4427251275
921PhosphorylationNSLSENQSLLRMPPW
HCCCCCHHHHCCCCC		40.7424719451
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of AT2A1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of AT2A1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of AT2A1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ITPR3_HUMANITPR3physical
22939629
Drug and Disease Associations
Kegg Disease
H01129 Brody myopathy
OMIM Disease
601003Brody myopathy (BRM)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of AT2A1_HUMAN

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Related Literatures of Post-Translational Modification

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