MZT2B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MZT2B_HUMAN
• UniProt AC: Q6NZ67
• Protein Name: Mitotic-spindle organizing protein 2B
• Gene Name: MZT2B
• Organism: Homo sapiens (Human).
• Sequence Length: 158
• Subcellular Localization: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, spindle .
• Protein Sequence: MAAQGVGPGPGSAAPPGLEAARQKLALRRKKVLSTEEMELYELAQAAGGAIDPDVFKILVDLLKLNVAPLAVFQMLKSMCAGQRLASEPQDPAAVSLPTSSVPETRGRNKGSAALGGALALAERSSREGSSQRMPRQPSATRLPKGGGPGKSPTRGST

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	GVGPGPGSAAPPGLE CCCCCCCCCCCCCHH	25.13	28122231
24	Ubiquitination	GLEAARQKLALRRKK CHHHHHHHHHHHHHC	30.12	-
31	Ubiquitination	KLALRRKKVLSTEEM HHHHHHHCCCCHHHH	46.74	-
34	Phosphorylation	LRRKKVLSTEEMELY HHHHCCCCHHHHHHH	36.44	30278072
35	Phosphorylation	RRKKVLSTEEMELYE HHHCCCCHHHHHHHH	31.63	28464451
41	Phosphorylation	STEEMELYELAQAAG CHHHHHHHHHHHHCC	8.80	22199227
87	Phosphorylation	CAGQRLASEPQDPAA HHHCHHHCCCCCCCC	55.17	28555341
96	Phosphorylation	PQDPAAVSLPTSSVP CCCCCCCCCCCCCCC	24.73	20071362
99	Phosphorylation	PAAVSLPTSSVPETR CCCCCCCCCCCCCCC	38.64	20071362
100	Phosphorylation	AAVSLPTSSVPETRG CCCCCCCCCCCCCCC	27.65	27251275
101	Phosphorylation	AVSLPTSSVPETRGR CCCCCCCCCCCCCCC	44.14	20071362
105	Phosphorylation	PTSSVPETRGRNKGS CCCCCCCCCCCCHHH	32.14	20071362
110	Ubiquitination	PETRGRNKGSAALGG CCCCCCCHHHHHHHH	53.53	-
112	Phosphorylation	TRGRNKGSAALGGAL CCCCCHHHHHHHHHH	16.39	29214152
125	Phosphorylation	ALALAERSSREGSSQ HHHHHHHHCCCCCCC	25.83	24719451
126	Phosphorylation	LALAERSSREGSSQR HHHHHHHCCCCCCCC	40.34	23312004
130	Phosphorylation	ERSSREGSSQRMPRQ HHHCCCCCCCCCCCC	20.67	26074081
131	Phosphorylation	RSSREGSSQRMPRQP HHCCCCCCCCCCCCC	32.44	26074081
133	Methylation	SREGSSQRMPRQPSA CCCCCCCCCCCCCCC	38.73	24388001
136	Methylation	GSSQRMPRQPSATRL CCCCCCCCCCCCCCC	52.26	24388009
139	Phosphorylation	QRMPRQPSATRLPKG CCCCCCCCCCCCCCC	33.65	30266825
141	Phosphorylation	MPRQPSATRLPKGGG CCCCCCCCCCCCCCC	36.76	30266825
152	Phosphorylation	KGGGPGKSPTRGST- CCCCCCCCCCCCCC-	37.10	23927012
154	Phosphorylation	GGPGKSPTRGST--- CCCCCCCCCCCC---	55.54	23927012
157	Phosphorylation	GKSPTRGST------ CCCCCCCCC------	27.87	30576142
158	Phosphorylation	KSPTRGST------- CCCCCCCC-------	45.51	20363803

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MZT2B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MZT2B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MZT2B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GCP2_HUMAN	TUBGCP2	physical	26186194
TBG1_HUMAN	TUBG1	physical	26186194
GCP5_HUMAN	TUBGCP5	physical	26186194
GCP3_HUMAN	TUBGCP3	physical	26186194
GCP6_HUMAN	TUBGCP6	physical	26186194
GCP4_HUMAN	TUBGCP4	physical	26186194
NDK7_HUMAN	NME7	physical	26186194
GCP5_HUMAN	TUBGCP5	physical	28514442
GCP6_HUMAN	TUBGCP6	physical	28514442
GCP4_HUMAN	TUBGCP4	physical	28514442
GCP2_HUMAN	TUBGCP2	physical	28514442
GCP3_HUMAN	TUBGCP3	physical	28514442
NDK7_HUMAN	NME7	physical	28514442
LG3BP_HUMAN	LGALS3BP	physical	28514442
TBG1_HUMAN	TUBG1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.