GCP5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GCP5_HUMAN
• UniProt AC: Q96RT8
• Protein Name: Gamma-tubulin complex component 5
• Gene Name: TUBGCP5
• Organism: Homo sapiens (Human).
• Sequence Length: 1024
• Subcellular Localization: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
• Protein Description: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome..
• Protein Sequence: MARHGPPWSRLDAQQERDVRELVRGVAGLQDEADPNFQLALNFAWSNFRFHRFLDVNSHKIEKTIEGIYEKFVIHSDLSKAASWKRLTEEFLNAPLPSIKEIKTDAHYSILSLLLCLSDSPSNSSYVETPRNKEVEKKDDFDWGKYLMEDEEMDIGPYMDTPNWSEESEEENDQQPLSREDSGIQVDRTPLEEQDQNRKLDPCISWKDEPDDRSWLEHHVVHQYWTARPSQFPHSLHLHSNLAAVWDQHLYSSDPLYVPDDRVLVTETQVIRETLWLLSGVKKLFIFQLIDGKVTVRNNIIVTHLTHSCLRSVLEQIAAYGQVVFRLQEFIDEVMGHSSESMLPGSGSVPKKSTEAPFRTYQAFMWALYKYFISFKEELAEIEKCIINNDTTITLAIVVDKLAPRLSQLKVLHKVFSTGVAEVPPDTRNVVRASHLLNTLYKAILEYDNVGEASEQTVSLLFSLWVETVRPYLQTVDEWIVHGHLWDGAREFIIQRNKNVPVNHRDFWYATYTLYSVSEKTENEEKMSDNASASSGSDQGPSSRQHTMVSFLKPVLKQIIMAGKSMQLLKNLQCAESTTCQAGARDAERKSLYTLFLESVQSRLRHGEDSTPQVLTEQQATKENLMKMQSIAESHLELDDVHDPLLAINFARMYLEQSDFHEKFAGGDVCVDRSSESVTCQTFELTLRSCLYPHIDKQYLDCCGNLMQTLKKDYRLVEYLQAMRNFFLMEGGDTMYDFYTSIFDKIREKETWQNVSFLNVQLQEAVGQRYPEDSSRLSISFENVDTAKKKLPVHILDGLTLSYKVPWPVDIVISLECQKIYNQVFLLLLQIKWAKYSLDVLLFGELVSTAEKPRLKEGLIHEQDTVAQFGPQKEPVRQQIHRMFLLRVKLMHFVNSLHNYIMTRILHSTGLEFQHQVEEAKDLDQLIKIHYRYLSTIHDRCLLREKVSFVKEAIMKVLNLALMFADGWQAGLGTWRMESIEKMESDFKNCHMFLVTILNKAVCRGSFPHLESLALSLMAGMEQS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
46	Ubiquitination	LALNFAWSNFRFHRF HHHHHHHHHCCEEEE	23.74	27667366
63	Ubiquitination	VNSHKIEKTIEGIYE CCCHHHHHHHHHHHH	59.27	29967540
64	Phosphorylation	NSHKIEKTIEGIYEK CCHHHHHHHHHHHHH	16.09	22210691
69	Phosphorylation	EKTIEGIYEKFVIHS HHHHHHHHHHHHCCC	24.75	22210691
83	Phosphorylation	SDLSKAASWKRLTEE CCHHHHHHHHHHHHH	37.68	24719451
98	Phosphorylation	FLNAPLPSIKEIKTD HHCCCCCCHHHHCCH	54.71	24719451
100	Ubiquitination	NAPLPSIKEIKTDAH CCCCCCHHHHCCHHH	58.69	29967540
113	Ubiquitination	AHYSILSLLLCLSDS HHHHHHHHHHHHCCC	3.67	22817900
138	Ubiquitination	RNKEVEKKDDFDWGK CCCCCCCCCCCCHHH	49.37	29967540
139	Ubiquitination	NKEVEKKDDFDWGKY CCCCCCCCCCCHHHH	73.25	22817900
151	Ubiquitination	GKYLMEDEEMDIGPY HHHHCCCCCCCCCCC	41.75	21963094
157	Ubiquitination	DEEMDIGPYMDTPNW CCCCCCCCCCCCCCC	22.93	22817900
177	Ubiquitination	EENDQQPLSREDSGI HHCCCCCCCHHHCCC	7.01	21890473
182	Phosphorylation	QPLSREDSGIQVDRT CCCCHHHCCCCCCCC	32.80	21815630
183	Ubiquitination	PLSREDSGIQVDRTP CCCHHHCCCCCCCCC	27.03	22817900
188	Methylation	DSGIQVDRTPLEEQD HCCCCCCCCCHHHHH	39.11	-
203	Ubiquitination	QNRKLDPCISWKDEP CCCCCCCCCCCCCCC	3.72	21890473
205	Phosphorylation	RKLDPCISWKDEPDD CCCCCCCCCCCCCCC	34.49	21815630
205	Ubiquitination	RKLDPCISWKDEPDD CCCCCCCCCCCCCCC	34.49	27667366
206	Ubiquitination	KLDPCISWKDEPDDR CCCCCCCCCCCCCCC	7.69	27667366
209	Ubiquitination	PCISWKDEPDDRSWL CCCCCCCCCCCCHHH	47.07	22817900
214	Ubiquitination	KDEPDDRSWLEHHVV CCCCCCCHHHHHHHH	42.90	22817900
220	Ubiquitination	RSWLEHHVVHQYWTA CHHHHHHHHHHHHCC	4.42	22817900
235	Ubiquitination	RPSQFPHSLHLHSNL CHHHCCCEEECCCCH	20.09	22817900
240	Ubiquitination	PHSLHLHSNLAAVWD CCEEECCCCHHHHHH	39.64	22817900
258	Ubiquitination	YSSDPLYVPDDRVLV CCCCCCCCCCCCEEE	5.74	21963094
264	Ubiquitination	YVPDDRVLVTETQVI CCCCCCEEEECHHHH	4.03	22817900
284	Ubiquitination	LLSGVKKLFIFQLID HHHHHCEEEEEEECC	3.09	21890473
303	Phosphorylation	VRNNIIVTHLTHSCL EECCEEEEHHCHHHH	10.76	24961811
306	Phosphorylation	NIIVTHLTHSCLRSV CEEEEHHCHHHHHHH	12.25	24961811
316	Ubiquitination	CLRSVLEQIAAYGQV HHHHHHHHHHHHHHH	26.85	22817900
321	Ubiquitination	LEQIAAYGQVVFRLQ HHHHHHHHHHHHHHH	14.74	22817900
346	Phosphorylation	SESMLPGSGSVPKKS CCCCCCCCCCCCCCC	26.42	-
348	Phosphorylation	SMLPGSGSVPKKSTE CCCCCCCCCCCCCCC	36.62	-
352	Ubiquitination	GSGSVPKKSTEAPFR CCCCCCCCCCCCCHH	57.44	27667366
353	Phosphorylation	SGSVPKKSTEAPFRT CCCCCCCCCCCCHHH	37.29	24719451
353	Ubiquitination	SGSVPKKSTEAPFRT CCCCCCCCCCCCHHH	37.29	27667366
360	Phosphorylation	STEAPFRTYQAFMWA CCCCCHHHHHHHHHH	21.99	24043423
361	Phosphorylation	TEAPFRTYQAFMWAL CCCCHHHHHHHHHHH	8.12	24043423
369	Phosphorylation	QAFMWALYKYFISFK HHHHHHHHHHHHHHH	8.90	24043423
374	Phosphorylation	ALYKYFISFKEELAE HHHHHHHHHHHHHHH	21.99	24719451
375	Ubiquitination	LYKYFISFKEELAEI HHHHHHHHHHHHHHH	11.18	22817900
376	Ubiquitination	YKYFISFKEELAEIE HHHHHHHHHHHHHHH	43.41	22817900
377	Ubiquitination	KYFISFKEELAEIEK HHHHHHHHHHHHHHH	57.12	22817900
379	Ubiquitination	FISFKEELAEIEKCI HHHHHHHHHHHHHHE	5.63	22817900
380	Ubiquitination	ISFKEELAEIEKCII HHHHHHHHHHHHHEE	20.99	22817900
401	Ubiquitination	TLAIVVDKLAPRLSQ EEEEEHHHHHHHHHH	34.63	22817900
402	Ubiquitination	LAIVVDKLAPRLSQL EEEEHHHHHHHHHHH	7.40	22817900
403	Ubiquitination	AIVVDKLAPRLSQLK EEEHHHHHHHHHHHH	7.91	22817900
407	Phosphorylation	DKLAPRLSQLKVLHK HHHHHHHHHHHHHHH	34.44	24719451
410	Ubiquitination	APRLSQLKVLHKVFS HHHHHHHHHHHHHHH	34.80	29967540
417	Ubiquitination	KVLHKVFSTGVAEVP HHHHHHHHCCCCCCC	27.52	21963094
418	Ubiquitination	VLHKVFSTGVAEVPP HHHHHHHCCCCCCCC	24.98	21963094
423	Ubiquitination	FSTGVAEVPPDTRNV HHCCCCCCCCCHHHH	6.34	22817900
424	Ubiquitination	STGVAEVPPDTRNVV HCCCCCCCCCHHHHH	16.74	22817900
439	Ubiquitination	RASHLLNTLYKAILE HHHHHHHHHHHHHHH	31.28	22817900
443	Ubiquitination	LLNTLYKAILEYDNV HHHHHHHHHHHCCCC	9.68	21890473
444	Ubiquitination	LNTLYKAILEYDNVG HHHHHHHHHHCCCCC	2.35	21890473
465	Ubiquitination	VSLLFSLWVETVRPY HHHHHHHHHHHHHHH	5.68	22817900
469	Ubiquitination	FSLWVETVRPYLQTV HHHHHHHHHHHHHCC	3.52	22817900
475	Ubiquitination	TVRPYLQTVDEWIVH HHHHHHHCCCCHHHH	27.59	22817900
476	Ubiquitination	VRPYLQTVDEWIVHG HHHHHHCCCCHHHHC	3.96	22817900
480	Ubiquitination	LQTVDEWIVHGHLWD HHCCCCHHHHCCCCC	1.22	22817900
481	Ubiquitination	QTVDEWIVHGHLWDG HCCCCHHHHCCCCCC	4.66	22817900
482	Ubiquitination	TVDEWIVHGHLWDGA CCCCHHHHCCCCCCH	14.60	22817900
483	Ubiquitination	VDEWIVHGHLWDGAR CCCHHHHCCCCCCHH	13.49	22817900
484	Ubiquitination	DEWIVHGHLWDGARE CCHHHHCCCCCCHHH	14.63	22817900
526	Ubiquitination	EKTENEEKMSDNASA CCCCCHHHCCCCCCC	37.21	21906983
527	Ubiquitination	KTENEEKMSDNASAS CCCCHHHCCCCCCCC	7.42	22817900
528	Phosphorylation	TENEEKMSDNASASS CCCHHHCCCCCCCCC	38.49	20860994
532	Phosphorylation	EKMSDNASASSGSDQ HHCCCCCCCCCCCCC	34.63	23090842
534	Phosphorylation	MSDNASASSGSDQGP CCCCCCCCCCCCCCC	32.51	23090842
535	Phosphorylation	SDNASASSGSDQGPS CCCCCCCCCCCCCCC	41.87	23090842
537	Phosphorylation	NASASSGSDQGPSSR CCCCCCCCCCCCCCC	28.80	22210691
542	Phosphorylation	SGSDQGPSSRQHTMV CCCCCCCCCCHHHHH	45.00	22210691
543	Phosphorylation	GSDQGPSSRQHTMVS CCCCCCCCCHHHHHH	38.81	20860994
546	Ubiquitination	QGPSSRQHTMVSFLK CCCCCCHHHHHHHHH	18.15	22817900
550	Phosphorylation	SRQHTMVSFLKPVLK CCHHHHHHHHHHHHH	17.65	24719451
550	Ubiquitination	SRQHTMVSFLKPVLK CCHHHHHHHHHHHHH	17.65	22817900
553	Ubiquitination	HTMVSFLKPVLKQII HHHHHHHHHHHHHHH	30.94	29967540
564	Ubiquitination	KQIIMAGKSMQLLKN HHHHHCCHHHHHHHH	32.96	21963094
565	Ubiquitination	QIIMAGKSMQLLKNL HHHHCCHHHHHHHHC	15.73	21963094
570	Acetylation	GKSMQLLKNLQCAES CHHHHHHHHCCCHHC	65.29	25953088
570	Ubiquitination	GKSMQLLKNLQCAES CHHHHHHHHCCCHHC	65.29	21906983
571	Ubiquitination	KSMQLLKNLQCAEST HHHHHHHHCCCHHCC	35.00	22817900
590	Ubiquitination	GARDAERKSLYTLFL CCCHHHHHHHHHHHH	36.00	21890473
591	Ubiquitination	ARDAERKSLYTLFLE CCHHHHHHHHHHHHH	32.59	21890473
610	Phosphorylation	RLRHGEDSTPQVLTE HHHCCCCCCHHHHCH	37.37	28555341
611	Phosphorylation	LRHGEDSTPQVLTEQ HHCCCCCCHHHHCHH	30.02	22067460
616	Phosphorylation	DSTPQVLTEQQATKE CCCHHHHCHHHHHHH	32.65	32645325
622	Ubiquitination	LTEQQATKENLMKMQ HCHHHHHHHHHHHHH	47.85	21906983
623	Ubiquitination	TEQQATKENLMKMQS CHHHHHHHHHHHHHH	51.77	22817900
627	Ubiquitination	ATKENLMKMQSIAES HHHHHHHHHHHHHHH	36.63	22817900
628	Ubiquitination	TKENLMKMQSIAESH HHHHHHHHHHHHHHH	2.05	22817900
630	Phosphorylation	ENLMKMQSIAESHLE HHHHHHHHHHHHHCC	21.92	32645325
631	Phosphorylation	NLMKMQSIAESHLEL HHHHHHHHHHHHCCC	2.51	32645325
641	Ubiquitination	SHLELDDVHDPLLAI HHCCCCCCCCHHHHH	5.72	22817900
642	Ubiquitination	HLELDDVHDPLLAIN HCCCCCCCCHHHHHH	37.66	22817900
643	Ubiquitination	LELDDVHDPLLAINF CCCCCCCCHHHHHHH	35.08	22817900
644	Ubiquitination	ELDDVHDPLLAINFA CCCCCCCHHHHHHHH	17.88	22817900
658	Phosphorylation	ARMYLEQSDFHEKFA HHHHHHCCHHHHHHC	32.63	22067460
663	Ubiquitination	EQSDFHEKFAGGDVC HCCHHHHHHCCCCEE	31.76	-
697	Ubiquitination	CLYPHIDKQYLDCCG HHCCCCCHHHHHHCH	39.99	-
705	Ubiquitination	QYLDCCGNLMQTLKK HHHHHCHHHHHHHHH	20.58	22817900
706	Ubiquitination	YLDCCGNLMQTLKKD HHHHCHHHHHHHHHH	1.31	22817900
709	Ubiquitination	CCGNLMQTLKKDYRL HCHHHHHHHHHHHHH	26.95	22817900
710	Ubiquitination	CGNLMQTLKKDYRLV CHHHHHHHHHHHHHH	3.50	22817900
711	Ubiquitination	GNLMQTLKKDYRLVE HHHHHHHHHHHHHHH	47.16	29967540
714	Phosphorylation	MQTLKKDYRLVEYLQ HHHHHHHHHHHHHHH	18.09	28555341
719	Phosphorylation	KDYRLVEYLQAMRNF HHHHHHHHHHHHHHC	9.16	28555341
770	Phosphorylation	QEAVGQRYPEDSSRL HHHHCCCCCCCCCCE	11.77	29449344
774	Phosphorylation	GQRYPEDSSRLSISF CCCCCCCCCCEEEEE	18.72	29449344
775	Phosphorylation	QRYPEDSSRLSISFE CCCCCCCCCEEEEEE	49.95	29449344
778	Phosphorylation	PEDSSRLSISFENVD CCCCCCEEEEEECHH	18.31	29449344
780	Phosphorylation	DSSRLSISFENVDTA CCCCEEEEEECHHHC	24.11	29449344
786	Phosphorylation	ISFENVDTAKKKLPV EEEECHHHCCCCCCE	35.77	24114839
788	Ubiquitination	FENVDTAKKKLPVHI EECHHHCCCCCCEEE	53.16	21906983
789	Ubiquitination	ENVDTAKKKLPVHIL ECHHHCCCCCCEEEE	58.01	22817900
790	Ubiquitination	NVDTAKKKLPVHILD CHHHCCCCCCEEEEC	58.26	22817900
791	Ubiquitination	VDTAKKKLPVHILDG HHHCCCCCCEEEECC	8.01	22817900
852	Ubiquitination	ELVSTAEKPRLKEGL HHCCCCCCCHHHCCC	32.73	22817900
853	Ubiquitination	LVSTAEKPRLKEGLI HCCCCCCCHHHCCCC	38.04	22817900
856	Ubiquitination	TAEKPRLKEGLIHEQ CCCCCHHHCCCCCCC	51.52	21906983
857	Ubiquitination	AEKPRLKEGLIHEQD CCCCHHHCCCCCCCC	64.92	22817900
873	Ubiquitination	VAQFGPQKEPVRQQI HHHHCCCCCCHHHHH	68.09	29967540
1012	Phosphorylation	GSFPHLESLALSLMA CCCHHHHHHHHHHHH	25.88	29759185
1012 (in isoform 2)	Phosphorylation	-	25.88	-
1016	Phosphorylation	HLESLALSLMAGMEQ HHHHHHHHHHHCCCC	15.53	29759185
1024	Phosphorylation	LMAGMEQS------- HHHCCCCC-------	28.96	29759185

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GCP5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GCP5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GCP5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CLUS_HUMAN	CLU	physical	26496610
P5CS_HUMAN	ALDH18A1	physical	26496610
TBG1_HUMAN	TUBG1	physical	26496610
AUXI_HUMAN	DNAJC6	physical	26496610
GCP3_HUMAN	TUBGCP3	physical	26496610
GCP2_HUMAN	TUBGCP2	physical	26496610
DAPK2_HUMAN	DAPK2	physical	26496610
GCP4_HUMAN	TUBGCP4	physical	26496610
NDK7_HUMAN	NME7	physical	26496610
PKHG1_HUMAN	PLEKHG1	physical	26496610
MZT2B_HUMAN	MZT2B	physical	26496610
GCP6_HUMAN	TUBGCP6	physical	26496610
NEDD1_HUMAN	NEDD1	physical	26496610
MZT1_HUMAN	MZT1	physical	26496610
MZT2A_HUMAN	MZT2A	physical	26496610
GCP6_HUMAN	TUBGCP6	physical	28514442
GCP4_HUMAN	TUBGCP4	physical	28514442
GCP3_HUMAN	TUBGCP3	physical	28514442
GCP2_HUMAN	TUBGCP2	physical	28514442
MZT2A_HUMAN	MZT2A	physical	28514442
TBG1_HUMAN	TUBG1	physical	28514442
NEDD1_HUMAN	NEDD1	physical	28514442
NDK7_HUMAN	NME7	physical	28514442
RICTR_HUMAN	RICTOR	physical	28514442
TM186_HUMAN	TMEM186	physical	28514442
ASPM_HUMAN	ASPM	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.