| UniProt ID | GCP3_HUMAN | |
|---|---|---|
| UniProt AC | Q96CW5 | |
| Protein Name | Gamma-tubulin complex component 3 | |
| Gene Name | TUBGCP3 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 907 | |
| Subcellular Localization | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. | |
| Protein Description | Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.. | |
| Protein Sequence | MATPDQKSPNVLLQNLCCRILGRSEADVAQQFQYAVRVIGSNFAPTVERDEFLVAEKIKKELIRQRREADAALFSELHRKLHSQGVLKNKWSILYLLLSLSEDPRRQPSKVSSYATLFAQALPRDAHSTPYYYARPQTLPLSYQDRSAQSAQSSGSVGSSGISSIGLCALSGPAPAPQSLLPGQSNQAPGVGDCLRQQLGSRLAWTLTANQPSSQATTSKGVPSAVSRNMTRSRREGDTGGTMEITEAALVRDILYVFQGIDGKNIKMNNTENCYKVEGKANLSRSLRDTAVRLSELGWLHNKIRRYTDQRSLDRSFGLVGQSFCAALHQELREYYRLLSVLHSQLQLEDDQGVNLGLESSLTLRRLLVWTYDPKIRLKTLAALVDHCQGRKGGELASAVHAYTKTGDPYMRSLVQHILSLVSHPVLSFLYRWIYDGELEDTYHEFFVASDPTVKTDRLWHDKYTLRKSMIPSFMTMDQSRKVLLIGKSINFLHQVCHDQTPTTKMIAVTKSAESPQDAADLFTDLENAFQGKIDAAYFETSKYLLDVLNKKYSLLDHMQAMRRYLLLGQGDFIRHLMDLLKPELVRPATTLYQHNLTGILETAVRATNAQFDSPEILRRLDVRLLEVSPGDTGWDVFSLDYHVDGPIATVFTRECMSHYLRVFNFLWRAKRMEYILTDIRKGHMCNAKLLRNMPEFSGVLHQCHILASEMVHFIHQMQYYITFEVLECSWDELWNKVQQAQDLDHIIAAHEVFLDTIISRCLLDSDSRALLNQLRAVFDQIIELQNAQDAIYRAALEELQRRLQFEEKKKQREIEGQWGVTAAEEEEENKRIGEFKESIPKMCSQLRILTHFYQGIVQQFLVLLTTSSDESLRFLSFRLDFNEHYKAREPRLRVSLGTRGRRSSHT | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MATPDQKSP ------CCCCCCCCH | 28.04 | 22814378 | |
| 8 | Phosphorylation | MATPDQKSPNVLLQN CCCCCCCCHHHHHHH | 18.97 | 25159151 | |
| 80 | Ubiquitination | LFSELHRKLHSQGVL HHHHHHHHHHHCCCH | 39.54 | - | |
| 83 | Phosphorylation | ELHRKLHSQGVLKNK HHHHHHHHCCCHHCH | 38.78 | 30576142 | |
| 88 | Ubiquitination | LHSQGVLKNKWSILY HHHCCCHHCHHHHHH | 54.82 | - | |
| 112 | Phosphorylation | RRQPSKVSSYATLFA CCCCCHHHHHHHHHH | 22.74 | 26074081 | |
| 113 | Phosphorylation | RQPSKVSSYATLFAQ CCCCHHHHHHHHHHH | 23.05 | 26074081 | |
| 114 | Phosphorylation | QPSKVSSYATLFAQA CCCHHHHHHHHHHHH | 8.97 | 26074081 | |
| 116 | Phosphorylation | SKVSSYATLFAQALP CHHHHHHHHHHHHCC | 17.74 | 26074081 | |
| 129 | Phosphorylation | LPRDAHSTPYYYARP CCCCCCCCCCEECCC | 12.87 | 28555341 | |
| 131 | Phosphorylation | RDAHSTPYYYARPQT CCCCCCCCEECCCCC | 14.81 | - | |
| 132 | Phosphorylation | DAHSTPYYYARPQTL CCCCCCCEECCCCCC | 7.58 | - | |
| 133 | Phosphorylation | AHSTPYYYARPQTLP CCCCCCEECCCCCCC | 7.12 | 17360941 | |
| 135 | Methylation | STPYYYARPQTLPLS CCCCEECCCCCCCCC | 14.03 | - | |
| 138 | Phosphorylation | YYYARPQTLPLSYQD CEECCCCCCCCCCCC | 32.78 | 28555341 | |
| 153 | Phosphorylation | RSAQSAQSSGSVGSS CCCHHHHHCCCCCCC | 36.06 | 28348404 | |
| 154 | Phosphorylation | SAQSAQSSGSVGSSG CCHHHHHCCCCCCCC | 24.02 | 28348404 | |
| 156 | Phosphorylation | QSAQSSGSVGSSGIS HHHHHCCCCCCCCCC | 25.83 | 28348404 | |
| 213 | Phosphorylation | TLTANQPSSQATTSK EEECCCCCCCCCCCC | 25.89 | 20860994 | |
| 214 | Phosphorylation | LTANQPSSQATTSKG EECCCCCCCCCCCCC | 30.44 | 28555341 | |
| 220 | Ubiquitination | SSQATTSKGVPSAVS CCCCCCCCCCCCHHH | 62.93 | 21906983 | |
| 220 (in isoform 1) | Ubiquitination | - | 62.93 | 21890473 | |
| 220 (in isoform 2) | Ubiquitination | - | 62.93 | 21890473 | |
| 220 (in isoform 3) | Ubiquitination | - | 62.93 | 21890473 | |
| 224 | Phosphorylation | TTSKGVPSAVSRNMT CCCCCCCCHHHHCCC | 38.61 | 29496963 | |
| 227 | Phosphorylation | KGVPSAVSRNMTRSR CCCCCHHHHCCCCCC | 20.04 | 22210691 | |
| 231 | Phosphorylation | SAVSRNMTRSRREGD CHHHHCCCCCCCCCC | 29.10 | 22210691 | |
| 243 | Sulfoxidation | EGDTGGTMEITEAAL CCCCCCCCHHHHHHH | 3.87 | 21406390 | |
| 256 | Phosphorylation | ALVRDILYVFQGIDG HHHHHHHHHHCCCCC | 10.27 | 25147952 | |
| 264 | Ubiquitination | VFQGIDGKNIKMNNT HHCCCCCCCCCCCCC | 52.32 | 21906983 | |
| 264 (in isoform 1) | Ubiquitination | - | 52.32 | 21890473 | |
| 264 (in isoform 2) | Ubiquitination | - | 52.32 | 21890473 | |
| 264 (in isoform 3) | Ubiquitination | - | 52.32 | 21890473 | |
| 267 | Ubiquitination | GIDGKNIKMNNTENC CCCCCCCCCCCCCCE | 44.99 | - | |
| 276 | Acetylation | NNTENCYKVEGKANL CCCCCEEEEECCHHH | 35.69 | 26051181 | |
| 276 | Ubiquitination | NNTENCYKVEGKANL CCCCCEEEEECCHHH | 35.69 | - | |
| 280 | Ubiquitination | NCYKVEGKANLSRSL CEEEEECCHHHCHHH | 22.16 | 21906983 | |
| 280 (in isoform 1) | Ubiquitination | - | 22.16 | 21890473 | |
| 280 (in isoform 2) | Ubiquitination | - | 22.16 | 21890473 | |
| 280 (in isoform 3) | Ubiquitination | - | 22.16 | 21890473 | |
| 284 | Phosphorylation | VEGKANLSRSLRDTA EECCHHHCHHHHHHH | 21.45 | 23927012 | |
| 286 | Phosphorylation | GKANLSRSLRDTAVR CCHHHCHHHHHHHHH | 25.12 | 23927012 | |
| 290 | Phosphorylation | LSRSLRDTAVRLSEL HCHHHHHHHHHHHHH | 22.18 | 20860994 | |
| 303 | Ubiquitination | ELGWLHNKIRRYTDQ HHHHHHHHHHHHHCC | 27.17 | 21890473 | |
| 303 | Ubiquitination | ELGWLHNKIRRYTDQ HHHHHHHHHHHHHCC | 27.17 | 21890473 | |
| 303 (in isoform 1) | Ubiquitination | - | 27.17 | 21890473 | |
| 303 (in isoform 2) | Ubiquitination | - | 27.17 | 21890473 | |
| 303 (in isoform 3) | Ubiquitination | - | 27.17 | 21890473 | |
| 375 | Ubiquitination | LVWTYDPKIRLKTLA HHHHCCHHHHHHHHH | 37.24 | 21906983 | |
| 375 (in isoform 1) | Ubiquitination | - | 37.24 | 21890473 | |
| 375 (in isoform 2) | Ubiquitination | - | 37.24 | 21890473 | |
| 375 (in isoform 3) | Ubiquitination | - | 37.24 | 21890473 | |
| 379 | Ubiquitination | YDPKIRLKTLAALVD CCHHHHHHHHHHHHH | 31.48 | - | |
| 379 (in isoform 3) | Ubiquitination | - | 31.48 | - | |
| 392 | Ubiquitination | VDHCQGRKGGELASA HHHHCCCCCCHHHHH | 77.44 | - | |
| 405 | Ubiquitination | SAVHAYTKTGDPYMR HHHHHHHCCCCHHHH | 37.52 | 21906983 | |
| 405 (in isoform 1) | Ubiquitination | - | 37.52 | 21890473 | |
| 405 (in isoform 2) | Ubiquitination | - | 37.52 | 21890473 | |
| 410 | Phosphorylation | YTKTGDPYMRSLVQH HHCCCCHHHHHHHHH | 15.20 | 23532336 | |
| 443 | Phosphorylation | DGELEDTYHEFFVAS CCCCCCCEEEEEECC | 16.21 | - | |
| 455 | Ubiquitination | VASDPTVKTDRLWHD ECCCCCCCCCCCCCC | 47.38 | 21906983 | |
| 455 (in isoform 1) | Ubiquitination | - | 47.38 | 21890473 | |
| 455 (in isoform 2) | Ubiquitination | - | 47.38 | 21890473 | |
| 463 | Ubiquitination | TDRLWHDKYTLRKSM CCCCCCCHHHCHHHC | 27.52 | 21890473 | |
| 463 | Ubiquitination | TDRLWHDKYTLRKSM CCCCCCCHHHCHHHC | 27.52 | 21890473 | |
| 463 (in isoform 1) | Ubiquitination | - | 27.52 | 21890473 | |
| 463 (in isoform 2) | Ubiquitination | - | 27.52 | 21890473 | |
| 464 | Phosphorylation | DRLWHDKYTLRKSMI CCCCCCHHHCHHHCC | 19.64 | 29759185 | |
| 465 | Phosphorylation | RLWHDKYTLRKSMIP CCCCCHHHCHHHCCC | 26.31 | 24719451 | |
| 469 | Phosphorylation | DKYTLRKSMIPSFMT CHHHCHHHCCCCCCC | 18.60 | 24043423 | |
| 473 | Phosphorylation | LRKSMIPSFMTMDQS CHHHCCCCCCCCCCC | 19.41 | 24043423 | |
| 476 | Phosphorylation | SMIPSFMTMDQSRKV HCCCCCCCCCCCCCE | 18.65 | 24043423 | |
| 480 | Phosphorylation | SFMTMDQSRKVLLIG CCCCCCCCCCEEEEC | 29.79 | 18767875 | |
| 482 | Ubiquitination | MTMDQSRKVLLIGKS CCCCCCCCEEEECCH | 42.34 | - | |
| 505 | Ubiquitination | HDQTPTTKMIAVTKS CCCCCCCEEEEEECC | 30.68 | - | |
| 511 | Ubiquitination | TKMIAVTKSAESPQD CEEEEEECCCCCHHH | 40.86 | - | |
| 512 | Phosphorylation | KMIAVTKSAESPQDA EEEEEECCCCCHHHH | 28.09 | 25159151 | |
| 515 | Phosphorylation | AVTKSAESPQDAADL EEECCCCCHHHHHHH | 27.81 | 25159151 | |
| 524 | Phosphorylation | QDAADLFTDLENAFQ HHHHHHHHHHHHHHC | 47.15 | 29632367 | |
| 543 | Ubiquitination | AAYFETSKYLLDVLN HHHHHHHHHHHHHHH | 47.54 | 21906983 | |
| 543 (in isoform 1) | Ubiquitination | - | 47.54 | 21890473 | |
| 543 (in isoform 2) | Ubiquitination | - | 47.54 | 21890473 | |
| 544 | Phosphorylation | AYFETSKYLLDVLNK HHHHHHHHHHHHHHH | 16.56 | 30266825 | |
| 551 | Ubiquitination | YLLDVLNKKYSLLDH HHHHHHHHHCCHHHH | 49.26 | 21890473 | |
| 551 | Ubiquitination | YLLDVLNKKYSLLDH HHHHHHHHHCCHHHH | 49.26 | 21890473 | |
| 551 (in isoform 1) | Ubiquitination | - | 49.26 | 21890473 | |
| 551 (in isoform 2) | Ubiquitination | - | 49.26 | 21890473 | |
| 608 | Phosphorylation | LETAVRATNAQFDSP HHHHHHHCCCCCCCH | 22.11 | 23186163 | |
| 614 | Phosphorylation | ATNAQFDSPEILRRL HCCCCCCCHHHHHHC | 26.22 | 27050516 | |
| 639 | Phosphorylation | DTGWDVFSLDYHVDG CCCCEEEEEEEEECC | 21.85 | 22468782 | |
| 642 | Phosphorylation | WDVFSLDYHVDGPIA CEEEEEEEEECCCCE | 14.72 | 22468782 | |
| 653 | Phosphorylation | GPIATVFTRECMSHY CCCEEHHHHHHHHHH | 22.63 | 22468782 | |
| 689 | Ubiquitination | KGHMCNAKLLRNMPE CCCCCCHHHHHCCHH | 33.78 | - | |
| 831 | Ubiquitination | AEEEEENKRIGEFKE HHHHHHHHCHHHHHH | 48.98 | 21906983 | |
| 831 (in isoform 1) | Ubiquitination | - | 48.98 | 21890473 | |
| 837 | Ubiquitination | NKRIGEFKESIPKMC HHCHHHHHHHHHHHH | 46.37 | 2190698 | |
| 837 (in isoform 1) | Ubiquitination | - | 46.37 | 21890473 | |
| 839 | Phosphorylation | RIGEFKESIPKMCSQ CHHHHHHHHHHHHHH | 44.79 | 20068231 | |
| 845 | Phosphorylation | ESIPKMCSQLRILTH HHHHHHHHHHHHHHH | 28.84 | 20068231 | |
| 866 | O-linked_Glycosylation | QQFLVLLTTSSDESL HHHHHHHCCCCCCHH | 22.07 | 28510447 | |
| 867 | O-linked_Glycosylation | QFLVLLTTSSDESLR HHHHHHCCCCCCHHH | 26.63 | 28510447 | |
| 872 | O-linked_Glycosylation | LTTSSDESLRFLSFR HCCCCCCHHHHHEEE | 29.81 | 28510447 | |
| 896 | Phosphorylation | REPRLRVSLGTRGRR CCCEEEEECCCCCCC | 18.04 | 30266825 | |
| 899 | Phosphorylation | RLRVSLGTRGRRSSH EEEEECCCCCCCCCC | 34.93 | 24732914 | |
| 904 | Phosphorylation | LGTRGRRSSHT---- CCCCCCCCCCC---- | 25.72 | - | |
| 905 | Phosphorylation | GTRGRRSSHT----- CCCCCCCCCC----- | 29.36 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of GCP3_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of GCP3_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of GCP3_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-512, AND MASSSPECTROMETRY. | |
