UGGG1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UGGG1_HUMAN
• UniProt AC: Q9NYU2
• Protein Name: UDP-glucose:glycoprotein glucosyltransferase 1
• Gene Name: UGGT1
• Organism: Homo sapiens (Human).
• Sequence Length: 1555
• Subcellular Localization: Endoplasmic reticulum lumen . Endoplasmic reticulum-Golgi intermediate compartment .
• Protein Description: Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation..
• Protein Sequence: MGCKGDASGACAAGALPVTGVCYKMGVLVVLTVLWLFSSVKADSKAITTSLTTKWFSTPLLLEASEFLAEDSQEKFWNFVEASQNIGSSDHDGTDYSYYHAILEAAFQFLSPLQQNLFKFCLSLRSYSATIQAFQQIAADEPPPEGCNSFFSVHGKKTCESDTLEALLLTASERPKPLLFKGDHRYPSSNPESPVVIFYSEIGSEEFSNFHRQLISKSNAGKINYVFRHYIFNPRKEPVYLSGYGVELAIKSTEYKAKDDTQVKGTEVNTTVIGENDPIDEVQGFLFGKLRDLHPDLEGQLKELRKHLVESTNEMAPLKVWQLQDLSFQTAARILASPVELALVVMKDLSQNFPTKARAITKTAVSSELRTEVEENQKYFKGTLGLQPGDSALFINGLHMDLDTQDIFSLFDVLRNEARVMEGLHRLGIEGLSLHNVLKLNIQPSEADYAVDIRSPAISWVNNLEVDSRYNSWPSSLQELLRPTFPGVIRQIRKNLHNMVFIVDPAHETTAELMNTAEMFLSNHIPLRIGFIFVVNDSEDVDGMQDAGVAVLRAYNYVAQEVDDYHAFQTLTHIYNKVRTGEKVKVEHVVSVLEKKYPYVEVNSILGIDSAYDRNRKEARGYYEQTGVGPLPVVLFNGMPFEREQLDPDELETITMHKILETTTFFQRAVYLGELPHDQDVVEYIMNQPNVVPRINSRILTAERDYLDLTASNNFFVDDYARFTILDSQGKTAAVANSMNYLTKKGMSSKEIYDDSFIRPVTFWIVGDFDSPSGRQLLYDAIKHQKSSNNVRISMINNPAKEISYENTQISRAIWAALQTQTSNAAKNFITKMAKEGAAEALAAGADIAEFSVGGMDFSLFKEVFESSKMDFILSHAVYCRDVLKLKKGQRAVISNGRIIGPLEDSELFNQDDFHLLENIILKTSGQKIKSHIQQLRVEEDVASDLVMKVDALLSAQPKGDPRIEYQFFEDRHSAIKLRPKEGETYFDVVAVVDPVTREAQRLAPLLLVLAQLINMNLRVFMNCQSKLSDMPLKSFYRYVLEPEISFTSDNSFAKGPIAKFLDMPQSPLFTLNLNTPESWMVESVRTPYDLDNIYLEEVDSVVAAEYELEYLLLEGHCYDITTGQPPRGLQFTLGTSANPVIVDTIVMANLGYFQLKANPGAWILRLRKGRSEDIYRIYSHDGTDSPPDADEVVIVLNNFKSKIIKVKVQKKADMVNEDLLSDGTSENESGFWDSFKWGFTGQKTEEVKQDKDDIINIFSVASGHLYERFLRIMMLSVLKNTKTPVKFWFLKNYLSPTFKEFIPYMANEYNFQYELVQYKWPRWLHQQTEKQRIIWGYKILFLDVLFPLVVDKFLFVDADQIVRTDLKELRDFNLDGAPYGYTPFCDSRREMDGYRFWKSGYWASHLAGRKYHISALYVVDLKKFRKIAAGDRLRGQYQGLSQDPNSLSNLDQDLPNNMIHQVPIKSLPQEWLWCETWCDDASKKRAKTIDLCNNPMTKEPKLEAAVRIVPEWQDYDQEIKQLQIRFQKEKETGALYKEKTKEPSREGPQKREEL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
63	Ubiquitination	FSTPLLLEASEFLAE CCHHHHHHHHHHHHH	50.55	24816145
96	Phosphorylation	SDHDGTDYSYYHAIL CCCCCCCHHHHHHHH	9.83	22817900
98	Phosphorylation	HDGTDYSYYHAILEA CCCCCHHHHHHHHHH	7.95	22817900
99	Phosphorylation	DGTDYSYYHAILEAA CCCCHHHHHHHHHHH	4.46	22817900
126	Phosphorylation	KFCLSLRSYSATIQA HHHHHHCHHHHHHHH	28.82	22496350
149	Ubiquitination	PPPEGCNSFFSVHGK CCCCCCCCCCEECCC	31.57	24816145
157	Ubiquitination	FFSVHGKKTCESDTL CCEECCCCCCCCCHH	64.10	-
172	Phosphorylation	EALLLTASERPKPLL HHHHHHCCCCCCCCC	28.98	22210691
216	Phosphorylation	NFHRQLISKSNAGKI HHHHHHHHHCCCCCC	38.33	24719451
217	Ubiquitination	FHRQLISKSNAGKIN HHHHHHHHCCCCCCC	40.51	29967540
230	Phosphorylation	INYVFRHYIFNPRKE CCEEEEEECCCCCCC	11.71	28152594
240	Phosphorylation	NPRKEPVYLSGYGVE CCCCCCEEECCCCEE	13.08	22817900
244	Phosphorylation	EPVYLSGYGVELAIK CCEEECCCCEEEEEE	18.02	22817900
253	Phosphorylation	VELAIKSTEYKAKDD EEEEEECCEEECCCC	38.03	-
255	Phosphorylation	LAIKSTEYKAKDDTQ EEEECCEEECCCCCC	19.14	-
266	O-linked_Glycosylation	DDTQVKGTEVNTTVI CCCCCCCEEEEEEEE	30.92	30059200
280	Ubiquitination	IGENDPIDEVQGFLF ECCCCCHHHHHHHHH	56.24	24816145
337	Phosphorylation	TAARILASPVELALV HHHHHHCCHHHHHHH	26.49	-
356	Ubiquitination	LSQNFPTKARAITKT HHCCCCHHHHHHHHH	35.79	29967540
362	Ubiquitination	TKARAITKTAVSSEL HHHHHHHHHHHCHHH	28.51	29967540
366	Ubiquitination	AITKTAVSSELRTEV HHHHHHHCHHHHHHH	18.68	24816145
378	Acetylation	TEVEENQKYFKGTLG HHHHHHHHHCCCCCC	65.32	27452117
378	Ubiquitination	TEVEENQKYFKGTLG HHHHHHHHHCCCCCC	65.32	-
445	Phosphorylation	LKLNIQPSEADYAVD EECCCCCCCCCEEEE	29.10	-
449	Phosphorylation	IQPSEADYAVDIRSP CCCCCCCEEEEECCC	18.64	-
487	Ubiquitination	LLRPTFPGVIRQIRK HHCCCCHHHHHHHHH	24.24	24816145
536	N-linked_Glycosylation	IGFIFVVNDSEDVDG EEEEEEECCCCCCCC	41.61	UniProtKB CARBOHYD
538	Phosphorylation	FIFVVNDSEDVDGMQ EEEEECCCCCCCCCC	30.41	24719451
545	Ubiquitination	SEDVDGMQDAGVAVL CCCCCCCCHHHHHHH	42.82	22817900
549	Ubiquitination	DGMQDAGVAVLRAYN CCCCHHHHHHHHHHH	3.40	21890473
554	Ubiquitination	AGVAVLRAYNYVAQE HHHHHHHHHHHHHCC	7.86	22817900
565	Phosphorylation	VAQEVDDYHAFQTLT HHCCCCHHHHHHHHH	7.20	-
573	Ubiquitination	HAFQTLTHIYNKVRT HHHHHHHHHHHHCCC	24.53	24816145
580	Phosphorylation	HIYNKVRTGEKVKVE HHHHHCCCCCCEEEE	53.32	-
585	2-Hydroxyisobutyrylation	VRTGEKVKVEHVVSV CCCCCCEEEEHHHHH	53.63	-
595	2-Hydroxyisobutyrylation	HVVSVLEKKYPYVEV HHHHHHHHCCCEEEH	54.14	-
656	Sulfoxidation	DELETITMHKILETT HHHHHHHHHHHHHHC	2.40	30846556
684	Phosphorylation	HDQDVVEYIMNQPNV CCHHHHHHHHCCCCC	8.21	-
714	Phosphorylation	LDLTASNNFFVDDYA CCCCCCCCEEECCCE	29.27	17287340
717	Phosphorylation	TASNNFFVDDYARFT CCCCCEEECCCEEEE	4.85	17287340
724	Phosphorylation	VDDYARFTILDSQGK ECCCEEEEEECCCCH	18.31	23532336
728	Phosphorylation	ARFTILDSQGKTAAV EEEEEECCCCHHHHH	37.07	23532336
732	Phosphorylation	ILDSQGKTAAVANSM EECCCCHHHHHHHHH	27.03	23532336
738	Phosphorylation	KTAAVANSMNYLTKK HHHHHHHHHHHHHHC	9.92	19060867
741	Phosphorylation	AVANSMNYLTKKGMS HHHHHHHHHHHCCCC	13.70	22817900
744	2-Hydroxyisobutyrylation	NSMNYLTKKGMSSKE HHHHHHHHCCCCCCC	44.74	-
748	Phosphorylation	YLTKKGMSSKEIYDD HHHHCCCCCCCCCCC	47.10	22817900
762	Ubiquitination	DSFIRPVTFWIVGDF CCCCCEEEEEEECCC	18.88	22817900
766	Ubiquitination	RPVTFWIVGDFDSPS CEEEEEEECCCCCCC	4.37	21890473
771	Ubiquitination	WIVGDFDSPSGRQLL EEECCCCCCCHHHHH	22.43	22817900
779	Phosphorylation	PSGRQLLYDAIKHQK CCHHHHHHHHHHHCC	16.36	24719451
790	Ubiquitination	KHQKSSNNVRISMIN HHCCCCCCEEEEEEC	26.79	24816145
793	Ubiquitination	KSSNNVRISMINNPA CCCCCEEEEEECCCC	2.60	24816145
795	Ubiquitination	SNNVRISMINNPAKE CCCEEEEEECCCCCC	3.37	24816145
801	Ubiquitination	SMINNPAKEISYENT EEECCCCCCCCCCHH	57.76	24816145
804	Phosphorylation	NNPAKEISYENTQIS CCCCCCCCCCHHHHH	27.73	24043423
805	Phosphorylation	NPAKEISYENTQISR CCCCCCCCCHHHHHH	20.89	24043423
808	Phosphorylation	KEISYENTQISRAIW CCCCCCHHHHHHHHH	18.49	24043423
811	Phosphorylation	SYENTQISRAIWAAL CCCHHHHHHHHHHHH	13.07	24043423
822	Phosphorylation	WAALQTQTSNAAKNF HHHHHHCCCHHHHHH	27.60	20068231
823	Phosphorylation	AALQTQTSNAAKNFI HHHHHCCCHHHHHHH	18.04	20068231
859	Phosphorylation	SVGGMDFSLFKEVFE ECCCCCHHHHHHHHH	28.73	24719451
876	Ubiquitination	KMDFILSHAVYCRDV CCHHHHHHCHHHHHH	18.77	24816145
879	Ubiquitination	FILSHAVYCRDVLKL HHHHHCHHHHHHHHC	5.20	24816145
881	Ubiquitination	LSHAVYCRDVLKLKK HHHCHHHHHHHHCCC	21.27	24816145
887	Ubiquitination	CRDVLKLKKGQRAVI HHHHHHCCCCCEEEE	53.95	24816145
930	2-Hydroxyisobutyrylation	KTSGQKIKSHIQQLR HCCCHHHHHHHHHHH	42.91	-
930	Ubiquitination	KTSGQKIKSHIQQLR HCCCHHHHHHHHHHH	42.91	29967540
931	Phosphorylation	TSGQKIKSHIQQLRV CCCHHHHHHHHHHHC	29.33	22210691
948	Sulfoxidation	DVASDLVMKVDALLS HHHHHHHHHHHHHHC	4.56	21406390
955	Phosphorylation	MKVDALLSAQPKGDP HHHHHHHCCCCCCCC	26.21	-
959	Ubiquitination	ALLSAQPKGDPRIEY HHHCCCCCCCCCEEE	64.96	29967540
966	Phosphorylation	KGDPRIEYQFFEDRH CCCCCEEEEEECCCC	14.30	23403867
969	Ubiquitination	PRIEYQFFEDRHSAI CCEEEEEECCCCCCE	5.87	22817900
972	Methylation	EYQFFEDRHSAIKLR EEEEECCCCCCEEEC	20.61	54427879
973	Ubiquitination	YQFFEDRHSAIKLRP EEEECCCCCCEEECC	33.62	21890473
978	Ubiquitination	DRHSAIKLRPKEGET CCCCCEEECCCCCCC	10.41	22817900
985	Phosphorylation	LRPKEGETYFDVVAV ECCCCCCCCEEEEEE	40.10	20068231
1026	Phosphorylation	RVFMNCQSKLSDMPL HHHHCCCHHHCCCCH	37.45	21406692
1029	Phosphorylation	MNCQSKLSDMPLKSF HCCCHHHCCCCHHHH	35.28	21406692
1034	Acetylation	KLSDMPLKSFYRYVL HHCCCCHHHHHHHHH	32.42	27452117
1038	Methylation	MPLKSFYRYVLEPEI CCHHHHHHHHHCCEE	17.05	115389007
1046	Phosphorylation	YVLEPEISFTSDNSF HHHCCEEEECCCCCC	22.32	28348404
1048	Phosphorylation	LEPEISFTSDNSFAK HCCEEEECCCCCCCC	28.51	24719451
1049	Phosphorylation	EPEISFTSDNSFAKG CCEEEECCCCCCCCC	32.55	28348404
1055	Ubiquitination	TSDNSFAKGPIAKFL CCCCCCCCCCHHHHC	64.31	-
1084	Phosphorylation	PESWMVESVRTPYDL CCCHHEEECCCCCCC	12.89	20071362
1145	Phosphorylation	ANPVIVDTIVMANLG CCCEEEEEEEEECCC	12.46	-
1228	N-linked_Glycosylation	LSDGTSENESGFWDS HCCCCCCCCCCCCCC	48.80	UniProtKB CARBOHYD
1241	O-linked_Glycosylation	DSFKWGFTGQKTEEV CCCCCCCCCCCHHHH	34.46	55833743
1263 (in isoform 2)	Ubiquitination	-	25.29	21890473
1272	Ubiquitination	HLYERFLRIMMLSVL HHHHHHHHHHHHHHH	16.43	22817900
1275	Ubiquitination	ERFLRIMMLSVLKNT HHHHHHHHHHHHHCC	2.04	22817900
1276	Ubiquitination	RFLRIMMLSVLKNTK HHHHHHHHHHHHCCC	1.45	21890473
1277	Phosphorylation	FLRIMMLSVLKNTKT HHHHHHHHHHHCCCC	13.91	10694380
1277	Ubiquitination	FLRIMMLSVLKNTKT HHHHHHHHHHHCCCC	13.91	22817900
1279	Ubiquitination	RIMMLSVLKNTKTPV HHHHHHHHHCCCCCH	2.96	21890473
1281	Ubiquitination	MMLSVLKNTKTPVKF HHHHHHHCCCCCHHH	42.52	21890473
1282	Phosphorylation	MLSVLKNTKTPVKFW HHHHHHCCCCCHHHH	34.41	21406692
1283	Ubiquitination	LSVLKNTKTPVKFWF HHHHHCCCCCHHHHH	61.29	22817900
1284	Ubiquitination	SVLKNTKTPVKFWFL HHHHCCCCCHHHHHH	31.13	22817900
1286	Ubiquitination	LKNTKTPVKFWFLKN HHCCCCCHHHHHHHH	10.92	22817900
1287	Ubiquitination	KNTKTPVKFWFLKNY HCCCCCHHHHHHHHC	37.77	22817900
1287 (in isoform 1)	Ubiquitination	-	37.77	21890473
1292	Ubiquitination	PVKFWFLKNYLSPTF CHHHHHHHHCCCHHH	33.79	22817900
1294	Phosphorylation	KFWFLKNYLSPTFKE HHHHHHHCCCHHHHH	13.63	20068231
1296	Phosphorylation	WFLKNYLSPTFKEFI HHHHHCCCHHHHHHH	16.13	20068231
1298	Phosphorylation	LKNYLSPTFKEFIPY HHHCCCHHHHHHHHH	43.92	20068231
1331	2-Hydroxyisobutyrylation	WLHQQTEKQRIIWGY HHHHHCHHHHHHHHH	48.54	-
1412	Phosphorylation	SHLAGRKYHISALYV HHHCCCCEEEEEEEE	11.74	29083192
1415	Phosphorylation	AGRKYHISALYVVDL CCCCEEEEEEEEEEH	10.02	29083192
1435	Methylation	IAAGDRLRGQYQGLS HHCCCCCCCCCCCCC	30.94	115919513
1516	Phosphorylation	IVPEWQDYDQEIKQL ECCCCCCHHHHHHHH	12.39	-
1538	2-Hydroxyisobutyrylation	KETGALYKEKTKEPS HHHCCCCCCCCCCCC	54.29	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UGGG1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UGGG1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UGGG1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ZW10_HUMAN	ZW10	physical	22939629
FNTB_HUMAN	FNTB	physical	22863883
2AAA_HUMAN	PPP2R1A	physical	22863883
SSU72_HUMAN	SSU72	physical	26344197
DNM3B_HUMAN	DNMT3B	physical	26496610
LG3BP_HUMAN	LGALS3BP	physical	26496610
RAD51_HUMAN	RAD51	physical	26496610
REQU_HUMAN	DPF2	physical	26496610
STX3_HUMAN	STX3	physical	26496610
ENPL_HUMAN	HSP90B1	physical	26496610
REPS2_HUMAN	REPS2	physical	26496610
CEPT1_HUMAN	CEPT1	physical	26496610
BAZ1A_HUMAN	BAZ1A	physical	26496610
SF3B1_HUMAN	SF3B1	physical	26496610
LTN1_HUMAN	LTN1	physical	26496610
SYIM_HUMAN	IARS2	physical	26496610
GL8D1_HUMAN	GLT8D1	physical	26496610
ZNFX1_HUMAN	ZNFX1	physical	26496610
RM55_HUMAN	MRPL55	physical	26496610
EME1_HUMAN	EME1	physical	26496610
DAB2P_HUMAN	DAB2IP	physical	26496610

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry.";
Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.;
Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-738; TYR-741 ANDSER-748, AND MASS SPECTROMETRY.
PubMed: 17287340