LTN1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LTN1_HUMAN
• UniProt AC: O94822
• Protein Name: E3 ubiquitin-protein ligase listerin
• Gene Name: LTN1
• Organism: Homo sapiens (Human).
• Sequence Length: 1766
• Protein Description: E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. [PubMed: 23685075]
• Protein Sequence: MGGKNKQRTKGNLRPSNSGRAAELLAKEQGTVPGFIGFGTSQSDLGYVPAIQGAEEIDSLVDSDFRMVLRKLSKKDVTTKLKAMQEFGTMCTERDTETVKGVLPYWPRIFCKISLDHDRRVREATQQAFEKLILKVKKQLAPYLKSLMGYWLMAQCDTYTPAAFAAKDAFEAAFPPSKQPEAIAFCKDEITSVLQDHLIKETPDTLSDPQTVPEEEREAKFYRVVTCSLLALKRLLCLLPDNELDSLEEKFKSLLSQNKFWKYGKHSVPQIRSAYFELVSALCQRIPQLMKEEASKVSPSVLLSIDDSDPIVCPALWEAVLYTLTTIEDCWLHVNAKKSVFPKLSTVIREGGRGLATVIYPYLLPFISKLPQSITNPKLDFFKNFLTSLVAGLSTERTKTSSLESSAVISAFFECLRFIMQQNLGEEEIEQMLVNDQLIPFIDAVLKDPGLQHGQLFNHLAETLSSWEAKADTEKDEKTAHNLENVLIHFWERLSEICVAKISEPEADVESVLGVSNLLQVLQKPKSSLKSSKKKNGKVRFADEILESNKENEKCVSSEGEKIEGWELTTEPSLTHNSSGLLSPLRKKPLEDLVCKLADISINYVNERKSEQHLRFLSTLLDSFSSSRVFKMLLGDEKQSIVQAKPLEIAKLVQKNPAVQFLYQKLIGWLNEDQRKDFGFLVDILYSALRCCDNDMERKKVLDDLTKVDLKWNSLLKIIEKACPSSDKHALVTPWLKGDILGEKLVNLADCLCNEDLESRVSSESHFSERWTLLSLVLSQHVKNDYLIGDVYVERIIVRLHETLFKTKKLSEAESSDSSVSFICDVAYNYFSSAKGCLLMPSSEDLLLTLFQLCAQSKEKTHLPDFLICKLKNTWLSGVNLLVHQTDSSYKESTFLHLSALWLKNQVQASSLDINSLQVLLSAVDDLLNTLLESEDSYLMGVYIGSVMPNDSEWEKMRQSLPMQWLHRPLLEGRLSLNYECFKTDFKEQDIKTLPSHLCTSALLSKMVLIALRKETVLENNELEKIIAELLYSLQWCEELDNPPIFLIGFCEILQKMNITYDNLRVLGNTSGLLQLLFNRSREHGTLWSLIIAKLILSRSISSDEVKPHYKRKESFFPLTEGNLHTIQSLCPFLSKEEKKEFSAQCIPALLGWTKKDLCSTNGGFGHLAIFNSCLQTKSIDDGELLHGILKIIISWKKEHEDIFLFSCNLSEASPEVLGVNIEIIRFLSLFLKYCSSPLAESEWDFIMCSMLAWLETTSENQALYSIPLVQLFACVSCDLACDLSAFFDSTTLDTIGNLPVNLISEWKEFFSQGIHSLLLPILVTVTGENKDVSETSFQNAMLKPMCETLTYISKEQLLSHKLPARLVADQKTNLPEYLQTLLNTLAPLLLFRARPVQIAVYHMLYKLMPELPQYDQDNLKSYGDEEEEPALSPPAALMSLLSIQEDLLENVLGCIPVGQIVTIKPLSEDFCYVLGYLLTWKLILTFFKAASSQLRALYSMYLRKTKSLNKLLYHLFRLMPENPTYAETAVEVPNKDPKTFFTEELQLSIRETTMLPYHIPHLACSVYHMTLKDLPAMVRLWWNSSEKRVFNIVDRFTSKYVSSVLSFQEISSVQTSTQLFNGMTVKARATTREVMATYTIEDIVIELIIQLPSNYPLGSIIVESGKRVGVAVQQWRNWMLQLSTYLTHQNGSIMEGLALWKNNVDKRFEGVEDCMICFSVIHGFNYSLPKKACRTCKKKFHSACLYKWFTSSNKSTCPLCRETFF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Phosphorylation	KQRTKGNLRPSNSGR CCCCCCCCCCCCHHH	13.36	20068231
13 (in isoform 3)	Phosphorylation	-	13.36	20068231
14	Phosphorylation	QRTKGNLRPSNSGRA CCCCCCCCCCCHHHH	36.28	20068231
14 (in isoform 3)	Phosphorylation	-	36.28	20068231
15	Phosphorylation	RTKGNLRPSNSGRAA CCCCCCCCCCHHHHH	40.82	20068231
15 (in isoform 3)	Phosphorylation	-	40.82	20068231
16	Phosphorylation	TKGNLRPSNSGRAAE CCCCCCCCCHHHHHH	36.87	29514088
18	Phosphorylation	GNLRPSNSGRAAELL CCCCCCCHHHHHHHH	33.71	20068231
18 (in isoform 3)	Phosphorylation	-	33.71	20068231
19 (in isoform 3)	Phosphorylation	-	27.74	20068231
20	Methylation	LRPSNSGRAAELLAK CCCCCHHHHHHHHHH	30.37	115920437
20 (in isoform 3)	Phosphorylation	-	30.37	20068231
26	Ubiquitination	GRAAELLAKEQGTVP HHHHHHHHHHCCCCC	26.43	21890473
64	Phosphorylation	IDSLVDSDFRMVLRK HHHHCCCCHHHHHHH	30.61	-
66	Methylation	SLVDSDFRMVLRKLS HHCCCCHHHHHHHHC	21.20	-
89	Phosphorylation	KAMQEFGTMCTERDT HHHHHHHCCCCCCCH	17.88	29449344
92	Phosphorylation	QEFGTMCTERDTETV HHHHCCCCCCCHHHH	24.19	29449344
96	Phosphorylation	TMCTERDTETVKGVL CCCCCCCHHHHCCCC	39.51	29449344
98	Phosphorylation	CTERDTETVKGVLPY CCCCCHHHHCCCCCC	29.61	29449344
126	Ubiquitination	RRVREATQQAFEKLI HHHHHHHHHHHHHHH	39.39	-
177	Ubiquitination	FEAAFPPSKQPEAIA HHHHCCCCCCCHHHH	44.13	-
191	Phosphorylation	AFCKDEITSVLQDHL HCCHHHHHHHHHHHH	15.67	20873877
192	Phosphorylation	FCKDEITSVLQDHLI CCHHHHHHHHHHHHC	26.88	20873877
224	Ubiquitination	REAKFYRVVTCSLLA HHHHHHHHHHHHHHH	2.59	-
228	Phosphorylation	FYRVVTCSLLALKRL HHHHHHHHHHHHHHH	19.63	25003641
233	Ubiquitination	TCSLLALKRLLCLLP HHHHHHHHHHHHHCC	35.08	-
246	Phosphorylation	LPDNELDSLEEKFKS CCCCHHHHHHHHHHH	50.75	23401153
246	Ubiquitination	LPDNELDSLEEKFKS CCCCHHHHHHHHHHH	50.75	-
259	Acetylation	KSLLSQNKFWKYGKH HHHHHCCCHHHHCCC	44.99	19608861
262	Acetylation	LSQNKFWKYGKHSVP HHCCCHHHHCCCCHH	47.46	19608861
276	Ubiquitination	PQIRSAYFELVSALC HHHHHHHHHHHHHHH	6.14	22817900
281	Ubiquitination	AYFELVSALCQRIPQ HHHHHHHHHHHHHHH	12.60	21890473
296	Ubiquitination	LMKEEASKVSPSVLL HHHHHHHCCCHHHEE	54.50	-
298	Ubiquitination	KEEASKVSPSVLLSI HHHHHCCCHHHEEEC	18.39	-
305	Acetylation	SPSVLLSIDDSDPIV CHHHEEECCCCCCCC	7.42	19608861
305	Ubiquitination	SPSVLLSIDDSDPIV CHHHEEECCCCCCCC	7.42	19608861
308	Acetylation	VLLSIDDSDPIVCPA HEEECCCCCCCCCHH	41.35	19608861
349	Ubiquitination	PKLSTVIREGGRGLA HHHHHHHCCCCCCHH	31.97	21890473
362	Ubiquitination	LATVIYPYLLPFISK HHHHHHHHHHHHHHC	12.14	21890473
366	Ubiquitination	IYPYLLPFISKLPQS HHHHHHHHHHCCCCC	11.26	22817900
387	Phosphorylation	DFFKNFLTSLVAGLS HHHHHHHHHHHHHCC	18.84	25690035
394	Phosphorylation	TSLVAGLSTERTKTS HHHHHHCCCCCCCCC	27.57	25690035
424	Ubiquitination	RFIMQQNLGEEEIEQ HHHHHCCCCHHHHHH	8.75	-
425	Ubiquitination	FIMQQNLGEEEIEQM HHHHCCCCHHHHHHH	48.06	22817900
428	Ubiquitination	QQNLGEEEIEQMLVN HCCCCHHHHHHHHHH	47.74	21890473
429	Ubiquitination	QNLGEEEIEQMLVND CCCCHHHHHHHHHHC	5.15	21890473
432	Ubiquitination	GEEEIEQMLVNDQLI CHHHHHHHHHHCCHH	2.68	22817900
448	Ubiquitination	FIDAVLKDPGLQHGQ HHHHHHCCCCCCHHH	38.04	21890473
516	Ubiquitination	VESVLGVSNLLQVLQ HHHHHCHHHHHHHHH	21.69	-
524	Ubiquitination	NLLQVLQKPKSSLKS HHHHHHHCCHHHCCC	50.69	29967540
570	Ubiquitination	IEGWELTTEPSLTHN ECCEEECCCCCCCCC	59.53	-
573	Phosphorylation	WELTTEPSLTHNSSG EEECCCCCCCCCCCC	39.40	28348404
575	Phosphorylation	LTTEPSLTHNSSGLL ECCCCCCCCCCCCCC	24.29	25627689
578	Phosphorylation	EPSLTHNSSGLLSPL CCCCCCCCCCCCCCC	20.41	25627689
579	Phosphorylation	PSLTHNSSGLLSPLR CCCCCCCCCCCCCCC	38.48	25627689
583	Phosphorylation	HNSSGLLSPLRKKPL CCCCCCCCCCCCCCH	27.25	25159151
596	Ubiquitination	PLEDLVCKLADISIN CHHHHHHHHHHCCCE	38.95	-
618	Phosphorylation	EQHLRFLSTLLDSFS HHHHHHHHHHHHHHC	17.81	-
619	Phosphorylation	QHLRFLSTLLDSFSS HHHHHHHHHHHHHCC	33.22	-
629	Phosphorylation	DSFSSSRVFKMLLGD HHHCCHHHHHHHHCC	6.13	-
633	Ubiquitination	SSRVFKMLLGDEKQS CHHHHHHHHCCCCHH	5.08	-
638	Ubiquitination	KMLLGDEKQSIVQAK HHHHCCCCHHHHHCC	54.83	21890473
644	Ubiquitination	EKQSIVQAKPLEIAK CCHHHHHCCHHHHHH	12.44	21890473
645	Ubiquitination	KQSIVQAKPLEIAKL CHHHHHCCHHHHHHH	32.80	-
651	Ubiquitination	AKPLEIAKLVQKNPA CCHHHHHHHHHHCHH	55.65	21890473
684	Ubiquitination	DFGFLVDILYSALRC CHHHHHHHHHHHHHH	2.79	21890473
697	Ubiquitination	RCCDNDMERKKVLDD HHCCCHHHHHHHHHH	65.30	21890473
698	Ubiquitination	CCDNDMERKKVLDDL HCCCHHHHHHHHHHH	37.14	22817900
701	Ubiquitination	NDMERKKVLDDLTKV CHHHHHHHHHHHHHC	8.76	22817900
703	Ubiquitination	MERKKVLDDLTKVDL HHHHHHHHHHHHCCH	52.43	21890473
706	O-linked_Glycosylation	KKVLDDLTKVDLKWN HHHHHHHHHCCHHHH	35.70	28510447
711	Ubiquitination	DLTKVDLKWNSLLKI HHHHCCHHHHHHHHH	39.61	32015554
714	Phosphorylation	KVDLKWNSLLKIIEK HCCHHHHHHHHHHHH	33.68	24719451
717	Ubiquitination	LKWNSLLKIIEKACP HHHHHHHHHHHHHCC	47.10	21890473
737	Ubiquitination	ALVTPWLKGDILGEK CCCCCCCCCCHHHHH	51.15	21890473
744	Ubiquitination	KGDILGEKLVNLADC CCCHHHHHHHHHHHH	56.81	-
746	Ubiquitination	DILGEKLVNLADCLC CHHHHHHHHHHHHHC	9.04	-
753	Ubiquitination	VNLADCLCNEDLESR HHHHHHHCCCCHHHH	7.05	-
757	Ubiquitination	DCLCNEDLESRVSSE HHHCCCCHHHHHCCC	5.40	-
762	Phosphorylation	EDLESRVSSESHFSE CCHHHHHCCCCHHHH	27.55	25841592
763	Phosphorylation	DLESRVSSESHFSER CHHHHHCCCCHHHHH	40.02	25841592
763	Ubiquitination	DLESRVSSESHFSER CHHHHHCCCCHHHHH	40.02	21890473
765	Phosphorylation	ESRVSSESHFSERWT HHHHCCCCHHHHHHH	31.60	25841592
767	Ubiquitination	RVSSESHFSERWTLL HHCCCCHHHHHHHHH	12.97	22817900
768	Phosphorylation	VSSESHFSERWTLLS HCCCCHHHHHHHHHH	22.34	25841592
769	Ubiquitination	SSESHFSERWTLLSL CCCCHHHHHHHHHHH	51.82	21890473
774	Ubiquitination	FSERWTLLSLVLSQH HHHHHHHHHHHHHHH	2.66	-
783	Ubiquitination	LVLSQHVKNDYLIGD HHHHHHHCCCEECCC	41.81	21890473
847	Ubiquitination	MPSSEDLLLTLFQLC CCCCHHHHHHHHHHH	5.48	22817900
850	Ubiquitination	SEDLLLTLFQLCAQS CHHHHHHHHHHHHHC	2.31	22817900
851	Ubiquitination	EDLLLTLFQLCAQSK HHHHHHHHHHHHHCC	4.37	21890473
906	Ubiquitination	SALWLKNQVQASSLD HHHHHHCCCCCCCCC	27.41	-
992	Ubiquitination	DFKEQDIKTLPSHLC CCCCCCHHHHCHHHH	52.91	21890473
1019	Ubiquitination	LRKETVLENNELEKI HCCCHHHCCCHHHHH	54.39	22817900
1024	Ubiquitination	VLENNELEKIIAELL HHCCCHHHHHHHHHH	35.71	21890473
1033	Ubiquitination	IIAELLYSLQWCEEL HHHHHHHHHHHHHHC	17.66	22817900
1038	Ubiquitination	LYSLQWCEELDNPPI HHHHHHHHHCCCCCE	59.65	21890473
1066	Ubiquitination	ITYDNLRVLGNTSGL CCCCCEEECCCHHHH	10.14	21890473
1100	Phosphorylation	AKLILSRSISSDEVK HHHHHHCCCCCCCCC	24.36	-
1140	Ubiquitination	FLSKEEKKEFSAQCI CCCHHHHHHHHHHHH	68.24	21890473
1168	Ubiquitination	TNGGFGHLAIFNSCL CCCCCCHHEHHHCCC	3.91	22817900
1171	Ubiquitination	GFGHLAIFNSCLQTK CCCHHEHHHCCCCCC	4.59	22817900
1172	Ubiquitination	FGHLAIFNSCLQTKS CCHHEHHHCCCCCCC	26.21	21890473
1182	Ubiquitination	LQTKSIDDGELLHGI CCCCCCCCCHHHHHH	51.28	22817900
1185	Ubiquitination	KSIDDGELLHGILKI CCCCCCHHHHHHHHH	5.38	22817900
1186	Ubiquitination	SIDDGELLHGILKII CCCCCHHHHHHHHHH	2.79	21890473
1336	O-linked_Glycosylation	ENKDVSETSFQNAML CCCCCCHHHHHHHHH	27.60	28510447
1337	O-linked_Glycosylation	NKDVSETSFQNAMLK CCCCCHHHHHHHHHH	22.30	28510447
1355	Ubiquitination	ETLTYISKEQLLSHK HHHHHCCHHHHHCCC	39.66	21890473
1387	Ubiquitination	QTLLNTLAPLLLFRA HHHHHHHHHHHHHHC	7.23	21890473
1401	Ubiquitination	ARPVQIAVYHMLYKL CCCHHHHHHHHHHHH	3.44	21890473
1408	Ubiquitination	VYHMLYKLMPELPQY HHHHHHHHCCCCCCC	4.35	-
1499	Phosphorylation	SSQLRALYSMYLRKT HHHHHHHHHHHHHHC	7.15	23663014
1500	Phosphorylation	SQLRALYSMYLRKTK HHHHHHHHHHHHHCH	11.20	23663014
1502	Phosphorylation	LRALYSMYLRKTKSL HHHHHHHHHHHCHHH	9.45	23663014
1612	Phosphorylation	VLSFQEISSVQTSTQ HHCHHHHCCCCCCCH	24.57	22210691
1616	Phosphorylation	QEISSVQTSTQLFNG HHHCCCCCCCHHHCC	31.42	22210691
1617	Phosphorylation	EISSVQTSTQLFNGM HHCCCCCCCHHHCCC	9.32	22210691
1747	Phosphorylation	KFHSACLYKWFTSSN HCHHHHHHHHHHCCC	13.17	25159151
1755	Ubiquitination	KWFTSSNKSTCPLCR HHHHCCCCCCCCCCH	49.44	-
1786	Ubiquitination	--------------------------- ---------------------------		-
1793	Phosphorylation	---------------------------------- ----------------------------------		-
1801	Ubiquitination	------------------------------------------ ------------------------------------------		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LTN1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LTN1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LTN1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBC_HUMAN	UBC	physical	19196968
UB2D2_HUMAN	UBE2D2	physical	19196968
DHCR7_HUMAN	DHCR7	physical	26496610
FEN1_HUMAN	FEN1	physical	26496610
HEMO_HUMAN	HPX	physical	26496610
KIF2A_HUMAN	KIF2A	physical	26496610
NPAT_HUMAN	NPAT	physical	26496610
SP100_HUMAN	SP100	physical	26496610
TAP1_HUMAN	TAP1	physical	26496610
CTDP1_HUMAN	CTDP1	physical	26496610
PLD3_HUMAN	PLD3	physical	26496610
CHM2B_HUMAN	CHMP2B	physical	26496610
CLSPN_HUMAN	CLSPN	physical	26496610
CEP97_HUMAN	CEP97	physical	26496610
ILKAP_HUMAN	ILKAP	physical	26496610
PNPT1_HUMAN	PNPT1	physical	26496610
KI18B_HUMAN	KIF18B	physical	26496610
TET3_HUMAN	TET3	physical	26496610
SC61B_HUMAN	SEC61B	physical	25877867
SSRA_HUMAN	SSR1	physical	25877867
RL6_HUMAN	RPL6	physical	25877867

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-259, AND MASS SPECTROMETRY.
PubMed: 19608861