| UniProt ID | RL6_HUMAN | |
|---|---|---|
| UniProt AC | Q02878 | |
| Protein Name | 60S ribosomal protein L6 | |
| Gene Name | RPL6 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 288 | |
| Subcellular Localization | Cytoplasm, cytosol . Cytoplasm . Rough endoplasmic reticulum . Detected on cytosolic polysomes (PubMed:25957688). Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity). | |
| Protein Description | Component of the large ribosomal subunit.; (Microbial infection) Specifically binds to domain C of the Tax-responsive enhancer element in the long terminal repeat of HTLV-I. [PubMed: 8457378] | |
| Protein Sequence | MAGEKVEKPDTKEKKPEAKKVDAGGKVKKGNLKAKKPKKGKPHCSRNPVLVRGIGRYSRSAMYSRKAMYKRKYSAAKSKVEKKKKEKVLATVTKPVGGDKNGGTRVVKLRKMPRYYPTEDVPRKLLSHGKKPFSQHVRKLRASITPGTILIILTGRHRGKRVVFLKQLASGLLLVTGPLVLNRVPLRRTHQKFVIATSTKIDISNVKIPKHLTDAYFKKKKLRKPRHQEGEIFDTEKEKYEITEQRKIDQKAVDSQILPKIKAIPQLQGYLRSVFALTNGIYPHKLVF | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MAGEKVEKP ------CCCCCCCCC | 34.55 | - | |
| 5 | Ubiquitination | ---MAGEKVEKPDTK ---CCCCCCCCCCCC | 55.57 | 19608861 | |
| 5 | Sumoylation | ---MAGEKVEKPDTK ---CCCCCCCCCCCC | 55.57 | 28112733 | |
| 5 | Acetylation | ---MAGEKVEKPDTK ---CCCCCCCCCCCC | 55.57 | 19608861 | |
| 8 | Ubiquitination | MAGEKVEKPDTKEKK CCCCCCCCCCCCCCC | 51.70 | - | |
| 11 | Phosphorylation | EKVEKPDTKEKKPEA CCCCCCCCCCCCCCC | 50.02 | 20068231 | |
| 26 | Acetylation | KKVDAGGKVKKGNLK CCCCCCCCCCCCCCC | 50.38 | 25953088 | |
| 26 | Ubiquitination | KKVDAGGKVKKGNLK CCCCCCCCCCCCCCC | 50.38 | - | |
| 52 | Methylation | SRNPVLVRGIGRYSR CCCCCCHHCCCCCCH | 27.18 | 16226847 | |
| 57 | Phosphorylation | LVRGIGRYSRSAMYS CHHCCCCCCHHHHHC | 11.83 | 28102081 | |
| 58 | Phosphorylation | VRGIGRYSRSAMYSR HHCCCCCCHHHHHCH | 20.56 | 28102081 | |
| 59 | Methylation | RGIGRYSRSAMYSRK HCCCCCCHHHHHCHH | 21.35 | 115492231 | |
| 60 | Phosphorylation | GIGRYSRSAMYSRKA CCCCCCHHHHHCHHH | 16.08 | 28102081 | |
| 63 | Phosphorylation | RYSRSAMYSRKAMYK CCCHHHHHCHHHHHH | 12.68 | 28102081 | |
| 64 | Phosphorylation | YSRSAMYSRKAMYKR CCHHHHHCHHHHHHH | 17.77 | 28102081 | |
| 74 | Phosphorylation | AMYKRKYSAAKSKVE HHHHHHHHHHHHHHH | 25.45 | 24719451 | |
| 77 | Ubiquitination | KRKYSAAKSKVEKKK HHHHHHHHHHHHHHH | 50.99 | - | |
| 87 | Acetylation | VEKKKKEKVLATVTK HHHHHHHCEEEEEEC | 51.97 | 25953088 | |
| 87 | Ubiquitination | VEKKKKEKVLATVTK HHHHHHHCEEEEEEC | 51.97 | - | |
| 87 | Malonylation | VEKKKKEKVLATVTK HHHHHHHCEEEEEEC | 51.97 | 26320211 | |
| 87 | 2-Hydroxyisobutyrylation | VEKKKKEKVLATVTK HHHHHHHCEEEEEEC | 51.97 | - | |
| 91 | Phosphorylation | KKEKVLATVTKPVGG HHHCEEEEEECCCCC | 25.25 | 21406692 | |
| 93 | Phosphorylation | EKVLATVTKPVGGDK HCEEEEEECCCCCCC | 25.85 | 21406692 | |
| 94 | Acetylation | KVLATVTKPVGGDKN CEEEEEECCCCCCCC | 33.11 | 25953088 | |
| 94 | Ubiquitination | KVLATVTKPVGGDKN CEEEEEECCCCCCCC | 33.11 | - | |
| 94 | Succinylation | KVLATVTKPVGGDKN CEEEEEECCCCCCCC | 33.11 | - | |
| 94 | Malonylation | KVLATVTKPVGGDKN CEEEEEECCCCCCCC | 33.11 | 26320211 | |
| 100 | Acetylation | TKPVGGDKNGGTRVV ECCCCCCCCCCEEEE | 61.85 | 25953088 | |
| 100 | Ubiquitination | TKPVGGDKNGGTRVV ECCCCCCCCCCEEEE | 61.85 | 21906983 | |
| 100 | 2-Hydroxyisobutyrylation | TKPVGGDKNGGTRVV ECCCCCCCCCCEEEE | 61.85 | - | |
| 115 | Phosphorylation | KLRKMPRYYPTEDVP EECCCCCCCCCCCCC | 14.13 | 28152594 | |
| 116 | Phosphorylation | LRKMPRYYPTEDVPR ECCCCCCCCCCCCCH | 12.64 | 28152594 | |
| 118 | Phosphorylation | KMPRYYPTEDVPRKL CCCCCCCCCCCCHHH | 28.79 | 28152594 | |
| 124 | Ubiquitination | PTEDVPRKLLSHGKK CCCCCCHHHHHCCCC | 47.94 | - | |
| 124 | 2-Hydroxyisobutyrylation | PTEDVPRKLLSHGKK CCCCCCHHHHHCCCC | 47.94 | - | |
| 127 | Phosphorylation | DVPRKLLSHGKKPFS CCCHHHHHCCCCCHH | 40.40 | 20068231 | |
| 130 | Ubiquitination | RKLLSHGKKPFSQHV HHHHHCCCCCHHHHH | 52.42 | 21906983 | |
| 131 | Acetylation | KLLSHGKKPFSQHVR HHHHCCCCCHHHHHH | 56.75 | 26051181 | |
| 131 | Ubiquitination | KLLSHGKKPFSQHVR HHHHCCCCCHHHHHH | 56.75 | 21906983 | |
| 134 | Phosphorylation | SHGKKPFSQHVRKLR HCCCCCHHHHHHHHH | 28.09 | 23312004 | |
| 143 | Phosphorylation | HVRKLRASITPGTIL HHHHHHHCCCCCEEE | 22.14 | 28450419 | |
| 145 | Phosphorylation | RKLRASITPGTILII HHHHHCCCCCEEEEE | 17.11 | 28450419 | |
| 148 | Phosphorylation | RASITPGTILIILTG HHCCCCCEEEEEEEC | 17.51 | 28450419 | |
| 154 | Phosphorylation | GTILIILTGRHRGKR CEEEEEEECCCCCCE | 23.04 | - | |
| 166 | Methylation | GKRVVFLKQLASGLL CCEEHHHHHHHHCCE | 31.62 | 30993971 | |
| 170 | Phosphorylation | VFLKQLASGLLLVTG HHHHHHHHCCEEEEC | 38.27 | 20068231 | |
| 176 | Phosphorylation | ASGLLLVTGPLVLNR HHCCEEEECCEECCC | 32.81 | 20068231 | |
| 192 | Ubiquitination | PLRRTHQKFVIATST CCCCCCCCEEEEECC | 33.71 | - | |
| 192 | 2-Hydroxyisobutyrylation | PLRRTHQKFVIATST CCCCCCCCEEEEECC | 33.71 | - | |
| 192 | Acetylation | PLRRTHQKFVIATST CCCCCCCCEEEEECC | 33.71 | 25825284 | |
| 198 | Phosphorylation | QKFVIATSTKIDISN CCEEEEECCEEEHHC | 20.77 | 21712546 | |
| 199 | Phosphorylation | KFVIATSTKIDISNV CEEEEECCEEEHHCC | 27.88 | 21712546 | |
| 200 | Ubiquitination | FVIATSTKIDISNVK EEEEECCEEEHHCCC | 37.84 | - | |
| 204 | Phosphorylation | TSTKIDISNVKIPKH ECCEEEHHCCCCCHH | 31.64 | 21815630 | |
| 207 | Acetylation | KIDISNVKIPKHLTD EEEHHCCCCCHHHHH | 58.50 | 23236377 | |
| 207 | Succinylation | KIDISNVKIPKHLTD EEEHHCCCCCHHHHH | 58.50 | 21906983 | |
| 207 | Ubiquitination | KIDISNVKIPKHLTD EEEHHCCCCCHHHHH | 58.50 | - | |
| 210 | Acetylation | ISNVKIPKHLTDAYF HHCCCCCHHHHHHHH | 55.51 | 25825284 | |
| 210 | 2-Hydroxyisobutyrylation | ISNVKIPKHLTDAYF HHCCCCCHHHHHHHH | 55.51 | - | |
| 210 | Malonylation | ISNVKIPKHLTDAYF HHCCCCCHHHHHHHH | 55.51 | 26320211 | |
| 210 | Ubiquitination | ISNVKIPKHLTDAYF HHCCCCCHHHHHHHH | 55.51 | 19608861 | |
| 213 | Phosphorylation | VKIPKHLTDAYFKKK CCCCHHHHHHHHHHH | 20.50 | 28152594 | |
| 216 | Phosphorylation | PKHLTDAYFKKKKLR CHHHHHHHHHHHCCC | 20.81 | 28152594 | |
| 218 | Methylation | HLTDAYFKKKKLRKP HHHHHHHHHHCCCCC | 51.51 | 19608861 | |
| 218 | Ubiquitination | HLTDAYFKKKKLRKP HHHHHHHHHHCCCCC | 51.51 | 21906983 | |
| 218 | 2-Hydroxyisobutyrylation | HLTDAYFKKKKLRKP HHHHHHHHHHCCCCC | 51.51 | - | |
| 218 | Acetylation | HLTDAYFKKKKLRKP HHHHHHHHHHCCCCC | 51.51 | 19608861 | |
| 219 | Ubiquitination | LTDAYFKKKKLRKPR HHHHHHHHHCCCCCC | 45.29 | - | |
| 220 | Ubiquitination | TDAYFKKKKLRKPRH HHHHHHHHCCCCCCC | 58.59 | - | |
| 224 | Ubiquitination | FKKKKLRKPRHQEGE HHHHCCCCCCCCCCC | 57.76 | - | |
| 237 | Acetylation | GEIFDTEKEKYEITE CCCCCCHHHHEECCC | 62.69 | 25953088 | |
| 237 | Ubiquitination | GEIFDTEKEKYEITE CCCCCCHHHHEECCC | 62.69 | 21906983 | |
| 239 | Acetylation | IFDTEKEKYEITEQR CCCCHHHHEECCCHH | 60.29 | 19608861 | |
| 239 | Methylation | IFDTEKEKYEITEQR CCCCHHHHEECCCHH | 60.29 | 19608861 | |
| 239 | Ubiquitination | IFDTEKEKYEITEQR CCCCHHHHEECCCHH | 60.29 | 21906983 | |
| 240 | Nitration | FDTEKEKYEITEQRK CCCHHHHEECCCHHC | 17.41 | - | |
| 247 | Ubiquitination | YEITEQRKIDQKAVD EECCCHHCCCHHHHH | 50.78 | - | |
| 251 | Acetylation | EQRKIDQKAVDSQIL CHHCCCHHHHHCCHH | 46.78 | 23236377 | |
| 251 | Ubiquitination | EQRKIDQKAVDSQIL CHHCCCHHHHHCCHH | 46.78 | 21906983 | |
| 251 | Sumoylation | EQRKIDQKAVDSQIL CHHCCCHHHHHCCHH | 46.78 | - | |
| 255 | Phosphorylation | IDQKAVDSQILPKIK CCHHHHHCCHHHHHH | 16.72 | 21712546 | |
| 260 | 2-Hydroxyisobutyrylation | VDSQILPKIKAIPQL HHCCHHHHHHHHHHH | 54.09 | - | |
| 260 | Succinylation | VDSQILPKIKAIPQL HHCCHHHHHHHHHHH | 54.09 | 27452117 | |
| 260 | Ubiquitination | VDSQILPKIKAIPQL HHCCHHHHHHHHHHH | 54.09 | - | |
| 260 | Acetylation | VDSQILPKIKAIPQL HHCCHHHHHHHHHHH | 54.09 | 26051181 | |
| 262 | Malonylation | SQILPKIKAIPQLQG CCHHHHHHHHHHHHH | 46.52 | 26320211 | |
| 262 | 2-Hydroxyisobutyrylation | SQILPKIKAIPQLQG CCHHHHHHHHHHHHH | 46.52 | - | |
| 262 | Ubiquitination | SQILPKIKAIPQLQG CCHHHHHHHHHHHHH | 46.52 | - | |
| 262 | Sumoylation | SQILPKIKAIPQLQG CCHHHHHHHHHHHHH | 46.52 | - | |
| 270 | Phosphorylation | AIPQLQGYLRSVFAL HHHHHHHHHHHHHHH | 5.98 | 28152594 | |
| 272 | Methylation | PQLQGYLRSVFALTN HHHHHHHHHHHHHHC | 23.45 | 115492223 | |
| 273 | Phosphorylation | QLQGYLRSVFALTNG HHHHHHHHHHHHHCC | 20.99 | 21712546 | |
| 278 | Phosphorylation | LRSVFALTNGIYPHK HHHHHHHHCCCCCCC | 28.15 | 28442448 | |
| 282 | Phosphorylation | FALTNGIYPHKLVF- HHHHCCCCCCCCCC- | 10.73 | 28152594 | |
| 285 | Ubiquitination | TNGIYPHKLVF---- HCCCCCCCCCC---- | 41.67 | 21906983 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RL6_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RL6_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RL6_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Acetylation | |
| Reference | PubMed |
| "Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY. | |
| "Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-5; LYS-210 AND LYS-239, ANDMASS SPECTROMETRY. | |
| Phosphorylation | |
| Reference | PubMed |
| "Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."; Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.; J. Proteome Res. 6:4150-4162(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-127, AND MASSSPECTROMETRY. | |
