RT23_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RT23_HUMAN
• UniProt AC: Q9Y3D9
• Protein Name: 28S ribosomal protein S23, mitochondrial
• Gene Name: MRPS23
• Organism: Homo sapiens (Human).
• Sequence Length: 190
• Subcellular Localization: Mitochondrion .
• Protein Sequence: MAGSRLETVGSIFSRTRDLVRAGVLKEKPLWFDVYDAFPPLREPVFQRPRVRYGKAKAPIQDIWYHEDRIRAKFYSVYGSGQRAFDLFNPNFKSTCQRFVEKYTELQKLGETDEEKLFVETGKALLAEGVILRRVGEARTQHGGSHVSRKSEHLSVRPQTALEENETQKEVPQDQHLEAPADQSKGLLPP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAGSRLETV ------CCCCCCCCH	25.35	25944712
8	Phosphorylation	MAGSRLETVGSIFSR CCCCCCCCHHHHHHH	34.46	23403867
11	Phosphorylation	SRLETVGSIFSRTRD CCCCCHHHHHHHHHH	19.00	24043423
14	Phosphorylation	ETVGSIFSRTRDLVR CCHHHHHHHHHHHHH	30.95	23403867
16	Phosphorylation	VGSIFSRTRDLVRAG HHHHHHHHHHHHHCC	27.60	24043423
21	Methylation	SRTRDLVRAGVLKEK HHHHHHHHCCCCCCC	32.68	16187653
55	Ubiquitination	RPRVRYGKAKAPIQD CCCCHHCCCCCCHHH	37.47	22817900
57	Ubiquitination	RVRYGKAKAPIQDIW CCHHCCCCCCHHHCE	59.17	21890473
57	Malonylation	RVRYGKAKAPIQDIW CCHHCCCCCCHHHCE	59.17	33225896
65	Phosphorylation	APIQDIWYHEDRIRA CCHHHCEECHHHHHH	8.82	-
73	Ubiquitination	HEDRIRAKFYSVYGS CHHHHHHEEEEECCC	34.68	-
73	Acetylation	HEDRIRAKFYSVYGS CHHHHHHEEEEECCC	34.68	23954790
73	Malonylation	HEDRIRAKFYSVYGS CHHHHHHEEEEECCC	34.68	26320211
78	Phosphorylation	RAKFYSVYGSGQRAF HHEEEEECCCCCHHH	10.30	28152594
80	Phosphorylation	KFYSVYGSGQRAFDL EEEEECCCCCHHHHC	17.67	28152594
93	Succinylation	DLFNPNFKSTCQRFV HCCCCCHHHHHHHHH	52.04	23954790
93	Ubiquitination	DLFNPNFKSTCQRFV HCCCCCHHHHHHHHH	52.04	-
93	Acetylation	DLFNPNFKSTCQRFV HCCCCCHHHHHHHHH	52.04	25953088
102	Acetylation	TCQRFVEKYTELQKL HHHHHHHHHHHHHHC	52.77	19608861
102	2-Hydroxyisobutyrylation	TCQRFVEKYTELQKL HHHHHHHHHHHHHHC	52.77	-
108	Acetylation	EKYTELQKLGETDEE HHHHHHHHCCCCCHH	71.70	23236377
108	Ubiquitination	EKYTELQKLGETDEE HHHHHHHHCCCCCHH	71.70	22817900
112	Phosphorylation	ELQKLGETDEEKLFV HHHHCCCCCHHHHHH	47.08	29396449
116	Acetylation	LGETDEEKLFVETGK CCCCCHHHHHHHHHH	45.22	25953088
145	Phosphorylation	ARTQHGGSHVSRKSE HHHCCCCCCCCCCCC	25.88	20860994

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RT23_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RT23_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RT23_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RT27_HUMAN	MRPS27	physical	22939629
SYQ_HUMAN	QARS	physical	22939629
USBP1_HUMAN	USHBP1	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-102, AND MASS SPECTROMETRY.
PubMed: 19608861