UniProt ID | MOV10_HUMAN | |
---|---|---|
UniProt AC | Q9HCE1 | |
Protein Name | Putative helicase MOV-10 | |
Gene Name | MOV10 | |
Organism | Homo sapiens (Human). | |
Sequence Length | 1003 | |
Subcellular Localization | Cytoplasm, P-body . | |
Protein Description | Probable RNA helicase. Required for miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC.; (Microbial infection) Required for RNA-directed transcription and replication of the human hepatitis delta virus (HDV). Interacts with small capped HDV RNAs derived from genomic hairpin structures that mark the initiation sites of RNA-dependent HDV RNA transcription.. | |
Protein Sequence | MPSKFSCRQLREAGQCFESFLVVRGLDMETDRERLRTIYNRDFKISFGTPAPGFSSMLYGMKIANLAYVTKTRVRFFRLDRWADVRFPEKRRMKLGSDISKHHKSLLAKIFYDRAEYLHGKHGVDVEVQGPHEARDGQLLIRLDLNRKEVLTLRLRNGGTQSVTLTHLFPLCRTPQFAFYNEDQELPCPLGPGECYELHVHCKTSFVGYFPATVLWELLGPGESGSEGAGTFYIARFLAAVAHSPLAAQLKPMTPFKRTRITGNPVVTNRIEEGERPDRAKGYDLELSMALGTYYPPPRLRQLLPMLLQGTSIFTAPKEIAEIKAQLETALKWRNYEVKLRLLLHLEELQMEHDIRHYDLESVPMTWDPVDQNPRLLTLEVPGVTESRPSVLRGDHLFALLSSETHQEDPITYKGFVHKVELDRVKLSFSMSLLSRFVDGLTFKVNFTFNRQPLRVQHRALELTGRWLLWPMLFPVAPRDVPLLPSDVKLKLYDRSLESNPEQLQAMRHIVTGTTRPAPYIIFGPPGTGKTVTLVEAIKQVVKHLPKAHILACAPSNSGADLLCQRLRVHLPSSIYRLLAPSRDIRMVPEDIKPCCNWDAKKGEYVFPAKKKLQEYRVLITTLITAGRLVSAQFPIDHFTHIFIDEAGHCMEPESLVAIAGLMEVKETGDPGGQLVLAGDPRQLGPVLRSPLTQKHGLGYSLLERLLTYNSLYKKGPDGYDPQFITKLLRNYRSHPTILDIPNQLYYEGELQACADVVDRERFCRWAGLPRQGFPIIFHGVMGKDEREGNSPSFFNPEEAATVTSYLKLLLAPSSKKGKARLSPRSVGVISPYRKQVEKIRYCITKLDRELRGLDDIKDLKVGSVEEFQGQERSVILISTVRSSQSFVQLDLDFNLGFLKNPKRFNVAVTRAKALLIIVGNPLLLGHDPDWKVFLEFCKENGGYTGCPFPAKLDLQQGQNLLQGLSKLSPSTSGPHSHDYLPQEREGEGGLSLQVEPEWRNEL | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
30 | Phosphorylation | VRGLDMETDRERLRT EECCCCCCCHHHHHH | 33.45 | - | |
46 | Phosphorylation | YNRDFKISFGTPAPG HHCCCEEEECCCCCC | 20.43 | 30206219 | |
46 (in isoform 3) | Phosphorylation | - | 20.43 | 30631047 | |
49 | Phosphorylation | DFKISFGTPAPGFSS CCEEEECCCCCCCHH | 17.80 | 30206219 | |
50 (in isoform 3) | Phosphorylation | - | 36.52 | 30631047 | |
55 | Phosphorylation | GTPAPGFSSMLYGMK CCCCCCCHHHHHHCH | 22.28 | 30206219 | |
56 | Phosphorylation | TPAPGFSSMLYGMKI CCCCCCHHHHHHCHH | 15.56 | 30206219 | |
59 | Phosphorylation | PGFSSMLYGMKIANL CCCHHHHHHCHHHHH | 13.41 | 30206219 | |
71 | Ubiquitination | ANLAYVTKTRVRFFR HHHHEEECCCEEEEE | 25.04 | 21906983 | |
71 (in isoform 1) | Ubiquitination | - | 25.04 | 21890473 | |
71 (in isoform 2) | Ubiquitination | - | 25.04 | 21890473 | |
90 | Ubiquitination | ADVRFPEKRRMKLGS CCCCCCHHHHHCCCC | 45.61 | - | |
94 | Methylation | FPEKRRMKLGSDISK CCHHHHHCCCCCHHH | 48.13 | 82980887 | |
94 | Ubiquitination | FPEKRRMKLGSDISK CCHHHHHCCCCCHHH | 48.13 | - | |
94 (in isoform 2) | Ubiquitination | - | 48.13 | - | |
97 | Phosphorylation | KRRMKLGSDISKHHK HHHHCCCCCHHHHHH | 42.05 | 29255136 | |
100 | Phosphorylation | MKLGSDISKHHKSLL HCCCCCHHHHHHHHH | 30.81 | 29449344 | |
101 | Ubiquitination | KLGSDISKHHKSLLA CCCCCHHHHHHHHHH | 50.49 | - | |
104 | Ubiquitination | SDISKHHKSLLAKIF CCHHHHHHHHHHHHH | 42.38 | - | |
109 | Acetylation | HHKSLLAKIFYDRAE HHHHHHHHHHHHHHH | 33.06 | 26051181 | |
109 | Ubiquitination | HHKSLLAKIFYDRAE HHHHHHHHHHHHHHH | 33.06 | 21890473 | |
109 (in isoform 1) | Ubiquitination | - | 33.06 | 21890473 | |
109 (in isoform 2) | Ubiquitination | - | 33.06 | 21890473 | |
121 | Ubiquitination | RAEYLHGKHGVDVEV HHHHHCCCCCCCCEE | 26.83 | - | |
148 | Acetylation | IRLDLNRKEVLTLRL EEEECCCCEEEEEEE | 51.61 | 19608861 | |
148 | Ubiquitination | IRLDLNRKEVLTLRL EEEECCCCEEEEEEE | 51.61 | - | |
152 | Phosphorylation | LNRKEVLTLRLRNGG CCCCEEEEEEECCCC | 18.27 | - | |
154 | Methylation | RKEVLTLRLRNGGTQ CCEEEEEEECCCCCE | 26.77 | 115483619 | |
160 | Phosphorylation | LRLRNGGTQSVTLTH EEECCCCCEEEEEEE | 21.04 | 17525332 | |
162 | Phosphorylation | LRNGGTQSVTLTHLF ECCCCCEEEEEEEEE | 19.53 | 23312004 | |
164 | Phosphorylation | NGGTQSVTLTHLFPL CCCCEEEEEEEEEHH | 31.05 | 18669648 | |
166 | Phosphorylation | GTQSVTLTHLFPLCR CCEEEEEEEEEHHCC | 13.73 | 23186163 | |
244 | Phosphorylation | FLAAVAHSPLAAQLK HHHHHHCCHHHHHCC | 16.33 | 26270265 | |
251 | Ubiquitination | SPLAAQLKPMTPFKR CHHHHHCCCCCCCCC | 22.21 | - | |
254 | Phosphorylation | AAQLKPMTPFKRTRI HHHCCCCCCCCCCEE | 33.82 | 27273156 | |
257 | Ubiquitination | LKPMTPFKRTRITGN CCCCCCCCCCEECCC | 54.81 | - | |
262 | Phosphorylation | PFKRTRITGNPVVTN CCCCCEECCCCEECC | 27.84 | 21406692 | |
268 | Phosphorylation | ITGNPVVTNRIEEGE ECCCCEECCCCCCCC | 21.00 | 21406692 | |
311 | Phosphorylation | LPMLLQGTSIFTAPK HHHHHCCCCCCCCCH | 12.99 | - | |
312 | Phosphorylation | PMLLQGTSIFTAPKE HHHHCCCCCCCCCHH | 23.64 | - | |
318 | Ubiquitination | TSIFTAPKEIAEIKA CCCCCCCHHHHHHHH | 60.33 | - | |
324 | Ubiquitination | PKEIAEIKAQLETAL CHHHHHHHHHHHHHH | 22.91 | - | |
332 | Ubiquitination | AQLETALKWRNYEVK HHHHHHHHHCCHHHH | 41.46 | - | |
339 | Ubiquitination | KWRNYEVKLRLLLHL HHCCHHHHHHHHHHH | 18.89 | - | |
358 | Phosphorylation | MEHDIRHYDLESVPM HHCCCCCCCCCCCCC | 16.63 | 27642862 | |
378 | Phosphorylation | DQNPRLLTLEVPGVT CCCCCEEEEECCCCC | 26.01 | - | |
387 | Phosphorylation | EVPGVTESRPSVLRG ECCCCCCCCCCHHCC | 39.88 | - | |
414 | Ubiquitination | QEDPITYKGFVHKVE CCCCCCEEEEEEEEE | 36.90 | 21890473 | |
414 (in isoform 1) | Ubiquitination | - | 36.90 | 21890473 | |
414 (in isoform 2) | Ubiquitination | - | 36.90 | 21890473 | |
419 | Ubiquitination | TYKGFVHKVELDRVK CEEEEEEEEECCEEE | 31.91 | - | |
428 | Phosphorylation | ELDRVKLSFSMSLLS ECCEEEEEEHHHHHH | 15.01 | 22210691 | |
430 | Phosphorylation | DRVKLSFSMSLLSRF CEEEEEEHHHHHHHH | 12.23 | 22210691 | |
432 | Phosphorylation | VKLSFSMSLLSRFVD EEEEEHHHHHHHHCC | 25.59 | 29978859 | |
435 | Phosphorylation | SFSMSLLSRFVDGLT EEHHHHHHHHCCCEE | 29.03 | 24719451 | |
489 | Acetylation | PLLPSDVKLKLYDRS CCCCCCCCEEECCCC | 44.91 | 25953088 | |
489 | Ubiquitination | PLLPSDVKLKLYDRS CCCCCCCCEEECCCC | 44.91 | 21890473 | |
489 (in isoform 1) | Ubiquitination | - | 44.91 | 21890473 | |
489 (in isoform 2) | Ubiquitination | - | 44.91 | 21890473 | |
491 | Ubiquitination | LPSDVKLKLYDRSLE CCCCCCEEECCCCCC | 39.00 | - | |
496 | Phosphorylation | KLKLYDRSLESNPEQ CEEECCCCCCCCHHH | 33.32 | 20068231 | |
499 | Phosphorylation | LYDRSLESNPEQLQA ECCCCCCCCHHHHHH | 64.08 | 21406692 | |
507 | Sulfoxidation | NPEQLQAMRHIVTGT CHHHHHHHHHHHHCC | 1.75 | 21406390 | |
512 | Phosphorylation | QAMRHIVTGTTRPAP HHHHHHHHCCCCCCC | 28.36 | 21406692 | |
514 | Phosphorylation | MRHIVTGTTRPAPYI HHHHHHCCCCCCCEE | 15.40 | 21406692 | |
515 | Phosphorylation | RHIVTGTTRPAPYII HHHHHCCCCCCCEEE | 35.68 | 24719451 | |
530 | Ubiquitination | FGPPGTGKTVTLVEA ECCCCCCHHHHHHHH | 39.39 | - | |
539 | Ubiquitination | VTLVEAIKQVVKHLP HHHHHHHHHHHHHCC | 44.05 | - | |
547 | Ubiquitination | QVVKHLPKAHILACA HHHHHCCCCEEEEEC | 59.98 | - | |
556 | Phosphorylation | HILACAPSNSGADLL EEEEECCCCCCHHHH | 25.71 | - | |
558 | Phosphorylation | LACAPSNSGADLLCQ EEECCCCCCHHHHHH | 39.43 | - | |
582 | Phosphorylation | IYRLLAPSRDIRMVP HHHHHCCCCCCCCCC | 36.66 | 20071362 | |
593 | Ubiquitination | RMVPEDIKPCCNWDA CCCCCCCCCCCCCCC | 44.30 | - | |
602 | Ubiquitination | CCNWDAKKGEYVFPA CCCCCCCCCCEEEEC | 59.71 | - | |
605 | Phosphorylation | WDAKKGEYVFPAKKK CCCCCCCEEEECCHH | 18.96 | 20068231 | |
610 | Ubiquitination | GEYVFPAKKKLQEYR CCEEEECCHHHHHHH | 51.16 | - | |
690 | Phosphorylation | QLGPVLRSPLTQKHG HCCCCCCCCCCCCCC | 21.79 | 27067055 | |
695 | Ubiquitination | LRSPLTQKHGLGYSL CCCCCCCCCCCCHHH | 34.11 | 21890473 | |
695 (in isoform 1) | Ubiquitination | - | 34.11 | 21890473 | |
695 (in isoform 2) | Ubiquitination | - | 34.11 | 21890473 | |
711 | Phosphorylation | ERLLTYNSLYKKGPD HHHHHHHHHHHCCCC | 23.74 | - | |
713 | Phosphorylation | LLTYNSLYKKGPDGY HHHHHHHHHCCCCCC | 15.52 | 27762562 | |
714 | Ubiquitination | LTYNSLYKKGPDGYD HHHHHHHHCCCCCCC | 57.45 | - | |
715 | Ubiquitination | TYNSLYKKGPDGYDP HHHHHHHCCCCCCCH | 63.22 | - | |
727 | Acetylation | YDPQFITKLLRNYRS CCHHHHHHHHHHCCC | 40.48 | 26051181 | |
727 | Ubiquitination | YDPQFITKLLRNYRS CCHHHHHHHHHHCCC | 40.48 | 21906983 | |
727 (in isoform 1) | Ubiquitination | - | 40.48 | 21890473 | |
727 (in isoform 2) | Ubiquitination | - | 40.48 | 21890473 | |
732 | Phosphorylation | ITKLLRNYRSHPTIL HHHHHHHCCCCCCEE | 13.68 | - | |
746 | Phosphorylation | LDIPNQLYYEGELQA EECCCCCEECCCHHH | 6.95 | - | |
747 | Phosphorylation | DIPNQLYYEGELQAC ECCCCCEECCCHHHH | 26.50 | - | |
784 | Ubiquitination | IFHGVMGKDEREGNS EEEEECCCCCCCCCC | 38.02 | - | |
791 | Phosphorylation | KDEREGNSPSFFNPE CCCCCCCCCCCCCHH | 32.55 | 25627689 | |
814 | Phosphorylation | LKLLLAPSSKKGKAR HHHHHCCCCCCCCCC | 49.54 | 29632367 | |
815 | Phosphorylation | KLLLAPSSKKGKARL HHHHCCCCCCCCCCC | 37.01 | 29632367 | |
816 | Acetylation | LLLAPSSKKGKARLS HHHCCCCCCCCCCCC | 70.63 | 25953088 | |
816 | Ubiquitination | LLLAPSSKKGKARLS HHHCCCCCCCCCCCC | 70.63 | - | |
817 | Ubiquitination | LLAPSSKKGKARLSP HHCCCCCCCCCCCCC | 68.54 | - | |
839 (in isoform 2) | Phosphorylation | - | 33.36 | 25599653 | |
846 | Acetylation | KIRYCITKLDRELRG HHHHHHHHHHHHHCC | 28.60 | 25953088 | |
846 | Ubiquitination | KIRYCITKLDRELRG HHHHHHHHHHHHHCC | 28.60 | - | |
852 | Methylation | TKLDRELRGLDDIKD HHHHHHHCCCCCCCC | 38.58 | 115483613 | |
853 (in isoform 2) | Phosphorylation | - | 46.19 | 25599653 | |
858 | Ubiquitination | LRGLDDIKDLKVGSV HCCCCCCCCCCCCCH | 65.09 | 21890473 | |
858 (in isoform 1) | Ubiquitination | - | 65.09 | 21890473 | |
861 | Ubiquitination | LDDIKDLKVGSVEEF CCCCCCCCCCCHHHC | 55.47 | - | |
880 | Phosphorylation | RSVILISTVRSSQSF CEEEEEEEECCCCCE | 16.97 | 20068231 | |
952 | Ubiquitination | TGCPFPAKLDLQQGQ CCCCCCCEECHHHHH | 42.65 | - | |
966 | Phosphorylation | QNLLQGLSKLSPSTS HHHHHHHHHCCCCCC | 38.07 | 23898821 | |
967 | Ubiquitination | NLLQGLSKLSPSTSG HHHHHHHHCCCCCCC | 59.01 | 21890473 | |
967 (in isoform 1) | Ubiquitination | - | 59.01 | 21890473 | |
969 | Phosphorylation | LQGLSKLSPSTSGPH HHHHHHCCCCCCCCC | 22.12 | 29255136 | |
971 | Phosphorylation | GLSKLSPSTSGPHSH HHHHCCCCCCCCCCC | 31.65 | 29255136 | |
972 | Phosphorylation | LSKLSPSTSGPHSHD HHHCCCCCCCCCCCC | 40.88 | 22167270 | |
973 | Phosphorylation | SKLSPSTSGPHSHDY HHCCCCCCCCCCCCC | 55.45 | 22167270 | |
977 | Phosphorylation | PSTSGPHSHDYLPQE CCCCCCCCCCCCCCC | 22.61 | 10997877 | |
980 | Phosphorylation | SGPHSHDYLPQEREG CCCCCCCCCCCCCCC | 18.17 | 23927012 | |
992 | Phosphorylation | REGEGGLSLQVEPEW CCCCCCCCCCCCHHH | 21.74 | 28555341 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MOV10_HUMAN !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MOV10_HUMAN !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MOV10_HUMAN !! |
Kegg Disease | ||||||
---|---|---|---|---|---|---|
There are no disease associations of PTM sites. | ||||||
OMIM Disease | ||||||
There are no disease associations of PTM sites. | ||||||
Kegg Drug | ||||||
There are no disease associations of PTM sites. | ||||||
DrugBank | ||||||
There are no disease associations of PTM sites. |
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Acetylation | |
Reference | PubMed |
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-148, AND MASS SPECTROMETRY. | |
Phosphorylation | |
Reference | PubMed |
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-977, AND MASSSPECTROMETRY. | |
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-254, AND MASSSPECTROMETRY. | |
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-160, AND MASSSPECTROMETRY. |