| UniProt ID | PIGN_HUMAN | |
|---|---|---|
| UniProt AC | O95427 | |
| Protein Name | GPI ethanolamine phosphate transferase 1 | |
| Gene Name | PIGN | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 931 | |
| Subcellular Localization |
Endoplasmic reticulum membrane Multi-pass membrane protein. |
|
| Protein Description | Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor (By similarity). May act as suppressor of replication stress and chromosome missegregation.. | |
| Protein Sequence | MLLFFTLGLLIHFVFFASIFDIYFTSPLVHGMTPQFTPLPPPARRLVLFVADGLRADALYELDENGNSRAPFIRNIIMHEGSWGISHTRVPTESRPGHVALIAGFYEDVSAVAKGWKENPVEFDSLFNESKYTWSWGSPDILPMFAKGASGDHVYTYSYDAKREDFGAQDATKLDTWVFDNVKDFFHHARNNQSLFSKINEEKIVFFLHLLGIDTNGHAHRPSSRDYKHNIKKVDDGVKEIVSMFNHFYGNDGKTTFIFTSDHGMTDWGSHGAGHPSETLTPLVTWGAGIKYPQRVSAQQFDDAFLKEWRLENWKRLDVNQADIAPLMTSLIGVPFPLNSVGILPVDYLNNTDLFKAESMFTNAVQILEQFKVKMTQKKEVTLPFLFTPFKLLSDSKQFNILRKARSYIKHRKFDEVVSLCKELIHLALKGLSYYHTYDRFFLGVNVVIGFVGWISYASLLIIKSHSNLIKGVSKEVKKPSHLLPCSFVAIGILVAFFLLIQACPWTYYVYGLLPLPIWYAVLREFQVIQDLVVSVLTYPLSHFVGYLLAFTLGIEVLVLSFFYRYMLTAGLTAFAAWPFLTRLWTRAKMTSLSWTFFSLLLAVFPLMPVVGRKPDISLVMGAGLLVLLLSLCVVTSLMKRKDSFIKEELLVHLLQVLSTVLSMYVVYSTQSSLLRKQGLPLMNQIISWATLASSLVVPLLSSPVLFQRLFSILLSLMSTYLLLSTGYEALFPLVLSCLMFVWINIEQETLQQSGVCCKQKLTSIQFSYNTDITQFRQLYLDDIRRAFFLVFFLVTAFFGTGNIASINSFDLASVYCFLTVFSPFMMGALMMWKILIPFVLVMCAFEAVQLTTQLSSKSLFLIVLVISDIMALHFFFLVKDYGSWLDIGTSISHYVIVMSMTIFLVFLNGLAQLLTTKKLRLCGKPKSHFM | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 82 | Phosphorylation | NIIMHEGSWGISHTR HHHHCCCCCCCCCCC | 21.10 | 30177828 | |
| 86 | Phosphorylation | HEGSWGISHTRVPTE CCCCCCCCCCCCCCC | 18.18 | 30177828 | |
| 117 | Ubiquitination | SAVAKGWKENPVEFD HHHHCCCCCCCCCHH | 57.17 | - | |
| 128 | N-linked_Glycosylation | VEFDSLFNESKYTWS CCHHHHCCCCCCCCC | 58.90 | UniProtKB CARBOHYD | |
| 162 | Ubiquitination | YTYSYDAKREDFGAQ EEEEEECCCHHCCCC | 54.12 | - | |
| 173 | Ubiquitination | FGAQDATKLDTWVFD CCCCCCHHCCCCCCC | 46.19 | - | |
| 192 | N-linked_Glycosylation | FFHHARNNQSLFSKI HHHHHHCCCHHHHHC | 27.54 | UniProtKB CARBOHYD | |
| 197 | Phosphorylation | RNNQSLFSKINEEKI HCCCHHHHHCCHHHH | 37.61 | 24719451 | |
| 223 | Phosphorylation | NGHAHRPSSRDYKHN CCCCCCCCCHHHCCC | 37.65 | 22461510 | |
| 224 | Phosphorylation | GHAHRPSSRDYKHNI CCCCCCCCHHHCCCC | 31.67 | 22461510 | |
| 227 | Phosphorylation | HRPSSRDYKHNIKKV CCCCCHHHCCCCCCC | 17.03 | 22461510 | |
| 307 | Ubiquitination | QFDDAFLKEWRLENW HCCHHHHHHHHHHCC | 49.10 | - | |
| 350 | N-linked_Glycosylation | ILPVDYLNNTDLFKA EEECCCCCCCCCCCC | 43.03 | UniProtKB CARBOHYD | |
| 379 | Ubiquitination | KVKMTQKKEVTLPFL CCCCCCCCEEECCCC | 47.82 | - | |
| 391 | Ubiquitination | PFLFTPFKLLSDSKQ CCCCCCHHHCCCCHH | 50.12 | - | |
| 397 | Ubiquitination | FKLLSDSKQFNILRK HHHCCCCHHHHHHHH | 64.99 | - | |
| 404 | Methylation | KQFNILRKARSYIKH HHHHHHHHHHHHHHC | 44.71 | - | |
| 404 | Trimethylation | KQFNILRKARSYIKH HHHHHHHHHHHHHHC | 44.71 | - | |
| 419 | Phosphorylation | RKFDEVVSLCKELIH CCHHHHHHHHHHHHH | 32.97 | 25690035 | |
| 471 | Ubiquitination | KSHSNLIKGVSKEVK HHCCHHHHCCCCCCC | 57.32 | - | |
| 591 | Phosphorylation | LWTRAKMTSLSWTFF HHHHHHHHHHHHHHH | 26.30 | 22210691 | |
| 592 | Phosphorylation | WTRAKMTSLSWTFFS HHHHHHHHHHHHHHH | 19.53 | 22210691 | |
| 596 | Phosphorylation | KMTSLSWTFFSLLLA HHHHHHHHHHHHHHH | 16.07 | 22210691 | |
| 618 | Phosphorylation | VGRKPDISLVMGAGL CCCCCCHHHHHHHHH | 23.45 | 22210691 | |
| 636 | Phosphorylation | LLSLCVVTSLMKRKD HHHHHHHHHHHHCCC | 8.85 | 22210691 | |
| 637 | Phosphorylation | LSLCVVTSLMKRKDS HHHHHHHHHHHCCCC | 18.17 | 22210691 | |
| 644 | Phosphorylation | SLMKRKDSFIKEELL HHHHCCCCCCCHHHH | 31.72 | 24719451 | |
| 673 | Phosphorylation | VVYSTQSSLLRKQGL HHHHCHHHHHHHCCC | 22.93 | 24719451 | |
| 823 | Phosphorylation | YCFLTVFSPFMMGAL HHHHHHHCHHHHHHH | 16.94 | 26074081 | |
| 927 | Ubiquitination | LRLCGKPKSHFM--- HHHCCCCHHHCC--- | 61.11 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PIGN_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PIGN_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PIGN_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of PIGN_HUMAN !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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