TM164_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TM164_HUMAN
• UniProt AC: Q5U3C3
• Protein Name: Transmembrane protein 164
• Gene Name: TMEM164
• Organism: Homo sapiens (Human).
• Sequence Length: 297
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Sequence: MSRYSYQSLLDWLYGGVDPSFAGNGGPDCAAFLSWQQRLLESVVVLTLALLEILVALRHILRQTKEDGRGSPGSQPEQVTQRPEEGKESLSKNLLLVALCLTFGVEVGFKFATKTVIYLLNPCHLVTMMHIFLLACPPCRGAIVVFKLQMHMLNGALLALLFPVVNTRLLPFELEIYYIQHVMLYVVPIYLLWKGGAYTPEPLSSFRWALLSTGLMFFYHFSVLQILGLVTEVNLNNMLCPAISDPFYGPWYRIWASGHQTLMTMTHGKLVILFSYMAGPLCKYLLDLLRLPAKKID

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
34	Phosphorylation	PDCAAFLSWQQRLLE CCHHHHHHHHHHHHH	19.18	-
64	Phosphorylation	LRHILRQTKEDGRGS HHHHHHHHCCCCCCC	29.93	22817900
71	Phosphorylation	TKEDGRGSPGSQPEQ HCCCCCCCCCCCCCH	25.40	29255136
74	Phosphorylation	DGRGSPGSQPEQVTQ CCCCCCCCCCCHHHC	46.04	25849741
80	Phosphorylation	GSQPEQVTQRPEEGK CCCCCHHHCCCHHHH	20.68	22817900
87	Ubiquitination	TQRPEEGKESLSKNL HCCCHHHHHHHHHHH	47.62	29901268

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TM164_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TM164_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TM164_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of TM164_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle.";
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.;
Mol. Cell 31:438-448(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-71, AND MASSSPECTROMETRY.
PubMed: 18691976