HDHD1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HDHD1_HUMAN
• UniProt AC: Q08623
• Protein Name: Pseudouridine-5'-phosphatase {ECO:0000312|HGNC:HGNC:16818}
• Gene Name: PUDP {ECO:0000312|HGNC:HGNC:16818}
• Organism: Homo sapiens (Human).
• Sequence Length: 228
• Protein Description: Dephosphorylates pseudouridine 5'-phosphate, a potential intermediate in rRNA degradation. Pseudouridine is then excreted intact in urine..
• Protein Sequence: MAAPPQPVTHLIFDMDGLLLDTERLYSVVFQEICNRYDKKYSWDVKSLVMGKKALEAAQIIIDVLQLPMSKEELVEESQTKLKEVFPTAALMPGAEKLIIHLRKHGIPFALATSSGSASFDMKTSRHKEFFSLFSHIVLGDDPEVQHGKPDPDIFLACAKRFSPPPAMEKCLVFEDAPNGVEAALAAGMQVVMVPDGNLSRDLTTKATLVLNSLQDFQPELFGLPSYE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
26	Phosphorylation	LLDTERLYSVVFQEI EECHHHHHHHHHHHH	12.97	24927040
27	Phosphorylation	LDTERLYSVVFQEIC ECHHHHHHHHHHHHH	19.18	20068231
53	Ubiquitination	KSLVMGKKALEAAQI HHHHHCHHHHHHHHH	53.10	-
83	Acetylation	EESQTKLKEVFPTAA HHHHHHHHHHCCHHH	54.08	26051181
106 (in isoform 4)	Malonylation	-	32.09	32601280
113	Phosphorylation	GIPFALATSSGSASF CCCEEEECCCCCCCC	25.03	27251275
114	Phosphorylation	IPFALATSSGSASFD CCEEEECCCCCCCCC	27.39	27251275
115	Phosphorylation	PFALATSSGSASFDM CEEEECCCCCCCCCC	32.20	27251275
117	Phosphorylation	ALATSSGSASFDMKT EEECCCCCCCCCCCC	23.76	27251275
119	Phosphorylation	ATSSGSASFDMKTSR ECCCCCCCCCCCCCC	24.39	26437602
120	Phosphorylation	TSSGSASFDMKTSRH CCCCCCCCCCCCCCC	12.14	32142685
137	Phosphorylation	FFSLFSHIVLGDDPE HHHHHHHHHHCCCHH	2.37	27251275
163	Phosphorylation	LACAKRFSPPPAMEK HHHHHHCCCCCHHHH	40.30	32142685
171 (in isoform 3)	Phosphorylation	-	2.20	22210691
172 (in isoform 3)	Phosphorylation	-	7.97	22210691
186	Phosphorylation	NGVEAALAAGMQVVM CHHHHHHHCCCEEEE	9.39	32142685

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HDHD1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HDHD1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HDHD1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CNDP2_HUMAN	CNDP2	physical	26344197
NANP_HUMAN	NANP	physical	26344197
DHPR_HUMAN	QDPR	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.