PDPR_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PDPR_HUMAN
• UniProt AC: Q8NCN5
• Protein Name: Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial
• Gene Name: PDPR
• Organism: Homo sapiens (Human).
• Sequence Length: 879
• Subcellular Localization: Mitochondrion matrix.
• Protein Description: Decreases the sensitivity of PDP1 to magnesium ions, and this inhibition is reversed by the polyamine spermine..
• Protein Sequence: MMFYRLLSIVGRQRASPGWQNWSSARNSTSAAEARSMALPTQAQVVICGGGITGTSVAYHLSKMGWKDIVLLEQGRLAAGSTRFCAGILSTARHLTIEQKMADYSNKLYYQLEQETGIQTGYTRTGSIFLAQTQDRLISLKRINAGLNVIGIPSEIISPKKVAELHHLLNVHDLVGAMHVPEDAVVSSADVALALASAASQNGVQIYDRTSVLHVMVKKGQVTGVETDKGQIECQYFVNCAGQWAYELGLSNEEPVSIPLHACEHFYLLTRPLETPLQSSTPTIVDADGRIYIRNWQGGILSGGFEKNPKPIFTEGKNQLEIQNLQEDWDHFEPLLSSLLRRMPELETLEIMKLVNCPETFTPDMRCIMGESPAVQGYFVLAGMNSAGLSFGGGAGKYLAEWMVHGYPSENVWELDLKRFGALQSSRTFLRHRVMEVMPLMYDLKVPRWDFQTGRQLRTSPLYDRLDAQGARWMEKHGFERPKYFVPPDKDLLALEQSKTFYKPDWFDIVESEVKCCKEAVCVIDMSSFTKFEITSTGDQALEVLQYLFSNDLDVPVGHIVHTGMLNEGGGYENDCSIARLNKRSFFMISPTDQQVHCWAWLKKHMPKDSNLLLEDVTWKYTALNLIGPRAVDVLSELSYAPMTPDHFPSLFCKEMSVGYANGIRVMSMTHTGEPGFMLYIPIEYALHVYNEVMSVGQKYGIRNAGYYALRSLRIEKFFAFWGQDINNLTTPLECGRESRVKLEKGMDFIGRDALLQQKQNGVYKRLTMFILDDHDSDLDLWPWWGEPIYRNGQYVGKTTSSAYSYSLERHVCLGFVHNFSEDTGEEQVVTADFINRGEYEIDIAGYRFQAKAKLYPVASLFTQKRRKDDMELSDLHGK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MMFYRLLSIVG ----CCHHHHHHHHC	5.18	-
8	Phosphorylation	MMFYRLLSIVGRQRA CCHHHHHHHHCCCCC	21.59	24043423
36	Phosphorylation	TSAAEARSMALPTQA CCHHHHHHCCCCCCC	18.56	-
41	Phosphorylation	ARSMALPTQAQVVIC HHHCCCCCCCEEEEE	37.07	-
100	Acetylation	RHLTIEQKMADYSNK HHCCHHHHHHHHCCC	24.22	25038526
100	Ubiquitination	RHLTIEQKMADYSNK HHCCHHHHHHHHCCC	24.22	21890473
104	Phosphorylation	IEQKMADYSNKLYYQ HHHHHHHHCCCHHHH	12.47	-
109	Phosphorylation	ADYSNKLYYQLEQET HHHCCCHHHHHHHHH	7.26	-
110	Phosphorylation	DYSNKLYYQLEQETG HHCCCHHHHHHHHHC	19.63	-
122	Phosphorylation	ETGIQTGYTRTGSIF HHCCCCCCCCCCEEE	9.09	-
136	Methylation	FLAQTQDRLISLKRI EEEECHHHHHHHHHH	24.89	115486923
139	Phosphorylation	QTQDRLISLKRINAG ECHHHHHHHHHHCCC	32.22	24719451
154	Phosphorylation	LNVIGIPSEIISPKK CCEEECCHHHCCHHH	39.23	28122231
158	Phosphorylation	GIPSEIISPKKVAEL ECCHHHCCHHHHHHH	36.01	24719451
160	Ubiquitination	PSEIISPKKVAELHH CHHHCCHHHHHHHHH	53.76	-
160	Acetylation	PSEIISPKKVAELHH CHHHCCHHHHHHHHH	53.76	30591207
161	Ubiquitination	SEIISPKKVAELHHL HHHCCHHHHHHHHHH	50.49	-
161	Acetylation	SEIISPKKVAELHHL HHHCCHHHHHHHHHH	50.49	30591201
210	Ubiquitination	GVQIYDRTSVLHVMV CCEEEECCCEEEEEE	21.93	21906983
223	Phosphorylation	MVKKGQVTGVETDKG EEECCCEEEEECCCC	27.85	-
302	Phosphorylation	NWQGGILSGGFEKNP CCCCCCCCCCCCCCC	34.64	21406692
310	Ubiquitination	GGFEKNPKPIFTEGK CCCCCCCCCCCCCCC	61.20	-
338	Phosphorylation	HFEPLLSSLLRRMPE HHHHHHHHHHHHCCC	31.24	24719451
442	Phosphorylation	MEVMPLMYDLKVPRW HHHHHHHCCCCCCCC	26.30	25147952
445	Ubiquitination	MPLMYDLKVPRWDFQ HHHHCCCCCCCCCCC	47.50	-
448	Methylation	MYDLKVPRWDFQTGR HCCCCCCCCCCCCCC	48.89	115486935
465	Methylation	RTSPLYDRLDAQGAR CCCCCHHHHHHHHHH	22.40	115486929
483	Ubiquitination	KHGFERPKYFVPPDK HCCCCCCCCCCCCCH	58.50	-
484	Phosphorylation	HGFERPKYFVPPDKD CCCCCCCCCCCCCHH	16.70	20068231
490	Ubiquitination	KYFVPPDKDLLALEQ CCCCCCCHHHHHHHH	56.92	-
498	Phosphorylation	DLLALEQSKTFYKPD HHHHHHHCCCCCCCC	25.04	21406692
502	Phosphorylation	LEQSKTFYKPDWFDI HHHCCCCCCCCHHHH	27.17	-
503	Ubiquitination	EQSKTFYKPDWFDIV HHCCCCCCCCHHHHH	32.10	-
528	Phosphorylation	VCVIDMSSFTKFEIT EEEEECCCCCEEEEE	30.23	24719451
610	Phosphorylation	KKHMPKDSNLLLEDV HHHCCCCCCEECCHH	35.19	21964256
621	Phosphorylation	LEDVTWKYTALNLIG CCHHHHHHHHHHHHC	6.71	24114839
630	Methylation	ALNLIGPRAVDVLSE HHHHHCHHHHHHHHH	41.87	115486941
644	Phosphorylation	ELSYAPMTPDHFPSL HHCCCCCCCCCCCCC	25.22	27273156
657	Phosphorylation	SLFCKEMSVGYANGI CCCCCCCCCCCCCCE	17.30	20068231
660	Phosphorylation	CKEMSVGYANGIRVM CCCCCCCCCCCEEEE	8.50	20068231
712	Phosphorylation	AGYYALRSLRIEKFF HHHHHHHHCCEEEEE	23.89	26670566
739	Phosphorylation	PLECGRESRVKLEKG CCCCCCHHHHHCCCC	40.80	-
745	2-Hydroxyisobutyrylation	ESRVKLEKGMDFIGR HHHHHCCCCCCCCCH	70.71	-
745	Ubiquitination	ESRVKLEKGMDFIGR HHHHHCCCCCCCCCH	70.71	-
759	Ubiquitination	RDALLQQKQNGVYKR HHHHHHHHHCCCCCE	32.54	-
759	Acetylation	RDALLQQKQNGVYKR HHHHHHHHHCCCCCE	32.54	23236377
765	Ubiquitination	QKQNGVYKRLTMFIL HHHCCCCCEEEEEEE	38.23	-
798	Ubiquitination	RNGQYVGKTTSSAYS ECCEEECEECCCCCC	38.29	-
801	Phosphorylation	QYVGKTTSSAYSYSL EEECEECCCCCCCCC	20.43	28152594
802	Phosphorylation	YVGKTTSSAYSYSLE EECEECCCCCCCCCH	29.18	28152594
804	Phosphorylation	GKTTSSAYSYSLERH CEECCCCCCCCCHHC	15.30	28152594
805	Phosphorylation	KTTSSAYSYSLERHV EECCCCCCCCCHHCE	14.15	28152594
806	Phosphorylation	TTSSAYSYSLERHVC ECCCCCCCCCHHCEE	12.47	28152594
807	Phosphorylation	TSSAYSYSLERHVCL CCCCCCCCCHHCEEE	20.15	28152594
840	Phosphorylation	DFINRGEYEIDIAGY EEEECCEEEEEECEE	22.47	-
854	Succinylation	YRFQAKAKLYPVASL EEEEEECEEHHHHHH	48.09	23954790
854	Acetylation	YRFQAKAKLYPVASL EEEEEECEEHHHHHH	48.09	25953088
865	Ubiquitination	VASLFTQKRRKDDME HHHHHCHHHCCCCCC	51.63	2190698

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PDPR_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PDPR_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PDPR_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of PDPR_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.