SPRY4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SPRY4_HUMAN
• UniProt AC: Q8WW59
• Protein Name: SPRY domain-containing protein 4
• Gene Name: SPRYD4
• Organism: Homo sapiens (Human).
• Sequence Length: 207
• Protein Sequence: MALLFARSLRLCRWGAKRLGVASTEAQRGVSFKLEEKTAHSSLALFRDDMGVKYGLVGLEPTKVALNVERFREWAVVLADTAVTSGRHYWEVTVKRSQQFRIGVADVDMSRDSCIGVDDRSWVFTYAQRKWYTMLANEKAPVEGIGQPEKVGLLLEYEAQKLSLVDVSQVSVVHTLQTDFRGPVVPAFALWDGELLTHSGLEVPEGL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
23	O-linked_Glycosylation	AKRLGVASTEAQRGV HHHHCCCCCHHHHCC	25.11	28510447
23	Phosphorylation	AKRLGVASTEAQRGV HHHHCCCCCHHHHCC	25.11	29083192
24	Phosphorylation	KRLGVASTEAQRGVS HHHCCCCCHHHHCCC	26.13	29083192
53	Acetylation	FRDDMGVKYGLVGLE HCCCCCCCEEEECCC	28.07	-
95	Acetylation	HYWEVTVKRSQQFRI EEEEEEEEECCCEEE	36.65	19608861
125	Phosphorylation	DDRSWVFTYAQRKWY CCCCEEEEEHHHHHH	14.34	23401153
126	Phosphorylation	DRSWVFTYAQRKWYT CCCEEEEEHHHHHHH	6.83	23401153
130	Acetylation	VFTYAQRKWYTMLAN EEEEHHHHHHHHHHC	32.26	19608861
139	Acetylation	YTMLANEKAPVEGIG HHHHHCCCCCCCCCC	58.77	23954790
139	Succinylation	YTMLANEKAPVEGIG HHHHHCCCCCCCCCC	58.77	-
139	Succinylation	YTMLANEKAPVEGIG HHHHHCCCCCCCCCC	58.77	-
150	Acetylation	EGIGQPEKVGLLLEY CCCCCHHHEEEEEEE	48.57	23954790
168	Phosphorylation	KLSLVDVSQVSVVHT ECCCCCHHHCEEEEE	22.02	30257219
171	Phosphorylation	LVDVSQVSVVHTLQT CCCHHHCEEEEECCC	15.70	30257219
175	Phosphorylation	SQVSVVHTLQTDFRG HHCEEEEECCCCCCC	14.67	30257219

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SPRY4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SPRY4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SPRY4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SPRY4_HUMAN	SPRYD4	physical	27499296
HOGA1_HUMAN	HOGA1	physical	27499296
IDE_HUMAN	IDE	physical	27499296
G6PI_HUMAN	GPI	physical	27499296
MPPB_HUMAN	PMPCB	physical	27499296
MPPA_HUMAN	PMPCA	physical	27499296
ECH1_HUMAN	ECH1	physical	27499296
ODBA_HUMAN	BCKDHA	physical	27499296
USMG5_HUMAN	USMG5	physical	27499296
ATP5I_HUMAN	ATP5I	physical	27499296
ATPG_HUMAN	ATP5C1	physical	27499296
CHCH2_HUMAN	CHCHD2	physical	27499296

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-95 AND LYS-130, AND MASSSPECTROMETRY.
PubMed: 19608861