HOGA1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HOGA1_HUMAN
• UniProt AC: Q86XE5
• Protein Name: 4-hydroxy-2-oxoglutarate aldolase, mitochondrial
• Gene Name: HOGA1
• Organism: Homo sapiens (Human).
• Sequence Length: 327
• Subcellular Localization: Mitochondrion .
• Protein Description: Catalyzes the final step in the metabolic pathway of hydroxyproline..
• Protein Sequence: MLGPQVWSSVRQGLSRSLSRNVGVWASGEGKKVDIAGIYPPVTTPFTATAEVDYGKLEENLHKLGTFPFRGFVVQGSNGEFPFLTSSERLEVVSRVRQAMPKNRLLLAGSGCESTQATVEMTVSMAQVGADAAMVVTPCYYRGRMSSAALIHHYTKVADLSPIPVVLYSVPANTGLDLPVDAVVTLSQHPNIVGMKDSGGDVTRIGLIVHKTRKQDFQVLAGSAGFLMASYALGAVGGVCALANVLGAQVCQLERLCCTGQWEDAQKLQHRLIEPNAAVTRRFGIPGLKKIMDWFGYYGGPCRAPLQELSPAEEEALRMDFTSNGWL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Phosphorylation	SSVRQGLSRSLSRNV HHHHHHHHHHHHHCC	27.01	17081983
17	Phosphorylation	VRQGLSRSLSRNVGV HHHHHHHHHHHCCEE	27.59	17081983
47	Phosphorylation	PPVTTPFTATAEVDY CCCCCCCEEEEECCC	25.05	19369195
77	Phosphorylation	RGFVVQGSNGEFPFL CEEEEECCCCCCCCC	25.27	28857561
154	Phosphorylation	SAALIHHYTKVADLS HHHHHCHHHCCCCCC	8.29	24260401
155	Phosphorylation	AALIHHYTKVADLSP HHHHCHHHCCCCCCC	18.06	24260401
280	Phosphorylation	IEPNAAVTRRFGIPG HCCCHHHHHHHCCCH	16.05	28857561
322	Phosphorylation	EALRMDFTSNGWL-- HHHHCCCCCCCCC--	19.61	24114839

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HOGA1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HOGA1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HOGA1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBP47_HUMAN	USP47	physical	26186194
LYRM7_HUMAN	LYRM7	physical	26186194
HOGA1_HUMAN	HOGA1	physical	27499296
ECH1_HUMAN	ECH1	physical	27499296
C1QBP_HUMAN	C1QBP	physical	27499296
RCC1L_HUMAN	WBSCR16	physical	27499296
UBP47_HUMAN	USP47	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.