dbPTM

UBP47_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	UBP47_HUMAN
UniProt AC	Q96K76
Protein Name	Ubiquitin carboxyl-terminal hydrolase 47
Gene Name	USP47
Organism	Homo sapiens (Human).
Sequence Length	1375
Subcellular Localization	Cytoplasm .
Protein Description	Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizing POLB thereby playing a role in base-excision repair (BER). Acts as a regulator of cell growth and genome integrity. May also indirectly regulate CDC25A expression at a transcriptional level..
Protein Sequence	MVPGEENQLVPKEDVFWRCRQNIFDEMKKKFLQIENAAEEPRVLCIIQDTTNSKTVNERITLNLPASTPVRKLFEDVANKVGYINGTFDLVWGNGINTADMAPLDHTSDKSLLDANFEPGKKNFLHLTDKDGEQPQILLEDSSAGEDSVHDRFIGPLPREGSGGSTSDYVSQSYSYSSILNKSETGYVGLVNQAMTCYLNSLLQTLFMTPEFRNALYKWEFEESEEDPVTSIPYQLQRLFVLLQTSKKRAIETTDVTRSFGWDSSEAWQQHDVQELCRVMFDALEQKWKQTEQADLINELYQGKLKDYVRCLECGYEGWRIDTYLDIPLVIRPYGSSQAFASVEEALHAFIQPEILDGPNQYFCERCKKKCDARKGLRFLHFPYLLTLQLKRFDFDYTTMHRIKLNDRMTFPEELDMSTFIDVEDEKSPQTESCTDSGAENEGSCHSDQMSNDFSNDDGVDEGICLETNSGTEKISKSGLEKNSLIYELFSVMVHSGSAAGGHYYACIKSFSDEQWYSFNDQHVSRITQEDIKKTHGGSSGSRGYYSSAFASSTNAYMLIYRLKDPARNAKFLEVDEYPEHIKNLVQKERELEEQEKRQREIERNTCKIKLFCLHPTKQVMMENKLEVHKDKTLKEAVEMAYKMMDLEEVIPLDCCRLVKYDEFHDYLERSYEGEEDTPMGLLLGGVKSTYMFDLLLETRKPDQVFQSYKPGEVMVKVHVVDLKAESVAAPITVRAYLNQTVTEFKQLISKAIHLPAETMRIVLERCYNDLRLLSVSSKTLKAEGFFRSNKVFVESSETLDYQMAFADSHLWKLLDRHANTIRLFVLLPEQSPVSYSKRTAYQKAGGDSGNVDDDCERVKGPVGSLKSVEAILEESTEKLKSLSLQQQQDGDNGDSSKSTETSDFENIESPLNERDSSASVDNRELEQHIQTSDPENFQSEERSDSDVNNDRSTSSVDSDILSSSHSSDTLCNADNAQIPLANGLDSHSITSSRRTKANEGKKETWDTAEEDSGTDSEYDESGKSRGEMQYMYFKAEPYAADEGSGEGHKWLMVHVDKRITLAAFKQHLEPFVGVLSSHFKVFRVYASNQEFESVRLNETLSSFSDDNKITIRLGRALKKGEYRVKVYQLLVNEQEPCKFLLDAVFAKGMTVRQSKEELIPQLREQCGLELSIDRFRLRKKTWKNPGTVFLDYHIYEEDINISSNWEVFLEVLDGVEKMKSMSQLAVLSRRWKPSEMKLDPFQEVVLESSSVDELREKLSEISGIPLDDIEFAKGRGTFPCDISVLDIHQDLDWNPKVSTLNVWPLYICDDGAVIFYRDKTEELMELTDEQRNELMKKESSRLQKTGHRVTYSPRKEKALKIYLDGAPNKDLTQD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
34	Ubiquitination	MKKKFLQIENAAEEP HHHHHHHHHCCCCCC	4.85	21890473
34	Acetylation	MKKKFLQIENAAEEP HHHHHHHHHCCCCCC	4.85	19608861
34	Ubiquitination	MKKKFLQIENAAEEP HHHHHHHHHCCCCCC	4.85	19608861
34 (in isoform 2)	Acetylation	-	4.85	-
34 (in isoform 2)	Ubiquitination	-	4.85	21890473
54 (in isoform 2)	Phosphorylation	-	59.57	24719451
55 (in isoform 2)	Phosphorylation	-	28.52	27251275
67	Phosphorylation	ITLNLPASTPVRKLF EEECCCCCCHHHHHH	31.16	26270265
68	Phosphorylation	TLNLPASTPVRKLFE EECCCCCCHHHHHHH	28.10	25159151
77 (in isoform 2)	Phosphorylation	-	5.07	27251275
101	Ubiquitination	NGINTADMAPLDHTS CCCCHHCCCCCCCCC	3.72	-
102	Acetylation	GINTADMAPLDHTSD CCCHHCCCCCCCCCC	11.31	-
102	Ubiquitination	GINTADMAPLDHTSD CCCHHCCCCCCCCCC	11.31	-
102	Acetylation	GINTADMAPLDHTSD CCCHHCCCCCCCCCC	11.31	19608861
102	Ubiquitination	GINTADMAPLDHTSD CCCHHCCCCCCCCCC	11.31	19608861
111	Phosphorylation	LDHTSDKSLLDANFE CCCCCCHHHHHCCCC	38.87	28555341
121	Acetylation	DANFEPGKKNFLHLT HCCCCCCCCCEEEEE	56.08	25953088
122	Acetylation	ANFEPGKKNFLHLTD CCCCCCCCCEEEEEC	59.87	19608861
122	Phosphorylation	ANFEPGKKNFLHLTD CCCCCCCCCEEEEEC	59.87	-
122	Ubiquitination	ANFEPGKKNFLHLTD CCCCCCCCCEEEEEC	59.87	21890473
122 (in isoform 1)	Ubiquitination	-	59.87	21890473
123	Phosphorylation	NFEPGKKNFLHLTDK CCCCCCCCEEEEECC	48.47	-
128	Phosphorylation	KKNFLHLTDKDGEQP CCCEEEEECCCCCCC	30.20	29978859
130	Ubiquitination	NFLHLTDKDGEQPQI CEEEEECCCCCCCEE	63.50	-
136 (in isoform 2)	Phosphorylation	-	38.36	24719451
142	Phosphorylation	PQILLEDSSAGEDSV CEEEEECCCCCCCCC	16.83	23401153
143	Phosphorylation	QILLEDSSAGEDSVH EEEEECCCCCCCCCC	53.25	25159151
146 (in isoform 2)	Phosphorylation	-	46.99	24719451
148	Phosphorylation	DSSAGEDSVHDRFIG CCCCCCCCCCCCCCC	19.63	23663014
162	Phosphorylation	GPLPREGSGGSTSDY CCCCCCCCCCCHHHH	34.92	28857561
165	Phosphorylation	PREGSGGSTSDYVSQ CCCCCCCCHHHHCCC	28.41	18669648
166	Phosphorylation	REGSGGSTSDYVSQS CCCCCCCHHHHCCCC	28.97	28857561
167	Phosphorylation	EGSGGSTSDYVSQSY CCCCCCHHHHCCCCE	28.74	28857561
169	Phosphorylation	SGGSTSDYVSQSYSY CCCCHHHHCCCCEEC	11.19	-
174	Phosphorylation	SDYVSQSYSYSSILN HHHCCCCEECHHHCC	12.18	-
176	Phosphorylation	YVSQSYSYSSILNKS HCCCCEECHHHCCCC	9.75	-
178	Phosphorylation	SQSYSYSSILNKSET CCCEECHHHCCCCCC	23.90	24719451
183	Phosphorylation	YSSILNKSETGYVGL CHHHCCCCCCCCHHH	39.04	24043423
185	Phosphorylation	SILNKSETGYVGLVN HHCCCCCCCCHHHHH	40.69	24043423
187	Phosphorylation	LNKSETGYVGLVNQA CCCCCCCCHHHHHHH	9.96	24043423
196	Phosphorylation	GLVNQAMTCYLNSLL HHHHHHHHHHHHHHH	10.87	24043423
198	Phosphorylation	VNQAMTCYLNSLLQT HHHHHHHHHHHHHHH	10.35	24043423
199	Ubiquitination	NQAMTCYLNSLLQTL HHHHHHHHHHHHHHH	3.69	21890473
199 (in isoform 2)	Ubiquitination	-	3.69	21890473
201	Phosphorylation	AMTCYLNSLLQTLFM HHHHHHHHHHHHHHC	28.06	24043423
205	Phosphorylation	YLNSLLQTLFMTPEF HHHHHHHHHHCCHHH	23.18	24043423
209	Phosphorylation	LLQTLFMTPEFRNAL HHHHHHCCHHHHHHH	16.60	24043423
214	Phosphorylation	FMTPEFRNALYKWEF HCCHHHHHHHHHEEC	39.35	-
224	Phosphorylation	YKWEFEESEEDPVTS HHEECCCCCCCCCCC	38.80	24719451
234	Phosphorylation	DPVTSIPYQLQRLFV CCCCCHHHHHHHHHH	21.86	24719451
267	Ubiquitination	FGWDSSEAWQQHDVQ CCCCCHHHHHHHCHH	16.01	-
267	Ubiquitination	FGWDSSEAWQQHDVQ CCCCCHHHHHHHCHH	16.01	-
269	Ubiquitination	WDSSEAWQQHDVQEL CCCHHHHHHHCHHHH	37.47	-
269	Ubiquitination	WDSSEAWQQHDVQEL CCCHHHHHHHCHHHH	37.47	-
284	Ubiquitination	CRVMFDALEQKWKQT HHHHHHHHHHHHHHH	8.46	-
287	Ubiquitination	MFDALEQKWKQTEQA HHHHHHHHHHHHHHH	47.16	21890473
287 (in isoform 1)	Ubiquitination	-	47.16	21890473
289	Ubiquitination	DALEQKWKQTEQADL HHHHHHHHHHHHHHH	55.14	-
304	Ubiquitination	INELYQGKLKDYVRC HHHHHHCCHHHHHHH	36.52	-
323	Phosphorylation	YEGWRIDTYLDIPLV CCCEEEEEEEECCEE	24.50	29978859
324	Phosphorylation	EGWRIDTYLDIPLVI CCEEEEEEEECCEEE	9.91	29978859
384	Phosphorylation	LRFLHFPYLLTLQLK CHHHCHHHHEEEECC	17.25	-
387	Phosphorylation	LHFPYLLTLQLKRFD HCHHHHEEEECCCCC	15.18	-
397	Phosphorylation	LKRFDFDYTTMHRIK CCCCCCCCCEEEEEE	12.24	-
398	Phosphorylation	KRFDFDYTTMHRIKL CCCCCCCCEEEEEEC	21.35	-
399	Phosphorylation	RFDFDYTTMHRIKLN CCCCCCCEEEEEECC	12.54	-
404	Acetylation	YTTMHRIKLNDRMTF CCEEEEEECCCCCCC	40.99	7932683
435	Phosphorylation	SPQTESCTDSGAENE CCCCCCCCCCCCCCC	42.34	28348404
437	Phosphorylation	QTESCTDSGAENEGS CCCCCCCCCCCCCCC	23.04	28348404
440 (in isoform 2)	Phosphorylation	-	60.38	-
444	Phosphorylation	SGAENEGSCHSDQMS CCCCCCCCCCCHHCC	11.50	28348404
447	Phosphorylation	ENEGSCHSDQMSNDF CCCCCCCCHHCCCCC	33.59	28348404
451	Phosphorylation	SCHSDQMSNDFSNDD CCCCHHCCCCCCCCC	27.84	28348404
455	Phosphorylation	DQMSNDFSNDDGVDE HHCCCCCCCCCCCCC	42.06	28348404
457	Ubiquitination	MSNDFSNDDGVDEGI CCCCCCCCCCCCCCC	53.49	-
487	Phosphorylation	LEKNSLIYELFSVMV CCCCCHHHHHHHHHH	16.33	-
504	Phosphorylation	GSAAGGHYYACIKSF CCCCCCEEEEEEEEC	8.95	-
505	Phosphorylation	SAAGGHYYACIKSFS CCCCCEEEEEEEECC	6.85	-
508	Phosphorylation	GGHYYACIKSFSDEQ CCEEEEEEEECCCHH	2.97	19664994
513	Ubiquitination	ACIKSFSDEQWYSFN EEEEECCCHHCCCCC	50.53	-
528	Phosphorylation	DQHVSRITQEDIKKT HHHHHHCCHHHHHHH	25.46	19664994
533	Ubiquitination	RITQEDIKKTHGGSS HCCHHHHHHHCCCCC	65.03	-
535	Phosphorylation	TQEDIKKTHGGSSGS CHHHHHHHCCCCCCC	22.28	-
539	Phosphorylation	IKKTHGGSSGSRGYY HHHHCCCCCCCCCCC	35.80	-
540	Phosphorylation	KKTHGGSSGSRGYYS HHHCCCCCCCCCCCH	44.02	30576142
546	Phosphorylation	SSGSRGYYSSAFASS CCCCCCCCHHCCCCC	10.04	18083107
547	Phosphorylation	SGSRGYYSSAFASST CCCCCCCHHCCCCCC	13.50	30576142
548	Phosphorylation	GSRGYYSSAFASSTN CCCCCCHHCCCCCCC	15.98	30576142
551	Ubiquitination	GYYSSAFASSTNAYM CCCHHCCCCCCCEEE	11.42	-
551	Ubiquitination	GYYSSAFASSTNAYM CCCHHCCCCCCCEEE	11.42	-
557	Phosphorylation	FASSTNAYMLIYRLK CCCCCCEEEEEEEEC	8.43	18083107
561	Phosphorylation	TNAYMLIYRLKDPAR CCEEEEEEEECCHHH	13.11	18083107
563	Ubiquitination	AYMLIYRLKDPARNA EEEEEEEECCHHHCC	4.07	-
568	Ubiquitination	YRLKDPARNAKFLEV EEECCHHHCCCEEEH	49.37	-
571	Ubiquitination	KDPARNAKFLEVDEY CCHHHCCCEEEHHHC	54.77	-
572	Ubiquitination	DPARNAKFLEVDEYP CHHHCCCEEEHHHCH	6.99	21890473
572 (in isoform 2)	Ubiquitination	-	6.99	21890473
590	Ubiquitination	KNLVQKERELEEQEK HHHHHHHHHHHHHHH	61.92	-
598	Ubiquitination	ELEEQEKRQREIERN HHHHHHHHHHHHHHH	39.78	-
610	Acetylation	ERNTCKIKLFCLHPT HHHHCEEEEEECCCC	22.47	25953088
618	Acetylation	LFCLHPTKQVMMENK EEECCCCHHHHHHCC	45.40	25953088
640	Ubiquitination	TLKEAVEMAYKMMDL HHHHHHHHHHHHCCH	3.87	-
640	Ubiquitination	TLKEAVEMAYKMMDL HHHHHHHHHHHHCCH	3.87	-
660	Acetylation	LDCCRLVKYDEFHDY CCHHHEEEHHHHHHH	52.13	25953088
660	Ubiquitination	LDCCRLVKYDEFHDY CCHHHEEEHHHHHHH	52.13	21890473
660 (in isoform 1)	Ubiquitination	-	52.13	21890473
661	Phosphorylation	DCCRLVKYDEFHDYL CHHHEEEHHHHHHHH	17.15	28851738
662 (in isoform 2)	Phosphorylation	-	46.50	24719451
689	Phosphorylation	LLLGGVKSTYMFDLL HCCCCCCHHHHHHHH	23.51	22210691
689 (in isoform 2)	Phosphorylation	-	23.51	24719451
690	Phosphorylation	LLGGVKSTYMFDLLL CCCCCCHHHHHHHHH	17.18	22210691
690 (in isoform 2)	Phosphorylation	-	17.18	24719451
691	Phosphorylation	LGGVKSTYMFDLLLE CCCCCHHHHHHHHHC	11.68	22210691
704	Ubiquitination	LETRKPDQVFQSYKP HCCCCCCCCCCCCCC	46.59	-
704	Ubiquitination	LETRKPDQVFQSYKP HCCCCCCCCCCCCCC	46.59	-
708	Phosphorylation	KPDQVFQSYKPGEVM CCCCCCCCCCCCCEE	24.53	22210691
710	Acetylation	DQVFQSYKPGEVMVK CCCCCCCCCCCEEEE	52.36	25953088
724	Ubiquitination	KVHVVDLKAESVAAP EEEEEECCCCCCCCC	45.72	-
727	Phosphorylation	VVDLKAESVAAPITV EEECCCCCCCCCHHH	23.16	21406692
733	Phosphorylation	ESVAAPITVRAYLNQ CCCCCCHHHHHHHCC	11.68	21406692
743	Phosphorylation	AYLNQTVTEFKQLIS HHHCCHHHHHHHHHH	38.81	-
744 (in isoform 2)	Phosphorylation	-	46.65	24719451
747 (in isoform 2)	Phosphorylation	-	49.72	27251275
748 (in isoform 2)	Phosphorylation	-	5.00	-
750	Phosphorylation	TEFKQLISKAIHLPA HHHHHHHHHHHCCCH	25.32	24719451
762	Ubiquitination	LPAETMRIVLERCYN CCHHHHHHHHHHHHC	2.62	-
762	Ubiquitination	LPAETMRIVLERCYN CCHHHHHHHHHHHHC	2.62	-
777	Phosphorylation	DLRLLSVSSKTLKAE CHHHEEEECCCCCEE	23.81	24719451
777 (in isoform 2)	Phosphorylation	-	23.81	24719451
778	Phosphorylation	LRLLSVSSKTLKAEG HHHEEEECCCCCEEC	27.75	24719451
779	Acetylation	RLLSVSSKTLKAEGF HHEEEECCCCCEECC	50.82	25953088
780	Phosphorylation	LLSVSSKTLKAEGFF HEEEECCCCCEECCC	35.12	-
780 (in isoform 2)	Phosphorylation	-	35.12	27251275
782	Acetylation	SVSSKTLKAEGFFRS EEECCCCCEECCCCC	50.01	25953088
782	Malonylation	SVSSKTLKAEGFFRS EEECCCCCEECCCCC	50.01	26320211
782	Ubiquitination	SVSSKTLKAEGFFRS EEECCCCCEECCCCC	50.01	-
788 (in isoform 2)	Phosphorylation	-	36.74	27251275
789 (in isoform 2)	Phosphorylation	-	35.53	-
797	Methylation	NKVFVESSETLDYQM CCEEEECCCCCCHHH	22.54	-
808 (in isoform 2)	Phosphorylation	-	30.09	27251275
812	Phosphorylation	AFADSHLWKLLDRHA HHCHHHHHHHHHHHC	5.48	20068231
815	Phosphorylation	DSHLWKLLDRHANTI HHHHHHHHHHHCCEE	4.89	18669648
815 (in isoform 2)	Phosphorylation	-	4.89	27251275
816	Phosphorylation	SHLWKLLDRHANTIR HHHHHHHHHHCCEEE	51.24	18691976
817	Methylation	HLWKLLDRHANTIRL HHHHHHHHHCCEEEE	30.68	115919641
817	Phosphorylation	HLWKLLDRHANTIRL HHHHHHHHHCCEEEE	30.68	-
818	Ubiquitination	LWKLLDRHANTIRLF HHHHHHHHCCEEEEE	24.01	-
818	Ubiquitination	LWKLLDRHANTIRLF HHHHHHHHCCEEEEE	24.01	-
822 (in isoform 2)	Phosphorylation	-	3.46	24719451
824	Ubiquitination	RHANTIRLFVLLPEQ HHCCEEEEEEECCCC	2.84	-
824	Ubiquitination	RHANTIRLFVLLPEQ HHCCEEEEEEECCCC	2.84	-
829 (in isoform 2)	Phosphorylation	-	33.16	-
830 (in isoform 2)	Phosphorylation	-	64.76	-
832	Phosphorylation	FVLLPEQSPVSYSKR EEECCCCCCCCCCHH	26.13	29255136
835	Phosphorylation	LPEQSPVSYSKRTAY CCCCCCCCCCHHCHH	27.37	29255136
836	Phosphorylation	PEQSPVSYSKRTAYQ CCCCCCCCCHHCHHH	20.60	28176443
837	Phosphorylation	EQSPVSYSKRTAYQK CCCCCCCCHHCHHHH	14.25	29255136
838	Acetylation	QSPVSYSKRTAYQKA CCCCCCCHHCHHHHC	45.60	25953088
838	Ubiquitination	QSPVSYSKRTAYQKA CCCCCCCHHCHHHHC	45.60	-
840	Ubiquitination	PVSYSKRTAYQKAGG CCCCCHHCHHHHCCC	33.19	-
844	Ubiquitination	SKRTAYQKAGGDSGN CHHCHHHHCCCCCCC	36.00	-
844 (in isoform 2)	Phosphorylation	-	36.00	24719451
845	Phosphorylation	KRTAYQKAGGDSGNV HHCHHHHCCCCCCCC	16.21	-
845 (in isoform 2)	Phosphorylation	-	16.21	27251275
847	Ubiquitination	TAYQKAGGDSGNVDD CHHHHCCCCCCCCCC	30.67	-
848	Phosphorylation	AYQKAGGDSGNVDDD HHHHCCCCCCCCCCC	53.07	-
849	Phosphorylation	YQKAGGDSGNVDDDC HHHCCCCCCCCCCCH	35.23	21815630
856	Phosphorylation	SGNVDDDCERVKGPV CCCCCCCHHHCCCCC	4.65	18669648
856 (in isoform 2)	Phosphorylation	-	4.65	24719451
857	Phosphorylation	GNVDDDCERVKGPVG CCCCCCHHHCCCCCC	68.45	18669648
861	Ubiquitination	DDCERVKGPVGSLKS CCHHHCCCCCCCHHH	21.19	-
865	Phosphorylation	RVKGPVGSLKSVEAI HCCCCCCCHHHHHHH	32.62	28060719
868	Phosphorylation	GPVGSLKSVEAILEE CCCCCHHHHHHHHHH	30.40	29396449
876	Phosphorylation	VEAILEESTEKLKSL HHHHHHHHHHHHHHC	32.27	25159151
877	Phosphorylation	EAILEESTEKLKSLS HHHHHHHHHHHHHCC	40.18	21815630
879 (in isoform 2)	Phosphorylation	-	62.39	27251275
883	Phosphorylation	STEKLKSLSLQQQQD HHHHHHHCCHHHCCC	5.91	-
890	Phosphorylation	LSLQQQQDGDNGDSS CCHHHCCCCCCCCCC	63.17	19664994
896	Phosphorylation	QDGDNGDSSKSTETS CCCCCCCCCCCCCCC	40.85	25159151
897	Phosphorylation	DGDNGDSSKSTETSD CCCCCCCCCCCCCCC	35.05	21815630
898	Phosphorylation	GDNGDSSKSTETSDF CCCCCCCCCCCCCCC	66.41	18669648
899	Phosphorylation	DNGDSSKSTETSDFE CCCCCCCCCCCCCCC	33.16	29632367
900	Phosphorylation	NGDSSKSTETSDFEN CCCCCCCCCCCCCCC	47.20	29632367
902	Phosphorylation	DSSKSTETSDFENIE CCCCCCCCCCCCCCC	33.41	29632367
903	Phosphorylation	SSKSTETSDFENIES CCCCCCCCCCCCCCC	33.79	28176443
910	Phosphorylation	SDFENIESPLNERDS CCCCCCCCCCCCCCC	30.78	19664994
912	Phosphorylation	FENIESPLNERDSSA CCCCCCCCCCCCCCC	16.89	19651622
913	Phosphorylation	ENIESPLNERDSSAS CCCCCCCCCCCCCCC	45.71	19651622
917	Phosphorylation	SPLNERDSSASVDNR CCCCCCCCCCCCCHH	33.74	18669648
918	Phosphorylation	PLNERDSSASVDNRE CCCCCCCCCCCCHHH	28.93	18669648
920	Phosphorylation	NERDSSASVDNRELE CCCCCCCCCCHHHHH	31.77	23186163
924	Phosphorylation	SSASVDNRELEQHIQ CCCCCCHHHHHHHHH	45.47	-
925 (in isoform 2)	Phosphorylation	-	64.01	24719451
927 (in isoform 2)	Phosphorylation	-	35.05	24719451
929 (in isoform 2)	Phosphorylation	-	12.54	-
932	Phosphorylation	ELEQHIQTSDPENFQ HHHHHHHCCCCCCCC	34.20	30266825
933	Phosphorylation	LEQHIQTSDPENFQS HHHHHHCCCCCCCCC	34.49	29255136
937 (in isoform 2)	Phosphorylation	-	45.72	27251275
940	Phosphorylation	SDPENFQSEERSDSD CCCCCCCCCCCCCCC	36.97	23401153
944	Phosphorylation	NFQSEERSDSDVNND CCCCCCCCCCCCCCC	44.75	30266825
946	Phosphorylation	QSEERSDSDVNNDRS CCCCCCCCCCCCCCC	44.71	30266825
953	Phosphorylation	SDVNNDRSTSSVDSD CCCCCCCCCCCCCHH	35.19	28270605
954	Phosphorylation	DVNNDRSTSSVDSDI CCCCCCCCCCCCHHH	26.39	28270605
955	Phosphorylation	VNNDRSTSSVDSDIL CCCCCCCCCCCHHHH	29.61	28270605
956	Phosphorylation	NNDRSTSSVDSDILS CCCCCCCCCCHHHHC	29.99	29496963
959	Phosphorylation	RSTSSVDSDILSSSH CCCCCCCHHHHCCCC	25.13	28270605
963	Phosphorylation	SVDSDILSSSHSSDT CCCHHHHCCCCCCCC	30.08	28270605
964	Phosphorylation	VDSDILSSSHSSDTL CCHHHHCCCCCCCCC	28.73	28270605
965	Phosphorylation	DSDILSSSHSSDTLC CHHHHCCCCCCCCCC	24.82	28270605
967	Phosphorylation	DILSSSHSSDTLCNA HHHCCCCCCCCCCCC	31.68	28857561
968	Phosphorylation	ILSSSHSSDTLCNAD HHCCCCCCCCCCCCC	29.23	28270605
970	Phosphorylation	SSSHSSDTLCNADNA CCCCCCCCCCCCCCC	34.85	28270605
970 (in isoform 2)	Ubiquitination	-	34.85	21890473
985	Phosphorylation	QIPLANGLDSHSITS CCCCCCCCCCCCCCC	6.48	-
993	Phosphorylation	DSHSITSSRRTKANE CCCCCCCCCCCCCCC	19.68	19651622
995	Phosphorylation	HSITSSRRTKANEGK CCCCCCCCCCCCCCC	42.39	19651622
997	Phosphorylation	ITSSRRTKANEGKKE CCCCCCCCCCCCCCC	47.61	19651622
1005	Phosphorylation	ANEGKKETWDTAEED CCCCCCCCCCCCCCC	37.20	23403867
1008	Phosphorylation	GKKETWDTAEEDSGT CCCCCCCCCCCCCCC	27.77	25072903
1013	Phosphorylation	WDTAEEDSGTDSEYD CCCCCCCCCCCCCCC	47.04	22617229
1015	Phosphorylation	TAEEDSGTDSEYDES CCCCCCCCCCCCCCC	40.06	22617229
1017	Phosphorylation	EEDSGTDSEYDESGK CCCCCCCCCCCCCCC	37.58	28102081
1019	Phosphorylation	DSGTDSEYDESGKSR CCCCCCCCCCCCCCC	29.03	23663014
1022	Phosphorylation	TDSEYDESGKSRGEM CCCCCCCCCCCCCEE	48.93	23663014
1025	Phosphorylation	EYDESGKSRGEMQYM CCCCCCCCCCEEEEE	49.39	28450419
1038	Ubiquitination	YMYFKAEPYAADEGS EEEEEECCCCCCCCC	28.99	-
1038	Ubiquitination	YMYFKAEPYAADEGS EEEEEECCCCCCCCC	28.99	-
1058	Ubiquitination	WLMVHVDKRITLAAF EEEEECCCCCHHHHH	44.61	2190698
1058 (in isoform 1)	Ubiquitination	-	44.61	21890473
1068	Phosphorylation	TLAAFKQHLEPFVGV HHHHHHHHHHHHHHH	32.52	-
1086	Phosphorylation	HFKVFRVYASNQEFE CEEEEEEEECCCCEE	10.47	24117733
1088	Phosphorylation	KVFRVYASNQEFESV EEEEEEECCCCEEEE	22.74	21815630
1094	Phosphorylation	ASNQEFESVRLNETL ECCCCEEEEECCCCH	20.19	24117733
1100	Phosphorylation	ESVRLNETLSSFSDD EEEECCCCHHHCCCC	30.76	20873877
1102	Phosphorylation	VRLNETLSSFSDDNK EECCCCHHHCCCCCC	36.44	20873877
1103	O-linked_Glycosylation	RLNETLSSFSDDNKI ECCCCHHHCCCCCCE	31.70	23301498
1103	Phosphorylation	RLNETLSSFSDDNKI ECCCCHHHCCCCCCE	31.70	20873877
1105	O-linked_Glycosylation	NETLSSFSDDNKITI CCCHHHCCCCCCEEE	46.10	23301498
1105	Phosphorylation	NETLSSFSDDNKITI CCCHHHCCCCCCEEE	46.10	20873877
1111	Phosphorylation	FSDDNKITIRLGRAL CCCCCCEEEEECHHH	11.14	28258704
1123	Phosphorylation	RALKKGEYRVKVYQL HHHHCCCEEEEEEEH	29.40	-
1133 (in isoform 2)	Phosphorylation	-	45.24	-
1135 (in isoform 2)	Phosphorylation	-	55.52	-
1136	Ubiquitination	QLLVNEQEPCKFLLD EHHHCCCCCCHHHHH	46.62	-
1155	Phosphorylation	KGMTVRQSKEELIPQ CCCCHHHCHHHHHHH	31.32	26270265
1201	Phosphorylation	HIYEEDINISSNWEV EEECCCCCCCCCHHH	40.17	20068231
1203	Phosphorylation	YEEDINISSNWEVFL ECCCCCCCCCHHHHH	17.09	20068231
1221	Phosphorylation	DGVEKMKSMSQLAVL HHHHHHHCHHHHHHH	21.84	20068231
1222	Sulfoxidation	GVEKMKSMSQLAVLS HHHHHHCHHHHHHHH	2.17	21406390
1223	Phosphorylation	VEKMKSMSQLAVLSR HHHHHCHHHHHHHHC	29.18	20068231
1229	Phosphorylation	MSQLAVLSRRWKPSE HHHHHHHHCCCCCHH	17.13	20068231
1233 (in isoform 2)	Phosphorylation	-	36.53	-
1238	Ubiquitination	RWKPSEMKLDPFQEV CCCCHHCCCCCHHHH	45.76	-
1252 (in isoform 2)	Phosphorylation	-	7.77	24719451
1254	Ubiquitination	LESSSVDELREKLSE HHCCCHHHHHHHHHH	47.79	-
1254	Ubiquitination	LESSSVDELREKLSE HHCCCHHHHHHHHHH	47.79	-
1264 (in isoform 2)	Phosphorylation	-	31.06	-
1265 (in isoform 2)	Phosphorylation	-	2.15	24719451
1274	Acetylation	LDDIEFAKGRGTFPC HHHCHHCCCCCCCCC	55.23	25953088
1274	Ubiquitination	LDDIEFAKGRGTFPC HHHCHHCCCCCCCCC	55.23	-
1301	Phosphorylation	WNPKVSTLNVWPLYI CCCCCCEECEEEEEE	3.66	20068231
1321	Phosphorylation	VIFYRDKTEELMELT EEEEECCHHHHHHCC	38.69	20068231
1325	Sulfoxidation	RDKTEELMELTDEQR ECCHHHHHHCCHHHH	4.48	21406390
1328	Phosphorylation	TEELMELTDEQRNEL HHHHHHCCHHHHHHH	24.96	20068231
1332	Phosphorylation	MELTDEQRNELMKKE HHCCHHHHHHHHHHH	36.22	20068231
1333	Phosphorylation	ELTDEQRNELMKKES HCCHHHHHHHHHHHH	46.58	18088087
1337	Acetylation	EQRNELMKKESSRLQ HHHHHHHHHHHHHHH	67.04	7667085
1340	Phosphorylation	NELMKKESSRLQKTG HHHHHHHHHHHHHHC	29.63	24719451
1341	Phosphorylation	ELMKKESSRLQKTGH HHHHHHHHHHHHHCC	37.79	-
1343	Phosphorylation	MKKESSRLQKTGHRV HHHHHHHHHHHCCCC	7.09	-
1346	Phosphorylation	ESSRLQKTGHRVTYS HHHHHHHHCCCCCCC	25.84	23312004
1351	Phosphorylation	QKTGHRVTYSPRKEK HHHCCCCCCCCCHHH	20.45	21815630
1352	Phosphorylation	KTGHRVTYSPRKEKA HHCCCCCCCCCHHHH	17.51	20068231
1353	Phosphorylation	TGHRVTYSPRKEKAL HCCCCCCCCCHHHHH	14.63	21712546
1363	Phosphorylation	KEKALKIYLDGAPNK HHHHHHEECCCCCCC	9.35	25159151
1373	Phosphorylation	GAPNKDLTQD----- CCCCCCCCCC-----	40.60	29214152

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	BTRC	Q9Y297	PMID:24658274

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of UBP47_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of UBP47_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KTNA1_HUMAN	KATNA1	physical	23904609
VATH_HUMAN	ATP6V1H	physical	22863883
GMPPB_HUMAN	GMPPB	physical	22863883
PDXD1_HUMAN	PDXDC1	physical	22863883
WDR44_HUMAN	WDR44	physical	22863883
PA2GA_HUMAN	PLA2G2A	physical	22118674
RECQ1_HUMAN	RECQL	physical	28514442
LETM1_HUMAN	LETM1	physical	28514442
CTBL1_HUMAN	CTNNBL1	physical	28514442
VRK1_HUMAN	VRK1	physical	28514442
RBM12_HUMAN	RBM12	physical	28514442
LYPA1_HUMAN	LYPLA1	physical	28514442
MCTS1_HUMAN	MCTS1	physical	28514442
NAA15_HUMAN	NAA15	physical	28514442
PP1R8_HUMAN	PPP1R8	physical	28514442
OTUB1_HUMAN	OTUB1	physical	28514442
TOM34_HUMAN	TOMM34	physical	28514442
SNX3_HUMAN	SNX3	physical	28514442
IST1_HUMAN	IST1	physical	28514442
SYNC_HUMAN	NARS	physical	28514442
NB5R3_HUMAN	CYB5R3	physical	28514442
RPR1B_HUMAN	RPRD1B	physical	28514442
NSDHL_HUMAN	NSDHL	physical	28514442
VIGLN_HUMAN	HDLBP	physical	28514442
GATA_HUMAN	QRSL1	physical	28514442
DENR_HUMAN	DENR	physical	28514442
ERF1_HUMAN	ETF1	physical	28514442
PUR8_HUMAN	ADSL	physical	28514442
CLPP_HUMAN	CLPP	physical	28514442
VAMP3_HUMAN	VAMP3	physical	28514442
FEN1_HUMAN	FEN1	physical	28514442
MDC1_HUMAN	MDC1	physical	28514442
TCEA1_HUMAN	TCEA1	physical	28514442
LRC40_HUMAN	LRRC40	physical	28514442
RPR1A_HUMAN	RPRD1A	physical	28514442
2A5D_HUMAN	PPP2R5D	physical	28514442
SNX6_HUMAN	SNX6	physical	28514442
DNJC2_HUMAN	DNAJC2	physical	28514442
PAK2_HUMAN	PAK2	physical	28514442
TRUA_HUMAN	PUS1	physical	28514442
RAD21_HUMAN	RAD21	physical	28514442
SYAP1_HUMAN	SYAP1	physical	28514442
EF1A2_HUMAN	EEF1A2	physical	28514442
PLSI_HUMAN	PLS1	physical	28514442
NUP53_HUMAN	NUP35	physical	28514442
SYFB_HUMAN	FARSB	physical	28514442
EEA1_HUMAN	EEA1	physical	28514442
HMGN5_HUMAN	HMGN5	physical	28514442
HELLS_HUMAN	HELLS	physical	28514442
SF3A3_HUMAN	SF3A3	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of UBP47_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-122, AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-832 AND SER-910, ANDMASS SPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-910, AND MASSSPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-832 AND SER-910, ANDMASS SPECTROMETRY.	18669648 [Abstract]
"Phosphoproteome of resting human platelets."; Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,Schuetz C., Walter U., Gambaryan S., Sickmann A.; J. Proteome Res. 7:526-534(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1353, AND MASSSPECTROMETRY.	18088087 [Abstract]
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-832, AND MASSSPECTROMETRY.	16964243 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-910, AND MASSSPECTROMETRY.	15302935 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-836, AND MASSSPECTROMETRY.	18691976 [Abstract]