dbPTM

EEA1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	EEA1_HUMAN
UniProt AC	Q15075
Protein Name	Early endosome antigen 1
Gene Name	EEA1
Organism	Homo sapiens (Human).
Sequence Length	1411
Subcellular Localization	Cytoplasm. Early endosome membrane Peripheral membrane protein.
Protein Description	Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking..
Protein Sequence	MLRRILQRTPGRVGSQGSDLDSSATPINTVDVNNESSSEGFICPQCMKSLGSADELFKHYEAVHDAGNDSGHGGESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKKILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIKHTQALNRKWAEDNEVQNCMACGKGFSVTVRRHHCRQCGNIFCAECSAKNALTPSSKKPVRVCDACFNDLQG

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	LRRILQRTPGRVGSQ HHHHHHCCCCCCCCC	19.68	24719451
12	Ubiquitination	ILQRTPGRVGSQGSD HHHCCCCCCCCCCCC	30.72	21890473
15	Phosphorylation	RTPGRVGSQGSDLDS CCCCCCCCCCCCCCC	28.63	30576142
18	Phosphorylation	GRVGSQGSDLDSSAT CCCCCCCCCCCCCCC	27.62	28857561
22	Phosphorylation	SQGSDLDSSATPINT CCCCCCCCCCCCCCE	29.21	28857561
23	Phosphorylation	QGSDLDSSATPINTV CCCCCCCCCCCCCEE	35.51	28857561
25	Phosphorylation	SDLDSSATPINTVDV CCCCCCCCCCCEEEC	27.01	24275569
29	Phosphorylation	SSATPINTVDVNNES CCCCCCCEEECCCCC	20.85	28348404
36	Phosphorylation	TVDVNNESSSEGFIC EEECCCCCCCCCCCC	41.09	28348404
37	Phosphorylation	VDVNNESSSEGFICP EECCCCCCCCCCCCH	26.65	28348404
38	Phosphorylation	DVNNESSSEGFICPQ ECCCCCCCCCCCCHH	51.52	28348404
49	Phosphorylation	ICPQCMKSLGSADEL CCHHHHHHCCCHHHH	15.87	23403867
52	Phosphorylation	QCMKSLGSADELFKH HHHHHCCCHHHHHHH	37.53	25159151
54	Ubiquitination	MKSLGSADELFKHYE HHHCCCHHHHHHHHH	55.62	22817900
57	Ubiquitination	LGSADELFKHYEAVH CCCHHHHHHHHHHHH	4.27	22817900
58	Ubiquitination	GSADELFKHYEAVHD CCHHHHHHHHHHHHH	58.88	21963094
60	Phosphorylation	ADELFKHYEAVHDAG HHHHHHHHHHHHHCC	13.23	27642862
64	Ubiquitination	FKHYEAVHDAGNDSG HHHHHHHHHCCCCCC	26.67	21890473
70	Phosphorylation	VHDAGNDSGHGGESN HHHCCCCCCCCCCCC	36.37	25159151
76	Phosphorylation	DSGHGGESNLALKRD CCCCCCCCCCCCCHH	40.18	23186163
81	2-Hydroxyisobutyrylation	GESNLALKRDDVTLL CCCCCCCCHHHHHHH	48.45	-
81	Ubiquitination	GESNLALKRDDVTLL CCCCCCCCHHHHHHH	48.45	32015554
98	Phosphorylation	EVQDLQASLKEEKWY HHHHHHHHHHHCHHC	27.32	25159151
100	Ubiquitination	QDLQASLKEEKWYSE HHHHHHHHHCHHCHH	62.42	21906983
103	Ubiquitination	QASLKEEKWYSEELK HHHHHHCHHCHHHHH	53.15	22817900
105	Phosphorylation	SLKEEKWYSEELKKE HHHHCHHCHHHHHHH	19.78	22817900
106	Ubiquitination	LKEEKWYSEELKKEL HHHCHHCHHHHHHHH	24.39	22817900
109	Ubiquitination	EKWYSEELKKELEKY CHHCHHHHHHHHHHH	9.36	22817900
112	Ubiquitination	YSEELKKELEKYQGL CHHHHHHHHHHHHCC	61.65	23503661
118	Ubiquitination	KELEKYQGLQQQEAK HHHHHHHCCCCCCCC	23.51	23503661
139	Phosphorylation	DSSAELQSLEQQLEE CCHHHHHHHHHHHHH	46.64	22817901
142	Ubiquitination	AELQSLEQQLEEAQT HHHHHHHHHHHHHHH	59.45	22817900
145	Ubiquitination	QSLEQQLEEAQTENF HHHHHHHHHHHHHCC	47.12	22817900
158	Acetylation	NFNIKQMKDLFEQKA CCCHHHHHHHHHHHH	49.11	12650379
158	Ubiquitination	NFNIKQMKDLFEQKA CCCHHHHHHHHHHHH	49.11	23503661
164	Acetylation	MKDLFEQKAAQLATE HHHHHHHHHHHHHHH	38.19	12650391
164	Ubiquitination	MKDLFEQKAAQLATE HHHHHHHHHHHHHHH	38.19	32015554
170	Ubiquitination	QKAAQLATEIADIKS HHHHHHHHHHHHHHH	36.19	23503661
176	2-Hydroxyisobutyrylation	ATEIADIKSKYDEER HHHHHHHHHHCHHHH	41.25	-
178	Methylation	EIADIKSKYDEERSL HHHHHHHHCHHHHHH	52.28	17567059
200	Ubiquitination	VTRLTEELNKEATVI HHHHHHHHHHHCHHH	10.12	23503661
202	Ubiquitination	RLTEELNKEATVIQD HHHHHHHHHCHHHHH	62.44	29967540
206	Ubiquitination	ELNKEATVIQDLKTE HHHHHCHHHHHHHHH	4.82	23503661
212	O-linked_Glycosylation	TVIQDLKTELLQRPG HHHHHHHHHHHCCCC	38.88	30379171
227	2-Hydroxyisobutyrylation	IEDVAVLKKELVQVQ CCHHHHHHHHHHHHH	37.29	-
227	Malonylation	IEDVAVLKKELVQVQ CCHHHHHHHHHHHHH	37.29	26320211
228	Ubiquitination	EDVAVLKKELVQVQT CHHHHHHHHHHHHHH	52.71	29967540
235	Phosphorylation	KELVQVQTLMDNMTL HHHHHHHHHHHCCCH	25.78	24719451
241	Phosphorylation	QTLMDNMTLERERES HHHHHCCCHHHHHHH	31.55	24719451
248	Phosphorylation	TLERERESEKLKDEC CHHHHHHHHHHHHHH	46.37	24719451
270	Phosphorylation	ASSEATISQLRSELA HCCHHHHHHHHHHHH	20.86	28985074
286	Phosphorylation	GPQEVAVYVQELQKL CHHHHHHHHHHHHHH	6.15	-
294	Malonylation	VQELQKLKSSVNELT HHHHHHHHHHHHHHH	47.96	26320211
295	Phosphorylation	QELQKLKSSVNELTQ HHHHHHHHHHHHHHH	50.37	20068231
296	Phosphorylation	ELQKLKSSVNELTQK HHHHHHHHHHHHHHH	27.63	-
301	Phosphorylation	KSSVNELTQKNQTLT HHHHHHHHHHHHHHH	31.17	-
318	Phosphorylation	LLKKEQDYTKLEEKH HHHHHHHHHHHHHHC	12.88	27642862
333	Acetylation	NEESVSKKNIQATLH CHHHHCHHHHHHHHH	52.34	25953088
342	2-Hydroxyisobutyrylation	IQATLHQKDLDCQQL HHHHHHHHCCCHHHH	49.89	-
342	Acetylation	IQATLHQKDLDCQQL HHHHHHHHCCCHHHH	49.89	26051181
342	Malonylation	IQATLHQKDLDCQQL HHHHHHHHCCCHHHH	49.89	26320211
351	Phosphorylation	LDCQQLQSRLSASET CCHHHHHHHHHCCHH	43.72	29214152
354	Phosphorylation	QQLQSRLSASETSLH HHHHHHHHCCHHCCC	28.74	30266825
356	Phosphorylation	LQSRLSASETSLHRI HHHHHHCCHHCCCHH	37.72	30266825
358	Phosphorylation	SRLSASETSLHRIHV HHHHCCHHCCCHHEE	33.81	30266825
359	Phosphorylation	RLSASETSLHRIHVE HHHCCHHCCCHHEEH	20.37	30266825
370	2-Hydroxyisobutyrylation	IHVELSEKGEATQKL HEEHHHHCCHHHHHH	59.69	-
382	Phosphorylation	QKLKEELSEVETKYQ HHHHHHHHHHHHHHH	42.76	-
387	Malonylation	ELSEVETKYQHLKAE HHHHHHHHHHHHHHH	29.43	26320211
392	Acetylation	ETKYQHLKAEFKQLQ HHHHHHHHHHHHHHH	43.69	23236377
392	Malonylation	ETKYQHLKAEFKQLQ HHHHHHHHHHHHHHH	43.69	32601280
396	Malonylation	QHLKAEFKQLQQQRE HHHHHHHHHHHHHHH	41.42	26320211
396	Ubiquitination	QHLKAEFKQLQQQRE HHHHHHHHHHHHHHH	41.42	32015554
422	Ubiquitination	EINQLHSKLLETERQ HHHHHHHHHHHHHHH	46.47	-
449	Sulfoxidation	QLSSEKLMDKEQQVA HHCHHHHCCHHHHHH	11.65	21406390
474	Phosphorylation	EQLKEKVTNSTELQH HHHHHHHCCHHHHHH	34.22	26657352
485	2-Hydroxyisobutyrylation	ELQHQLDKTKQQHQE HHHHHHHHHHHHHHH	67.24	-
485	Malonylation	ELQHQLDKTKQQHQE HHHHHHHHHHHHHHH	67.24	26320211
486	Phosphorylation	LQHQLDKTKQQHQEQ HHHHHHHHHHHHHHH	33.48	26657352
499	Phosphorylation	EQQALQQSTTAKLRE HHHHHHHHHHHHHHH	18.11	26657352
521	2-Hydroxyisobutyrylation	VLRQIGDKDQKIQNL HHHHHCCHHHHHHHH	57.77	-
534	Malonylation	NLEALLQKSKENISL HHHHHHHHHHHHHHH	64.56	26320211
536	Malonylation	EALLQKSKENISLLE HHHHHHHHHHHHHHH	62.91	26320211
540	O-linked_Glycosylation	QKSKENISLLEKERE HHHHHHHHHHHHHHH	38.18	30379171
540	Phosphorylation	QKSKENISLLEKERE HHHHHHHHHHHHHHH	38.18	24719451
544	2-Hydroxyisobutyrylation	ENISLLEKEREDLYA HHHHHHHHHHHHHHH	63.14	-
544	Ubiquitination	ENISLLEKEREDLYA HHHHHHHHHHHHHHH	63.14	32015554
552	Ubiquitination	EREDLYAKIQAGEGE HHHHHHHHHHCCCCH	23.07	29967540
560	Phosphorylation	IQAGEGETAVLNQLQ HHCCCCHHHHHHHHH	32.68	24719451
592	Ubiquitination	KNQSESHKQAQENLH HHHHHHHHHHHHHHH	57.52	29967540
618	Phosphorylation	AAQDRVLSLETSVNE HHHHHHHHHHHHHHH	22.69	28258704
621	Phosphorylation	DRVLSLETSVNELNS HHHHHHHHHHHHHHH	43.18	22817900
628	Phosphorylation	TSVNELNSQLNESKE HHHHHHHHHHHHHHH	48.98	22817900
634	Acetylation	NSQLNESKEKVSQLD HHHHHHHHHHHHHHH	56.21	7959827
638	Phosphorylation	NESKEKVSQLDIQIK HHHHHHHHHHHHHHH	35.77	23312004
645	Acetylation	SQLDIQIKAKTELLL HHHHHHHHHHHHHHH	27.70	7959839
647	Malonylation	LDIQIKAKTELLLSA HHHHHHHHHHHHHCH	37.21	32601280
688	Phosphorylation	QELNKITTQLDQVTA HHHHHHHHHHHHHHH	30.52	20068231
694	Phosphorylation	TTQLDQVTAKLQDKQ HHHHHHHHHHHHHHH	16.67	20068231
700	Acetylation	VTAKLQDKQEHCSQL HHHHHHHHHHHHHHH	44.62	26051181
700	Malonylation	VTAKLQDKQEHCSQL HHHHHHHHHHHHHHH	44.62	26320211
717	2-Hydroxyisobutyrylation	HLKEYKEKYLSLEQK HHHHHHHHHHCHHHH	47.54	-
743	2-Hydroxyisobutyrylation	EADSLEVKASKEQAL HHHHHHHHHCHHHHH	37.25	-
761	Phosphorylation	QQQRQLNTDLELRAT HHHHHHCCHHHHHHH	51.02	20068231
791	2-Hydroxyisobutyrylation	TRLDLQKKSEALESI HHHHHHHHHHHHHHH	40.34	-
791	Malonylation	TRLDLQKKSEALESI HHHHHHHHHHHHHHH	40.34	26320211
799	Malonylation	SEALESIKQKLTKQE HHHHHHHHHHCCHHH	51.14	26320211
824	Ubiquitination	ETLSQETKIQHEELN HHHHHHHHHCHHHHH	39.35	29967540
836	Phosphorylation	ELNNRIQTTVTELQK HHHHHHHHHHHHHHH	22.36	20068231
837	Phosphorylation	LNNRIQTTVTELQKV HHHHHHHHHHHHHHH	14.73	20068231
839	Phosphorylation	NRIQTTVTELQKVKM HHHHHHHHHHHHHHH	28.96	20068231
848	"N6,N6-dimethyllysine"	LQKVKMEKEALMTEL HHHHHHHHHHHHHHH	44.80	-
848	Methylation	LQKVKMEKEALMTEL HHHHHHHHHHHHHHH	44.80	23644510
852	Sulfoxidation	KMEKEALMTELSTVK HHHHHHHHHHHHHHH	3.36	21406390
853	Phosphorylation	MEKEALMTELSTVKD HHHHHHHHHHHHHHH	34.32	26657352
856	Phosphorylation	EALMTELSTVKDKLS HHHHHHHHHHHHHHH	25.56	26657352
857	Phosphorylation	ALMTELSTVKDKLSK HHHHHHHHHHHHHHH	44.17	24719451
859	Malonylation	MTELSTVKDKLSKVS HHHHHHHHHHHHHHH	49.59	26320211
863	Phosphorylation	STVKDKLSKVSDSLK HHHHHHHHHHHHHHH	36.43	-
864	Malonylation	TVKDKLSKVSDSLKN HHHHHHHHHHHHHHC	57.08	26320211
870	Acetylation	SKVSDSLKNSKSEFE HHHHHHHHCCHHHHH	64.23	25953088
884	2-Hydroxyisobutyrylation	EKENQKGKAAILDLE HHHHHHHHHHHHHHH	41.50	-
884	Ubiquitination	EKENQKGKAAILDLE HHHHHHHHHHHHHHH	41.50	-
895	Ubiquitination	LDLEKTCKELKHQLQ HHHHHHHHHHHHHHH	71.90	-
898	Malonylation	EKTCKELKHQLQVQM HHHHHHHHHHHHHHH	30.32	26320211
905	Sulfoxidation	KHQLQVQMENTLKEQ HHHHHHHHHHHHHHH	4.50	30846556
908	Phosphorylation	LQVQMENTLKEQKEL HHHHHHHHHHHHHHH	26.38	-
923	2-Hydroxyisobutyrylation	KKSLEKEKEASHQLK HHHHHHHHHHHHHHH	70.42	-
926	Phosphorylation	LEKEKEASHQLKLEL HHHHHHHHHHHHHHH	16.92	24719451
935	Phosphorylation	QLKLELNSMQEQLIQ HHHHHHHHHHHHHHH	34.17	20068231
936	Sulfoxidation	LKLELNSMQEQLIQA HHHHHHHHHHHHHHH	5.04	21406390
973	Malonylation	QSSEQKKKQIEALQG HCHHHHHHHHHHHHH	64.64	26320211
983	Acetylation	EALQGELKIAVLQKT HHHHHHHHHHHHHHH	25.07	26051181
995	Ubiquitination	QKTELENKLQQQLTQ HHHHHHHHHHHHHHH	37.99	29967540
1011	2-Hydroxyisobutyrylation	AQELAAEKEKISVLQ HHHHHHHHHHHHHHH	60.63	-
1015	Phosphorylation	AAEKEKISVLQNNYE HHHHHHHHHHHCHHH	28.04	-
1021	Phosphorylation	ISVLQNNYEKSQETF HHHHHCHHHHHHHHH	32.08	27050516
1024	Phosphorylation	LQNNYEKSQETFKQL HHCHHHHHHHHHHHH	22.70	24719451
1027	Phosphorylation	NYEKSQETFKQLQSD HHHHHHHHHHHHHHH	28.61	-
1029	Ubiquitination	EKSQETFKQLQSDFY HHHHHHHHHHHHHHH	58.48	32015554
1075	Malonylation	NQIGNQNKLIQELKT CCCCCHHHHHHHHHH	36.88	26320211
1081	Acetylation	NKLIQELKTAKATLE HHHHHHHHHHHHHHH	45.76	25953088
1081	Malonylation	NKLIQELKTAKATLE HHHHHHHHHHHHHHH	45.76	26320211
1093	2-Hydroxyisobutyrylation	TLEQDSAKKEQQLQE HHHHHHHHHHHHHHH	61.88	-
1093	Acetylation	TLEQDSAKKEQQLQE HHHHHHHHHHHHHHH	61.88	26051181
1110	Malonylation	KALQDIQKEKSLKEK HHHHHHHHHHCHHHH	68.40	26320211
1124	O-linked_Glycosylation	KELVNEKSKLAEIEE HHHCCCHHHHHHHHH	27.07	30379171
1125	Ubiquitination	ELVNEKSKLAEIEEI HHCCCHHHHHHHHHH	63.89	32015554
1133	2-Hydroxyisobutyrylation	LAEIEEIKCRQEKEI HHHHHHHHHHHHHHH	27.01	-
1133	Acetylation	LAEIEEIKCRQEKEI HHHHHHHHHHHHHHH	27.01	19811039
1138	Acetylation	EIKCRQEKEITKLNE HHHHHHHHHHHHHHH	46.18	23749302
1142	Acetylation	RQEKEITKLNEELKS HHHHHHHHHHHHHHH	55.78	19811711
1142	Malonylation	RQEKEITKLNEELKS HHHHHHHHHHHHHHH	55.78	26320211
1156	Malonylation	SHKLESIKEITNLKD HCCCHHHHHHCCHHH	52.95	26320211
1159	Phosphorylation	LESIKEITNLKDAKQ CHHHHHHCCHHHHHH	35.27	-
1162	Malonylation	IKEITNLKDAKQLLI HHHHCCHHHHHHHHH	58.68	26320211
1162	Ubiquitination	IKEITNLKDAKQLLI HHHHCCHHHHHHHHH	58.68	32015554
1165	2-Hydroxyisobutyrylation	ITNLKDAKQLLIQQK HCCHHHHHHHHHHHH	52.17	-
1165	Acetylation	ITNLKDAKQLLIQQK HCCHHHHHHHHHHHH	52.17	23236377
1165	Malonylation	ITNLKDAKQLLIQQK HCCHHHHHHHHHHHH	52.17	26320211
1178	2-Hydroxyisobutyrylation	QKLELQGKADSLKAA HHHHHCCCHHHHHHH	35.74	-
1178	Malonylation	QKLELQGKADSLKAA HHHHHCCCHHHHHHH	35.74	26320211
1178	Ubiquitination	QKLELQGKADSLKAA HHHHHCCCHHHHHHH	35.74	-
1183	Malonylation	QGKADSLKAAVEQEK CCCHHHHHHHHHHHH	37.95	26320211
1183	Ubiquitination	QGKADSLKAAVEQEK CCCHHHHHHHHHHHH	37.95	29967540
1252	Phosphorylation	ALNENLGTVKKEWQS HHHCCCCHHHHHHHH	32.11	-
1254	Malonylation	NENLGTVKKEWQSSQ HCCCCHHHHHHHHHH	44.83	26320211
1254	Ubiquitination	NENLGTVKKEWQSSQ HCCCCHHHHHHHHHH	44.83	32015554
1265	Phosphorylation	QSSQRRVSELEKQTD HHHHHHHHHHHHHHH	34.35	28857561
1273	Ubiquitination	ELEKQTDDLRGEIAV HHHHHHHHHHHHEEH	41.47	24816145
1301	Ubiquitination	ALLERCLKGEGEIEK HHHHHHHHCCCHHHH	59.55	32015554
1308	Malonylation	KGEGEIEKLQTKVLE HCCCHHHHHHHHHHH	52.11	26320211
1312	Ubiquitination	EIEKLQTKVLELQRK HHHHHHHHHHHHHHH	31.68	32015554
1319	Malonylation	KVLELQRKLDNTTAA HHHHHHHHHCCHHHH	47.43	26320211
1319	Ubiquitination	KVLELQRKLDNTTAA HHHHHHHHHCCHHHH	47.43	24816145
1325	Ubiquitination	RKLDNTTAAVQELGR HHHCCHHHHHHHHHH	12.00	24816145
1336	Phosphorylation	ELGRENQSLQIKHTQ HHHHHCCCCCCHHHH	33.55	28857561
1340	Ubiquitination	ENQSLQIKHTQALNR HCCCCCCHHHHHHHH	27.86	32015554
1361	Ubiquitination	EVQNCMACGKGFSVT CCCHHCCCCCCEEEE	2.00	24816145
1366	Phosphorylation	MACGKGFSVTVRRHH CCCCCCEEEEEHHHH	26.08	28857561
1368	Phosphorylation	CGKGFSVTVRRHHCR CCCCEEEEEHHHHCC	13.70	24719451
1386	Phosphorylation	NIFCAECSAKNALTP CEEEEECHHCCCCCC	33.51	28857561
1392	Phosphorylation	CSAKNALTPSSKKPV CHHCCCCCCCCCCCC	20.79	29396449
1394	Phosphorylation	AKNALTPSSKKPVRV HCCCCCCCCCCCCHH	49.94	29396449
1395	Phosphorylation	KNALTPSSKKPVRVC CCCCCCCCCCCCHHC	45.99	29396449

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
1392	T	Phosphorylation	Kinase	MAPK14	Q16539	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of EEA1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of EEA1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RB22A_HUMAN	RAB22A	physical	11870209
EEA1_HUMAN	EEA1	physical	11741531
STX12_HUMAN	STX12	physical	10458612
NSF_HUMAN	NSF	physical	10458612
RABE1_HUMAN	RABEP1	physical	10458612
EEA1_HUMAN	EEA1	physical	10024533
PDC6I_HUMAN	PDCD6IP	physical	20929444
RABE1_HUMAN	RABEP1	physical	10720461
RABX5_HUMAN	RABGEF1	physical	10720461
ACK1_HUMAN	TNK2	physical	18262180
EEA1_HUMAN	EEA1	physical	21556036
PIBF1_HUMAN	PIBF1	physical	27173435
SNX27_HUMAN	SNX27	physical	27173435

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of EEA1_HUMAN

Related Literatures of Post-Translational Modification