RB22A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RB22A_HUMAN
• UniProt AC: Q9UL26
• Protein Name: Ras-related protein Rab-22A
• Gene Name: RAB22A
• Organism: Homo sapiens (Human).
• Sequence Length: 194
• Subcellular Localization: Endosome membrane ; Lipid-anchor . Cell membrane ; Lipid-anchor . Early endosome . Late endosome . Cell projection, ruffle . Cytoplasmic vesicle . Cytoplasmic vesicle, phagosome . Cytoplasmic vesicle, phagosome membrane ; Lipid-anchor ; Cytoplasmic side .
• Protein Description: Plays a role in endocytosis and intracellular protein transport. Mediates trafficking of TF from early endosomes to recycling endosomes. [PubMed: 16537905 Required for NGF-mediated endocytosis of NTRK1, and subsequent neurite outgrowth]
• Protein Sequence: MALRELKVCLLGDTGVGKSSIVWRFVEDSFDPNINPTIGASFMTKTVQYQNELHKFLIWDTAGQERFRALAPMYYRGSAAAIIVYDITKEETFSTLKNWVKELRQHGPPNIVVAIAGNKCDLIDVREVMERDAKDYADSIHAIFVETSAKNAININELFIEISRRIPSTDANLPSGGKGFKLRRQPSEPKRSCC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Ubiquitination	-MALRELKVCLLGDT -CCCCCEEEEEECCC	26.58	-
14	Phosphorylation	KVCLLGDTGVGKSSI EEEEECCCCCCCHHH	31.78	-
19	Phosphorylation	GDTGVGKSSIVWRFV CCCCCCCHHHHHHHH	21.26	-
20	Phosphorylation	DTGVGKSSIVWRFVE CCCCCCHHHHHHHHC	25.33	-
94	Phosphorylation	ITKEETFSTLKNWVK CCCHHHHHHHHHHHH	40.00	22210691
95	Phosphorylation	TKEETFSTLKNWVKE CCHHHHHHHHHHHHH	37.24	22210691
101	Acetylation	STLKNWVKELRQHGP HHHHHHHHHHHHHCC	42.52	-
101	Ubiquitination	STLKNWVKELRQHGP HHHHHHHHHHHHHCC	42.52	-
147	Phosphorylation	IHAIFVETSAKNAIN EEEEEEECCCCCCCC	28.78	27251275
148	Phosphorylation	HAIFVETSAKNAINI EEEEEECCCCCCCCH	24.60	27251275
163	Phosphorylation	NELFIEISRRIPSTD HHHHHHHHCCCCCCC	11.61	27251275
175	Phosphorylation	STDANLPSGGKGFKL CCCCCCCCCCCCCCC	64.44	21815630
178	Ubiquitination	ANLPSGGKGFKLRRQ CCCCCCCCCCCCCCC	65.78	33845483
181	Ubiquitination	PSGGKGFKLRRQPSE CCCCCCCCCCCCCCC	50.15	-
187	Phosphorylation	FKLRRQPSEPKRSCC CCCCCCCCCCCCCCC	59.18	29691806
190	Ubiquitination	RRQPSEPKRSCC--- CCCCCCCCCCCC---	53.55	24816145
193	Geranylgeranylation	PSEPKRSCC------ CCCCCCCCC------	3.56	-
194	Geranylgeranylation	SEPKRSCC------- CCCCCCCC-------	7.05	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RB22A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RB22A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RB22A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EEA1_HUMAN	EEA1	physical	11870209
RABX5_HUMAN	RABGEF1	physical	19759177
RAB5A_HUMAN	RAB5A	physical	19759177

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-101, AND MASS SPECTROMETRY.
PubMed: 19608861