PIBF1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PIBF1_HUMAN
• UniProt AC: Q8WXW3
• Protein Name: Progesterone-induced-blocking factor 1
• Gene Name: PIBF1
• Organism: Homo sapiens (Human).
• Sequence Length: 757
• Subcellular Localization: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm . Secreted . In progesterone-treated astrocytoma cells a 57 kDa protein and isoform 1 (90 kDa) have been described, both being located in the intracellular medium and secr
• Protein Description: Plays a role in ciliogenesis.; Isoform 1: Pericentriolar protein required to maintain mitotic spindle pole integrity. [PubMed: 21224392 Required for the centrosomal accumulation of PCM1 and the recruitment of centriolar satellite proteins such as BBS4. Via association with PCM1 may be involved in primary cilia formation]
• Protein Sequence: MSRKISKESKKVNISSSLESEDISLETTVPTDDISSSEEREGKVRITRQLIERKELLHNIQLLKIELSQKTMMIDNLKVDYLTKIEELEEKLNDALHQKQLLTLRLDNQLAFQQKDASKYQELMKQEMETILLRQKQLEETNLQLREKAGDVRRNLRDFELTEEQYIKLKAFPEDQLSIPEYVSVRFYELVNPLRKEICELQVKKNILAEELSTNKNQLKQLTETYEEDRKNYSEVQIRCQRLALELADTKQLIQQGDYRQENYDKVKSERDALEQEVIELRRKHEILEASHMIQTKERSELSKEVVTLEQTVTLLQKDKEYLNRQNMELSVRCAHEEDRLERLQAQLEESKKAREEMYEKYVASRDHYKTEYENKLHDELEQIRLKTNQEIDQLRNASREMYERENRNLREARDNAVAEKERAVMAEKDALEKHDQLLDRYRELQLSTESKVTEFLHQSKLKSFESERVQLLQEETARNLTQCQLECEKYQKKLEVLTKEFYSLQASSEKRITELQAQNSEHQARLDIYEKLEKELDEIIMQTAEIENEDEAERVLFSYGYGANVPTTAKRRLKQSVHLARRVLQLEKQNSLILKDLEHRKDQVTQLSQELDRANSLLNQTQQPYRYLIESVRQRDSKIDSLTESIAQLEKDVSNLNKEKSALLQTKNQMALDLEQLLNHREELAAMKQILVKMHSKHSENSLLLTKTEPKHVTENQKSKTLNVPKEHEDNIFTPKPTLFTKKEAPEWSKKQKMKT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Phosphorylation	ESKKVNISSSLESED HHCCCCCCCCCCCCC	14.52	26471730
16	Phosphorylation	SKKVNISSSLESEDI HCCCCCCCCCCCCCC	34.84	26471730
17	Phosphorylation	KKVNISSSLESEDIS CCCCCCCCCCCCCCC	29.39	26471730
20	Phosphorylation	NISSSLESEDISLET CCCCCCCCCCCCEEE	45.95	26471730
24	Phosphorylation	SLESEDISLETTVPT CCCCCCCCEEEECCC	32.26	26471730
27	Phosphorylation	SEDISLETTVPTDDI CCCCCEEEECCCCCC	38.08	26471730
28	Phosphorylation	EDISLETTVPTDDIS CCCCEEEECCCCCCC	18.34	26471730
36	Phosphorylation	VPTDDISSSEEREGK CCCCCCCCCHHHCCC	41.94	25627689
68	Phosphorylation	QLLKIELSQKTMMID HHHHHHHCCCCCCCC	19.48	26074081
71	Phosphorylation	KIELSQKTMMIDNLK HHHHCCCCCCCCCCC	12.34	26074081
84	Ubiquitination	LKVDYLTKIEELEEK CCHHHHHHHHHHHHH	45.59	29967540
91	Ubiquitination	KIEELEEKLNDALHQ HHHHHHHHHHHHHHH	43.12	29967540
99	Ubiquitination	LNDALHQKQLLTLRL HHHHHHHHHHHHHHH	31.97	29967540
115	Ubiquitination	NQLAFQQKDASKYQE CCHHHHHHCHHHHHH	44.47	21906983
115 (in isoform 1)	Ubiquitination	-	44.47	21906983
119	Ubiquitination	FQQKDASKYQELMKQ HHHHCHHHHHHHHHH	53.31	22817900
119	Acetylation	FQQKDASKYQELMKQ HHHHCHHHHHHHHHH	53.31	25953088
125	Ubiquitination	SKYQELMKQEMETIL HHHHHHHHHHHHHHH	56.59	29967540
128	Ubiquitination	QELMKQEMETILLRQ HHHHHHHHHHHHHHH	5.22	22817900
136	Ubiquitination	ETILLRQKQLEETNL HHHHHHHHHHHHHCH	50.87	29967540
167 (in isoform 2)	Ubiquitination	-	4.15	21906983
168	Ubiquitination	LTEEQYIKLKAFPED CCHHHHHHCCCCCHH	38.71	29967540
204	Ubiquitination	EICELQVKKNILAEE HHHHHHHHHHHHHHH	27.43	29967540
204	2-Hydroxyisobutyrylation	EICELQVKKNILAEE HHHHHHHHHHHHHHH	27.43	-
205	Ubiquitination	ICELQVKKNILAEEL HHHHHHHHHHHHHHH	50.82	29967540
213	Phosphorylation	NILAEELSTNKNQLK HHHHHHHCCCHHHHH	32.96	26546556
214	Phosphorylation	ILAEELSTNKNQLKQ HHHHHHCCCHHHHHH	63.94	23403867
216	Ubiquitination	AEELSTNKNQLKQLT HHHHCCCHHHHHHHH	46.27	29967540
220	Ubiquitination	STNKNQLKQLTETYE CCCHHHHHHHHHHHH	33.23	29967540
231	Ubiquitination	ETYEEDRKNYSEVQI HHHHHHHCCHHHHHH	72.98	29967540
251 (in isoform 1)	Ubiquitination	-	43.59	21906983
251	Ubiquitination	ALELADTKQLIQQGD HHHHHHHHHHHHCCC	43.59	21906983
284	Ubiquitination	EVIELRRKHEILEAS HHHHHHHHHHHHHHH	38.87	29967540
304	Ubiquitination	KERSELSKEVVTLEQ HCHHHHHHHHEHHHH	68.12	29967540
307	Ubiquitination	SELSKEVVTLEQTVT HHHHHHHEHHHHHHH	5.47	22817900
311	Ubiquitination	KEVVTLEQTVTLLQK HHHEHHHHHHHHHHH	44.37	22817900
318	Ubiquitination	QTVTLLQKDKEYLNR HHHHHHHHCHHHHHH	71.40	29967540
336	Ubiquitination	ELSVRCAHEEDRLER EEHHHHCCHHHHHHH	42.47	22817900
340	Ubiquitination	RCAHEEDRLERLQAQ HHCCHHHHHHHHHHH	41.55	22817900
342	Ubiquitination	AHEEDRLERLQAQLE CCHHHHHHHHHHHHH	52.84	27667366
351	Phosphorylation	LQAQLEESKKAREEM HHHHHHHHHHHHHHH	30.04	29449344
352	Ubiquitination	QAQLEESKKAREEMY HHHHHHHHHHHHHHH	54.45	29967540
371	Ubiquitination	ASRDHYKTEYENKLH HCCHHHHHHHHHHHH	36.31	27667366
376	Ubiquitination	YKTEYENKLHDELEQ HHHHHHHHHHHHHHH	34.95	29967540
387	Ubiquitination	ELEQIRLKTNQEIDQ HHHHHHHHCHHHHHH	35.26	29967540
421	Ubiquitination	RDNAVAEKERAVMAE HHHHHHHHHHHHHHH	42.64	33845483
434	Ubiquitination	AEKDALEKHDQLLDR HHHHHHHHHHHHHHH	54.02	33845483
441	Methylation	KHDQLLDRYRELQLS HHHHHHHHHHHHHCC	32.17	115487517
452	Ubiquitination	LQLSTESKVTEFLHQ HHCCCHHHHHHHHHH	47.12	29967540
461	Acetylation	TEFLHQSKLKSFESE HHHHHHHHCCCHHHH	54.05	25953088
461	Ubiquitination	TEFLHQSKLKSFESE HHHHHHHHCCCHHHH	54.05	32015554
463	Ubiquitination	FLHQSKLKSFESERV HHHHHHCCCHHHHHH	57.76	33845483
477	Phosphorylation	VQLLQEETARNLTQC HHHHHHHHHHHHHHH	30.11	26503514
490	Ubiquitination	QCQLECEKYQKKLEV HHHHHHHHHHHHHHH	65.72	32015554
494	Ubiquitination	ECEKYQKKLEVLTKE HHHHHHHHHHHHHHH	34.06	29967540
503	Phosphorylation	EVLTKEFYSLQASSE HHHHHHHHHHHCCCH	15.01	24114839
504	Phosphorylation	VLTKEFYSLQASSEK HHHHHHHHHHCCCHH	21.23	24114839
508	Phosphorylation	EFYSLQASSEKRITE HHHHHHCCCHHHHHH	26.52	24114839
509	Phosphorylation	FYSLQASSEKRITEL HHHHHCCCHHHHHHH	50.59	24114839
519	Ubiquitination	RITELQAQNSEHQAR HHHHHHHCCCHHHHH	40.81	32015554
532	Ubiquitination	ARLDIYEKLEKELDE HHHHHHHHHHHHHHH	45.00	29967540
571	Ubiquitination	ANVPTTAKRRLKQSV CCCCHHHHHHHHHHH	35.64	32015554
585	Ubiquitination	VHLARRVLQLEKQNS HHHHHHHHHHHHHCC	4.57	22817900
589	Ubiquitination	RRVLQLEKQNSLILK HHHHHHHHHCCCHHH	64.47	22817900
592	Phosphorylation	LQLEKQNSLILKDLE HHHHHHCCCHHHCHH	17.81	24719451
596	Ubiquitination	KQNSLILKDLEHRKD HHCCCHHHCHHHCHH	53.96	29967540
600	Ubiquitination	LILKDLEHRKDQVTQ CHHHCHHHCHHHHHH	49.76	32015554
602	Ubiquitination	LKDLEHRKDQVTQLS HHCHHHCHHHHHHHH	55.19	29967540
614	Ubiquitination	QLSQELDRANSLLNQ HHHHHHHHHHHHHHH	48.57	22817900
618	Ubiquitination	ELDRANSLLNQTQQP HHHHHHHHHHHCCHH	5.37	22817900
620	Ubiquitination	DRANSLLNQTQQPYR HHHHHHHHHCCHHHH	48.42	27667366
628	Phosphorylation	QTQQPYRYLIESVRQ HCCHHHHHHHHHHHH	13.24	23403867
639	Ubiquitination	SVRQRDSKIDSLTES HHHHCCHHHHHHHHH	55.62	29967540
642	Phosphorylation	QRDSKIDSLTESIAQ HCCHHHHHHHHHHHH	40.44	23403867
644	Phosphorylation	DSKIDSLTESIAQLE CHHHHHHHHHHHHHH	31.47	23403867
646	Phosphorylation	KIDSLTESIAQLEKD HHHHHHHHHHHHHHH	20.28	23403867
649	Ubiquitination	SLTESIAQLEKDVSN HHHHHHHHHHHHHHH	48.78	27667366
652	Ubiquitination	ESIAQLEKDVSNLNK HHHHHHHHHHHHCCH	72.52	29967540
662	Phosphorylation	SNLNKEKSALLQTKN HHCCHHHHHHHHHHH	25.82	22210691
665	Ubiquitination	NKEKSALLQTKNQMA CHHHHHHHHHHHHHH	6.42	22817900
667	Phosphorylation	EKSALLQTKNQMALD HHHHHHHHHHHHHHC	31.75	22210691
669	Ubiquitination	SALLQTKNQMALDLE HHHHHHHHHHHHCHH	40.00	22817900
697	Phosphorylation	QILVKMHSKHSENSL HHHHHHHCCCCCCCE	28.68	-
698	Ubiquitination	ILVKMHSKHSENSLL HHHHHHCCCCCCCEE	36.15	29967540
700	Phosphorylation	VKMHSKHSENSLLLT HHHHCCCCCCCEEEE	42.06	25159151
700	Ubiquitination	VKMHSKHSENSLLLT HHHHCCCCCCCEEEE	42.06	27667366
703	Phosphorylation	HSKHSENSLLLTKTE HCCCCCCCEEEECCC	19.15	25159151
708	Ubiquitination	ENSLLLTKTEPKHVT CCCEEEECCCCCCCC	51.35	22817900
708 (in isoform 1)	Ubiquitination	-	51.35	21906983
712	Ubiquitination	LLTKTEPKHVTENQK EEECCCCCCCCCCCC	44.46	22817900
721	Ubiquitination	VTENQKSKTLNVPKE CCCCCCCCCCCCCHH	65.16	29967540
721	Acetylation	VTENQKSKTLNVPKE CCCCCCCCCCCCCHH	65.16	30591307
727	Acetylation	SKTLNVPKEHEDNIF CCCCCCCHHHCCCCC	68.38	30591313
735	Phosphorylation	EHEDNIFTPKPTLFT HHCCCCCCCCCCCCC	26.97	28555341
737	Ubiquitination	EDNIFTPKPTLFTKK CCCCCCCCCCCCCCC	47.80	32015554
741	Ubiquitination	FTPKPTLFTKKEAPE CCCCCCCCCCCCCCH	11.79	22817900
743	Ubiquitination	PKPTLFTKKEAPEWS CCCCCCCCCCCCHHH	41.08	27667366
751	2-Hydroxyisobutyrylation	KEAPEWSKKQKMKT- CCCCHHHHHHCCCC-	61.36	-
772	Ubiquitination	---------------------- ----------------------		27667366

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PIBF1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PIBF1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PIBF1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
AHI1_HUMAN	AHI1	physical	27173435
SNX27_HUMAN	SNX27	physical	27173435
AT2B2_HUMAN	ATP2B2	physical	27173435
NHRF2_HUMAN	SLC9A3R2	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.