AT2B2_HUMAN - dbPTM
AT2B2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID AT2B2_HUMAN
UniProt AC Q01814
Protein Name Plasma membrane calcium-transporting ATPase 2
Gene Name ATP2B2
Organism Homo sapiens (Human).
Sequence Length 1243
Subcellular Localization Cell junction, synapse . Cell membrane
Multi-pass membrane protein .
Protein Description This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell..
Protein Sequence MGDMTNSDFYSKNQRNESSHGGEFGCTMEELRSLMELRGTEAVVKIKETYGDTEAICRRLKTSPVEGLPGTAPDLEKRKQIFGQNFIPPKKPKTFLQLVWEALQDVTLIILEIAAIISLGLSFYHPPGEGNEGCATAQGGAEDEGEAEAGWIEGAAILLSVICVVLVTAFNDWSKEKQFRGLQSRIEQEQKFTVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLKIDESSLTGESDQVRKSVDKDPMLLSGTHVMEGSGRMLVTAVGVNSQTGIIFTLLGAGGEEEEKKDKKGVKKGDGLQLPAADGAAASNAADSANASLVNGKMQDGNVDASQSKAKQQDGAAAMEMQPLKSAEGGDADDRKKASMHKKEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFTVDTFVVNKKPWLPECTPVYVQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQAYVGDVHYKEIPDPSSINTKTMELLINAIAINSAYTTKILPPEKEGALPRQVGNKTECGLLGFVLDLKQDYEPVRSQMPEEKLYKVYTFNSVRKSMSTVIKLPDESFRMYSKGASEIVLKKCCKILNGAGEPRVFRPRDRDEMVKKVIEPMACDGLRTICVAYRDFPSSPEPDWDNENDILNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIHPGEDFLCLEGKEFNRRIRNEKGEIEQERIDKIWPKLRVLARSSPTDKHTLVKGIIDSTHTEQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTETLLLRKPYGRNKPLISRTMMKNILGHAVYQLALIFTLLFVGEKMFQIDSGRNAPLHSPPSEHYTIIFNTFVMMQLFNEINARKIHGERNVFDGIFRNPIFCTIVLGTFAIQIVIVQFGGKPFSCSPLQLDQWMWCIFIGLGELVWGQVIATIPTSRLKFLKEAGRLTQKEEIPEEELNEDVEEIDHAERELRRGQILWFRGLNRIQTQIRVVKAFRSSLYEGLEKPESRTSIHNFMAHPEFRIEDSQPHIPLIDDTDLEEDAALKQNSSPPSSLNKNNSAIDSGINLTTDTSKSATSSSPGSPIHSLETSL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
5Phosphorylation---MGDMTNSDFYSK
---CCCCCHHHHHCC		35.99-
18PhosphorylationSKNQRNESSHGGEFG
CCCCCCCCCCCCCCC		31.0528857561
19PhosphorylationKNQRNESSHGGEFGC
CCCCCCCCCCCCCCC		21.7025072903
62PhosphorylationAICRRLKTSPVEGLP
HHHHHHCCCCCCCCC		42.7425307156
63PhosphorylationICRRLKTSPVEGLPG
HHHHHCCCCCCCCCC		25.9227251275
71PhosphorylationPVEGLPGTAPDLEKR
CCCCCCCCCCCHHHH		32.8327251275
177UbiquitinationFNDWSKEKQFRGLQS
CCCCCHHHHHHHHHH		59.48-
184PhosphorylationKQFRGLQSRIEQEQK
HHHHHHHHHHHHHCC		40.02-
218PhosphorylationGDIAQVKYGDLLPAD
CCCCCCCCCCEECCC		19.60-
280PhosphorylationVTAVGVNSQTGIIFT
EEEEEECCCCCEEEE		27.06-
282PhosphorylationAVGVNSQTGIIFTLL
EEEECCCCCEEEEEE		30.1223403867
287PhosphorylationSQTGIIFTLLGAGGE
CCCCEEEEEECCCCC		15.6323403867
301AcetylationEEEEKKDKKGVKKGD
CHHHHCCCCCCCCCC		61.3818585153
346PhosphorylationGNVDASQSKAKQQDG
CCCCHHHHHHHHHCC		31.8917287340
364PhosphorylationMEMQPLKSAEGGDAD
HHCCCCCCCCCCCHH		38.96-
383UbiquitinationASMHKKEKSVLQGKL
HHHHHHHHHHHHHHH		55.53-
389AcetylationEKSVLQGKLTKLAVQ
HHHHHHHHHHHHHHH		39.77-
389UbiquitinationEKSVLQGKLTKLAVQ
HHHHHHHHHHHHHHH		39.77-
431 (in isoform 4)Ubiquitination-49.1821890473
431 (in isoform 6)Ubiquitination-49.1821890473
449PhosphorylationKFFIIGVTVLVVAVP
HHHHHCEEEEEEECC		11.69-
462 (in isoform 3)Ubiquitination-8.4121890473
462 (in isoform 5)Ubiquitination-8.4121890473
469PhosphorylationAVTISLAYSVKKMMK
HHHHHHHHHHHHHHC		21.20-
470PhosphorylationVTISLAYSVKKMMKD
HHHHHHHHHHHHHCC		23.12-
476UbiquitinationYSVKKMMKDNNLVRH
HHHHHHHCCCCHHHH		54.53-
476 (in isoform 1)Ubiquitination-54.5321890473
476 (in isoform 2)Ubiquitination-54.5321890473
498PhosphorylationGNATAICSDKTGTLT
CCCEEEECCCCCCEE		35.71-
528PhosphorylationYKEIPDPSSINTKTM
CCCCCCHHHCCHHHH		51.7524173317
532PhosphorylationPDPSSINTKTMELLI
CCHHHCCHHHHHHHH		26.6524173317
597PhosphorylationQMPEEKLYKVYTFNS
CCCHHHHHEEEEHHH		14.9626552605
600PhosphorylationEEKLYKVYTFNSVRK
HHHHHEEEEHHHHCH		11.0625332170
601PhosphorylationEKLYKVYTFNSVRKS
HHHHEEEEHHHHCHH		21.2325332170
604PhosphorylationYKVYTFNSVRKSMST
HEEEEHHHHCHHHCE		21.0726552605
624PhosphorylationDESFRMYSKGASEIV
CHHHCCCCCCCHHHH		18.4424719451
725 (in isoform 4)Ubiquitination-2.9221890473
725 (in isoform 6)Ubiquitination-2.9221890473
726PhosphorylationKCQRAGITVRMVTGD
HHHHCCCEEEEECCC		10.92-
735 (in isoform 4)Ubiquitination-6.0421890473
735 (in isoform 6)Ubiquitination-6.0421890473
756 (in isoform 3)Ubiquitination-3.0821890473
756 (in isoform 5)Ubiquitination-3.0821890473
766 (in isoform 3)Ubiquitination-5.1121890473
766 (in isoform 5)Ubiquitination-5.1121890473
770UbiquitinationNRRIRNEKGEIEQER
HHHHHCCCCCCCHHH		66.4521906983
770 (in isoform 1)Ubiquitination-66.4521890473
770 (in isoform 2)Ubiquitination-66.4521890473
780UbiquitinationIEQERIDKIWPKLRV
CCHHHHHHHHHHHHH		44.28-
780 (in isoform 1)Ubiquitination-44.2821890473
780 (in isoform 2)Ubiquitination-44.2821890473
784 (in isoform 4)Ubiquitination-33.6521890473
784 (in isoform 6)Ubiquitination-33.6521890473
791PhosphorylationKLRVLARSSPTDKHT
HHHHHHCCCCCCHHH		34.7529514088
792PhosphorylationLRVLARSSPTDKHTL
HHHHHCCCCCCHHHH		26.6829514088
794PhosphorylationVLARSSPTDKHTLVK
HHHCCCCCCHHHHHH		60.6829514088
796UbiquitinationARSSPTDKHTLVKGI
HCCCCCCHHHHHHHH		40.75-
798PhosphorylationSSPTDKHTLVKGIID
CCCCCHHHHHHHHHC		38.7023911959
815 (in isoform 3)Ubiquitination-2.4121890473
815 (in isoform 5)Ubiquitination-2.4121890473
818PhosphorylationQRQVVAVTGDGTNDG
CCEEEEEECCCCCCC		21.59-
822PhosphorylationVAVTGDGTNDGPALK
EEEECCCCCCCHHHH		34.57-
829UbiquitinationTNDGPALKKADVGFA
CCCCHHHHHCCCEEE		48.2821906983
829 (in isoform 1)Ubiquitination-48.2821890473
829 (in isoform 2)Ubiquitination-48.2821890473
854PhosphorylationEASDIILTDDNFSSI
HHHHEEECCCCHHHH		30.7922964224
899 (in isoform 4)Ubiquitination-3.7221890473
899 (in isoform 6)Ubiquitination-3.7221890473
930 (in isoform 3)Ubiquitination-36.3121890473
930 (in isoform 5)Ubiquitination-36.3121890473
940PhosphorylationTLLLRKPYGRNKPLI
EEEECCCCCCCCCCC		31.58-
944UbiquitinationRKPYGRNKPLISRTM
CCCCCCCCCCCCHHH		39.58-
944 (in isoform 1)Ubiquitination-39.5821890473
944 (in isoform 2)Ubiquitination-39.5821890473
1097MethylationKFLKEAGRLTQKEEI
HHHHHHCCCCCCHHC		41.43-
1104 (in isoform 4)Phosphorylation-5.6626437602
1107 (in isoform 4)Phosphorylation-63.5326437602
1112 (in isoform 6)Ubiquitination-52.6421890473
1116 (in isoform 4)Phosphorylation-2.7326437602
1117 (in isoform 4)Phosphorylation-37.9227732954
1118 (in isoform 7)Phosphorylation-34.8426437602
1119 (in isoform 4)Phosphorylation-17.5027732954
1120 (in isoform 4)Phosphorylation-43.1827732954
1121 (in isoform 7)Phosphorylation-49.3726437602
1122 (in isoform 4)Phosphorylation-37.8327732954
1129 (in isoform 4)Phosphorylation-2.4525850435
1130 (in isoform 4)Phosphorylation-5.1925850435
1130 (in isoform 7)Phosphorylation-5.1926437602
1131 (in isoform 7)Phosphorylation-3.8827732954
1132 (in isoform 4)Phosphorylation-36.7925850435
1133 (in isoform 7)Phosphorylation-20.1727732954
1134 (in isoform 7)Phosphorylation-3.2027732954
1135 (in isoform 3)Phosphorylation-41.6626437602
1136 (in isoform 7)Phosphorylation-27.6827732954
1138 (in isoform 3)Phosphorylation-24.9026437602
1139PhosphorylationRGLNRIQTQIRVVKA
ECCCHHHHHHHHHHH		24.4822817900
1143 (in isoform 5)Ubiquitination-5.7521890473
1143 (in isoform 7)Phosphorylation-5.7525850435
1144 (in isoform 7)Phosphorylation-2.3825850435
1146 (in isoform 7)Phosphorylation-8.0925850435
1147 (in isoform 3)Phosphorylation-6.8826437602
1148 (in isoform 3)Phosphorylation-30.1427732954
1149PhosphorylationRVVKAFRSSLYEGLE
HHHHHHHHHHHHCCC		20.4521945579
1149 (in isoform 2)Phosphorylation-20.4526437602
1150PhosphorylationVVKAFRSSLYEGLEK
HHHHHHHHHHHCCCC		30.6221945579
1150 (in isoform 3)Phosphorylation-30.6227732954
1151 (in isoform 3)Phosphorylation-4.8127732954
1152PhosphorylationKAFRSSLYEGLEKPE
HHHHHHHHHCCCCCC		15.2021945579
1152 (in isoform 2)Phosphorylation-15.2026437602
1153 (in isoform 3)Phosphorylation-63.7027732954
1157UbiquitinationSLYEGLEKPESRTSI
HHHHCCCCCCCCCCH		60.1622053931
1157 (in isoform 1)Ubiquitination-60.1621890473
1160PhosphorylationEGLEKPESRTSIHNF
HCCCCCCCCCCHHHH		49.7621955146
1160 (in isoform 3)Phosphorylation-49.7625850435
1161 (in isoform 2)Phosphorylation-30.7226437602
1161 (in isoform 3)Phosphorylation-30.7225850435
1162PhosphorylationLEKPESRTSIHNFMA
CCCCCCCCCHHHHCC		41.1128857561
1162 (in isoform 2)Phosphorylation-41.1127732954
1163PhosphorylationEKPESRTSIHNFMAH
CCCCCCCCHHHHCCC		22.2728857561
1163 (in isoform 3)Phosphorylation-22.2725850435
1164 (in isoform 2)Phosphorylation-2.8127732954
1165 (in isoform 2)Phosphorylation-22.6527732954
1167 (in isoform 2)Phosphorylation-2.5727732954
1174 (in isoform 2)Phosphorylation-29.7125850435
1175 (in isoform 2)Phosphorylation-9.2925850435
1177 (in isoform 2)Phosphorylation-50.6425850435
1178PhosphorylationPEFRIEDSQPHIPLI
CCEECCCCCCCCCCC		32.5927732954
1188PhosphorylationHIPLIDDTDLEEDAA
CCCCCCCCCHHHHHH		38.44-
1200PhosphorylationDAALKQNSSPPSSLN
HHHHHCCCCCCHHHC		41.5526852163
1201PhosphorylationAALKQNSSPPSSLNK
HHHHCCCCCCHHHCC		48.6725332170
1204PhosphorylationKQNSSPPSSLNKNNS
HCCCCCCHHHCCCCC		51.3329507054
1205PhosphorylationQNSSPPSSLNKNNSA
CCCCCCHHHCCCCCC		41.5629507054
1211PhosphorylationSSLNKNNSAIDSGIN
HHHCCCCCCCCCCCC		35.678428366
1223PhosphorylationGINLTTDTSKSATSS
CCCCCCCCCCCCCCC		35.6425307156
1226PhosphorylationLTTDTSKSATSSSPG
CCCCCCCCCCCCCCC		36.2223403867
1228PhosphorylationTDTSKSATSSSPGSP
CCCCCCCCCCCCCCC		35.9130576142
1229PhosphorylationDTSKSATSSSPGSPI
CCCCCCCCCCCCCCC		28.6530576142
1230PhosphorylationTSKSATSSSPGSPIH
CCCCCCCCCCCCCCC		35.8830576142
1231PhosphorylationSKSATSSSPGSPIHS
CCCCCCCCCCCCCCC		32.8028176443
1234PhosphorylationATSSSPGSPIHSLET
CCCCCCCCCCCCCCC		24.8630278072
1238PhosphorylationSPGSPIHSLETSL--
CCCCCCCCCCCCC--		28.7230278072
1241PhosphorylationSPIHSLETSL-----
CCCCCCCCCC-----		40.3930278072
1242PhosphorylationPIHSLETSL------
CCCCCCCCC------		23.7830278072
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
1139TPhosphorylationKinasePRKCAP05696
GPS
1139TPhosphorylationKinasePKC-Uniprot
1201SPhosphorylationKinasePKA-Uniprot
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of AT2B2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of AT2B2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
DLG1_HUMANDLG1physical
11274188
DLG4_RATDlg4physical
11274188
DLG1_RATDlg1physical
11274188
DLG2_RATDlg2physical
11274188
DLG3_HUMANDLG3physical
11274188
DLG2_HUMANDLG2physical
11274188
AOFB_HUMANMAOBphysical
28514442
AT2B3_HUMANATP2B3physical
28514442
GPAT1_HUMANGPAMphysical
28514442
NRM_HUMANNRMphysical
28514442
F174A_HUMANFAM174Aphysical
28514442
ABCD1_HUMANABCD1physical
28514442
TM168_HUMANTMEM168physical
28514442
AT2B4_HUMANATP2B4physical
28514442
DGAT1_HUMANDGAT1physical
28514442
APOD_HUMANAPODphysical
28514442
GOLM1_HUMANGOLM1physical
28514442
H17B6_HUMANHSD17B6physical
28514442
LEMD2_HUMANLEMD2physical
28514442
CLUS_HUMANCLUphysical
28514442
DHRS7_HUMANDHRS7physical
28514442
B3A2_HUMANSLC4A2physical
28514442
PIGN_HUMANPIGNphysical
28514442
MPC2_HUMANMPC2physical
28514442
STEA3_HUMANSTEAP3physical
28514442
OSTC_HUMANOSTCphysical
28514442
CERS6_HUMANCERS6physical
28514442
GOLI4_HUMANGOLIM4physical
28514442
AR6P1_HUMANARL6IP1physical
28514442
FZD7_HUMANFZD7physical
28514442
ERMP1_HUMANERMP1physical
28514442
TOR1A_HUMANTOR1Aphysical
28514442
S38A9_HUMANSLC38A9physical
28514442
CHSS1_HUMANCHSY1physical
28514442
PIGO_HUMANPIGOphysical
28514442
CO4A_HUMANC4Aphysical
28514442
FACR2_HUMANFAR2physical
28514442
CSCL1_HUMANTMEM63Aphysical
28514442
MRP7_HUMANABCC10physical
28514442
MRP4_HUMANABCC4physical
28514442
GHDC_HUMANGHDCphysical
28514442
CSCL2_HUMANTMEM63Bphysical
28514442
MUCL1_HUMANMUCL1physical
28514442
ERG1_HUMANSQLEphysical
28514442
ATG9A_HUMANATG9Aphysical
28514442
BAP31_HUMANBCAP31physical
28514442
ZA2G_HUMANAZGP1physical
28514442
AG10A_HUMANALG10physical
28514442
ABCD4_HUMANABCD4physical
28514442
TRABD_HUMANTRABDphysical
28514442
PCX3_HUMANPCNXL3physical
28514442
ALG8_HUMANALG8physical
28514442
TNPO3_HUMANTNPO3physical
28514442
S47A1_HUMANSLC47A1physical
28514442
SRPRB_HUMANSRPRBphysical
28514442
CAB45_HUMANSDF4physical
28514442
GLBL2_HUMANGLB1L2physical
28514442
ABCB9_HUMANABCB9physical
28514442
S26A6_HUMANSLC26A6physical
28514442
S15A4_HUMANSLC15A4physical
28514442
BTBD9_HUMANBTBD9physical
28514442
GOGA5_HUMANGOLGA5physical
28514442
TIM23_HUMANTIMM23physical
28514442
ATP9A_HUMANATP9Aphysical
28514442
MIRO2_HUMANRHOT2physical
28514442
LCLT1_HUMANLCLAT1physical
28514442
UXS1_HUMANUXS1physical
28514442
S4A7_HUMANSLC4A7physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of AT2B2_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1242, AND MASSSPECTROMETRY.
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1231; SER-1234;SER-1238; THR-1241 AND SER-1242, AND MASS SPECTROMETRY.

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