S15A4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: S15A4_HUMAN
• UniProt AC: Q8N697
• Protein Name: Solute carrier family 15 member 4
• Gene Name: SLC15A4
• Organism: Homo sapiens (Human).
• Sequence Length: 577
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Description: Proton oligopeptide cotransporter. Transports free histidine and certain di- and tripeptides..
• Protein Sequence: MEGSGGGAGERAPLLGARRAAAAAAAAGAFAGRRAACGAVLLTELLERAAFYGITSNLVLFLNGAPFCWEGAQASEALLLFMGLTYLGSPFGGWLADARLGRARAILLSLALYLLGMLAFPLLAAPATRAALCGSARLLNCTAPGPDAAARCCSPATFAGLVLVGLGVATVKANITPFGADQVKDRGPEATRRFFNWFYWSINLGAILSLGGIAYIQQNVSFVTGYAIPTVCVGLAFVVFLCGQSVFITKPPDGSAFTDMFKILTYSCCSQKRSGERQSNGEGIGVFQQSSKQSLFDSCKMSHGGPFTEEKVEDVKALVKIVPVFLALIPYWTVYFQMQTTYVLQSLHLRIPEISNITTTPHTLPAAWLTMFDAVLILLLIPLKDKLVDPILRRHGLLPSSLKRIAVGMFFVMCSAFAAGILESKRLNLVKEKTINQTIGNVVYHAADLSLWWQVPQYLLIGISEIFASIAGLEFAYSAAPKSMQSAIMGLFFFFSGVGSFVGSGLLALVSIKAIGWMSSHTDFGNINGCYLNYYFFLLAAIQGATLLLFLIISVKYDHHRDHQRSRANGVPTSRRA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MEGSGGGAGER ----CCCCCCCCCCC	22.43	23401153
109	Phosphorylation	RARAILLSLALYLLG HHHHHHHHHHHHHHH	14.25	-
113	Phosphorylation	ILLSLALYLLGMLAF HHHHHHHHHHHHHHH	8.35	-
128	Phosphorylation	PLLAAPATRAALCGS HHHHCHHHHHHHHHC	21.56	-
135	Phosphorylation	TRAALCGSARLLNCT HHHHHHHCCHHHCCC	14.82	-
142	Phosphorylation	SARLLNCTAPGPDAA CCHHHCCCCCCCCHH	34.51	30631047
184	Ubiquitination	PFGADQVKDRGPEAT CCCHHHHHHCCHHHH	35.75	33845483
272	Ubiquitination	TYSCCSQKRSGERQS HHHHHCCCCCCCCCC	32.03	21963094
272 (in isoform 1)	Ubiquitination	-	32.03	21890473
274	Phosphorylation	SCCSQKRSGERQSNG HHHCCCCCCCCCCCC	52.63	26471730
279	Phosphorylation	KRSGERQSNGEGIGV CCCCCCCCCCCCCEE	53.69	19060867
290	Phosphorylation	GIGVFQQSSKQSLFD CCEEEECCCCHHHHH	28.81	22777824
291	Phosphorylation	IGVFQQSSKQSLFDS CEEEECCCCHHHHHH	30.31	22777824
292	Ubiquitination	GVFQQSSKQSLFDSC EEEECCCCHHHHHHC	49.50	23000965
292 (in isoform 1)	Ubiquitination	-	49.50	21890473
294	Phosphorylation	FQQSSKQSLFDSCKM EECCCCHHHHHHCCC	34.44	22210691
298	Phosphorylation	SKQSLFDSCKMSHGG CCHHHHHHCCCCCCC	14.33	23401153
300	Ubiquitination	QSLFDSCKMSHGGPF HHHHHHCCCCCCCCC	47.60	29967540
302	Phosphorylation	LFDSCKMSHGGPFTE HHHHCCCCCCCCCCH	12.41	22210691
311	Ubiquitination	GGPFTEEKVEDVKAL CCCCCHHHHHHHHHH	44.70	29901268
316 (in isoform 1)	Ubiquitination	-	48.61	21890473
316	Ubiquitination	EEKVEDVKALVKIVP HHHHHHHHHHHHHHH	48.61	33845483
322	Ubiquitination	VKALVKIVPVFLALI HHHHHHHHHHHHHHH	2.47	21890473
340	Phosphorylation	TVYFQMQTTYVLQSL HHHHHHHHHHHHHHH	18.10	24043423
341	Phosphorylation	VYFQMQTTYVLQSLH HHHHHHHHHHHHHHH	8.50	24043423
342	Ubiquitination	YFQMQTTYVLQSLHL HHHHHHHHHHHHHHC	11.53	23000965
342	Phosphorylation	YFQMQTTYVLQSLHL HHHHHHHHHHHHHHC	11.53	24043423
346	Phosphorylation	QTTYVLQSLHLRIPE HHHHHHHHHHCCCCC	17.37	24043423
477	Phosphorylation	IAGLEFAYSAAPKSM HHCHHHHHHCCCHHH	12.26	-
478	Phosphorylation	AGLEFAYSAAPKSMQ HCHHHHHHCCCHHHH	17.96	-
504	Phosphorylation	GVGSFVGSGLLALVS CCHHHHHHHHHHHHH	22.44	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of S15A4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of S15A4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of S15A4_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of S15A4_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.