AT2B3_HUMAN - dbPTM
AT2B3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID AT2B3_HUMAN
UniProt AC Q16720
Protein Name Plasma membrane calcium-transporting ATPase 3
Gene Name ATP2B3
Organism Homo sapiens (Human).
Sequence Length 1220
Subcellular Localization Cell membrane
Multi-pass membrane protein.
Protein Description This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell..
Protein Sequence MGDMANSSIEFHPKPQQQRDVPQAGGFGCTLAELRTLMELRGAEALQKIEEAYGDVSGLCRRLKTSPTEGLADNTNDLEKRRQIYGQNFIPPKQPKTFLQLVWEALQDVTLIILEVAAIVSLGLSFYAPPGEESEACGNVSGGAEDEGEAEAGWIEGAAILLSVICVVLVTAFNDWSKEKQFRGLQSRIEQEQKFTVIRNGQLLQVPVAALVVGDIAQVKYGDLLPADGVLIQANDLKIDESSLTGESDHVRKSADKDPMLLSGTHVMEGSGRMVVTAVGVNSQTGIIFTLLGAGGEEEEKKDKKGKQQDGAMESSQTKAKKQDGAVAMEMQPLKSAEGGEMEEREKKKANAPKKEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFVIETFVVEGRTWLAECTPVYVQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQSYLGDTHYKEIPAPSALTPKILDLLVHAISINSAYTTKILPPEKEGALPRQVGNKTECALLGFVLDLKRDFQPVREQIPEDKLYKVYTFNSVRKSMSTVIRMPDGGFRLFSKGASEILLKKCTNILNSNGELRGFRPRDRDDMVRKIIEPMACDGLRTICIAYRDFSAGQEPDWDNENEVVGDLTCIAVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAAKCGIIQPGEDFLCLEGKEFNRRIRNEKGEIEQERLDKVWPKLRVLARSSPTDKHTLVKGIIDSTTGEQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTESLLLRKPYGRDKPLISRTMMKNILGHAVYQLAIIFTLLFVGELFFDIDSGRNAPLHSPPSEHYTIIFNTFVMMQLFNEINARKIHGERNVFDGIFSNPIFCTIVLGTFGIQIVIVQFGGKPFSCSPLSTEQWLWCLFVGVGELVWGQVIATIPTSQLKCLKEAGHGPGKDEMTDEELAEGEEEIDHAERELRRGQILWFRGLNRIQTQIRVVKAFRSSLYEGLEKPESKTSIHNFMATPEFLINDYTHNIPLIDDTDVDENEERLRAPPPPSPNQNNNAIDSGIYLTTHVTKSATSSVFSSSPGSPLHSVETSL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
7Phosphorylation-MGDMANSSIEFHPK
-CCCCCCCCCCCCCC		24.1327732954
8PhosphorylationMGDMANSSIEFHPKP
CCCCCCCCCCCCCCH		26.4127732954
75PhosphorylationTEGLADNTNDLEKRR
CCCCCCCCCHHHHHH		30.5625307156
80UbiquitinationDNTNDLEKRRQIYGQ
CCCCHHHHHHHHHCC		61.2430230243
180UbiquitinationFNDWSKEKQFRGLQS
CCCCCHHHHHHHHHH		59.48-
187PhosphorylationKQFRGLQSRIEQEQK
HHHHHHHHHHHHHHC		40.02-
194UbiquitinationSRIEQEQKFTVIRNG
HHHHHHHCEEEEECC		42.1021890473
221PhosphorylationGDIAQVKYGDLLPAD
CCHHHCCCCCEECCC		19.60-
243PhosphorylationDLKIDESSLTGESDH
CEEECHHHCCCCCHH		28.09-
277PhosphorylationGSGRMVVTAVGVNSQ
CCCCEEEEEEEECCC		12.29-
283PhosphorylationVTAVGVNSQTGIIFT
EEEEEECCCCCEEEE		27.06-
290PhosphorylationSQTGIIFTLLGAGGE
CCCCEEEEEECCCCC		15.6323403867
321UbiquitinationESSQTKAKKQDGAVA
HHHHHHHHHCCCCEE		53.1523503661
335UbiquitinationAMEMQPLKSAEGGEM
EEEEEECCCCCCCCC		55.0623503661
335 (in isoform 2)Ubiquitination-55.06-
336PhosphorylationMEMQPLKSAEGGEME
EEEEECCCCCCCCCH		38.96-
347UbiquitinationGEMEEREKKKANAPK
CCCHHHHHHHCCCCH		66.8423503661
357UbiquitinationANAPKKEKSVLQGKL
CCCCHHHHHHHHHHH		55.53-
363AcetylationEKSVLQGKLTKLAVQ
HHHHHHHHHHHHHHH		39.77-
363UbiquitinationEKSVLQGKLTKLAVQ
HHHHHHHHHHHHHHH		39.77-
423PhosphorylationKFFIIGVTVLVVAVP
HHHHHCEEEEEEECC		11.69-
436UbiquitinationVPEGLPLAVTISLAY
CCCCCCHHHHHHHHH		8.4127667366
436 (in isoform 3)Ubiquitination-8.4121890473
436 (in isoform 4)Ubiquitination-8.4121890473
436 (in isoform 6)Ubiquitination-8.4121890473
436 (in isoform 8)Ubiquitination-8.4121890473
443PhosphorylationAVTISLAYSVKKMMK
HHHHHHHHHHHHHHC		21.20-
444PhosphorylationVTISLAYSVKKMMKD
HHHHHHHHHHHHHCC		23.12-
450UbiquitinationYSVKKMMKDNNLVRH
HHHHHHHCCCCHHHH		54.5329901268
450 (in isoform 1)Ubiquitination-54.5321890473
450 (in isoform 2)Ubiquitination-54.5321890473
450 (in isoform 5)Ubiquitination-54.5321890473
450 (in isoform 7)Ubiquitination-54.5321890473
462UbiquitinationVRHLDACETMGNATA
HHHHHHHHHCCCCEE		43.4827667366
472PhosphorylationGNATAICSDKTGTLT
CCCEEEECCCCCCEE		35.71-
488PhosphorylationNRMTVVQSYLGDTHY
CCEEEHHHHHCCCCC		15.6625690035
489PhosphorylationRMTVVQSYLGDTHYK
CEEEHHHHHCCCCCC		9.5219845377
495PhosphorylationSYLGDTHYKEIPAPS
HHHCCCCCCCCCCCC		16.6524719451
502PhosphorylationYKEIPAPSALTPKIL
CCCCCCCCCCCHHHH		37.7124719451
505PhosphorylationIPAPSALTPKILDLL
CCCCCCCCHHHHHHH		23.4224719451
531UbiquitinationTKILPPEKEGALPRQ
CCCCCCCCCCCCCCC		68.1930230243
543PhosphorylationPRQVGNKTECALLGF
CCCCCCHHHHHHHHH		40.05-
571PhosphorylationQIPEDKLYKVYTFNS
CCCCCCEEEEEEHHH		12.2626552605
574PhosphorylationEDKLYKVYTFNSVRK
CCCEEEEEEHHHHHH		11.0625332170
575PhosphorylationDKLYKVYTFNSVRKS
CCEEEEEEHHHHHHH		21.2325332170
578PhosphorylationYKVYTFNSVRKSMST
EEEEEHHHHHHHCCE		21.0725159151
580DimethylationVYTFNSVRKSMSTVI
EEEHHHHHHHCCEEE		25.75-
584PhosphorylationNSVRKSMSTVIRMPD
HHHHHHCCEEEECCC		26.98-
585PhosphorylationSVRKSMSTVIRMPDG
HHHHHCCEEEECCCC		16.00-
598PhosphorylationDGGFRLFSKGASEIL
CCCEEEECCCHHHHH		34.4724719451
700PhosphorylationKCQRAGITVRMVTGD
HHHHCCCEEEEECCC		10.92-
730UbiquitinationQPGEDFLCLEGKEFN
CCCCCEEEECCHHHH		3.0821963094
730 (in isoform 3)Ubiquitination-3.0821890473
730 (in isoform 4)Ubiquitination-3.0821890473
730 (in isoform 6)Ubiquitination-3.0821890473
730 (in isoform 8)Ubiquitination-3.0821890473
744UbiquitinationNRRIRNEKGEIEQER
HHHHHCCCCCHHHHH		66.4521906983
744 (in isoform 1)Ubiquitination-66.4521890473
744 (in isoform 2)Ubiquitination-66.4521890473
744 (in isoform 5)Ubiquitination-66.4521890473
744 (in isoform 7)Ubiquitination-66.4521890473
756UbiquitinationQERLDKVWPKLRVLA
HHHHHHHHHHHHHHH		7.0521963094
765PhosphorylationKLRVLARSSPTDKHT
HHHHHHCCCCCCHHH		34.7529514088
766PhosphorylationLRVLARSSPTDKHTL
HHHHHCCCCCCHHHH		26.6829514088
768PhosphorylationVLARSSPTDKHTLVK
HHHCCCCCCHHHHEE		60.6829514088
770UbiquitinationARSSPTDKHTLVKGI
HCCCCCCHHHHEEEE		40.75-
772PhosphorylationSSPTDKHTLVKGIID
CCCCCHHHHEEEEEE		38.7023911959
789UbiquitinationTGEQRQVVAVTGDGT
CCCEEEEEEEECCCC		2.4121890473
789 (in isoform 3)Ubiquitination-2.4121890473
789 (in isoform 4)Ubiquitination-2.4121890473
789 (in isoform 6)Ubiquitination-2.4121890473
789 (in isoform 8)Ubiquitination-2.4121890473
790UbiquitinationGEQRQVVAVTGDGTN
CCEEEEEEEECCCCC		8.3623503661
792PhosphorylationQRQVVAVTGDGTNDG
EEEEEEEECCCCCCC		21.59-
796PhosphorylationVAVTGDGTNDGPALK
EEEECCCCCCCHHHH		34.57-
803UbiquitinationTNDGPALKKADVGFA
CCCCHHHHHCCCEEE		48.2833845483
803 (in isoform 1)Ubiquitination-48.2821890473
803 (in isoform 2)Ubiquitination-48.2821890473
803 (in isoform 5)Ubiquitination-48.2821890473
803 (in isoform 7)Ubiquitination-48.2821890473
804UbiquitinationNDGPALKKADVGFAM
CCCHHHHHCCCEEEH		51.1523503661
815UbiquitinationGFAMGIAGTDVAKEA
EEEHHCCCCHHHHHH		22.1121890473
816UbiquitinationFAMGIAGTDVAKEAS
EEHHCCCCHHHHHHH		20.4823503661
823UbiquitinationTDVAKEASDIILTDD
CHHHHHHHCEEECCC		30.3623503661
837UbiquitinationDNFTSIVKAVMWGRN
CCHHHHHHHHHCCCC		33.3323503661
849UbiquitinationGRNVYDSISKFLQFQ
CCCHHHHHHHHHHHC		4.7923503661
1079PhosphorylationGPGKDEMTDEELAEG
CCCCCCCCHHHHHHC		37.9126471730
1110 (in isoform 3)Phosphorylation-27.6827732954
1110 (in isoform 6)Phosphorylation-27.6827732954
1112 (in isoform 3)Phosphorylation-24.9027732954
1112 (in isoform 6)Phosphorylation-24.9027732954
1113PhosphorylationRGLNRIQTQIRVVKA
ECCCHHHHHHHHHHH		24.4822210691
1123PhosphorylationRVVKAFRSSLYEGLE
HHHHHHHHHHHHCCC		20.45-
1124PhosphorylationVVKAFRSSLYEGLEK
HHHHHHHHHHHCCCC		30.6222817900
1124 (in isoform 2)Phosphorylation-30.6227732954
1124 (in isoform 5)Phosphorylation-30.6227732954
1126PhosphorylationKAFRSSLYEGLEKPE
HHHHHHHHHCCCCCC		15.2025884760
1126 (in isoform 2)Phosphorylation-15.2027732954
1126 (in isoform 5)Phosphorylation-15.2027732954
1134 (in isoform 3)Phosphorylation-50.16-
1134 (in isoform 6)Phosphorylation-50.16-
1148 (in isoform 2)Phosphorylation-3.22-
1148 (in isoform 5)Phosphorylation-3.22-
1157 (in isoform 3)Phosphorylation-28.69-
1171 (in isoform 2)Phosphorylation-6.56-
1215PhosphorylationSPGSPLHSVETSL--
CCCCCCCCCCCCC--		29.3627732954
1218PhosphorylationSPLHSVETSL-----
CCCCCCCCCC-----		32.9227732954
1219PhosphorylationPLHSVETSL------
CCCCCCCCC------		20.6927732954
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
1113TPhosphorylationKinasePKC-Uniprot
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of AT2B3_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of AT2B3_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CALX_HUMANCANXphysical
26344197
CLGN_HUMANCLGNphysical
26344197
COX2_HUMANCOX2physical
26344197
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
302500Spinocerebellar ataxia, X-linked 1 (SCAX1)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of AT2B3_HUMAN

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Related Literatures of Post-Translational Modification

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