CLGN_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CLGN_HUMAN
• UniProt AC: O14967
• Protein Name: Calmegin
• Gene Name: CLGN
• Organism: Homo sapiens (Human).
• Sequence Length: 610
• Subcellular Localization: Endoplasmic reticulum membrane; Single-pass type I membrane protein.
• Protein Description: Functions during spermatogenesis as a chaperone for a range of client proteins that are important for sperm adhesion onto the egg zona pellucida and for subsequent penetration of the zona pellucida. Required for normal sperm migration from the uterus into the oviduct. Required for normal male fertility. Binds calcium ions (By similarity)..
• Protein Sequence: MHFQAFWLCLGLLFISINAEFMDDDVETEDFEENSEEIDVNESELSSEIKYKTPQPIGEVYFAETFDSGRLAGWVLSKAKKDDMDEEISIYDGRWEIEELKENQVPGDRGLVLKSRAKHHAISAVLAKPFIFADKPLIVQYEVNFQDGIDCGGAYIKLLADTDDLILENFYDKTSYIIMFGPDKCGEDYKLHFIFRHKHPKTGVFEEKHAKPPDVDLKKFFTDRKTHLYTLVMNPDDTFEVLVDQTVVNKGSLLEDVVPPIKPPKEIEDPNDKKPEEWDERAKIPDPSAVKPEDWDESEPAQIEDSSVVKPAGWLDDEPKFIPDPNAEKPDDWNEDTDGEWEAPQILNPACRIGCGEWKPPMIDNPKYKGVWRPPLVDNPNYQGIWSPRKIPNPDYFEDDHPFLLTSFSALGLELWSMTSDIYFDNFIICSEKEVADHWAADGWRWKIMIANANKPGVLKQLMAAAEGHPWLWLIYLVTAGVPIALITSFCWPRKVKKKHKDTEYKKTDICIPQTKGVLEQEEKEEKAALEKPMDLEEEKKQNDGEMLEKEEESEPEEKSEEEIEIIEGQEESNQSNKSGSEDEMKEADESTGSGDGPIKSVRKRRVRKD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
101	Ubiquitination	RWEIEELKENQVPGD CEEHHHHHHCCCCCC	58.88	-
109	Methylation	ENQVPGDRGLVLKSR HCCCCCCCCEEEHHH	46.38	-
128	Acetylation	AISAVLAKPFIFADK HHHHHHCCCEEECCC	35.98	-
189	Phosphorylation	PDKCGEDYKLHFIFR CCCCCCCEEEEEEEE	15.90	28152594
190	Acetylation	DKCGEDYKLHFIFRH CCCCCCEEEEEEEEC	48.05	25953088
190	Ubiquitination	DKCGEDYKLHFIFRH CCCCCCEEEEEEEEC	48.05	-
291	Acetylation	IPDPSAVKPEDWDES CCCHHHCCCCCCCCC	42.26	30587689
387	Phosphorylation	PNYQGIWSPRKIPNP CCCCCCCCCCCCCCC	16.95	24719451
508	Phosphorylation	KDTEYKKTDICIPQT CCCCCCCCCEECCCC	26.84	28555341
554	Phosphorylation	MLEKEEESEPEEKSE HHHHHHCCCCCCCCH	62.83	20363803
560	Phosphorylation	ESEPEEKSEEEIEII CCCCCCCCHHHEEEE	54.22	21955146
573	Phosphorylation	IIEGQEESNQSNKSG EECCHHHCCCCCCCC	39.14	29514088
576	Phosphorylation	GQEESNQSNKSGSED CHHHCCCCCCCCCHH	50.94	29514088
579	Phosphorylation	ESNQSNKSGSEDEMK HCCCCCCCCCHHHHH	52.37	25849741
581	Phosphorylation	NQSNKSGSEDEMKEA CCCCCCCCHHHHHHH	49.30	28355574
591	Phosphorylation	EMKEADESTGSGDGP HHHHHHHCCCCCCCC	38.32	28355574
592	Phosphorylation	MKEADESTGSGDGPI HHHHHHCCCCCCCCC	33.06	25849741
594	Phosphorylation	EADESTGSGDGPIKS HHHHCCCCCCCCCCH	33.52	25159151
601	Phosphorylation	SGDGPIKSVRKRRVR CCCCCCCHHHHHCCC	28.07	20363803

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CLGN_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CLGN_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CLGN_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ADAM2_HUMAN	ADAM2	physical	11784061
XK_HUMAN	XK	physical	21988832
GDE1_HUMAN	GDE1	physical	21988832
FBXL4_HUMAN	FBXL4	physical	24035498
MRP1_HUMAN	ABCC1	physical	26344197
CALU_HUMAN	CALU	physical	26344197
ENPL_HUMAN	HSP90B1	physical	26344197
KDSR_HUMAN	KDSR	physical	26344197
RAB1A_HUMAN	RAB1A	physical	26344197
RCN1_HUMAN	RCN1	physical	26344197
RPN2_HUMAN	RPN2	physical	26344197
TERA_HUMAN	VCP	physical	26344197
TECT2_HUMAN	TCTN2	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-560 AND SER-576, ANDMASS SPECTROMETRY.
PubMed: 17081983