XK_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: XK_HUMAN
• UniProt AC: P51811
• Protein Name: Membrane transport protein XK
• Gene Name: XK
• Organism: Homo sapiens (Human).
• Sequence Length: 444
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Description: May be involved in sodium-dependent transport of neutral amino acids or oligopeptides..
• Protein Sequence: MKFPASVLASVFLFVAETTAALSLSSTYRSGGDRMWQALTLLFSLLPCALVQLTLLFVHRDLSRDRPLVLLLHLLQLGPLFRCFEVFCIYFQSGNNEEPYVSITKKRQMPKNGLSEEIEKEVGQAEGKLITHRSAFSRASVIQAFLGSAPQLTLQLYISVMQQDVTVGRSLLMTISLLSIVYGALRCNILAIKIKYDEYEVKVKPLAYVCIFLWRSFEIATRVVVLVLFTSVLKTWVVVIILINFFSFFLYPWILFWCSGSPFPENIEKALSRVGTTIVLCFLTLLYTGINMFCWSAVQLKIDSPDLISKSHNWYQLLVYYMIRFIENAILLLLWYLFKTDIYMYVCAPLLVLQLLIGYCTAILFMLVFYQFFHPCKKLFSSSVSEGFQRWLRCFCWACRQQKPCEPIGKEDLQSSRDRDETPSSSKTSPEPGQFLNAEDLCSA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
63	Phosphorylation	LFVHRDLSRDRPLVL HHHHCCCCCCCHHHH	36.10	27966365
100	Phosphorylation	SGNNEEPYVSITKKR CCCCCCCEEEEECCC	15.31	-
102	Phosphorylation	NNEEPYVSITKKRQM CCCCCEEEEECCCCC	20.78	-
104	Phosphorylation	EEPYVSITKKRQMPK CCCEEEEECCCCCCC	24.02	-
115	Phosphorylation	QMPKNGLSEEIEKEV CCCCCCCCHHHHHHH	34.28	-
120	Ubiquitination	GLSEEIEKEVGQAEG CCCHHHHHHHHHCCC	64.46	29967540
140	Phosphorylation	RSAFSRASVIQAFLG HHHHCHHHHHHHHHC	20.74	25072903
148	Phosphorylation	VIQAFLGSAPQLTLQ HHHHHHCCCCCHHHH	38.63	25072903
153	Phosphorylation	LGSAPQLTLQLYISV HCCCCCHHHHHHHHH	13.76	25072903
157	Phosphorylation	PQLTLQLYISVMQQD CCHHHHHHHHHHHCC	4.34	25072903
159	Phosphorylation	LTLQLYISVMQQDVT HHHHHHHHHHHCCCC	9.66	25072903
166	Phosphorylation	SVMQQDVTVGRSLLM HHHHCCCCHHHHHHH	26.07	25072903
383	Phosphorylation	CKKLFSSSVSEGFQR HHHHHCCCHHHHHHH	28.59	9647734
415	Phosphorylation	IGKEDLQSSRDRDET CCHHHHHCCCCCCCC	34.34	21815630
416	Phosphorylation	GKEDLQSSRDRDETP CHHHHHCCCCCCCCC	25.82	28060719
422	Phosphorylation	SSRDRDETPSSSKTS CCCCCCCCCCCCCCC	32.53	-
424	Phosphorylation	RDRDETPSSSKTSPE CCCCCCCCCCCCCCC	55.45	21712546
425	Phosphorylation	DRDETPSSSKTSPEP CCCCCCCCCCCCCCC	36.74	21712546
426	Phosphorylation	RDETPSSSKTSPEPG CCCCCCCCCCCCCCC	44.27	-
428	Phosphorylation	ETPSSSKTSPEPGQF CCCCCCCCCCCCCCC	52.00	25627689
429	Phosphorylation	TPSSSKTSPEPGQFL CCCCCCCCCCCCCCC	30.88	25159151

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
63	S	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
63	S	Phosphorylation	Kinase	PKC_GROUP	-	PhosphoELM
383	S	Phosphorylation	Kinase	CK2-FAMILY	-	GPS
383	S	Phosphorylation	Kinase	CK2_GROUP	-	PhosphoELM

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of XK_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of XK_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of XK_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• H00655: McLeod syndrome
• H00832: Core neuroacanthocytosis syndromes, including: Chorea-acanthocytosis (ChAc); McLeod syndrome (MLS);
• OMIM Disease
• 300842: McLeod syndrome (MLS)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-63, AND MASSSPECTROMETRY.
PubMed: 17081983