MRP1_HUMAN - dbPTM
MRP1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MRP1_HUMAN
UniProt AC P33527
Protein Name Multidrug resistance-associated protein 1
Gene Name ABCC1
Organism Homo sapiens (Human).
Sequence Length 1531
Subcellular Localization Cell membrane
Multi-pass membrane protein .
Protein Description Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency..
Protein Sequence MALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRHDRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLATFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFSLLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYSMAKDAGLV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
19 (in isoform 1)N-linked_Glycosylation-20.90-
19N-linked_GlycosylationSDPLWDWNVTWNTSN
CCCCCCCCCEECCCC
20.909295302
19N-linked_GlycosylationSDPLWDWNVTWNTSN
CCCCCCCCCEECCCC
20.909295302
19 (in isoform 3)N-linked_Glycosylation-20.90-
19 (in isoform 4)N-linked_Glycosylation-20.90-
19 (in isoform 5)N-linked_Glycosylation-20.90-
23 (in isoform 1)N-linked_Glycosylation-25.02-
23N-linked_GlycosylationWDWNVTWNTSNPDFT
CCCCCEECCCCCCHH
25.029295302
23N-linked_GlycosylationWDWNVTWNTSNPDFT
CCCCCEECCCCCCHH
25.029295302
23 (in isoform 3)N-linked_Glycosylation-25.02-
23 (in isoform 4)N-linked_Glycosylation-25.02-
23 (in isoform 5)N-linked_Glycosylation-25.02-
64UbiquitinationLSRHDRGYIQMTPLN
HHHCCCCCEEECCCC
6.7327667366
66UbiquitinationRHDRGYIQMTPLNKT
HCCCCCEEECCCCCH
22.6323503661
72UbiquitinationIQMTPLNKTKTALGF
EEECCCCCHHHHHHH
60.1121906983
72 (in isoform 1)Ubiquitination-60.1121890473
72 (in isoform 2)Ubiquitination-60.1121890473
72 (in isoform 3)Ubiquitination-60.1121890473
72 (in isoform 4)Ubiquitination-60.1121890473
72 (in isoform 5)Ubiquitination-60.1121890473
72 (in isoform 6)Ubiquitination-60.1121890473
72 (in isoform 7)Ubiquitination-60.1121890473
72 (in isoform 8)Ubiquitination-60.1121890473
72 (in isoform 9)Ubiquitination-60.1121890473
74UbiquitinationMTPLNKTKTALGFLL
ECCCCCHHHHHHHHH
33.1523503661
90UbiquitinationIVCWADLFYSFWERS
HHHHHHHHHHHHHHC
5.0327667366
92UbiquitinationCWADLFYSFWERSRG
HHHHHHHHHHHHCCC
19.2923503661
159PhosphorylationILRSKIMTALKEDAQ
HHHHHHHHHHHHHHC
32.1029496963
176UbiquitinationLFRDITFYVYFSLLL
HHHHHHHHHHHHHHH
5.8923503661
189UbiquitinationLLIQLVLSCFSDRSP
HHHHHHHHHHCCCCC
12.9723503661
192UbiquitinationQLVLSCFSDRSPLFS
HHHHHHHCCCCCCCC
36.1223503661
193UbiquitinationLVLSCFSDRSPLFSE
HHHHHHCCCCCCCCC
34.5223503661
204UbiquitinationLFSETIHDPNPCPES
CCCCCCCCCCCCCHH
40.6027667366
210UbiquitinationHDPNPCPESSASFLS
CCCCCCCHHHHHHHH
65.1327667366
216UbiquitinationPESSASFLSRITFWW
CHHHHHHHHHHHHHH
2.8923503661
217PhosphorylationESSASFLSRITFWWI
HHHHHHHHHHHHHHH
21.4524719451
218UbiquitinationSSASFLSRITFWWIT
HHHHHHHHHHHHHHH
33.8323503661
220UbiquitinationASFLSRITFWWITGL
HHHHHHHHHHHHHHH
16.4623503661
222UbiquitinationFLSRITFWWITGLIV
HHHHHHHHHHHHHHH
4.1223503661
231UbiquitinationITGLIVRGYRQPLEG
HHHHHHCCCCCCCCC
15.8723503661
233UbiquitinationGLIVRGYRQPLEGSD
HHHHCCCCCCCCCCC
34.1721890473
234UbiquitinationLIVRGYRQPLEGSDL
HHHCCCCCCCCCCCC
38.1523503661
235UbiquitinationIVRGYRQPLEGSDLW
HHCCCCCCCCCCCCC
24.3123503661
237UbiquitinationRGYRQPLEGSDLWSL
CCCCCCCCCCCCCCC
64.4321890473
238UbiquitinationGYRQPLEGSDLWSLN
CCCCCCCCCCCCCCC
33.8623503661
239UbiquitinationYRQPLEGSDLWSLNK
CCCCCCCCCCCCCCC
21.8323503661
245UbiquitinationGSDLWSLNKEDTSEQ
CCCCCCCCCCCCCCC
39.9121890473
246UbiquitinationSDLWSLNKEDTSEQV
CCCCCCCCCCCCCCH
63.3621906983
246 (in isoform 1)Ubiquitination-63.3621890473
246 (in isoform 2)Ubiquitination-63.3621890473
246 (in isoform 3)Ubiquitination-63.3621890473
246 (in isoform 4)Ubiquitination-63.3621890473
246 (in isoform 5)Ubiquitination-63.3621890473
246 (in isoform 6)Ubiquitination-63.3621890473
246 (in isoform 7)Ubiquitination-63.3621890473
246 (in isoform 8)Ubiquitination-63.3621890473
246 (in isoform 9)Ubiquitination-63.3621890473
249PhosphorylationWSLNKEDTSEQVVPV
CCCCCCCCCCCHHHH
34.9451183799
249UbiquitinationWSLNKEDTSEQVVPV
CCCCCCCCCCCHHHH
34.9422817900
250UbiquitinationSLNKEDTSEQVVPVL
CCCCCCCCCCHHHHH
38.0527667366
251UbiquitinationLNKEDTSEQVVPVLV
CCCCCCCCCHHHHHH
49.8723503661
252UbiquitinationNKEDTSEQVVPVLVK
CCCCCCCCHHHHHHH
41.0727667366
254UbiquitinationEDTSEQVVPVLVKNW
CCCCCCHHHHHHHHH
2.4423503661
255UbiquitinationDTSEQVVPVLVKNWK
CCCCCHHHHHHHHHH
18.1823503661
256UbiquitinationTSEQVVPVLVKNWKK
CCCCHHHHHHHHHHH
6.9327667366
258UbiquitinationEQVVPVLVKNWKKEC
CCHHHHHHHHHHHHH
4.6023503661
259UbiquitinationQVVPVLVKNWKKECA
CHHHHHHHHHHHHHH
53.5921906983
259 (in isoform 1)Ubiquitination-53.5921890473
259 (in isoform 2)Ubiquitination-53.5921890473
259 (in isoform 3)Ubiquitination-53.5921890473
259 (in isoform 4)Ubiquitination-53.5921890473
259 (in isoform 5)Ubiquitination-53.5921890473
259 (in isoform 6)Ubiquitination-53.5921890473
259 (in isoform 7)Ubiquitination-53.5921890473
259 (in isoform 8)Ubiquitination-53.5921890473
259 (in isoform 9)Ubiquitination-53.5921890473
262UbiquitinationPVLVKNWKKECAKTR
HHHHHHHHHHHHHHC
48.3523503661
263UbiquitinationVLVKNWKKECAKTRK
HHHHHHHHHHHHHCC
50.0323503661
264UbiquitinationLVKNWKKECAKTRKQ
HHHHHHHHHHHHCCC
35.6623503661
266UbiquitinationKNWKKECAKTRKQPV
HHHHHHHHHHCCCCE
19.8327667366
272UbiquitinationCAKTRKQPVKVVYSS
HHHHCCCCEEEEEEC
30.8227667366
274UbiquitinationKTRKQPVKVVYSSKD
HHCCCCEEEEEECCC
32.4433845483
275UbiquitinationTRKQPVKVVYSSKDP
HCCCCEEEEEECCCC
5.0721890473
277PhosphorylationKQPVKVVYSSKDPAQ
CCCEEEEEECCCCCC
15.3723312004
277UbiquitinationKQPVKVVYSSKDPAQ
CCCEEEEEECCCCCC
15.3723503661
278PhosphorylationQPVKVVYSSKDPAQP
CCEEEEEECCCCCCC
21.2125002506
278UbiquitinationQPVKVVYSSKDPAQP
CCEEEEEECCCCCCC
21.2123503661
279PhosphorylationPVKVVYSSKDPAQPK
CEEEEEECCCCCCCC
24.3246156703
279UbiquitinationPVKVVYSSKDPAQPK
CEEEEEECCCCCCCC
24.3227667366
280UbiquitinationVKVVYSSKDPAQPKE
EEEEEECCCCCCCCC
62.8921906983
280 (in isoform 1)Ubiquitination-62.8921890473
280 (in isoform 2)Ubiquitination-62.8921890473
280 (in isoform 3)Ubiquitination-62.8921890473
280 (in isoform 4)Ubiquitination-62.8921890473
280 (in isoform 5)Ubiquitination-62.8921890473
280 (in isoform 6)Ubiquitination-62.8921890473
280 (in isoform 7)Ubiquitination-62.8921890473
280 (in isoform 8)Ubiquitination-62.8921890473
280 (in isoform 9)Ubiquitination-62.8921890473
281UbiquitinationKVVYSSKDPAQPKES
EEEEECCCCCCCCCC
45.7923503661
282UbiquitinationVVYSSKDPAQPKESS
EEEECCCCCCCCCCC
36.2123503661
283UbiquitinationVYSSKDPAQPKESSK
EEECCCCCCCCCCCC
48.7321890473
286UbiquitinationSKDPAQPKESSKVDA
CCCCCCCCCCCCCCC
59.1433845483
287UbiquitinationKDPAQPKESSKVDAN
CCCCCCCCCCCCCCC
67.9121890473
288PhosphorylationDPAQPKESSKVDANE
CCCCCCCCCCCCCCH
41.4026657352
289PhosphorylationPAQPKESSKVDANEE
CCCCCCCCCCCCCHH
37.4830266825
290UbiquitinationAQPKESSKVDANEEV
CCCCCCCCCCCCHHH
54.1121906983
290 (in isoform 1)Ubiquitination-54.1121890473
290 (in isoform 2)Ubiquitination-54.1121890473
290 (in isoform 3)Ubiquitination-54.1121890473
290 (in isoform 4)Ubiquitination-54.1121890473
290 (in isoform 5)Ubiquitination-54.1121890473
290 (in isoform 6)Ubiquitination-54.1121890473
290 (in isoform 7)Ubiquitination-54.1121890473
290 (in isoform 8)Ubiquitination-54.1121890473
290 (in isoform 9)Ubiquitination-54.1121890473
291UbiquitinationQPKESSKVDANEEVE
CCCCCCCCCCCHHHH
10.1821890473
292UbiquitinationPKESSKVDANEEVEA
CCCCCCCCCCHHHHE
47.6227667366
295UbiquitinationSSKVDANEEVEALIV
CCCCCCCHHHHEEEE
66.2021890473
298UbiquitinationVDANEEVEALIVKSP
CCCCHHHHEEEEECC
40.8327667366
299UbiquitinationDANEEVEALIVKSPQ
CCCHHHHEEEEECCC
14.0421890473
303UbiquitinationEVEALIVKSPQKEWN
HHHEEEEECCCCCCC
49.8021890473
303UbiquitinationEVEALIVKSPQKEWN
HHHEEEEECCCCCCC
49.8021963094
303 (in isoform 1)Ubiquitination-49.8021890473
303 (in isoform 2)Ubiquitination-49.8021890473
303 (in isoform 3)Ubiquitination-49.8021890473
303 (in isoform 4)Ubiquitination-49.8021890473
303 (in isoform 5)Ubiquitination-49.8021890473
303 (in isoform 6)Ubiquitination-49.8021890473
303 (in isoform 7)Ubiquitination-49.8021890473
303 (in isoform 8)Ubiquitination-49.8021890473
303 (in isoform 9)Ubiquitination-49.8021890473
304UbiquitinationVEALIVKSPQKEWNP
HHEEEEECCCCCCCH
22.9723503661
307UbiquitinationLIVKSPQKEWNPSLF
EEEECCCCCCCHHHH
68.9921890473
307UbiquitinationLIVKSPQKEWNPSLF
EEEECCCCCCCHHHH
68.9927667366
307 (in isoform 1)Ubiquitination-68.9921890473
307 (in isoform 2)Ubiquitination-68.9921890473
307 (in isoform 3)Ubiquitination-68.9921890473
307 (in isoform 4)Ubiquitination-68.9921890473
307 (in isoform 5)Ubiquitination-68.9921890473
307 (in isoform 6)Ubiquitination-68.9921890473
307 (in isoform 7)Ubiquitination-68.9921890473
307 (in isoform 8)Ubiquitination-68.9921890473
307 (in isoform 9)Ubiquitination-68.9921890473
308UbiquitinationIVKSPQKEWNPSLFK
EEECCCCCCCHHHHH
47.4423503661
311UbiquitinationSPQKEWNPSLFKVLY
CCCCCCCHHHHHHHH
33.2222817900
312PhosphorylationPQKEWNPSLFKVLYK
CCCCCCHHHHHHHHH
43.1324719451
315UbiquitinationEWNPSLFKVLYKTFG
CCCHHHHHHHHHHHH
36.3021890473
315UbiquitinationEWNPSLFKVLYKTFG
CCCHHHHHHHHHHHH
36.3021890473
315 (in isoform 1)Ubiquitination-36.3021890473
315 (in isoform 2)Ubiquitination-36.3021890473
315 (in isoform 3)Ubiquitination-36.3021890473
315 (in isoform 4)Ubiquitination-36.3021890473
315 (in isoform 5)Ubiquitination-36.3021890473
315 (in isoform 6)Ubiquitination-36.3021890473
315 (in isoform 7)Ubiquitination-36.3021890473
315 (in isoform 8)Ubiquitination-36.3021890473
315 (in isoform 9)Ubiquitination-36.3021890473
319UbiquitinationSLFKVLYKTFGPYFL
HHHHHHHHHHHHHHH
32.9622817900
321UbiquitinationFKVLYKTFGPYFLMS
HHHHHHHHHHHHHHH
8.9721890473
325UbiquitinationYKTFGPYFLMSFFFK
HHHHHHHHHHHHHHH
5.3421890473
333UbiquitinationLMSFFFKAIHDLMMF
HHHHHHHHHHHHHHH
10.1321890473
337UbiquitinationFFKAIHDLMMFSGPQ
HHHHHHHHHHHCCHH
1.3322817900
346UbiquitinationMFSGPQILKLLIKFV
HHCCHHHHHHHHHHH
2.4224816145
351UbiquitinationQILKLLIKFVNDTKA
HHHHHHHHHHCCCCC
43.1433845483
388UbiquitinationLHQYFHICFVSGMRI
HHHHHHHHHHCCCCH
1.7524816145
392UbiquitinationFHICFVSGMRIKTAV
HHHHHHCCCCHHHHH
12.2324816145
396UbiquitinationFVSGMRIKTAVIGAV
HHCCCCHHHHHHHHH
21.7733845483
396 (in isoform 1)Ubiquitination-21.7721890473
396 (in isoform 2)Ubiquitination-21.7721890473
396 (in isoform 3)Ubiquitination-21.7721890473
396 (in isoform 4)Ubiquitination-21.7721890473
396 (in isoform 5)Ubiquitination-21.7721890473
396 (in isoform 6)Ubiquitination-21.7721890473
396 (in isoform 7)Ubiquitination-21.7721890473
396 (in isoform 8)Ubiquitination-21.7721890473
396 (in isoform 9)Ubiquitination-21.7721890473
404PhosphorylationTAVIGAVYRKALVIT
HHHHHHHHHHEEEEC
13.0824114839
406UbiquitinationVIGAVYRKALVITNS
HHHHHHHHEEEECCC
28.5229967540
408UbiquitinationGAVYRKALVITNSAR
HHHHHHEEEECCCCC
3.0024816145
416UbiquitinationVITNSARKSSTVGEI
EECCCCCCCCCHHHH
48.7721906983
416 (in isoform 1)Ubiquitination-48.7721890473
416 (in isoform 2)Ubiquitination-48.7721890473
416 (in isoform 3)Ubiquitination-48.7721890473
416 (in isoform 4)Ubiquitination-48.7721890473
416 (in isoform 5)Ubiquitination-48.7721890473
416 (in isoform 6)Ubiquitination-48.7721890473
416 (in isoform 7)Ubiquitination-48.7721890473
416 (in isoform 8)Ubiquitination-48.7721890473
416 (in isoform 9)Ubiquitination-48.7721890473
417PhosphorylationITNSARKSSTVGEIV
ECCCCCCCCCHHHHH
26.2028348404
418PhosphorylationTNSARKSSTVGEIVN
CCCCCCCCCHHHHHH
30.1028348404
419PhosphorylationNSARKSSTVGEIVNL
CCCCCCCCHHHHHHH
39.3528348404
426UbiquitinationTVGEIVNLMSVDAQR
CHHHHHHHHCCCHHH
1.5527667366
428UbiquitinationGEIVNLMSVDAQRFM
HHHHHHHCCCHHHHH
21.7322817900
433UbiquitinationLMSVDAQRFMDLATY
HHCCCHHHHHHHHHH
30.4921890473
434UbiquitinationMSVDAQRFMDLATYI
HCCCHHHHHHHHHHH
2.7224816145
443UbiquitinationDLATYINMIWSAPLQ
HHHHHHHHHHHHHHH
2.1121890473
446UbiquitinationTYINMIWSAPLQVIL
HHHHHHHHHHHHHHH
14.7522817900
455UbiquitinationPLQVILALYLLWLNL
HHHHHHHHHHHHHHH
2.5123503661
457UbiquitinationQVILALYLLWLNLGP
HHHHHHHHHHHHHCH
2.6223503661
465PhosphorylationLWLNLGPSVLAGVAV
HHHHHCHHHHHHHHH
28.1525332170
468UbiquitinationNLGPSVLAGVAVMVL
HHCHHHHHHHHHEEE
14.3027667366
470UbiquitinationGPSVLAGVAVMVLMV
CHHHHHHHHHEEEEE
2.7822817900
472UbiquitinationSVLAGVAVMVLMVPV
HHHHHHHHEEEEECH
2.2427667366
474UbiquitinationLAGVAVMVLMVPVNA
HHHHHHEEEEECHHH
2.2122817900
475UbiquitinationAGVAVMVLMVPVNAV
HHHHHEEEEECHHHH
1.2221890473
479UbiquitinationVMVLMVPVNAVMAMK
HEEEEECHHHHHHHC
4.9621890473
485UbiquitinationPVNAVMAMKTKTYQV
CHHHHHHHCCCCEEE
2.8221890473
487PhosphorylationNAVMAMKTKTYQVAH
HHHHHHCCCCEEEEC
18.6125332170
488UbiquitinationAVMAMKTKTYQVAHM
HHHHHCCCCEEEECC
39.4522817900
489PhosphorylationVMAMKTKTYQVAHMK
HHHHCCCCEEEECCC
25.1529083192
489UbiquitinationVMAMKTKTYQVAHMK
HHHHCCCCEEEECCC
25.1521890473
490PhosphorylationMAMKTKTYQVAHMKS
HHHCCCCEEEECCCC
11.5318083107
490UbiquitinationMAMKTKTYQVAHMKS
HHHCCCCEEEECCCC
11.5322817900
492UbiquitinationMKTKTYQVAHMKSKD
HCCCCEEEECCCCCC
2.5222817900
495UbiquitinationKTYQVAHMKSKDNRI
CCEEEECCCCCCHHH
3.6521890473
496UbiquitinationTYQVAHMKSKDNRIK
CEEEECCCCCCHHHH
44.4821906983
496 (in isoform 1)Ubiquitination-44.4821890473
496 (in isoform 2)Ubiquitination-44.4821890473
496 (in isoform 3)Ubiquitination-44.4821890473
496 (in isoform 4)Ubiquitination-44.4821890473
496 (in isoform 5)Ubiquitination-44.4821890473
496 (in isoform 6)Ubiquitination-44.4821890473
496 (in isoform 7)Ubiquitination-44.4821890473
496 (in isoform 8)Ubiquitination-44.4821890473
496 (in isoform 9)Ubiquitination-44.4821890473
497PhosphorylationYQVAHMKSKDNRIKL
EEEECCCCCCHHHHH
37.3523186163
497UbiquitinationYQVAHMKSKDNRIKL
EEEECCCCCCHHHHH
37.3523503661
498AcetylationQVAHMKSKDNRIKLM
EEECCCCCCHHHHHH
54.2020167786
498UbiquitinationQVAHMKSKDNRIKLM
EEECCCCCCHHHHHH
54.2022817900
499UbiquitinationVAHMKSKDNRIKLMN
EECCCCCCHHHHHHH
57.6523503661
501UbiquitinationHMKSKDNRIKLMNEI
CCCCCCHHHHHHHHH
37.2423503661
503UbiquitinationKSKDNRIKLMNEILN
CCCCHHHHHHHHHHH
38.1521890473
503AcetylationKSKDNRIKLMNEILN
CCCCHHHHHHHHHHH
38.1520167786
503SuccinylationKSKDNRIKLMNEILN
CCCCHHHHHHHHHHH
38.15-
503SuccinylationKSKDNRIKLMNEILN
CCCCHHHHHHHHHHH
38.1521890473
503UbiquitinationKSKDNRIKLMNEILN
CCCCHHHHHHHHHHH
38.1522817900
503 (in isoform 1)Ubiquitination-38.1521890473
503 (in isoform 2)Ubiquitination-38.1521890473
503 (in isoform 3)Ubiquitination-38.1521890473
503 (in isoform 4)Ubiquitination-38.1521890473
503 (in isoform 5)Ubiquitination-38.1521890473
503 (in isoform 6)Ubiquitination-38.1521890473
503 (in isoform 7)Ubiquitination-38.1521890473
503 (in isoform 8)Ubiquitination-38.1521890473
503 (in isoform 9)Ubiquitination-38.1521890473
505UbiquitinationKDNRIKLMNEILNGI
CCHHHHHHHHHHHHH
3.4321890473
508UbiquitinationRIKLMNEILNGIKVL
HHHHHHHHHHHHHHH
2.8422817900
513UbiquitinationNEILNGIKVLKLYAW
HHHHHHHHHHHHHHH
42.8021890473
513UbiquitinationNEILNGIKVLKLYAW
HHHHHHHHHHHHHHH
42.8022817900
513 (in isoform 1)Ubiquitination-42.8021890473
513 (in isoform 2)Ubiquitination-42.8021890473
513 (in isoform 3)Ubiquitination-42.8021890473
513 (in isoform 4)Ubiquitination-42.8021890473
513 (in isoform 5)Ubiquitination-42.8021890473
513 (in isoform 6)Ubiquitination-42.8021890473
513 (in isoform 7)Ubiquitination-42.8021890473
513 (in isoform 8)Ubiquitination-42.8021890473
513 (in isoform 9)Ubiquitination-42.8021890473
514UbiquitinationEILNGIKVLKLYAWE
HHHHHHHHHHHHHHH
5.5727667366
516UbiquitinationLNGIKVLKLYAWELA
HHHHHHHHHHHHHHH
42.3033845483
517UbiquitinationNGIKVLKLYAWELAF
HHHHHHHHHHHHHHH
2.8523503661
519UbiquitinationIKVLKLYAWELAFKD
HHHHHHHHHHHHHCC
12.0523503661
521UbiquitinationVLKLYAWELAFKDKV
HHHHHHHHHHHCCCC
23.2721890473
525UbiquitinationYAWELAFKDKVLAIR
HHHHHHHCCCCHHHC
51.5421906983
525 (in isoform 1)Ubiquitination-51.5421890473
525 (in isoform 2)Ubiquitination-51.5421890473
525 (in isoform 3)Ubiquitination-51.5421890473
525 (in isoform 4)Ubiquitination-51.5421890473
525 (in isoform 5)Ubiquitination-51.5421890473
525 (in isoform 6)Ubiquitination-51.5421890473
525 (in isoform 7)Ubiquitination-51.5421890473
525 (in isoform 8)Ubiquitination-51.5421890473
525 (in isoform 9)Ubiquitination-51.5421890473
527UbiquitinationWELAFKDKVLAIRQE
HHHHHCCCCHHHCHH
39.4733845483
531UbiquitinationFKDKVLAIRQEELKV
HCCCCHHHCHHHHHH
4.0121890473
534UbiquitinationKVLAIRQEELKVLKK
CCHHHCHHHHHHHHH
56.2922817900
543UbiquitinationLKVLKKSAYLSAVGT
HHHHHHHHCHHHHHH
20.4023503661
545UbiquitinationVLKKSAYLSAVGTFT
HHHHHHCHHHHHHHH
2.3723503661
566UbiquitinationLVALCTFAVYVTIDE
HHHHHHHEEEEEECC
3.5821987572
605UbiquitinationILPMVISSIVQASVS
HHHHHHHHHHHHHHH
18.6921987572
608UbiquitinationMVISSIVQASVSLKR
HHHHHHHHHHHHHHH
26.6721987572
612UbiquitinationSIVQASVSLKRLRIF
HHHHHHHHHHHHEEE
26.1921987572
628UbiquitinationSHEELEPDSIERRPV
CCCCCCCCCCCCCCC
53.5221987572
636UbiquitinationSIERRPVKDGGGTNS
CCCCCCCCCCCCCCC
54.0321906983
636 (in isoform 1)Ubiquitination-54.0321890473
636 (in isoform 2)Ubiquitination-54.0321890473
636 (in isoform 3)Ubiquitination-54.0321890473
636 (in isoform 4)Ubiquitination-54.0321890473
636 (in isoform 5)Ubiquitination-54.0321890473
636 (in isoform 6)Ubiquitination-54.0321890473
636 (in isoform 7)Ubiquitination-54.0321890473
636 (in isoform 8)Ubiquitination-54.0321890473
636 (in isoform 9)Ubiquitination-54.0321890473
654UbiquitinationRNATFTWARSDPPTL
ECEEEEEECCCCCCC
9.6821987572
703UbiquitinationDKVEGHVAIKGSVAY
HCCCCEEEEECCEEE
7.6627667366
705UbiquitinationVEGHVAIKGSVAYVP
CCCEEEEECCEEEEC
35.0833845483
732UbiquitinationNILFGCQLEEPYYRS
CCCCCCCCCCHHHHH
10.5427667366
732 (in isoform 5)Phosphorylation-10.54-
742UbiquitinationPYYRSVIQACALLPD
HHHHHHHHHHHHCCC
28.3827667366
744UbiquitinationYRSVIQACALLPDLE
HHHHHHHHHHCCCCE
1.2521890473
745UbiquitinationRSVIQACALLPDLEI
HHHHHHHHHCCCCEE
18.3627667366
745 (in isoform 2)Ubiquitination-18.3621890473
745 (in isoform 6)Ubiquitination-18.3621890473
748UbiquitinationIQACALLPDLEILPS
HHHHHHCCCCEECCC
45.0222817900
749UbiquitinationQACALLPDLEILPSG
HHHHHCCCCEECCCC
57.8327667366
750UbiquitinationACALLPDLEILPSGD
HHHHCCCCEECCCCC
4.1023503661
755 (in isoform 2)Ubiquitination-50.2921890473
755 (in isoform 6)Ubiquitination-50.2921890473
764UbiquitinationDRTEIGEKGVNLSGG
CCCCCCCCCCCCCCC
64.0533845483
765UbiquitinationRTEIGEKGVNLSGGQ
CCCCCCCCCCCCCCH
14.8327667366
773UbiquitinationVNLSGGQKQRVSLAR
CCCCCCHHHHHHHHH
43.2627667366
776 (in isoform 5)Ubiquitination-5.2121890473
776 (in isoform 8)Ubiquitination-5.2121890473
777PhosphorylationGGQKQRVSLARAVYS
CCHHHHHHHHHHHHC
20.6423532336
777UbiquitinationGGQKQRVSLARAVYS
CCHHHHHHHHHHHHC
20.6422817900
779UbiquitinationQKQRVSLARAVYSNA
HHHHHHHHHHHHCCC
7.0023503661
779 (in isoform 5)Ubiquitination-7.0021890473
779 (in isoform 8)Ubiquitination-7.0021890473
783UbiquitinationVSLARAVYSNADIYL
HHHHHHHHCCCCEEE
8.6721890473
786UbiquitinationARAVYSNADIYLFDD
HHHHHCCCCEEEECC
9.9121890473
787UbiquitinationRAVYSNADIYLFDDP
HHHHCCCCEEEECCC
34.0222817900
788 (in isoform 1)Phosphorylation-2.75-
789UbiquitinationVYSNADIYLFDDPLS
HHCCCCEEEECCCHH
11.2323503661
790UbiquitinationYSNADIYLFDDPLSA
HCCCCEEEECCCHHH
3.7621890473
790 (in isoform 5)Phosphorylation-3.76-
791UbiquitinationSNADIYLFDDPLSAV
CCCCEEEECCCHHHH
5.8627667366
791 (in isoform 3)Phosphorylation-5.86-
792UbiquitinationNADIYLFDDPLSAVD
CCCEEEECCCHHHHH
54.7623503661
793 (in isoform 5)Ubiquitination-38.4121890473
793 (in isoform 8)Ubiquitination-38.4121890473
794UbiquitinationDIYLFDDPLSAVDAH
CEEEECCCHHHHHHH
30.0221963094
796UbiquitinationYLFDDPLSAVDAHVG
EEECCCHHHHHHHHH
31.4723503661
797UbiquitinationLFDDPLSAVDAHVGK
EECCCHHHHHHHHHH
15.7621963094
800 (in isoform 5)Phosphorylation-7.83-
802 (in isoform 5)Phosphorylation-13.48-
803 (in isoform 5)Phosphorylation-13.12-
804UbiquitinationAVDAHVGKHIFENVI
HHHHHHHHHHHHCCC
32.2233845483
804 (in isoform 1)Ubiquitination-32.2221890473
804 (in isoform 4)Ubiquitination-32.2221890473
804 (in isoform 5)Phosphorylation-32.22-
804 (in isoform 9)Ubiquitination-32.2221890473
805 (in isoform 5)Phosphorylation-24.84-
806UbiquitinationDAHVGKHIFENVIGP
HHHHHHHHHHCCCCC
5.4421890473
810UbiquitinationGKHIFENVIGPKGML
HHHHHHCCCCCCCCC
4.1622817900
811UbiquitinationKHIFENVIGPKGMLK
HHHHHCCCCCCCCCC
13.5821963094
812UbiquitinationHIFENVIGPKGMLKN
HHHHCCCCCCCCCCC
17.3723503661
814UbiquitinationFENVIGPKGMLKNKT
HHCCCCCCCCCCCCC
52.3021890473
814UbiquitinationFENVIGPKGMLKNKT
HHCCCCCCCCCCCCC
52.3022817900
814 (in isoform 1)Ubiquitination-52.3021890473
814 (in isoform 4)Ubiquitination-52.3021890473
814 (in isoform 9)Ubiquitination-52.3021890473
815 (in isoform 5)Phosphorylation-29.77-
818UbiquitinationIGPKGMLKNKTRILV
CCCCCCCCCCCEEEE
47.7222817900
820UbiquitinationPKGMLKNKTRILVTH
CCCCCCCCCEEEEEC
37.2823503661
821UbiquitinationKGMLKNKTRILVTHS
CCCCCCCCEEEEECC
32.1321963094
821 (in isoform 5)Ubiquitination-32.1321890473
821 (in isoform 8)Ubiquitination-32.1321890473
824UbiquitinationLKNKTRILVTHSMSY
CCCCCEEEEECCCCC
3.0721963094
830PhosphorylationILVTHSMSYLPQVDV
EEEECCCCCCCCCEE
26.9122210691
831PhosphorylationLVTHSMSYLPQVDVI
EEECCCCCCCCCEEE
17.4822210691
832UbiquitinationVTHSMSYLPQVDVII
EECCCCCCCCCEEEE
1.5521890473
832 (in isoform 2)Ubiquitination-1.5521890473
832 (in isoform 6)Ubiquitination-1.5521890473
835 (in isoform 2)Ubiquitination-6.3221890473
835 (in isoform 3)Ubiquitination-6.3221890473
835 (in isoform 6)Ubiquitination-6.3221890473
835 (in isoform 7)Ubiquitination-6.3221890473
836UbiquitinationMSYLPQVDVIIVMSG
CCCCCCCEEEEEEEC
22.2022817900
837 (in isoform 5)Ubiquitination-3.1921890473
837 (in isoform 8)Ubiquitination-3.1921890473
838UbiquitinationYLPQVDVIIVMSGGK
CCCCCEEEEEEECCC
1.3721963094
838 (in isoform 3)Ubiquitination-1.3721890473
838 (in isoform 7)Ubiquitination-1.3721890473
839UbiquitinationLPQVDVIIVMSGGKI
CCCCEEEEEEECCCH
1.8221987572
843UbiquitinationDVIIVMSGGKISEMG
EEEEEEECCCHHHCC
24.2623503661
844UbiquitinationVIIVMSGGKISEMGS
EEEEEECCCHHHCCC
19.4723503661
846 (in isoform 1)Phosphorylation-4.82-
847PhosphorylationVMSGGKISEMGSYQE
EEECCCHHHCCCHHH
25.6472550283
847 (in isoform 4)Phosphorylation-25.64-
849 (in isoform 2)Ubiquitination-3.2721890473
849 (in isoform 3)Phosphorylation-3.27-
849 (in isoform 6)Ubiquitination-3.2721890473
850UbiquitinationGGKISEMGSYQELLA
CCCHHHCCCHHHHHH
21.1021963094
852PhosphorylationKISEMGSYQELLARD
CHHHCCCHHHHHHCC
10.56110743885
852 (in isoform 3)Ubiquitination-10.5621890473
852 (in isoform 7)Ubiquitination-10.5621890473
853UbiquitinationISEMGSYQELLARDG
HHHCCCHHHHHHCCC
36.2421963094
856 (in isoform 1)Phosphorylation-3.46-
858 (in isoform 1)Phosphorylation-42.75-
859 (in isoform 1)Phosphorylation-47.36-
859 (in isoform 3)Phosphorylation-47.36-
860 (in isoform 1)Phosphorylation-19.62-
860UbiquitinationQELLARDGAFAEFLR
HHHHHCCCHHHHHHH
19.6221963094
861 (in isoform 1)Phosphorylation-12.55-
861 (in isoform 3)Phosphorylation-12.55-
862 (in isoform 3)Phosphorylation-9.05-
863UbiquitinationLARDGAFAEFLRTYA
HHCCCHHHHHHHHHC
13.1921963094
863 (in isoform 3)Phosphorylation-13.19-
864 (in isoform 3)Phosphorylation-38.47-
866UbiquitinationDGAFAEFLRTYASTE
CCHHHHHHHHHCCCH
2.7721963094
867UbiquitinationGAFAEFLRTYASTEQ
CHHHHHHHHHCCCHH
30.8927667366
870UbiquitinationAEFLRTYASTEQEQD
HHHHHHHCCCHHHHH
14.9021963094
871 (in isoform 1)Phosphorylation-23.28-
871PhosphorylationEFLRTYASTEQEQDA
HHHHHHCCCHHHHHH
23.2820068231
871UbiquitinationEFLRTYASTEQEQDA
HHHHHHCCCHHHHHH
23.2823503661
872PhosphorylationFLRTYASTEQEQDAE
HHHHHCCCHHHHHHH
33.25110743893
874 (in isoform 3)Phosphorylation-54.46-
877UbiquitinationASTEQEQDAEENGVT
CCCHHHHHHHHHCCC
56.0221963094
877 (in isoform 2)Ubiquitination-56.0221890473
877 (in isoform 6)Ubiquitination-56.0221890473
880UbiquitinationEQEQDAEENGVTGVS
HHHHHHHHHCCCCCC
62.0921963094
880 (in isoform 3)Ubiquitination-62.0921890473
880 (in isoform 7)Ubiquitination-62.0921890473
883UbiquitinationQDAEENGVTGVSGPG
HHHHHHCCCCCCCCC
6.7621963094
884UbiquitinationDAEENGVTGVSGPGK
HHHHHCCCCCCCCCH
33.0121963094
886UbiquitinationEENGVTGVSGPGKEA
HHHCCCCCCCCCHHH
4.3421963094
887PhosphorylationENGVTGVSGPGKEAK
HHCCCCCCCCCHHHH
40.3828555341
891UbiquitinationTGVSGPGKEAKQMEN
CCCCCCCHHHHHCCC
58.6021906983
891 (in isoform 1)Ubiquitination-58.6021890473
891 (in isoform 4)Ubiquitination-58.6021890473
891 (in isoform 5)N-linked_Glycosylation-58.60-
893 (in isoform 2)Ubiquitination-15.7421890473
893 (in isoform 6)Ubiquitination-15.7421890473
894UbiquitinationSGPGKEAKQMENGML
CCCCHHHHHCCCCEE
51.7921906983
894 (in isoform 1)Ubiquitination-51.7921890473
894 (in isoform 4)Ubiquitination-51.7921890473
895UbiquitinationGPGKEAKQMENGMLV
CCCHHHHHCCCCEEE
52.0121987572
896SulfoxidationPGKEAKQMENGMLVT
CCHHHHHCCCCEEEE
4.2121406390
896 (in isoform 3)Ubiquitination-4.2121890473
896 (in isoform 7)Ubiquitination-4.2121890473
899UbiquitinationEAKQMENGMLVTDSA
HHHHCCCCEEEECHH
9.4823503661
900UbiquitinationAKQMENGMLVTDSAG
HHHCCCCEEEECHHH
4.0321963094
903PhosphorylationMENGMLVTDSAGKQL
CCCCEEEECHHHHHH
21.9220068231
904 (in isoform 9)Ubiquitination-29.0721890473
905PhosphorylationNGMLVTDSAGKQLQR
CCEEEECHHHHHHHH
29.5625159151
905UbiquitinationNGMLVTDSAGKQLQR
CCEEEECHHHHHHHH
29.5621987572
905 (in isoform 4)Phosphorylation-29.56-
908UbiquitinationLVTDSAGKQLQRQLS
EEECHHHHHHHHHHH
47.7721890473
908UbiquitinationLVTDSAGKQLQRQLS
EEECHHHHHHHHHHH
47.7721963094
908 (in isoform 1)Ubiquitination-47.7721890473
908 (in isoform 4)Ubiquitination-47.7721890473
909UbiquitinationVTDSAGKQLQRQLSS
EECHHHHHHHHHHHC
41.7421963094
910UbiquitinationTDSAGKQLQRQLSSS
ECHHHHHHHHHHHCC
5.3023503661
912UbiquitinationSAGKQLQRQLSSSSS
HHHHHHHHHHHCCCC
48.2621963094
913UbiquitinationAGKQLQRQLSSSSSY
HHHHHHHHHHCCCCC
32.5123503661
915PhosphorylationKQLQRQLSSSSSYSG
HHHHHHHHCCCCCCC
21.6022167270
915 (in isoform 4)Phosphorylation-21.60-
916PhosphorylationQLQRQLSSSSSYSGD
HHHHHHHCCCCCCCC
42.7129255136
916UbiquitinationQLQRQLSSSSSYSGD
HHHHHHHCCCCCCCC
42.7123503661
917PhosphorylationLQRQLSSSSSYSGDI
HHHHHHCCCCCCCCH
21.6729255136
917UbiquitinationLQRQLSSSSSYSGDI
HHHHHHCCCCCCCCH
21.6723503661
917 (in isoform 4)Phosphorylation-21.67-
918PhosphorylationQRQLSSSSSYSGDIS
HHHHHCCCCCCCCHH
34.939393905
918 (in isoform 4)Phosphorylation-34.93-
918 (in isoform 9)Ubiquitination-34.9321890473
919PhosphorylationRQLSSSSSYSGDISR
HHHHCCCCCCCCHHH
25.8419664994
919 (in isoform 4)Phosphorylation-25.84-
920PhosphorylationQLSSSSSYSGDISRH
HHHCCCCCCCCHHHH
20.7223927012
920 (in isoform 4)Phosphorylation-20.72-
921PhosphorylationLSSSSSYSGDISRHH
HHCCCCCCCCHHHHC
31.7529255136
925PhosphorylationSSYSGDISRHHNSTA
CCCCCCHHHHCCCHH
30.2427273156
925 (in isoform 9)Phosphorylation-30.2421406692
926UbiquitinationSYSGDISRHHNSTAE
CCCCCHHHHCCCHHH
35.1021963094
926 (in isoform 9)Phosphorylation-35.1021406692
927 (in isoform 9)Phosphorylation-20.0721406692
928UbiquitinationSGDISRHHNSTAELQ
CCCHHHHCCCHHHHH
28.9121987572
928 (in isoform 9)Phosphorylation-28.9121406692
929 (in isoform 9)Phosphorylation-34.6221406692
930PhosphorylationDISRHHNSTAELQKA
CHHHHCCCHHHHHHH
25.3323927012
930 (in isoform 4)Phosphorylation-25.33-
930 (in isoform 9)Phosphorylation-25.3327642862
931PhosphorylationISRHHNSTAELQKAE
HHHHCCCHHHHHHHH
29.4827273156
931 (in isoform 9)Phosphorylation-29.4821406692
932UbiquitinationSRHHNSTAELQKAEA
HHHCCCHHHHHHHHH
18.4723503661
933UbiquitinationRHHNSTAELQKAEAK
HHCCCHHHHHHHHHH
52.3923503661
935 (in isoform 9)Phosphorylation-34.1221406692
936UbiquitinationNSTAELQKAEAKKEE
CCHHHHHHHHHHHHH
61.9021906983
936 (in isoform 1)Ubiquitination-61.9021890473
936 (in isoform 4)Ubiquitination-61.9021890473
940UbiquitinationELQKAEAKKEETWKL
HHHHHHHHHHHHHHH
52.8223503661
940 (in isoform 9)Phosphorylation-52.8221406692
941UbiquitinationLQKAEAKKEETWKLM
HHHHHHHHHHHHHHH
68.7623503661
944PhosphorylationAEAKKEETWKLMEAD
HHHHHHHHHHHHHHH
29.0523403867
946UbiquitinationAKKEETWKLMEADKA
HHHHHHHHHHHHHHC
45.4329967540
946 (in isoform 9)Ubiquitination-45.4321890473
947 (in isoform 1)N-linked_Glycosylation-2.57-
950 (in isoform 3)N-linked_Glycosylation-15.05-
952UbiquitinationWKLMEADKAQTGQVK
HHHHHHHHCCCCCEE
49.8221906983
952 (in isoform 1)Ubiquitination-49.8221890473
952 (in isoform 4)Ubiquitination-49.8221890473
954UbiquitinationLMEADKAQTGQVKLS
HHHHHHCCCCCEEHH
52.4821987572
955PhosphorylationMEADKAQTGQVKLSV
HHHHHCCCCCEEHHH
34.1528270605
958UbiquitinationDKAQTGQVKLSVYWD
HHCCCCCEEHHHHHH
7.7323503661
959UbiquitinationKAQTGQVKLSVYWDY
HCCCCCEEHHHHHHH
27.4423503661
961PhosphorylationQTGQVKLSVYWDYMK
CCCCEEHHHHHHHHH
13.88124926601
962 (in isoform 9)Ubiquitination-8.9721890473
963PhosphorylationGQVKLSVYWDYMKAI
CCEEHHHHHHHHHHH
6.8128270605
963 (in isoform 5)Ubiquitination-6.8121890473
963 (in isoform 8)Ubiquitination-6.8121890473
966PhosphorylationKLSVYWDYMKAIGLF
EHHHHHHHHHHHHHH
6.0828270605
981UbiquitinationISFLSIFLFMCNHVS
HHHHHHHHHHHHHHH
2.2623503661
1006N-linked_GlycosylationWTDDPIVNGTQEHTK
CCCCCCCCCCCCCCE
48.819295302
1006N-linked_GlycosylationWTDDPIVNGTQEHTK
CCCCCCCCCCCCCCE
48.819295302
1006 (in isoform 4)N-linked_Glycosylation-48.81-
1008UbiquitinationDDPIVNGTQEHTKVR
CCCCCCCCCCCCEEE
26.1123503661
1019 (in isoform 2)Ubiquitination-8.0321890473
1019 (in isoform 6)Ubiquitination-8.0321890473
1022 (in isoform 3)Ubiquitination-5.6321890473
1022 (in isoform 7)Ubiquitination-5.6321890473
1037UbiquitinationVFGYSMAVSIGGILA
EHHHEEEHHHHHHHH
2.9923503661
1047UbiquitinationGGILASRCLHVDLLH
HHHHHHHCCCHHHHH
2.6023503661
1050UbiquitinationLASRCLHVDLLHSIL
HHHHCCCHHHHHHHH
3.4223503661
1054UbiquitinationCLHVDLLHSILRSPM
CCCHHHHHHHHHCCC
21.7923503661
1066 (in isoform 5)Ubiquitination-46.9421890473
1066 (in isoform 8)Ubiquitination-46.9421890473
1070UbiquitinationFFERTPSGNLVNRFS
HHHCCCCCCHHHHHH
32.4723503661
1072 (in isoform 5)Ubiquitination-4.0521890473
1072 (in isoform 8)Ubiquitination-4.0521890473
1078UbiquitinationNLVNRFSKELDTVDS
CHHHHHHHHHHHHHH
60.6321906983
1078 (in isoform 1)Ubiquitination-60.6321890473
1078 (in isoform 4)Ubiquitination-60.6321890473
1084UbiquitinationSKELDTVDSMIPEVI
HHHHHHHHHHHHHHH
34.2821963094
1088 (in isoform 9)Ubiquitination-22.5921890473
1090UbiquitinationVDSMIPEVIKMFMGS
HHHHHHHHHHHHHHH
4.2327667366
1096UbiquitinationEVIKMFMGSLFNVIG
HHHHHHHHHHHHHHH
15.2123503661
1111UbiquitinationACIVILLATPIAAII
HHHHHHHHCCHHHHH
14.1121963094
1117UbiquitinationLATPIAAIIIPPLGL
HHCCHHHHHCCCHHH
1.8527667366
1122 (in isoform 2)Ubiquitination-7.9621890473
1122 (in isoform 6)Ubiquitination-7.9621890473
1125 (in isoform 3)Ubiquitination-2.4021890473
1125 (in isoform 7)Ubiquitination-2.4021890473
1128 (in isoform 2)Ubiquitination-2.2821890473
1128 (in isoform 6)Ubiquitination-2.2821890473
1131 (in isoform 3)Ubiquitination-21.4021890473
1131 (in isoform 7)Ubiquitination-21.4021890473
1140UbiquitinationYVASSRQLKRLESVS
HHHCHHHHHHHHHCC
3.2021963094
1145PhosphorylationRQLKRLESVSRSPVY
HHHHHHHHCCCCCCH
29.9554885567
1146UbiquitinationQLKRLESVSRSPVYS
HHHHHHHCCCCCCHH
3.9327667366
1147PhosphorylationLKRLESVSRSPVYSH
HHHHHHCCCCCCHHH
36.0026699800
1150UbiquitinationLESVSRSPVYSHFNE
HHHCCCCCCHHHHHH
28.1421963094
1150 (in isoform 5)Ubiquitination-28.1421890473
1150 (in isoform 8)Ubiquitination-28.1421890473
1153UbiquitinationVSRSPVYSHFNETLL
CCCCCCHHHHHHHHH
23.1021963094
1156UbiquitinationSPVYSHFNETLLGVS
CCCHHHHHHHHHCHH
35.6027667366
1157UbiquitinationPVYSHFNETLLGVSV
CCHHHHHHHHHCHHH
39.6321963094
1157 (in isoform 5)Ubiquitination-39.6321890473
1157 (in isoform 8)Ubiquitination-39.6321890473
1159UbiquitinationYSHFNETLLGVSVIR
HHHHHHHHHCHHHHH
2.9827667366
1163UbiquitinationNETLLGVSVIRAFEE
HHHHHCHHHHHHHHH
15.2727667366
1168UbiquitinationGVSVIRAFEEQERFI
CHHHHHHHHHHHHHH
8.3527667366
1173UbiquitinationRAFEEQERFIHQSDL
HHHHHHHHHHCHHHC
35.2021963094
1175UbiquitinationFEEQERFIHQSDLKV
HHHHHHHHCHHHCCC
3.4623503661
1179UbiquitinationERFIHQSDLKVDENQ
HHHHCHHHCCCCCCC
43.8927667366
1181UbiquitinationFIHQSDLKVDENQKA
HHCHHHCCCCCCCCC
53.2621906983
1181 (in isoform 1)Ubiquitination-53.2621890473
1181 (in isoform 4)Ubiquitination-53.2621890473
1187UbiquitinationLKVDENQKAYYPSIV
CCCCCCCCCCCCHHH
50.3521906983
1187 (in isoform 1)Ubiquitination-50.3521890473
1187 (in isoform 4)Ubiquitination-50.3521890473
1191 (in isoform 9)Ubiquitination-12.6121890473
1195UbiquitinationAYYPSIVANRWLAVR
CCCCHHHHHCCHHHH
9.7427667366
1197 (in isoform 9)Ubiquitination-21.7621890473
1199UbiquitinationSIVANRWLAVRLECV
HHHHHCCHHHHHHHH
2.5921963094
1202UbiquitinationANRWLAVRLECVGNC
HHCCHHHHHHHHHHH
21.1123503661
1205UbiquitinationWLAVRLECVGNCIVL
CHHHHHHHHHHHHHH
5.8627667366
1206 (in isoform 2)Ubiquitination-4.5121890473
1206 (in isoform 6)Ubiquitination-4.5121890473
1209 (in isoform 3)Ubiquitination-1.5521890473
1209 (in isoform 7)Ubiquitination-1.5521890473
1213 (in isoform 2)Ubiquitination-2.3021890473
1213 (in isoform 6)Ubiquitination-2.3021890473
1216 (in isoform 3)Ubiquitination-2.2521890473
1216 (in isoform 7)Ubiquitination-2.2521890473
1224UbiquitinationFAVISRHSLSAGLVG
HHHHHHCCCCCCCCC
23.9427667366
1231UbiquitinationSLSAGLVGLSVSYSL
CCCCCCCCEEEEEEE
19.7823503661
1234UbiquitinationAGLVGLSVSYSLQVT
CCCCCEEEEEEEHHH
8.1827667366
1236UbiquitinationLVGLSVSYSLQVTTY
CCCEEEEEEEHHHHH
15.9621963094
1237UbiquitinationVGLSVSYSLQVTTYL
CCEEEEEEEHHHHHH
12.5727667366
1241UbiquitinationVSYSLQVTTYLNWLV
EEEEEHHHHHHHHHH
9.2127667366
1243PhosphorylationYSLQVTTYLNWLVRM
EEEHHHHHHHHHHHH
6.6721253578
1244UbiquitinationSLQVTTYLNWLVRMS
EEHHHHHHHHHHHHC
3.3123503661
1248UbiquitinationTTYLNWLVRMSSEME
HHHHHHHHHHCCCCC
3.4923503661
1254 (in isoform 5)Ubiquitination-9.2221890473
1254 (in isoform 8)Ubiquitination-9.2221890473
1257UbiquitinationMSSEMETNIVAVERL
HCCCCCCCEEEEHHH
17.2727667366
1263UbiquitinationTNIVAVERLKEYSET
CCEEEEHHHHHHCCC
44.4521963094
1264UbiquitinationNIVAVERLKEYSETE
CEEEEHHHHHHCCCC
2.9023503661
1265UbiquitinationIVAVERLKEYSETEK
EEEEHHHHHHCCCCC
61.9121906983
1265 (in isoform 1)Ubiquitination-61.9121890473
1265 (in isoform 4)Ubiquitination-61.9121890473
1267PhosphorylationAVERLKEYSETEKEA
EEHHHHHHCCCCCCC
15.3729978859
1268PhosphorylationVERLKEYSETEKEAP
EHHHHHHCCCCCCCC
38.8529978859
1270PhosphorylationRLKEYSETEKEAPWQ
HHHHHCCCCCCCCCC
46.5529978859
1272UbiquitinationKEYSETEKEAPWQIQ
HHHCCCCCCCCCCCC
67.6021906983
1272 (in isoform 1)Ubiquitination-67.6021890473
1272 (in isoform 4)Ubiquitination-67.6021890473
1274 (in isoform 2)Ubiquitination-23.00-
1275 (in isoform 9)Ubiquitination-25.2921890473
1282 (in isoform 9)Ubiquitination-17.1621890473
1283UbiquitinationWQIQETAPPSSWPQV
CCCCCCCCCCCCCCC
36.4027667366
1290UbiquitinationPPSSWPQVGRVEFRN
CCCCCCCCCEEEEHH
4.6623503661
1292UbiquitinationSSWPQVGRVEFRNYC
CCCCCCCEEEEHHHH
26.4021963094
1299UbiquitinationRVEFRNYCLRYREDL
EEEEHHHHHHHHHCC
1.6723503661
1302UbiquitinationFRNYCLRYREDLDFV
EHHHHHHHHHCCCEE
12.8521963094
1305UbiquitinationYCLRYREDLDFVLRH
HHHHHHHCCCEEEEE
42.4121963094
1309UbiquitinationYREDLDFVLRHINVT
HHHCCCEEEEEEEEE
4.6021963094
1310 (in isoform 2)Ubiquitination-3.1321890473
1310 (in isoform 6)Ubiquitination-3.1321890473
1313 (in isoform 3)Ubiquitination-3.4221890473
1313 (in isoform 7)Ubiquitination-3.4221890473
1322UbiquitinationVTINGGEKVGIVGRT
EEEECCCEEEEEECC
49.38-
1322 (in isoform 8)Ubiquitination-49.3821890473
1325UbiquitinationNGGEKVGIVGRTGAG
ECCCEEEEEECCCCC
3.1221963094
1328UbiquitinationEKVGIVGRTGAGKSS
CEEEEEECCCCCCCC
21.0623503661
1333UbiquitinationVGRTGAGKSSLTLGL
EECCCCCCCCEEEEE
36.0221963094
1338UbiquitinationAGKSSLTLGLFRINE
CCCCCEEEEEEEECC
7.3223503661
1341UbiquitinationSSLTLGLFRINESAE
CCEEEEEEEECCCCC
7.5623503661
1345UbiquitinationLGLFRINESAEGEII
EEEEEECCCCCCCEE
49.2923503661
1346 (in isoform 8)Ubiquitination-27.4221890473
1351UbiquitinationNESAEGEIIIDGINI
CCCCCCCEEEECEEE
5.0021963094
1360UbiquitinationIDGINIAKIGLHDLR
EECEEEEEEECCCCE
33.2533845483
1361UbiquitinationDGINIAKIGLHDLRF
ECEEEEEEECCCCEE
5.4023503661
1369UbiquitinationGLHDLRFKITIIPQD
ECCCCEEEEEEECCC
32.2921906983
1369 (in isoform 1)Ubiquitination-32.2921890473
1369 (in isoform 4)Ubiquitination-32.2921890473
1378 (in isoform 6)Ubiquitination-13.0221890473
1379 (in isoform 9)Ubiquitination-3.2621890473
1381 (in isoform 7)Ubiquitination-24.2621890473
1387UbiquitinationFSGSLRMNLDPFSQY
ECCEECCCCCCHHHC
34.5523503661
1387 (in isoform 5)Ubiquitination-34.5521890473
1402 (in isoform 6)Ubiquitination-12.2521890473
1405UbiquitinationEVWTSLELAHLKDFV
HHHHHHHHHHHHHHH
4.4022053931
1405 (in isoform 7)Ubiquitination-4.4021890473
1411 (in isoform 5)Ubiquitination-4.4621890473
1432UbiquitinationEGGENLSVGQRQLVC
CCCCCCCHHHHHHHH
9.4922053931
1437 (in isoform 4)Ubiquitination-2.9821890473
1443 (in isoform 2)Ubiquitination-12.8221890473
1446 (in isoform 3)Ubiquitination-45.5121890473
1461UbiquitinationDEATAAVDLETDDLI
ECCCCCCCCCCHHHH
33.7822053931
1461 (in isoform 4)Ubiquitination-33.7821890473
1467 (in isoform 2)Ubiquitination-4.2321890473
1470 (in isoform 3)Ubiquitination-20.8621890473
1471UbiquitinationTDDLIQSTIRTQFED
CHHHHHHHHHHHHCC
9.7122053931
1474UbiquitinationLIQSTIRTQFEDCTV
HHHHHHHHHHCCCCC
33.4922053931
1478UbiquitinationTIRTQFEDCTVLTIA
HHHHHHCCCCCHHHH
34.3822053931
1494UbiquitinationRLNTIMDYTRVIVLD
HHHHHCCCCEEEEEE
4.5022053931
1502UbiquitinationTRVIVLDKGEIQEYG
CEEEEEECHHHHHHC
55.0422053931
1502 (in isoform 1)Ubiquitination-55.0421890473
1508PhosphorylationDKGEIQEYGAPSDLL
ECHHHHHHCCCHHHH
11.3818180459
1512 (in isoform 9)Ubiquitination-40.1221890473
1520UbiquitinationDLLQQRGLFYSMAKD
HHHHHCCHHHHHHHH
3.8722053931
1522PhosphorylationLQQRGLFYSMAKDAG
HHHCCHHHHHHHHCC
11.5423312004
1523PhosphorylationQQRGLFYSMAKDAGL
HHCCHHHHHHHHCCC
12.6223312004
1526UbiquitinationGLFYSMAKDAGLV--
CHHHHHHHHCCCC--
39.2029967540
1526 (in isoform 1)Ubiquitination-39.2021890473
1536 (in isoform 9)Ubiquitination-21890473

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
249TPhosphorylationKinaseCSNK2A1P68400
GPS

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MRP1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MRP1_HUMAN !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
NDUF3_HUMANNDUFAF3physical
22939629
PUF60_HUMANPUF60physical
22939629
RM17_HUMANMRPL17physical
22939629
NDUB9_HUMANNDUFB9physical
22939629
RS7_HUMANRPS7physical
22939629
VDAC3_HUMANVDAC3physical
22939629
TMX2_HUMANTMX2physical
22939629
TMCO1_HUMANTMCO1physical
22939629
PGRC2_HUMANPGRMC2physical
22939629
RAVR1_HUMANRAVER1physical
22939629
STX4_HUMANSTX4physical
22939629
VATF_HUMANATP6V1Fphysical
22939629
ODB2_HUMANDBTphysical
22939629
STT3B_HUMANSTT3Bphysical
22939629
ODPX_HUMANPDHXphysical
22939629
SURF1_HUMANSURF1physical
22939629
PDC6I_HUMANPDCD6IPphysical
22939629
VATH_HUMANATP6V1Hphysical
22939629
SAFB1_HUMANSAFBphysical
22939629
TMOD2_HUMANTMOD2physical
22939629
ZA2G_HUMANAZGP1physical
21988832
NPM_HUMANNPM1physical
21988832
TRAF3_HUMANTRAF3physical
21988832
MRP1_HUMANABCC1physical
17264072
MRP1_HUMANABCC1physical
21090806
ECHM_HUMANECHS1physical
26344197
HNRPL_HUMANHNRNPLphysical
26344197
PRS8_HUMANPSMC5physical
26344197
PSMD2_HUMANPSMD2physical
26344197
TEBP_HUMANPTGES3physical
26344197
SEC63_HUMANSEC63physical
26344197
VDAC1_HUMANVDAC1physical
26344197
VDAC2_HUMANVDAC2physical
26344197
VDAC3_HUMANVDAC3physical
26344197
ATPA_HUMANATP5A1physical
22188235
EF1A1_HUMANEEF1A1physical
22188235
CSK21_HUMANCSNK2A1physical
22695718

Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
D00475 Probenecid (JP16/USP/INN); Benemid (TN)
DrugBank
DB05812Abiraterone
DB00345Aminohippurate
DB00701Amprenavir
DB01072Atazanavir
DB01076Atorvastatin
DB02659Cholic Acid
DB01394Colchicine
DB00286Conjugated Estrogens
DB00091Cyclosporine
DB00970Dactinomycin
DB00694Daunorubicin
DB00586Diclofenac
DB01248Docetaxel
DB00997Doxorubicin
DB00445Epirubicin
DB00199Erythromycin
DB00773Etoposide
DB00693Fluorescein
DB00143Glutathione
DB01016Glyburide
DB01050Ibuprofen
DB01177Idarubicin
DB00224Indinavir
DB00328Indomethacin
DB00762Irinotecan
DB00602Ivermectin
DB00709Lamivudine
DB00563Methotrexate
DB00834Mifepristone
DB01204Mitoxantrone
DB01165Ofloxacin
DB01229Paclitaxel
DB01174Phenobarbital
DB01032Probenecid
DB00396Progesterone
DB01045Rifampicin
DB00503Ritonavir
DB01098Rosuvastatin
DB01232Saquinavir
DB06335Saxagliptin
DB01138Sulfinpyrazone
DB05294Vandetanib
DB08881Vemurafenib
DB00661Verapamil
DB00570Vinblastine
DB00541Vincristine
DB00399Zoledronate
Regulatory Network of MRP1_HUMAN

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Related Literatures of Post-Translational Modification
N-linked Glycosylation
ReferencePubMed
"Membrane topology of the multidrug resistance protein (MRP). A studyof glycosylation-site mutants reveals an extracytosolic NH2terminus.";
Hipfner D.R., Almquist K.C., Leslie E.M., Gerlach J.H., Grant C.E.,Deeley R.G., Cole S.P.C.;
J. Biol. Chem. 272:23623-23630(1997).
Cited for: TOPOLOGY, AND GLYCOSYLATION AT ASN-19; ASN-23 AND ASN-1006.
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-915, AND MASSSPECTROMETRY.
"Large-scale proteomics analysis of the human kinome.";
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.;
Mol. Cell. Proteomics 8:1751-1764(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-930, AND MASSSPECTROMETRY.
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-917, AND MASSSPECTROMETRY.
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle.";
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.;
Mol. Cell 31:438-448(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-915, AND MASSSPECTROMETRY.

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