| UniProt ID | TMOD2_HUMAN | |
|---|---|---|
| UniProt AC | Q9NZR1 | |
| Protein Name | Tropomodulin-2 | |
| Gene Name | TMOD2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 351 | |
| Subcellular Localization | Cytoplasm, cytoskeleton. | |
| Protein Description | Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity).. | |
| Protein Sequence | MALPFQKELEKYKNIDEDELLGKLSEEELKQLENVLDDLDPESAMLPAGFRQKDQTQKAATGPFDREHLLMYLEKEALEQKDREDFVPFTGEKKGRVFIPKEKPIETRKEEKVTLDPELEEALASASDTELYDLAAVLGVHNLLNNPKFDEETANNKGGKGPVRNVVKGEKVKPVFEEPPNPTNVEISLQQMKANDPSLQEVNLNNIKNIPIPTLREFAKALETNTHVKKFSLAATRSNDPVAIAFADMLKVNKTLTSLNIESNFITGTGILALVEALKENDTLTEIKIDNQRQQLGTAVEMEIAQMLEENSRILKFGYQFTKQGPRTRVAAAITKNNDLVRKKRVEADRR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 12 | Phosphorylation | FQKELEKYKNIDEDE HHHHHHHHCCCCHHH | 10.41 | 27642862 | |
| 25 | Phosphorylation | DELLGKLSEEELKQL HHHHHHCCHHHHHHH | 46.58 | 21815630 | |
| 101 | Ubiquitination | KGRVFIPKEKPIETR CCEEEEECCCCCCCC | 73.82 | 24816145 | |
| 127 | Phosphorylation | EEALASASDTELYDL HHHHHCCCCHHHHHH | 42.44 | - | |
| 132 | Phosphorylation | SASDTELYDLAAVLG CCCCHHHHHHHHHHC | 11.59 | - | |
| 171 | Acetylation | RNVVKGEKVKPVFEE CCCCCCCCEECCCCC | 65.31 | 25953088 | |
| 208 | Sumoylation | EVNLNNIKNIPIPTL CCCCCCCCCCCCCHH | 51.45 | - | |
| 283 | O-linked_Glycosylation | EALKENDTLTEIKID HHHHHCCCEEEEEEC | 47.35 | 29351928 | |
| 283 | Phosphorylation | EALKENDTLTEIKID HHHHHCCCEEEEEEC | 47.35 | 22985185 | |
| 285 | O-linked_Glycosylation | LKENDTLTEIKIDNQ HHHCCCEEEEEECHH | 37.44 | 29351928 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TMOD2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TMOD2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TMOD2_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| A4_HUMAN | APP | physical | 21832049 | |
| GELS_HUMAN | GSN | physical | 26186194 | |
| ADSV_HUMAN | SCIN | physical | 26186194 | |
| RIR2B_HUMAN | RRM2B | physical | 26186194 | |
| PABP3_HUMAN | PABPC3 | physical | 26344197 | |
| TIM16_HUMAN | PAM16 | physical | 26344197 | |
| RUVB2_HUMAN | RUVBL2 | physical | 26344197 | |
| GLYM_HUMAN | SHMT2 | physical | 26344197 | |
| ST1C3_HUMAN | SULT1C3 | physical | 26344197 | |
| SYVC_HUMAN | VARS | physical | 26344197 | |
| ADSV_HUMAN | SCIN | physical | 28514442 | |
| GELS_HUMAN | GSN | physical | 28514442 | |
| MYO6_HUMAN | MYO6 | physical | 28514442 | |
| RIR2B_HUMAN | RRM2B | physical | 28514442 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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