MYO6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MYO6_HUMAN
• UniProt AC: Q9UM54
• Protein Name: Unconventional myosin-VI
• Gene Name: MYO6
• Organism: Homo sapiens (Human).
• Sequence Length: 1294
• Subcellular Localization: Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Golgi apparatus. Nucleus. Cytoplasm, perinuclear region. Membrane, clathrin-coated pit. Cell projection, ruffle membrane; Peripheral membrane protein. Also present in endocyc
• Protein Description: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments. Has slow rate of actin-activated ADP release due to weak ATP binding. Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration. Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway. Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells. May act as a regulator of F-actin dynamics. May play a role in transporting DAB2 from the plasma membrane to specific cellular targets. Required for structural integrity of inner ear hair cells (By similarity)..
• Protein Sequence: MEDGKPVWAPHPTDGFQMGNIVDIGPDSLTIEPLNQKGKTFLALINQVFPAEEDSKKDVEDNCSLMYLNEATLLHNIKVRYSKDRIYTYVANILIAVNPYFDIPKIYSSEAIKSYQGKSLGTRPPHVFAIADKAFRDMKVLKMSQSIIVSGESGAGKTENTKFVLRYLTESYGTGQDIDDRIVEANPLLEAFGNAKTVRNNNSSRFGKFVEIHFNEKSSVVGGFVSHYLLEKSRICVQGKEERNYHIFYRLCAGASEDIREKLHLSSPDNFRYLNRGCTRYFANKETDKQILQNRKSPEYLKAGSMKDPLLDDHGDFIRMCTAMKKIGLDDEEKLDLFRVVAGVLHLGNIDFEEAGSTSGGCNLKNKSAQSLEYCAELLGLDQDDLRVSLTTRVMLTTAGGTKGTVIKVPLKVEQANNARDALAKTVYSHLFDHVVNRVNQCFPFETSSYFIGVLDIAGFEYFEHNSFEQFCINYCNEKLQQFFNERILKEEQELYQKEGLGVNEVHYVDNQDCIDLIEAKLVGILDILDEENRLPQPSDQHFTSAVHQKHKDHFRLTIPRKSKLAVHRNIRDDEGFIIRHFAGAVCYETTQFVEKNNDALHMSLESLICESRDKFIRELFESSTNNNKDTKQKAGKLSFISVGNKFKTQLNLLLDKLRSTGASFIRCIKPNLKMTSHHFEGAQILSQLQCSGMVSVLDLMQGGYPSRASFHELYNMYKKYMPDKLARLDPRLFCKALFKALGLNENDYKFGLTKVFFRPGKFAEFDQIMKSDPDHLAELVKRVNHWLTCSRWKKVQWCSLSVIKLKNKIKYRAEACIKMQKTIRMWLCKRRHKPRIDGLVKVGTLKKRLDKFNEVVSVLKDGKPEMNKQIKNLEISIDTLMAKIKSTMMTQEQIQKEYDALVKSSEELLSALQKKKQQEEEAERLRRIQEEMEKERKRREEDEKRRRKEEEERRMKLEMEAKRKQEEEERKKREDDEKRIQAEVEAQLARQKEEESQQQAVLEQERRDRELALRIAQSEAELISDEAQADLALRRSLDSYPVSKNDGTRPKMTPEQMAKEMSEFLSRGPAVLATKAAAGTKKYDLSKWKYAELRDTINTSCDIELLAACREEFHRRLKVYHAWKSKNKKRNTETEQRAPKSVTDYDFAPFLNNSPQQNPAAQIPARQREIEMNRQQRFFRIPFIRPADQYKDPQSKKKGWWYAHFDGPWIARQMELHPDKPPILLVAGKDDMEMCELNLEETGLTRKRGAEILPRQFEEIWERCGGIQYLQNAIESRQARPTYATAMLQSLLK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
56	Acetylation	FPAEEDSKKDVEDNC CCCCCCCCCCCCCCC	66.37	24431707
56	Ubiquitination	FPAEEDSKKDVEDNC CCCCCCCCCCCCCCC	66.37	32015554
57	Acetylation	PAEEDSKKDVEDNCS CCCCCCCCCCCCCCE	71.59	24469751
78	Ubiquitination	ATLLHNIKVRYSKDR HHHHCCEEEEECCCH	26.44	32015554
82	Phosphorylation	HNIKVRYSKDRIYTY CCEEEEECCCHHHHH	19.95	18452278
88	Phosphorylation	YSKDRIYTYVANILI ECCCHHHHHHHHHHH	14.78	-
100	Phosphorylation	ILIAVNPYFDIPKIY HHHHCCCCCCCCCCC	14.53	-
107	Phosphorylation	YFDIPKIYSSEAIKS CCCCCCCCCHHHHHH	16.57	20068231
108	Phosphorylation	FDIPKIYSSEAIKSY CCCCCCCCHHHHHHC	25.77	20068231
109	Phosphorylation	DIPKIYSSEAIKSYQ CCCCCCCHHHHHHCC	17.67	20068231
113	Ubiquitination	IYSSEAIKSYQGKSL CCCHHHHHHCCCCCC	50.59	29967540
114	Phosphorylation	YSSEAIKSYQGKSLG CCHHHHHHCCCCCCC	19.30	20068231
115	Phosphorylation	SSEAIKSYQGKSLGT CHHHHHHCCCCCCCC	19.11	20068231
119	Phosphorylation	IKSYQGKSLGTRPPH HHHCCCCCCCCCCCC	38.56	20068231
122	Phosphorylation	YQGKSLGTRPPHVFA CCCCCCCCCCCCHHE	45.34	20068231
133	Ubiquitination	HVFAIADKAFRDMKV CHHEEECHHHHCCCH	40.16	32015554
144	Phosphorylation	DMKVLKMSQSIIVSG CCCHHEECCEEEEEC	21.13	22210691
167	Phosphorylation	NTKFVLRYLTESYGT CHHHHHHHHHHHHCC	17.51	-
196	Ubiquitination	LEAFGNAKTVRNNNS HHHHCCCCEECCCCC	52.10	21906983
196 (in isoform 1)	Ubiquitination	-	52.10	21890473
196 (in isoform 3)	Ubiquitination	-	52.10	21890473
196 (in isoform 4)	Ubiquitination	-	52.10	21890473
196 (in isoform 5)	Ubiquitination	-	52.10	21890473
218	Phosphorylation	EIHFNEKSSVVGGFV EEEECCCCCHHHHHH	23.37	20068231
219	Phosphorylation	IHFNEKSSVVGGFVS EEECCCCCHHHHHHH	31.71	28348404
226	Phosphorylation	SVVGGFVSHYLLEKS CHHHHHHHHHHHHHC	12.26	28509920
227	Ubiquitination	VVGGFVSHYLLEKSR HHHHHHHHHHHHHCC	16.38	29901268
228	Phosphorylation	VGGFVSHYLLEKSRI HHHHHHHHHHHHCCE	12.89	20068231
232	Ubiquitination	VSHYLLEKSRICVQG HHHHHHHHCCEEEEC	45.03	29901268
240	Acetylation	SRICVQGKEERNYHI CCEEEECCHHHCCHH	39.03	26051181
266	Phosphorylation	IREKLHLSSPDNFRY HHHHHCCCCCCCHHH	29.13	21082442
267	Phosphorylation	REKLHLSSPDNFRYL HHHHCCCCCCCHHHH	42.50	25159151
297	Phosphorylation	QILQNRKSPEYLKAG HHHHCCCCHHHHHCC	21.52	21815630
297	Ubiquitination	QILQNRKSPEYLKAG HHHHCCCCHHHHHCC	21.52	32015554
300	Phosphorylation	QNRKSPEYLKAGSMK HCCCCHHHHHCCCCC	19.52	18083107
302	Ubiquitination	RKSPEYLKAGSMKDP CCCHHHHHCCCCCCC	50.20	27667366
306	Sulfoxidation	EYLKAGSMKDPLLDD HHHHCCCCCCCCCCC	5.81	30846556
307	Malonylation	YLKAGSMKDPLLDDH HHHCCCCCCCCCCCH	58.87	26320211
307	Ubiquitination	YLKAGSMKDPLLDDH HHHCCCCCCCCCCCH	58.87	32015554
326	Acetylation	RMCTAMKKIGLDDEE HHHHHHHHHCCCCHH	28.99	30584313
334	Acetylation	IGLDDEEKLDLFRVV HCCCCHHHHHHHHHH	45.30	23236377
357	Phosphorylation	IDFEEAGSTSGGCNL CCHHHCCCCCCCCCC	26.84	27251275
397	Phosphorylation	LTTRVMLTTAGGTKG EEEEEEEEECCCCCC	9.12	23403867
398	Phosphorylation	TTRVMLTTAGGTKGT EEEEEEEECCCCCCE	21.24	23403867
402	Phosphorylation	MLTTAGGTKGTVIKV EEEECCCCCCEEEEE	25.94	28152594
405	Phosphorylation	TAGGTKGTVIKVPLK ECCCCCCEEEEEECC	22.18	22617229
412	Ubiquitination	TVIKVPLKVEQANNA EEEEEECCHHHHCCH	37.34	27667366
425	Ubiquitination	NARDALAKTVYSHLF CHHHHHHHHHHHHHH	39.10	21890473
425 (in isoform 1)	Ubiquitination	-	39.10	21890473
425 (in isoform 3)	Ubiquitination	-	39.10	21890473
425 (in isoform 4)	Ubiquitination	-	39.10	21890473
425 (in isoform 5)	Ubiquitination	-	39.10	21890473
426	Phosphorylation	ARDALAKTVYSHLFD HHHHHHHHHHHHHHH	21.04	30387612
475	Phosphorylation	FEQFCINYCNEKLQQ HHHHHHHHHHHHHHH	4.09	18452278
490	Ubiquitination	FFNERILKEEQELYQ HHHHHHHHHHHHHHH	57.76	-
558	Phosphorylation	HKDHFRLTIPRKSKL CCCCEEEECCCCCCE	25.36	29514088
604	Phosphorylation	NNDALHMSLESLICE CCHHHHHCHHHHHHH	20.45	25849741
629	Ubiquitination	ESSTNNNKDTKQKAG HHCCCCCCCHHHHHC	69.74	-
632	Ubiquitination	TNNNKDTKQKAGKLS CCCCCCHHHHHCCEE	60.99	23503661
634	Ubiquitination	NNKDTKQKAGKLSFI CCCCHHHHHCCEEEE	61.74	23503661
637	Ubiquitination	DTKQKAGKLSFISVG CHHHHHCCEEEEEEC	45.90	23503661
639	Phosphorylation	KQKAGKLSFISVGNK HHHHCCEEEEEECHH	24.82	28857561
646	Ubiquitination	SFISVGNKFKTQLNL EEEEECHHHHHHHHH	42.16	23000965
646 (in isoform 1)	Ubiquitination	-	42.16	21890473
646 (in isoform 2)	Ubiquitination	-	42.16	-
646 (in isoform 3)	Ubiquitination	-	42.16	21890473
646 (in isoform 4)	Ubiquitination	-	42.16	21890473
646 (in isoform 5)	Ubiquitination	-	42.16	21890473
648	Ubiquitination	ISVGNKFKTQLNLLL EEECHHHHHHHHHHH	36.65	23000965
648 (in isoform 1)	Ubiquitination	-	36.65	21890473
648 (in isoform 3)	Ubiquitination	-	36.65	21890473
648 (in isoform 4)	Ubiquitination	-	36.65	21890473
648 (in isoform 5)	Ubiquitination	-	36.65	21890473
649	Phosphorylation	SVGNKFKTQLNLLLD EECHHHHHHHHHHHH	41.23	24719451
652	Ubiquitination	NKFKTQLNLLLDKLR HHHHHHHHHHHHHHH	20.87	33845483
657	2-Hydroxyisobutyrylation	QLNLLLDKLRSTGAS HHHHHHHHHHHCCCH	45.85	-
657	Ubiquitination	QLNLLLDKLRSTGAS HHHHHHHHHHHCCCH	45.85	33845483
660	Phosphorylation	LLLDKLRSTGASFIR HHHHHHHHCCCHHHH	41.45	21406692
661	Phosphorylation	LLDKLRSTGASFIRC HHHHHHHCCCHHHHH	30.27	21406692
664	Phosphorylation	KLRSTGASFIRCIKP HHHHCCCHHHHHHCC	23.66	21406692
721	Phosphorylation	LYNMYKKYMPDKLAR HHHHHHHHCCHHHHC	15.10	29496963
736	Ubiquitination	LDPRLFCKALFKALG CCHHHHHHHHHHHCC	40.57	23000965
736 (in isoform 2)	Ubiquitination	-	40.57	-
740	Ubiquitination	LFCKALFKALGLNEN HHHHHHHHHCCCCCC	43.48	23000965
745	Ubiquitination	LFKALGLNENDYKFG HHHHCCCCCCCCCCC	44.20	32015554
749	Phosphorylation	LGLNENDYKFGLTKV CCCCCCCCCCCEEEE	21.57	-
750	Ubiquitination	GLNENDYKFGLTKVF CCCCCCCCCCEEEEE	35.50	23000965
750 (in isoform 1)	Ubiquitination	-	35.50	21890473
750 (in isoform 3)	Ubiquitination	-	35.50	21890473
750 (in isoform 4)	Ubiquitination	-	35.50	21890473
750 (in isoform 5)	Ubiquitination	-	35.50	21890473
755	Ubiquitination	DYKFGLTKVFFRPGK CCCCCEEEEEECCCC	41.93	23000965
755 (in isoform 1)	Ubiquitination	-	41.93	21890473
755 (in isoform 2)	Ubiquitination	-	41.93	-
755 (in isoform 3)	Ubiquitination	-	41.93	21890473
755 (in isoform 4)	Ubiquitination	-	41.93	21890473
755 (in isoform 5)	Ubiquitination	-	41.93	21890473
782	Ubiquitination	DHLAELVKRVNHWLT HHHHHHHHHHHHHHH	64.35	21906983
782 (in isoform 1)	Ubiquitination	-	64.35	21890473
782 (in isoform 3)	Ubiquitination	-	64.35	21890473
782 (in isoform 4)	Ubiquitination	-	64.35	21890473
782 (in isoform 5)	Ubiquitination	-	64.35	21890473
795	Ubiquitination	LTCSRWKKVQWCSLS HHCCCCCCCEEEEEE	32.47	-
814	Ubiquitination	KNKIKYRAEACIKMQ CHHHCHHHHHHHHHH	12.97	32015554
819	Ubiquitination	YRAEACIKMQKTIRM HHHHHHHHHHHHHHH	34.85	32015554
845	Phosphorylation	DGLVKVGTLKKRLDK CCEEECCHHHHHHHH	38.09	19276368
856	Ubiquitination	RLDKFNEVVSVLKDG HHHHHHHHHHHHHCC	4.00	32015554
861	Ubiquitination	NEVVSVLKDGKPEMN HHHHHHHHCCCHHHH	63.38	32015554
877	Phosphorylation	QIKNLEISIDTLMAK HHHHEEEHHHHHHHH	12.68	26074081
880	Phosphorylation	NLEISIDTLMAKIKS HEEEHHHHHHHHHHH	19.43	26074081
886	Ubiquitination	DTLMAKIKSTMMTQE HHHHHHHHHHHCCHH	38.88	21906983
886 (in isoform 1)	Ubiquitination	-	38.88	21890473
886 (in isoform 3)	Ubiquitination	-	38.88	21890473
886 (in isoform 4)	Ubiquitination	-	38.88	21890473
886 (in isoform 5)	Ubiquitination	-	38.88	21890473
887	Phosphorylation	TLMAKIKSTMMTQEQ HHHHHHHHHHCCHHH	25.63	26074081
888	Phosphorylation	LMAKIKSTMMTQEQI HHHHHHHHHCCHHHH	13.13	18452278
891	Phosphorylation	KIKSTMMTQEQIQKE HHHHHHCCHHHHHHH	20.38	18452278
897	Ubiquitination	MTQEQIQKEYDALVK CCHHHHHHHHHHHHH	60.93	21906983
897 (in isoform 1)	Ubiquitination	-	60.93	21890473
897 (in isoform 3)	Ubiquitination	-	60.93	21890473
897 (in isoform 4)	Ubiquitination	-	60.93	21890473
897 (in isoform 5)	Ubiquitination	-	60.93	21890473
911	Phosphorylation	KSSEELLSALQKKKQ HCHHHHHHHHHHHHH	39.29	-
915	Ubiquitination	ELLSALQKKKQQEEE HHHHHHHHHHHHHHH	63.89	27667366
935	Acetylation	RIQEEMEKERKRREE HHHHHHHHHHHHHHH	62.60	26051181
988	Ubiquitination	IQAEVEAQLARQKEE HHHHHHHHHHHHHHH	23.34	33845483
993	Ubiquitination	EAQLARQKEEESQQQ HHHHHHHHHHHHHHH	62.63	21906983
993 (in isoform 1)	Ubiquitination	-	62.63	21890473
993 (in isoform 3)	Ubiquitination	-	62.63	21890473
993 (in isoform 4)	Ubiquitination	-	62.63	21890473
993 (in isoform 5)	Ubiquitination	-	62.63	21890473
997	Phosphorylation	ARQKEEESQQQAVLE HHHHHHHHHHHHHHH	36.25	27422710
1019	Phosphorylation	LALRIAQSEAELISD HHHHHHHHHHHHHCH	29.74	26657352
1025	Phosphorylation	QSEAELISDEAQADL HHHHHHHCHHHHHHH	41.86	28348404
1037	Phosphorylation	ADLALRRSLDSYPVS HHHHHHHHHHCCCCC	30.05	28258704
1039	Ubiquitination	LALRRSLDSYPVSKN HHHHHHHHCCCCCCC	47.58	29901268
1043	Ubiquitination	RSLDSYPVSKNDGTR HHHHCCCCCCCCCCC	10.92	29901268
1044	Phosphorylation	SLDSYPVSKNDGTRP HHHCCCCCCCCCCCC	22.64	28258704
1044	Ubiquitination	SLDSYPVSKNDGTRP HHHCCCCCCCCCCCC	22.64	23000965
1044 (in isoform 2)	Ubiquitination	-	22.64	-
1044 (in isoform 5)	Ubiquitination	-	22.64	21890473
1045	Ubiquitination	LDSYPVSKNDGTRPK HHCCCCCCCCCCCCC	60.33	32142685
1049	Phosphorylation	PVSKNDGTRPKMTPE CCCCCCCCCCCCCHH	46.81	28258704
1050	Ubiquitination	VSKNDGTRPKMTPEQ CCCCCCCCCCCCHHH	34.08	23000965
1051	Ubiquitination	SKNDGTRPKMTPEQM CCCCCCCCCCCHHHH	30.52	27667366
1052	Ubiquitination	KNDGTRPKMTPEQMA CCCCCCCCCCHHHHH	52.71	29901268
1053	Ubiquitination	NDGTRPKMTPEQMAK CCCCCCCCCHHHHHH	9.29	32142685
1054	Phosphorylation	DGTRPKMTPEQMAKE CCCCCCCCHHHHHHH	29.78	28348404
1054	Ubiquitination	DGTRPKMTPEQMAKE CCCCCCCCHHHHHHH	29.78	23000965
1056	Ubiquitination	TRPKMTPEQMAKEMS CCCCCCHHHHHHHHH	43.77	32015554
1058	Ubiquitination	PKMTPEQMAKEMSEF CCCCHHHHHHHHHHH	5.69	21890473
1058 (in isoform 5)	Ubiquitination	-	5.69	21890473
1060	Ubiquitination	MTPEQMAKEMSEFLS CCHHHHHHHHHHHHH	48.91	23000965
1061	Ubiquitination	TPEQMAKEMSEFLSR CHHHHHHHHHHHHHC	38.10	27667366
1063	Ubiquitination	EQMAKEMSEFLSRGP HHHHHHHHHHHHCCH	26.70	23000965
1067	Ubiquitination	KEMSEFLSRGPAVLA HHHHHHHHCCHHHHH	40.28	23000965
1067 (in isoform 1)	Ubiquitination	-	40.28	21890473
1068	Ubiquitination	EMSEFLSRGPAVLAT HHHHHHHCCHHHHHH	58.21	21890473
1069	Ubiquitination	MSEFLSRGPAVLATK HHHHHHCCHHHHHHH	15.90	23000965
1070	Ubiquitination	SEFLSRGPAVLATKA HHHHHCCHHHHHHHH	20.34	27667366
1073	Ubiquitination	LSRGPAVLATKAAAG HHCCHHHHHHHHCCC	5.64	23000965
1074	Ubiquitination	SRGPAVLATKAAAGT HCCHHHHHHHHCCCC	10.64	27667366
1075	Phosphorylation	RGPAVLATKAAAGTK CCHHHHHHHHCCCCC	19.63	22210691
1075	Ubiquitination	RGPAVLATKAAAGTK CCHHHHHHHHCCCCC	19.63	32015554
1076	Ubiquitination	GPAVLATKAAAGTKK CHHHHHHHHCCCCCC	30.35	23000965
1076 (in isoform 3)	Ubiquitination	-	30.35	21890473
1076 (in isoform 4)	Ubiquitination	-	30.35	21890473
1077	Ubiquitination	PAVLATKAAAGTKKY HHHHHHHHCCCCCCC	9.74	21890473
1079	Ubiquitination	VLATKAAAGTKKYDL HHHHHHCCCCCCCCH	30.92	32015554
1081	Ubiquitination	ATKAAAGTKKYDLSK HHHHCCCCCCCCHHH	21.45	21890473
1081 (in isoform 1)	Ubiquitination	-	21.45	21890473
1082	Ubiquitination	TKAAAGTKKYDLSKW HHHCCCCCCCCHHHC	48.71	23000965
1083	Ubiquitination	KAAAGTKKYDLSKWK HHCCCCCCCCHHHCC	43.78	27667366
1084	Phosphorylation	AAAGTKKYDLSKWKY HCCCCCCCCHHHCCH	24.54	26552605
1087	Phosphorylation	GTKKYDLSKWKYAEL CCCCCCHHHCCHHHH	33.31	26552605
1087	Ubiquitination	GTKKYDLSKWKYAEL CCCCCCHHHCCHHHH	33.31	23000965
1087 (in isoform 2)	Ubiquitination	-	33.31	-
1087 (in isoform 5)	Ubiquitination	-	33.31	21890473
1088	Ubiquitination	TKKYDLSKWKYAELR CCCCCHHHCCHHHHH	55.81	32015554
1090	Ubiquitination	KYDLSKWKYAELRDT CCCHHHCCHHHHHHH	38.02	21890473
1090 (in isoform 4)	Ubiquitination	-	38.02	21890473
1093	Ubiquitination	LSKWKYAELRDTINT HHHCCHHHHHHHCCC	41.05	23000965
1097	Phosphorylation	KYAELRDTINTSCDI CHHHHHHHCCCCCHH	15.08	21082442
1097	Ubiquitination	KYAELRDTINTSCDI CHHHHHHHCCCCCHH	15.08	21890473
1098	Ubiquitination	YAELRDTINTSCDIE HHHHHHHCCCCCHHH	6.57	29967540
1100	Phosphorylation	ELRDTINTSCDIELL HHHHHCCCCCHHHHH	27.21	21082442
1103	Ubiquitination	DTINTSCDIELLAAC HHCCCCCHHHHHHHH	36.84	23000965
1104	Ubiquitination	TINTSCDIELLAACR HCCCCCHHHHHHHHH	4.75	32142685
1106	Ubiquitination	NTSCDIELLAACREE CCCCHHHHHHHHHHH	3.94	23000965
1109	Neddylation	CDIELLAACREEFHR CHHHHHHHHHHHHHH	7.89	32015554
1109	Ubiquitination	CDIELLAACREEFHR CHHHHHHHHHHHHHH	7.89	23000965
1110	Ubiquitination	DIELLAACREEFHRR HHHHHHHHHHHHHHH	4.71	23000965
1110 (in isoform 1)	Ubiquitination	-	4.71	21890473
1112	Ubiquitination	ELLAACREEFHRRLK HHHHHHHHHHHHHHH	65.97	23000965
1114 (in isoform 5)	Phosphorylation	-	4.68	-
1116	Ubiquitination	ACREEFHRRLKVYHA HHHHHHHHHHHHHHH	51.45	23000965
1119	Ubiquitination	EEFHRRLKVYHAWKS HHHHHHHHHHHHHHC	38.65	23000965
1119 (in isoform 4)	Ubiquitination	-	38.65	21890473
1121	Phosphorylation	FHRRLKVYHAWKSKN HHHHHHHHHHHHCCC	5.57	28152594
1121	Ubiquitination	FHRRLKVYHAWKSKN HHHHHHHHHHHHCCC	5.57	29967540
1125	Ubiquitination	LKVYHAWKSKNKKRN HHHHHHHHCCCCCCC	52.95	23000965
1126	Phosphorylation	KVYHAWKSKNKKRNT HHHHHHHCCCCCCCC	30.66	24719451
1128	Neddylation	YHAWKSKNKKRNTET HHHHHCCCCCCCCHH	63.27	32015554
1128	Ubiquitination	YHAWKSKNKKRNTET HHHHHCCCCCCCCHH	63.27	21890473
1132	Ubiquitination	KSKNKKRNTETEQRA HCCCCCCCCHHHHHC	51.66	23000965
1132 (in isoform 1)	Ubiquitination	-	51.66	21890473
1133	O-linked_Glycosylation	SKNKKRNTETEQRAP CCCCCCCCHHHHHCC	48.60	30379171
1135	O-linked_Glycosylation	NKKRNTETEQRAPKS CCCCCCHHHHHCCCC	35.07	30379171
1137	Phosphorylation	KRNTETEQRAPKSVT CCCCHHHHHCCCCCC	55.01	17389395
1141	Neddylation	ETEQRAPKSVTDYDF HHHHHCCCCCCCCCC	57.48	32015554
1141	Ubiquitination	ETEQRAPKSVTDYDF HHHHHCCCCCCCCCC	57.48	23000965
1142	Phosphorylation	TEQRAPKSVTDYDFA HHHHCCCCCCCCCCH	29.23	26356563
1142 (in isoform 6)	Phosphorylation	-	29.23	22199227
1144	Phosphorylation	QRAPKSVTDYDFAPF HHCCCCCCCCCCHHH	35.61	26356563
1144 (in isoform 6)	Phosphorylation	-	35.61	22199227
1146	Phosphorylation	APKSVTDYDFAPFLN CCCCCCCCCCHHHCC	12.00	27259358
1146 (in isoform 4)	Phosphorylation	-	12.00	-
1146 (in isoform 6)	Phosphorylation	-	12.00	21609022
1151	Ubiquitination	TDYDFAPFLNNSPQQ CCCCCHHHCCCCCCC	11.63	23000965
1151 (in isoform 5)	Ubiquitination	-	11.63	21890473
1155	Phosphorylation	FAPFLNNSPQQNPAA CHHHCCCCCCCCCCH	24.02	25849741
1155	Ubiquitination	FAPFLNNSPQQNPAA CHHHCCCCCCCCCCH	24.02	30230243
1156	Ubiquitination	APFLNNSPQQNPAAQ HHHCCCCCCCCCCHH	41.73	23000965
1157	Ubiquitination	PFLNNSPQQNPAAQI HHCCCCCCCCCCHHC	56.34	23000965
1158	Ubiquitination	FLNNSPQQNPAAQIP HCCCCCCCCCCHHCC	62.35	23503661
1160	Ubiquitination	NNSPQQNPAAQIPAR CCCCCCCCCHHCCHH	25.32	23000965
1160 (in isoform 2)	Ubiquitination	-	25.32	-
1161	Ubiquitination	NSPQQNPAAQIPARQ CCCCCCCCHHCCHHH	21.39	23000965
1165	Ubiquitination	QNPAAQIPARQREIE CCCCHHCCHHHHHHH	14.87	23000965
1166	Ubiquitination	NPAAQIPARQREIEM CCCHHCCHHHHHHHH	23.13	23000965
1167	Ubiquitination	PAAQIPARQREIEMN CCHHCCHHHHHHHHH	30.63	23000965
1168	Ubiquitination	AAQIPARQREIEMNR CHHCCHHHHHHHHHH	49.84	23503661
1170	Ubiquitination	QIPARQREIEMNRQQ HCCHHHHHHHHHHHH	34.66	23000965
1174	Ubiquitination	RQREIEMNRQQRFFR HHHHHHHHHHHHHCC	26.31	23000965
1175	Ubiquitination	QREIEMNRQQRFFRI HHHHHHHHHHHHCCC	32.47	23000965
1176	Ubiquitination	REIEMNRQQRFFRIP HHHHHHHHHHHCCCC	33.52	23000965
1177	Ubiquitination	EIEMNRQQRFFRIPF HHHHHHHHHHCCCCC	40.69	23503661
1179	Ubiquitination	EMNRQQRFFRIPFIR HHHHHHHHCCCCCCC	4.13	23000965
1180	Ubiquitination	MNRQQRFFRIPFIRP HHHHHHHCCCCCCCC	8.24	23000965
1181	Ubiquitination	NRQQRFFRIPFIRPA HHHHHHCCCCCCCCH	32.72	23503661
1183	Ubiquitination	QQRFFRIPFIRPADQ HHHHCCCCCCCCHHH	17.85	23000965
1183 (in isoform 1)	Ubiquitination	-	17.85	21890473
1183 (in isoform 4)	Ubiquitination	-	17.85	21890473
1184	Ubiquitination	QRFFRIPFIRPADQY HHHCCCCCCCCHHHC	7.42	23000965
1185	Ubiquitination	RFFRIPFIRPADQYK HHCCCCCCCCHHHCC	4.29	23000965
1186	Ubiquitination	FFRIPFIRPADQYKD HCCCCCCCCHHHCCC	22.26	23503661
1188	Ubiquitination	RIPFIRPADQYKDPQ CCCCCCCHHHCCCCC	13.49	23000965
1189	Ubiquitination	IPFIRPADQYKDPQS CCCCCCHHHCCCCCC	55.83	23000965
1190	Ubiquitination	PFIRPADQYKDPQSK CCCCCHHHCCCCCCC	49.64	23503661
1191	Phosphorylation	FIRPADQYKDPQSKK CCCCHHHCCCCCCCC	20.22	-
1192	Ubiquitination	IRPADQYKDPQSKKK CCCHHHCCCCCCCCC	58.25	23000965
1192 (in isoform 3)	Ubiquitination	-	58.25	21890473
1196	Phosphorylation	DQYKDPQSKKKGWWY HHCCCCCCCCCCEEE	52.40	-
1197	Ubiquitination	QYKDPQSKKKGWWYA HCCCCCCCCCCEEEE	53.94	23000965
1198	Ubiquitination	YKDPQSKKKGWWYAH CCCCCCCCCCEEEEE	62.86	23000965
1199	Ubiquitination	KDPQSKKKGWWYAHF CCCCCCCCCEEEEEC	64.60	23503661
1253	Ubiquitination	TRKRGAEILPRQFEE CCHHCCCCCHHHHHH	6.77	23000965
1257	Ubiquitination	GAEILPRQFEEIWER CCCCCHHHHHHHHHH	48.43	32015554
1262	Ubiquitination	PRQFEEIWERCGGIQ HHHHHHHHHHCCHHH	7.11	23000965
1262 (in isoform 2)	Ubiquitination	-	7.11	-
1263	Ubiquitination	RQFEEIWERCGGIQY HHHHHHHHHCCHHHH	43.70	23000965
1272	Ubiquitination	CGGIQYLQNAIESRQ CCHHHHHHHHHHHCC	32.16	23000965
1276	Ubiquitination	QYLQNAIESRQARPT HHHHHHHHHCCCCHH	37.14	23000965
1281	Ubiquitination	AIESRQARPTYATAM HHHHCCCCHHHHHHH	18.76	23000965
1283	Phosphorylation	ESRQARPTYATAMLQ HHCCCCHHHHHHHHH	21.89	25106551
1284	Phosphorylation	SRQARPTYATAMLQS HCCCCHHHHHHHHHH	12.49	25106551
1285	Ubiquitination	RQARPTYATAMLQSL CCCCHHHHHHHHHHH	7.43	23000965
1291	Phosphorylation	YATAMLQSLLK---- HHHHHHHHHHC----	31.54	24719451
1294	Ubiquitination	AMLQSLLK------- HHHHHHHC-------	64.68	23000965

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MYO6_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MYO6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MYO6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DAB2_HUMAN	DAB2	physical	11967127
DAB2_HUMAN	DAB2	physical	11906161
GIPC1_HUMAN	GIPC1	physical	12857860
DAB1_HUMAN	DAB1	physical	11967127
TAXB1_HUMAN	TAX1BP1	physical	17635994
CACO2_HUMAN	CALCOCO2	physical	17635994
OPTN_HUMAN	OPTN	physical	15837803
DAB2_HUMAN	DAB2	physical	15837803
LMTK2_HUMAN	LMTK2	physical	19855435
GIPC1_HUMAN	GIPC1	physical	19855435
AP2A1_HUMAN	AP2A1	physical	11447109
CLH1_HUMAN	CLTC	physical	11447109
CAZA1_HUMAN	CAPZA1	physical	9852149
RPB1_HUMAN	POLR2A	physical	16949370
LMTK2_HUMAN	LMTK2	physical	18429820
DAB2_HUMAN	DAB2	physical	18429820
DAB2_HUMAN	DAB2	physical	17187061
LMTK2_HUMAN	LMTK2	physical	18029400
TOM1_HUMAN	TOM1	physical	23023224
TM1L2_HUMAN	TOM1L2	physical	23023224
MYO6_HUMAN	MYO6	physical	22992744
DPP9_HUMAN	DPP9	physical	26344197
NHLC2_HUMAN	NHLRC2	physical	26344197
TAXB1_HUMAN	TAX1BP1	physical	26451915
CACO2_HUMAN	CALCOCO2	physical	26451915
OPTN_HUMAN	OPTN	physical	26451915
UBC_HUMAN	UBC	physical	26971995
GIPC1_HUMAN	GIPC1	physical	26971995
CACO2_HUMAN	CALCOCO2	physical	26971995
OPTN_HUMAN	OPTN	physical	26971995
TAXB1_HUMAN	TAX1BP1	physical	26971995
CLH1_HUMAN	CLTC	physical	26950368
SC16A_HUMAN	SEC16A	physical	26950368
AP2B1_HUMAN	AP2B1	physical	26950368
AP2A2_HUMAN	AP2A2	physical	26950368
AP2A1_HUMAN	AP2A1	physical	26950368
AP2M1_HUMAN	AP2M1	physical	26950368
EPN4_HUMAN	CLINT1	physical	26950368
P3C2A_HUMAN	PIK3C2A	physical	26950368
PICAL_HUMAN	PICALM	physical	26950368
EPS15_HUMAN	EPS15	physical	26950368
REPS2_HUMAN	REPS2	physical	26950368
COPB2_HUMAN	COPB2	physical	26950368
DDB1_HUMAN	DDB1	physical	26950368
SYEP_HUMAN	EPRS	physical	26950368
DCAF1_HUMAN	VPRBP	physical	26950368
DCTN1_HUMAN	DCTN1	physical	26950368
NOG1_HUMAN	GTPBP4	physical	26950368
ARHGC_HUMAN	ARHGEF12	physical	26950368
YTDC2_HUMAN	YTHDC2	physical	26950368
DCTN2_HUMAN	DCTN2	physical	26950368
DOCK7_HUMAN	DOCK7	physical	26950368
POTEI_HUMAN	POTEI	physical	28514442
NEB1_HUMAN	PPP1R9A	physical	28514442
CUED1_HUMAN	CUEDC1	physical	28514442
ARHGC_HUMAN	ARHGEF12	physical	28514442
GELS_HUMAN	GSN	physical	28514442
REPS1_HUMAN	REPS1	physical	28514442
DOCK7_HUMAN	DOCK7	physical	27018747
OPTN_HUMAN	OPTN	physical	19805065
DAB2_HUMAN	DAB2	physical	19805065
MYO6_HUMAN	MYO6	physical	19805065

Drug and Disease Associations

• Kegg Disease
• H00604: Deafness, autosomal dominant
• H00605: Deafness, autosomal recessive
• OMIM Disease
• 606346: Deafness, autosomal dominant, 22 (DFNA22)
• 607821: Deafness, autosomal recessive, 37 (DFNB37)
• 606346: Deafness, sensorineural, with hypertrophic cardiomyopathy (DFNHCM)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Multiple reaction monitoring for robust quantitative proteomicanalysis of cellular signaling networks.";
Wolf-Yadlin A., Hautaniemi S., Lauffenburger D.A., White F.M.;
Proc. Natl. Acad. Sci. U.S.A. 104:5860-5865(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-1146, AND MASSSPECTROMETRY.
PubMed: 17389395