DAB1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DAB1_HUMAN
• UniProt AC: O75553
• Protein Name: Disabled homolog 1
• Gene Name: DAB1
• Organism: Homo sapiens (Human).
• Sequence Length: 588
• Protein Description: Adapter molecule functioning in neural development. May regulate SIAH1 activity..
• Protein Sequence: MSTETELQVAVKTSAKKDSRKKGQDRSEATLIKRFKGEGVRYKAKLIGIDEVSAARGDKLCQDSMMKLKGVVAGARSKGEHKQKIFLTISFGGIKIFDEKTGALQHHHAVHEISYIAKDITDHRAFGYVCGKEGNHRFVAIKTAQAAEPVILDLRDLFQLIYELKQREELEKKAQKDKQCEQAVYQTILEEDVEDPVYQYIVFEAGHEPIRDPETEENIYQVPTSQKKEGVYDVPKSQPVSNGYSFEDFEERFAAATPNRNLPTDFDEIFEATKAVTQLELFGDMSTPPDITSPPTPATPGDAFIPSSSQTLPASADVFSSVPFGTAAVPSGYVAMGAVLPSFWGQQPLVQQQMVMGAQPPVAQVMPGAQPIAWGQPGLFPATQQPWPTVAGQFPPAAFMPTQTVMPLPAAMFQGPLTPLATVPGTSDSTRSSPQTDKPRQKMGKETFKDFQMAQPPPVPSRKPDQPSLTCTSEAFSSYFNKVGVAQDTDDCDDFDISQLNLTPVTSTTPSTNSPPTPAPRQSSPSKSSASHASDPTTDDIFEEGFESPSKSEEQEAPDGSQASSNSDPFGEPSGEPSGDNISPQAGS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
43	Ubiquitination	KGEGVRYKAKLIGID CCCCCCEEEEEECCC	28.60	-
45	Ubiquitination	EGVRYKAKLIGIDEV CCCCEEEEEECCCHH	36.16	-
64	Phosphorylation	GDKLCQDSMMKLKGV CCCCCHHHHHHHHHH	8.56	26657352
77	Phosphorylation	GVVAGARSKGEHKQK HHHHCCCCCCCCCCC	44.47	26657352
84	Sumoylation	SKGEHKQKIFLTISF CCCCCCCCEEEEEEE	39.98	-
185 (in isoform 5)	Phosphorylation	-	11.71	28674419
185 (in isoform 4)	Phosphorylation	-	11.71	28674419
185	Phosphorylation	KQCEQAVYQTILEED HHHHHHHHHHHHHHH	11.71	10959835
198	Phosphorylation	EDVEDPVYQYIVFEA HHCCCCCCEEEEEEC	10.86	11279201
200	Phosphorylation	VEDPVYQYIVFEAGH CCCCCCEEEEEECCC	4.95	10959835
220	Phosphorylation	PETEENIYQVPTSQK CCCCCCEEECCCCCC	18.29	19116273
224	Phosphorylation	ENIYQVPTSQKKEGV CCEEECCCCCCCCCC	44.95	26434552
225	Phosphorylation	NIYQVPTSQKKEGVY CEEECCCCCCCCCCC	33.65	26434552
232	Phosphorylation	SQKKEGVYDVPKSQP CCCCCCCCCCCCCCC	23.29	25884760
491	Phosphorylation	GVAQDTDDCDDFDIS CCCCCCCCCCCCCHH	39.58	12077184
506	Phosphorylation	QLNLTPVTSTTPSTN HCCCEECCCCCCCCC	22.89	-
515	Phosphorylation	TTPSTNSPPTPAPRQ CCCCCCCCCCCCCCC	38.56	12077184
524	Phosphorylation	TPAPRQSSPSKSSAS CCCCCCCCCCCCCCC	25.50	19472218
526	Phosphorylation	APRQSSPSKSSASHA CCCCCCCCCCCCCCC	47.30	-
548	Phosphorylation	IFEEGFESPSKSEEQ HHHHCCCCCCCCCCC	32.01	12077184

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
524	S	Phosphorylation	Kinase	CDK5	Q00535	Uniprot
524	S	Phosphorylation	Kinase	CDK-FAMILY	-	GPS
524	S	Phosphorylation	Kinase	CDK_GROUP	-	PhosphoELM
548	S	Phosphorylation	Kinase	CDK-FAMILY	-	GPS
548	S	Phosphorylation	Kinase	CDK_GROUP	-	PhosphoELM
-	K	Ubiquitination	E3 ubiquitin ligase	SOCS4	Q8WXH5	PMID:24210661

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
524	S	Phosphorylation	Also phosphorylated on Ser-524 independently of reelin signaling.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DAB1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SIAH1_HUMAN	SIAH1	physical	12646221
LRP1_HUMAN	LRP1	physical	10827173
LRP2_HUMAN	LRP2	physical	10827173
LRP2_HUMAN	LRP2	physical	12508107
APLP1_HUMAN	APLP1	physical	10460257
A4_HUMAN	APP	physical	10460257
APLP2_HUMAN	APLP2	physical	10460257
LDLR_HUMAN	LDLR	physical	9837937
LRP1_HUMAN	LRP1	physical	9837937
SH3K1_HUMAN	SH3KBP1	physical	18076569
A4_HUMAN	APP	physical	21832049
ERBB2_HUMAN	ERBB2	physical	16273093
ERBB3_HUMAN	ERBB3	physical	16273093
MBNL1_HUMAN	MBNL1	physical	25416956
ROR2_HUMAN	ROR2	physical	25416956
PIN1_HUMAN	PIN1	physical	25416956
RSMB_HUMAN	SNRPB	physical	25416956
TCEA2_HUMAN	TCEA2	physical	25416956
HYAL3_HUMAN	HYAL3	physical	25416956
BHE40_HUMAN	BHLHE40	physical	25416956
PPIG_HUMAN	PPIG	physical	25416956
MAGD1_HUMAN	MAGED1	physical	25416956
DAZP2_HUMAN	DAZAP2	physical	25416956
SERF2_HUMAN	SERF2	physical	25416956
SIRB1_HUMAN	SIRPB1	physical	25416956
SIRBL_HUMAN	SIRPB1	physical	25416956
ARI5A_HUMAN	ARID5A	physical	25416956
CLASR_HUMAN	CLASRP	physical	25416956
POGZ_HUMAN	POGZ	physical	25416956
F168A_HUMAN	FAM168A	physical	25416956
RFOX2_HUMAN	RBFOX2	physical	25416956
ZBT32_HUMAN	ZBTB32	physical	25416956
VENTX_HUMAN	VENTX	physical	25416956
TOLIP_HUMAN	TOLLIP	physical	25416956
UBP53_HUMAN	USP53	physical	25416956
ZCH10_HUMAN	ZCCHC10	physical	25416956
NTAQ1_HUMAN	WDYHV1	physical	25416956
STRBP_HUMAN	STRBP	physical	25416956
MBNL3_HUMAN	MBNL3	physical	25416956
SMAP2_HUMAN	SMAP2	physical	25416956
HMBX1_HUMAN	HMBOX1	physical	25416956
RAM_HUMAN	FAM103A1	physical	25416956
RHXF2_HUMAN	RHOXF2	physical	25416956
LNX1_HUMAN	LNX1	physical	25416956
ZC3HA_HUMAN	ZC3H10	physical	25416956
CA094_HUMAN	C1orf94	physical	25416956
NAF1_HUMAN	NAF1	physical	25416956
HNRLL_HUMAN	HNRNPLL	physical	25416956
ZN488_HUMAN	ZNF488	physical	25416956
PR20E_HUMAN	PRR20A	physical	25416956
PR20C_HUMAN	PRR20A	physical	25416956
PR20D_HUMAN	PRR20A	physical	25416956
PR20B_HUMAN	PRR20A	physical	25416956
PR20A_HUMAN	PRR20A	physical	25416956
CIART_HUMAN	CIART	physical	25416956
TMTC3_HUMAN	TMTC3	physical	25416956
TEANC_HUMAN	TCEANC	physical	25416956
LEG9B_HUMAN	LGALS9B	physical	25416956
KRA81_HUMAN	KRTAP8-1	physical	25416956
KR195_HUMAN	KRTAP19-5	physical	25416956
KR197_HUMAN	KRTAP19-7	physical	25416956
LEG9C_HUMAN	LGALS9C	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.