UBP53_HUMAN - dbPTM
UBP53_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID UBP53_HUMAN
UniProt AC Q70EK8
Protein Name Inactive ubiquitin carboxyl-terminal hydrolase 53
Gene Name USP53 {ECO:0000312|HGNC:HGNC:29255}
Organism Homo sapiens (Human).
Sequence Length 1073
Subcellular Localization Cell junction, tight junction .
Protein Description Tight junction-associated protein that is involved in the survival of auditory hair cells and hearing. Maybe by modulating the barrier properties and mechanical stability of tight junctions (By similarity). Has no peptidase activity. [PubMed: 14715245]
Protein Sequence MAWVKFLRKPGGNLGKVYQPGSMLSLAPTKGLLNEPGQNSCFLNSAVQVLWQLDIFRRSLRVLTGHVCQGDACIFCALKTIFAQFQHSREKALPSDNIRHALAESFKDEQRFQLGLMDDAAECFENMLERIHFHIVPSRDADMCTSKSCITHQKFAMTLYEQCVCRSCGASSDPLPFTEFVRYISTTALCNEVERMLERHERFKPEMFAELLQAANTTDDYRKCPSNCGQKIKIRRVLMNCPEIVTIGLVWDSEHSDLTEAVVRNLATHLYLPGLFYRVTDENAKNSELNLVGMICYTSQHYCAFAFHTKSSKWVFFDDANVKEIGTRWKDVVSKCIRCHFQPLLLFYANPDGTAVSTEDALRQVISWSHYKSVAENMGCEKPVIHKSDNLKENGFGDQAKQRENQKFPTDNISSSNRSHSHTGVGKGPAKLSHIDQREKIKDISRECALKAIEQKNLLSSQRKDLEKGQRKDLGRHRDLVDEDLSHFQSGSPPAPNGFKQHGNPHLYHSQGKGSYKHDRVVPQSRASAQIISSSKSQILAPGEKITGKVKSDNGTGYDTDSSQDSRDRGNSCDSSSKSRNRGWKPMRETLNVDSIFSESEKRQHSPRHKPNISNKPKSSKDPSFSNWPKENPKQKGLMTIYEDEMKQEIGSRSSLESNGKGAEKNKGLVEGKVHGDNWQMQRTESGYESSDHISNGSTNLDSPVIDGNGTVMDISGVKETVCFSDQITTSNLNKERGDCTSLQSQHHLEGFRKELRNLEAGYKSHEFHPESHLQIKNHLIKRSHVHEDNGKLFPSSSLQIPKDHNAREHIHQSDEQKLEKPNECKFSEWLNIENSERTGLPFHVDNSASGKRVNSNEPSSLWSSHLRTVGLKPETAPLIQQQNIMDQCYFENSLSTECIIRSASRSDGCQMPKLFCQNLPPPLPPKKYAITSVPQSEKSESTPDVKLTEVFKATSHLPKHSLSTASEPSLEVSTHMNDERHKETFQVRECFGNTPNCPSSSSTNDFQANSGAIDAFCQPELDSISTCPNETVSLTTYFSVDSCMTDTYRLKYHQRPKLSFPESSGFCNNSLS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
18PhosphorylationGGNLGKVYQPGSMLS
CCCCCCCCCCCCCHH		16.6924248375
22PhosphorylationGKVYQPGSMLSLAPT
CCCCCCCCCHHCCCC		24.1928857561
25PhosphorylationYQPGSMLSLAPTKGL
CCCCCCHHCCCCCCC		17.5328857561
29PhosphorylationSMLSLAPTKGLLNEP
CCHHCCCCCCCCCCC		31.9424248375
95PhosphorylationSREKALPSDNIRHAL
HHHHCCCCCCHHHHH		44.11-
148PhosphorylationADMCTSKSCITHQKF
CCCCCCCHHHHHHHH		15.5430266825
151PhosphorylationCTSKSCITHQKFAMT
CCCCHHHHHHHHHHH		23.6830266825
231UbiquitinationCPSNCGQKIKIRRVL
CCCCCCCHHHHHHHH		31.11-
328MethylationNVKEIGTRWKDVVSK
CHHHHHHHHHHHHHH		32.9824411277
369PhosphorylationLRQVISWSHYKSVAE
HHHHHCHHHHHHHHH		15.33-
490PhosphorylationEDLSHFQSGSPPAPN
HHHHHHHCCCCCCCC		40.0525850435
492PhosphorylationLSHFQSGSPPAPNGF
HHHHHCCCCCCCCCC		32.7225850435
510PhosphorylationGNPHLYHSQGKGSYK
CCCCCCCCCCCCCCC		27.3728348404
572PhosphorylationDSRDRGNSCDSSSKS
CCCCCCCCCCCCHHH		23.33-
590PhosphorylationGWKPMRETLNVDSIF
CCCCHHHHCCHHHCC		17.1730576142
619PhosphorylationNISNKPKSSKDPSFS
CCCCCCCCCCCCCCC		51.6626657352
642PhosphorylationQKGLMTIYEDEMKQE
CCCCEEEEHHHHHHH		14.2527642862
658PhosphorylationGSRSSLESNGKGAEK
HCCHHHHHCCCCCCC		57.0624114839
725PhosphorylationVKETVCFSDQITTSN
CCEEEEECCEEECCC		24.3928842319
763PhosphorylationLRNLEAGYKSHEFHP
HHHHHHHHCCCCCCC		19.1627067055
765PhosphorylationNLEAGYKSHEFHPES
HHHHHHCCCCCCCHH		21.5527067055
772PhosphorylationSHEFHPESHLQIKNH
CCCCCCHHHHHHHCH		33.6727067055
796PhosphorylationDNGKLFPSSSLQIPK
CCCEECCCCCCCCCC		25.8122617229
798PhosphorylationGKLFPSSSLQIPKDH
CEECCCCCCCCCCCC		28.7322617229
839PhosphorylationNIENSERTGLPFHVD
CCCCCCCCCCCEEEC		38.73-
848PhosphorylationLPFHVDNSASGKRVN
CCEEECCCCCCCCCC		21.24-
929PhosphorylationPPLPPKKYAITSVPQ
CCCCCCCCEEEECCC		14.9029496907
949PhosphorylationSTPDVKLTEVFKATS
CCCCCCHHHHHHHHC		25.1230576142
955PhosphorylationLTEVFKATSHLPKHS
HHHHHHHHCCCCCCC		19.7830576142
956PhosphorylationTEVFKATSHLPKHSL
HHHHHHHCCCCCCCC		28.0830576142
1060PhosphorylationYHQRPKLSFPESSGF
ECCCCCCCCCCCCCC		44.9030576142
1071PhosphorylationSSGFCNNSLS-----
CCCCCCCCCC-----		18.9230576142
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of UBP53_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of UBP53_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of UBP53_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ARGI1_HUMANARG1physical
19615732
ZA2G_HUMANAZGP1physical
19615732
BLMH_HUMANBLMHphysical
19615732
CATA_HUMANCATphysical
19615732
CYTA_HUMANCSTAphysical
19615732
DSG1_HUMANDSG1physical
19615732
FLNC_HUMANFLNCphysical
19615732
HCFC1_HUMANHCFC1physical
19615732
2AAB_HUMANPPP2R1Bphysical
19615732
PSA6_HUMANPSMA6physical
19615732
RL26_HUMANRPL26physical
19615732
TGM3_HUMANTGM3physical
19615732
RAD50_HUMANRAD50physical
19615732
CASPE_HUMANCASP14physical
19615732
CPNE7_HUMANCPNE7physical
19615732
YAED1_HUMANYAE1D1physical
19615732
K2C1B_HUMANKRT77physical
19615732
DDB2_HUMANDDB2physical
23159851
ZEB1_HUMANZEB1physical
29119051
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of UBP53_HUMAN

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Related Literatures of Post-Translational Modification

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